iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007987

Ensembl Protein ID

AAS54862

UniProt Accession

Q74Z34; UBC6_ASHGO

Genbank Protein ID

AAS54862.1

Protein Name

Ubiquitin-conjugating enzyme E2 6; E2 ubiquitin-conjugating enzyme 6; Ubiquitin carrier protein UBC6; Ubiquitin-protein ligase UBC6

Genbank Nucleotide ID

AE016820

Gene Name

UBC6; AGR372W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AGR372W	AAS54862	AAS54862

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.90e-32	108.1	9	128

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.eeekWspalsves 100
           Rl ke+k ++++pp++i+a p+++ ++  w+++i+Gp++tpYe+g+++ ++ fp+dYPf+PP +++lt+  ++ + en+++Cls+ + ++++W+p +sv++
   Q: 9    RLSKEYKMMTENPPPYIVAAPKED-NILVWHYVITGPPETPYEDGQYHGTLVFPNDYPFNPPAIRMLTP--NGRFRENTRLCLSMSDyHPDTWNPSWSVAT 106
           89**********************.9*******************************************..9**************889************ PP
   S: 101  vllsiqsllaepnpesplneea 122
           +l+++ s++++ + + +  e+ 
   Q: 107  ILTGLLSFMTTDESSIGTMEST 128
           *********7765554444433 PP

Organism

Ashbya gossypii

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.

Protein Sequence
(Fasta)

MASRQAYKRL SKEYKMMTEN PPPYIVAAPK EDNILVWHYV ITGPPETPYE DGQYHGTLVF 60
PNDYPFNPPA IRMLTPNGRF RENTRLCLSM SDYHPDTWNP SWSVATILTG LLSFMTTDES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATCAA GACAGGCGTA CAAGCGGCTC TCAAAGGAGT ACAAAATGAT GACCGAGAAC 60
CCCCCGCCCT ACATCGTGGC AGCACCAAAG GAAGACAATA TCCTGGTGTG GCACTACGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

ago:AGOS_AGR372W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001180	Aegilops tauschii	47.30	7.00e-22	95.90
IUUC-Aml-002152	Ailuropoda melanoleuca	53.18	3.00e-54	202.00
IUUC-Atr-003156	Amborella trichopoda	45.86	2.00e-47	179.00
IUUC-Apl-004224	Anas platyrhynchos	54.55	1.00e-50	191.00
IUUC-Aca-005049	Anolis carolinensis	50.29	4.00e-52	195.00
IUUC-Aly-005734	Arabidopsis lyrata	36.97	2.00e-44	169.00
IUUC-Ath-006640	Arabidopsis thaliana	45.00	9.00e-42	160.00
IUUC-Acl-008060	Aspergillus clavatus	59.31	2.00e-53	199.00
IUUC-Afl-008561	Aspergillus flavus	57.93	1.00e-52	197.00
IUUC-Afu-008860	Aspergillus fumigatus	59.31	3.00e-53	199.00
IUUC-Ani-009333	Aspergillus nidulans	48.97	2.00e-53	199.00
IUUC-Ang-009810	Aspergillus niger	59.31	3.00e-53	199.00
IUUC-Aor-010127	Aspergillus oryzae	57.93	1.00e-52	197.00
IUUC-Ate-010362	Aspergillus terreus	57.93	8.00e-53	197.00
IUUC-Ame-010627	Astyanax mexicanus	48.91	2.00e-52	196.00
IUUC-Bgr-012069	Blumeria graminis	58.62	2.00e-53	200.00
IUUC-Bta-012472	Bos taurus	52.60	7.00e-54	201.00
IUUC-Bci-013843	Botrytis cinerea	59.31	6.00e-52	195.00
IUUC-Bdi-014467	Brachypodium distachyon	50.00	3.00e-49	185.00
IUUC-Bol-016116	Brassica oleracea	45.62	6.00e-43	164.00
IUUC-Bra-017777	Brassica rapa	45.62	2.00e-42	162.00
IUUC-Cel-018278	Caenorhabditis elegans	49.73	6.00e-47	177.00
IUUC-Cja-018817	Callithrix jacchus	53.10	2.00e-46	177.00
IUUC-Cfa-020885	Canis familiaris	53.18	3.00e-54	202.00
IUUC-Cpo-022326	Cavia porcellus	42.40	4.00e-54	202.00
IUUC-Cre-022635	Chlamydomonas reinhardtii	50.92	1.00e-48	183.00
IUUC-Csa-023646	Chlorocebus sabaeus	52.60	3.00e-54	202.00
IUUC-Cho-025075	Choloepus hoffmanni	44.52	5.00e-33	131.00
IUUC-Cin-025389	Ciona intestinalis	55.28	5.00e-53	197.00
IUUC-Csv-026315	Ciona savignyi	44.29	6.00e-54	201.00
IUUC-Cgl-026602	Colletotrichum gloeosporioides	60.42	2.00e-51	193.00
IUUC-Cne-026808	Cryptococcus neoformans	51.75	7.00e-44	167.00
IUUC-Cme-027189	Cyanidioschyzon merolae	36.36	5.00e-24	102.00
IUUC-Dre-028455	Danio rerio	49.46	5.00e-53	198.00
IUUC-Dno-029667	Dasypus novemcinctus	52.02	2.00e-53	199.00
IUUC-Dor-030747	Dipodomys ordii	50.68	3.00e-41	159.00
IUUC-Dse-031231	Dothistroma septosporum	55.24	8.00e-49	184.00
IUUC-Dme-031841	Drosophila melanogaster	51.88	7.00e-51	191.00
IUUC-Ete-032258	Echinops telfairi	47.19	1.00e-47	181.00
IUUC-Eca-034179	Equus caballus	43.07	5.00e-33	132.00
IUUC-Eeu-034443	Erinaceus europaeus	41.50	5.00e-40	155.00
IUUC-Fca-036167	Felis catus	48.00	3.00e-42	162.00
IUUC-Fal-037114	Ficedula albicollis	54.55	1.00e-50	190.00
IUUC-Fox-037957	Fusarium oxysporum	64.80	6.00e-49	184.00
IUUC-Fso-038277	Fusarium solani	61.38	1.00e-52	197.00
IUUC-Gmo-039501	Gadus morhua	51.23	6.00e-52	194.00
IUUC-Ggr-040010	Gaeumannomyces graminis	59.44	2.00e-51	193.00
IUUC-Gga-041257	Gallus gallus	53.90	3.00e-50	189.00
IUUC-Gac-041433	Gasterosteus aculeatus	50.87	2.00e-52	196.00
IUUC-Gma-044091	Glycine max	38.56	3.00e-44	169.00
IUUC-Ggo-044437	Gorilla gorilla	54.74	1.00e-45	174.00
IUUC-Hsa-046693	Homo sapiens	52.02	8.00e-54	201.00
IUUC-Hvu-047328	Hordeum vulgare	43.57	2.00e-34	137.00
IUUC-Itr-048477	Ictidomys tridecemlineatus	52.02	1.00e-53	200.00
IUUC-Kpa-049391	Komagataella pastoris	48.73	1.00e-61	226.00
IUUC-Lch-049617	Latimeria chalumnae	54.55	2.00e-51	192.00
IUUC-Lpe-050949	Leersia perrieri	48.33	2.00e-47	179.00
IUUC-Loc-052157	Lepisosteus oculatus	50.87	8.00e-53	197.00
IUUC-Lma-053128	Leptosphaeria maculans	58.62	1.00e-51	194.00
IUUC-Laf-054455	Loxodonta africana	52.02	1.00e-53	200.00
IUUC-Mcc-054756	Macaca mulatta	52.60	3.00e-54	202.00
IUUC-Meu-056106	Macropus eugenii	54.47	7.00e-40	155.00
IUUC-Mor-057202	Magnaporthe oryzae	45.07	9.00e-52	194.00
IUUC-Mpo-057349	Magnaporthe poae	59.44	2.00e-51	192.00
IUUC-Mtr-058271	Medicago truncatula	36.51	3.00e-41	159.00
IUUC-Mla-058894	Melampsora laricipopulina	59.44	8.00e-54	200.00
IUUC-Mga-059493	Meleagris gallopavo	53.90	3.00e-50	189.00
IUUC-Mvi-060232	Microbotryum violaceum	50.30	3.00e-49	186.00
IUUC-Mmr-060957	Microcebus murinus	42.40	2.00e-53	199.00
IUUC-Mdo-062141	Monodelphis domestica	52.60	4.00e-54	202.00
IUUC-Mmu-063882	Mus musculus	52.02	1.00e-53	200.00
IUUC-Mac-064510	Musa acuminata	48.24	1.00e-46	177.00
IUUC-Mpu-065902	Mustela putorius furo	53.18	3.00e-54	202.00
IUUC-Mlu-068008	Myotis lucifugus	52.02	5.00e-52	195.00
IUUC-Nfi-068515	Neosartorya fischeri	59.31	2.00e-53	199.00
IUUC-Ncr-068755	Neurospora crassa	60.00	7.00e-53	198.00
IUUC-Nle-069166	Nomascus leucogenys	43.07	7.00e-33	132.00
IUUC-Opr-071201	Ochotona princeps	48.85	9.00e-39	150.00
IUUC-Ont-071311	Oreochromis niloticus	50.87	2.00e-52	196.00
IUUC-Oan-073310	Ornithorhynchus anatinus	51.45	1.00e-52	197.00
IUUC-Ocu-074514	Oryctolagus cuniculus	52.02	2.00e-53	200.00
IUUC-Oba-075200	Oryza barthii	48.35	7.00e-48	181.00
IUUC-Obr-076396	Oryza brachyantha	39.52	1.00e-48	184.00
IUUC-Ogl-077398	Oryza glaberrima	48.35	8.00e-48	181.00
IUUC-Ogu-078362	Oryza glumaepatula	48.35	7.00e-48	181.00
IUUC-Oin-079625	Oryza indica	48.35	7.00e-48	181.00
IUUC-Olo-080620	Oryza longistaminata	36.82	1.00e-29	120.00
IUUC-Ome-081187	Oryza meridionalis	48.35	8.00e-48	181.00
IUUC-Oni-082271	Oryza nivara	48.35	8.00e-48	181.00
IUUC-Opu-083487	Oryza punctata	48.35	8.00e-48	181.00
IUUC-Oru-085263	Oryza rufipogon	48.35	7.00e-48	181.00
IUUC-Osa-085694	Oryza sativa	48.35	7.00e-48	181.00
IUUC-Ola-086450	Oryzias latipes	41.80	5.00e-53	198.00
IUUC-Olu-087733	Ostreococcus lucimarinus	39.77	9.00e-31	124.00
IUUC-Oga-088054	Otolemur garnettii	47.09	1.00e-48	184.00
IUUC-Oar-089486	Ovis aries	52.60	6.00e-54	201.00
IUUC-Ptr-091314	Pan troglodytes	43.07	7.00e-33	132.00
IUUC-Pan-092633	Papio anubis	52.60	3.00e-54	202.00
IUUC-Psi-093668	Pelodiscus sinensis	42.74	3.00e-31	126.00
IUUC-Pno-095025	Phaeosphaeria nodorum	58.62	3.00e-52	196.00
IUUC-Ppa-095641	Physcomitrella patens	46.58	3.00e-45	172.00
IUUC-Pfo-096423	Poecilia formosa	54.19	5.00e-51	192.00
IUUC-Pab-097771	Pongo abelii	52.60	3.00e-54	202.00
IUUC-Pop-099714	Populus trichocarpa	39.61	3.00e-45	172.00
IUUC-Pca-100493	Procavia capensis	45.99	2.00e-33	132.00
IUUC-Ppe-102054	Prunus persica	37.19	2.00e-44	170.00
IUUC-Pva-102224	Pteropus vampyrus	53.18	6.00e-54	201.00
IUUC-Pgr-103332	Puccinia graminis	51.72	8.00e-53	197.00
IUUC-Ptt-103894	Puccinia triticina	55.70	1.00e-49	186.00
IUUC-Pte-104166	Pyrenophora teres	55.94	1.00e-49	187.00
IUUC-Pyt-104570	Pyrenophora triticirepentis	55.94	1.00e-49	187.00
IUUC-Rno-105593	Rattus norvegicus	52.02	1.00e-53	200.00
IUUC-Sce-106212	Saccharomyces cerevisiae	55.20	4.00e-76	275.00
IUUC-Sha-106767	Sarcophilus harrisii	52.02	1.00e-53	201.00
IUUC-Sja-107907	Schizosaccharomyces japonicus	60.00	1.00e-61	227.00
IUUC-Spo-108094	Schizosaccharomyces pombe	60.61	7.00e-61	224.00
IUUC-Ssl-108556	Sclerotinia sclerotiorum	57.93	1.00e-51	193.00
IUUC-Smo-108965	Selaginella moellendorffii	46.55	8.00e-46	174.00
IUUC-Sit-110407	Setaria italica	51.23	1.00e-47	180.00
IUUC-Sly-110845	Solanum lycopersicum	43.50	1.00e-41	160.00
IUUC-Stu-112336	Solanum tuberosum	46.88	1.00e-41	160.00
IUUC-Sar-113063	Sorex araneus	43.70	2.00e-33	134.00
IUUC-Sbi-114327	Sorghum bicolor	51.23	1.00e-47	180.00
IUUC-Sre-115170	Sporisorium reilianum	52.91	3.00e-50	189.00
IUUC-Ssc-116385	Sus scrofa	52.60	6.00e-54	201.00
IUUC-Tgu-117041	Taeniopygia guttata	54.55	9.00e-51	191.00
IUUC-Tru-117697	Takifugu rubripes	50.87	6.00e-53	198.00
IUUC-Tsy-119024	Tarsius syrichta	40.08	2.00e-45	172.00
IUUC-Tni-120466	Tetraodon nigroviridis	50.30	1.00e-49	187.00
IUUC-Tca-121569	Theobroma cacao	44.44	1.00e-41	160.00
IUUC-Tre-121882	Trichoderma reesei	59.31	1.00e-52	197.00
IUUC-Tvi-122466	Trichoderma virens	58.62	2.00e-52	196.00
IUUC-Tae-124592	Triticum aestivum	49.11	2.00e-47	180.00
IUUC-Tur-126536	Triticum urartu	47.78	1.00e-46	177.00
IUUC-Tme-127051	Tuber melanosporum	64.83	2.00e-56	210.00
IUUC-Tbe-128095	Tupaia belangeri	54.55	2.00e-39	152.00
IUUC-Ttr-128466	Tursiops truncatus	52.02	1.00e-53	200.00
IUUC-Uma-129383	Ustilago maydis	52.33	1.00e-49	187.00
IUUC-Vda-130013	Verticillium dahliae	60.29	1.00e-48	184.00
IUUC-Vpa-130404	Vicugna pacos	42.96	1.00e-32	130.00
IUUC-Vvi-131251	Vitis vinifera	45.00	8.00e-40	155.00
IUUC-Xtr-132408	Xenopus tropicalis	44.13	3.00e-55	206.00
IUUC-Xma-133893	Xiphophorus maculatus	54.19	2.00e-51	192.00
IUUC-Yli-134618	Yarrowia lipolytica	67.83	3.00e-60	222.00
IUUC-Zma-135216	Zea mays	48.81	2.00e-47	180.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence