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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046168
UUCD1 version UUC-HoS-00075
Ensembl Protein ID ENSP00000283195.6
UniProt Accession P49792; Q13074; Q15280; Q53TE2; Q59FH7; RBP2_HUMAN
Genbank Protein ID AAC41758.1; BAA07662.1; AAY14984.1; BAD92720.1; AAA85838.1
Protein Name E3 SUMO-protein ligase RanBP2; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; p270
Genbank Nucleotide ID L41840; D42063; AC010095; AB209483; U19248
Gene Name RANBP2; NUP358
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000153201.15 ENST00000283195.10 ENSP00000283195.6
ENSG00000153201.15 ENST00000425282.4 ENSP00000398970.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 20543581; 18492068; 20429939; 17101795; 18439914; 18946085; 20087442; 17264123
UBD/ZnF/NZF NZF 15029239; 16332688
Classification
Family E-value Score Start End
UBD/ZnF/NZF 8.50e-49 164.4 1480 1507
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           e+qW+CsaC  +Ne++++kC++C++pR+
   Q: 1480 EGQWDCSACLVQNEGSSTKCAACQNPRK 1507
           79*************************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726).
 E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726).
Protein Sequence
(Fasta)
MRRSKADVER YIASVQGSTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP 60
KAHRFLGLLY ELEENTDKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWLER 120
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Protein Fasta Sequence


>IUUC-Hsa-046168|E3,E3 activity/Other;UBD,NZF|Homo sapiens
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Nucleotide Sequence
(Fasta)
CACAGTGGTC CTCCGCCGGC TACGGCGCTG CGTCACTGGT TTGCAGGCGC TTTCCTCTTG 60
GAAGTGGCGA CTGCTGCGGG CCTGAGCGCT GGTCTCACGC GCCTCGGGAG CCAGGTTGGC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046168|E3,E3 activity/Other;UBD,NZF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0802--TPR repeat
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR029000--Cyclophilin-like_dom
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR022011--IR1-M
IPR011993--PH_dom-like
IPR000156--Ran_bind_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR001876--Znf_RanBP2
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS50196--RANBD1
PS50005--TPR
PS50293--TPR_REGION
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF12185--IR1-M
PF00160--Pro_isomerase
PF00638--Ran_BP1
PF00641--zf-RanBP
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00160--RanBD
SM00028--TPR
SM00547--ZnF_RBZ
Gene Ontology

GO:0005642--C:annulate lamellae
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005635--C:nuclear envelope
GO:0042405--C:nuclear inclusion body
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0044614--C:nuclear pore cytoplasmic filaments
GO:0044615--C:nuclear pore nuclear basket
GO:0016874--F:ligase activity
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0008536--F:Ran GTPase binding
GO:0003723--F:RNA binding
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0051642--P:centrosome localization
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0031047--P:gene silencing by RNA
GO:0075733--P:intracellular transport of virus
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0006406--P:mRNA export from nucleus
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0043547--P:positive regulation of GTPase activity
GO:0046604--P:positive regulation of mitotic centrosome separation
GO:0006457--P:protein folding
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0006405--P:RNA export from nucleus
GO:0007062--P:sister chromatid cohesion
GO:0007051--P:spindle organization
GO:0006409--P:tRNA export from nucleus
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process
GO:0019083--P:viral transcription
KEGG hsa:5903
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002141 Ailuropoda melanoleuca 87.05 0.00e+00 5348.00
IUUC-Apl-004213 Anas platyrhynchos 64.25 0.00e+00 1039.00
IUUC-Aca-005244 Anolis carolinensis 64.41 0.00e+00 2016.00
IUUC-Ame-011486 Astyanax mexicanus 54.39 0.00e+00 1306.00
IUUC-Bta-012952 Bos taurus 81.60 0.00e+00 2799.00
IUUC-Cja-019112 Callithrix jacchus 93.74 0.00e+00 5756.00
IUUC-Cfa-020158 Canis familiaris 83.10 0.00e+00 5054.00
IUUC-Cpo-022292 Cavia porcellus 79.73 0.00e+00 2582.00
IUUC-Csa-023696 Chlorocebus sabaeus 95.91 0.00e+00 5880.00
IUUC-Cho-024560 Choloepus hoffmanni 75.50 0.00e+00 979.00
IUUC-Dre-027540 Danio rerio 47.92 0.00e+00 1336.00
IUUC-Dno-029177 Dasypus novemcinctus 84.25 0.00e+00 2807.00
IUUC-Dor-030161 Dipodomys ordii 84.69 0.00e+00 1533.00
IUUC-Dme-032206 Drosophila melanogaster 33.93 2.00e-42 169.00
IUUC-Ete-032679 Echinops telfairi 80.45 0.00e+00 2120.00
IUUC-Eca-034415 Equus caballus 87.30 0.00e+00 5314.00
IUUC-Eeu-035195 Erinaceus europaeus 75.79 0.00e+00 2026.00
IUUC-Fca-036339 Felis catus 86.50 0.00e+00 2843.00
IUUC-Fal-036665 Ficedula albicollis 61.59 0.00e+00 1982.00
IUUC-Gmo-038469 Gadus morhua 45.43 0.00e+00 1255.00
IUUC-Gga-041154 Gallus gallus 62.68 0.00e+00 1805.00
IUUC-Gac-042057 Gasterosteus aculeatus 51.08 0.00e+00 1562.00
IUUC-Itr-049075 Ictidomys tridecemlineatus 83.02 0.00e+00 2713.00
IUUC-Lch-050060 Latimeria chalumnae 58.16 0.00e+00 3430.00
IUUC-Loc-052650 Lepisosteus oculatus 55.24 0.00e+00 1662.00
IUUC-Laf-053667 Loxodonta africana 84.32 0.00e+00 2880.00
IUUC-Mcc-055115 Macaca mulatta 97.09 0.00e+00 5965.00
IUUC-Mga-059419 Meleagris gallopavo 60.62 0.00e+00 1943.00
IUUC-Mmr-061001 Microcebus murinus 89.47 0.00e+00 5634.00
IUUC-Mdo-061922 Monodelphis domestica 69.08 0.00e+00 2211.00
IUUC-Mmu-063291 Mus musculus 84.33 0.00e+00 2856.00
IUUC-Mpu-066011 Mustela putorius furo 87.98 0.00e+00 2664.00
IUUC-Mlu-067422 Myotis lucifugus 85.96 0.00e+00 5269.00
IUUC-Nle-069190 Nomascus leucogenys 95.59 0.00e+00 5721.00
IUUC-Opr-070420 Ochotona princeps 79.05 0.00e+00 2404.00
IUUC-Ont-071362 Oreochromis niloticus 52.87 0.00e+00 1623.00
IUUC-Oan-072832 Ornithorhynchus anatinus 69.89 0.00e+00 2240.00
IUUC-Ocu-073902 Oryctolagus cuniculus 83.47 0.00e+00 2905.00
IUUC-Ola-087304 Oryzias latipes 49.59 0.00e+00 2699.00
IUUC-Oga-088196 Otolemur garnettii 85.84 0.00e+00 3029.00
IUUC-Oar-089627 Ovis aries 81.33 0.00e+00 2762.00
IUUC-Ptr-091152 Pan troglodytes 98.88 0.00e+00 6115.00
IUUC-Pan-091914 Papio anubis 97.15 0.00e+00 5612.00
IUUC-Psi-093994 Pelodiscus sinensis 68.69 0.00e+00 2331.00
IUUC-Pma-094629 Petromyzon marinus 36.32 0.00e+00 940.00
IUUC-Pfo-096897 Poecilia formosa 53.08 0.00e+00 1301.00
IUUC-Pab-097566 Pongo abelii 98.35 0.00e+00 4381.00
IUUC-Pca-100141 Procavia capensis 80.04 0.00e+00 4734.00
IUUC-Pva-102323 Pteropus vampyrus 83.35 0.00e+00 1890.00
IUUC-Rno-105473 Rattus norvegicus 86.57 0.00e+00 2982.00
IUUC-Sha-106537 Sarcophilus harrisii 77.64 0.00e+00 2558.00
IUUC-Sar-113031 Sorex araneus 87.98 0.00e+00 1274.00
IUUC-Ssc-115622 Sus scrofa 81.76 0.00e+00 4435.00
IUUC-Tgu-116781 Taeniopygia guttata 60.51 0.00e+00 1914.00
IUUC-Tru-118684 Takifugu rubripes 55.06 0.00e+00 980.00
IUUC-Tsy-119490 Tarsius syrichta 86.24 0.00e+00 1481.00
IUUC-Tbe-127349 Tupaia belangeri 87.71 0.00e+00 1824.00
IUUC-Ttr-128883 Tursiops truncatus 84.65 0.00e+00 2387.00
IUUC-Vpa-130224 Vicugna pacos 80.94 0.00e+00 2606.00
IUUC-Xtr-132557 Xenopus tropicalis 54.43 0.00e+00 1731.00
Created Date 25-Jun-2017

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