iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000011757.4	ENSBTAT00000015615.4	ENSBTAP00000015615.4
ENSBTAG00000011757.4	ENSBTAT00000043175.1	ENSBTAP00000040765.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	7.80e-09	35.5	273	311

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ +  
   Q: 273  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVS 311
           89****************************999998876 PP

Organism

Bos taurus

Functional Description
(View)

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity).

Protein Sequence
(Fasta)

MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DSRERHEHGN ERRRRGNTES VSNGRAPSSS 60
QQVVEQEEEE DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT 120

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Nucleotide Sequence
(Fasta)

GGAAACAAAA TAGCGGATGC TCGGGAAGGA ACCTCGGCTG CTAGAGGCCG GTGGTGGTGG 60
CGGTGAGGAA AGGGTAGGTT CCCGAAGGGG AGTTGGGGGT GACAGGAACG CGCCTCACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0031410--C:cytoplasmic vesicle
GO:0043198--C:dendritic shaft
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0098793--C:presynapse
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005262--F:calcium channel activity
GO:0004175--F:endopeptidase activity
GO:0000186--P:activation of MAPKK activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0042982--P:amyloid precursor protein metabolic process
GO:0000045--P:autophagosome assembly
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0001568--P:blood vessel development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0001708--P:cell fate specification
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0050673--P:epithelial cell proliferation
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0051402--P:neuron apoptotic process
GO:0048666--P:neuron development
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0043085--P:positive regulation of catalytic activity
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

KEGG

bta:282705

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	33.44	2.00e-22	101.00
IUUC-Aml-001648	Ailuropoda melanoleuca	93.97	4.00e-172	597.00
IUUC-Atr-003039	Amborella trichopoda	33.71	2.00e-39	156.00
IUUC-Apl-003727	Anas platyrhynchos	78.84	4.00e-177	613.00
IUUC-Aca-004582	Anolis carolinensis	77.39	1.00e-178	619.00
IUUC-Aly-005455	Arabidopsis lyrata	30.25	4.00e-34	139.00
IUUC-Ath-006730	Arabidopsis thaliana	31.52	2.00e-35	142.00
IUUC-Ame-011500	Astyanax mexicanus	77.15	3.00e-148	518.00
IUUC-Bdi-014196	Brachypodium distachyon	32.41	8.00e-29	121.00
IUUC-Bol-015841	Brassica oleracea	34.60	8.00e-32	131.00
IUUC-Cel-018553	Caenorhabditis elegans	52.87	2.00e-99	356.00
IUUC-Cja-019994	Callithrix jacchus	90.30	0.00e+00	647.00
IUUC-Cfa-020074	Canis familiaris	92.05	0.00e+00	730.00
IUUC-Cpo-022237	Cavia porcellus	88.22	0.00e+00	667.00
IUUC-Csa-023537	Chlorocebus sabaeus	89.54	0.00e+00	729.00
IUUC-Cho-024735	Choloepus hoffmanni	78.29	0.00e+00	640.00
IUUC-Cin-025780	Ciona intestinalis	61.37	2.00e-124	439.00
IUUC-Csv-025967	Ciona savignyi	61.93	2.00e-120	425.00
IUUC-Dre-028689	Danio rerio	75.98	2.00e-144	505.00
IUUC-Dno-029758	Dasypus novemcinctus	87.27	0.00e+00	692.00
IUUC-Dor-030609	Dipodomys ordii	69.67	2.00e-165	575.00
IUUC-Dme-031929	Drosophila melanogaster	55.31	3.00e-111	395.00
IUUC-Ete-032487	Echinops telfairi	76.82	3.00e-79	288.00
IUUC-Eeu-035134	Erinaceus europaeus	90.54	3.00e-147	513.00
IUUC-Fca-036243	Felis catus	92.47	0.00e+00	727.00
IUUC-Fal-036600	Ficedula albicollis	80.04	3.00e-177	614.00
IUUC-Gmo-039665	Gadus morhua	67.21	4.00e-113	401.00
IUUC-Gga-040993	Gallus gallus	79.83	6.00e-180	623.00
IUUC-Gac-042342	Gasterosteus aculeatus	65.73	4.00e-128	451.00
IUUC-Gma-043822	Glycine max	37.81	1.00e-23	103.00
IUUC-Ggo-044859	Gorilla gorilla	86.87	4.00e-154	536.00
IUUC-Hsa-046822	Homo sapiens	89.75	0.00e+00	731.00
IUUC-Hvu-047141	Hordeum vulgare	35.29	3.00e-25	109.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	90.36	9.00e-154	535.00
IUUC-Lch-049946	Latimeria chalumnae	67.43	3.00e-141	494.00
IUUC-Lpe-051132	Leersia perrieri	33.24	3.00e-29	122.00
IUUC-Laf-053979	Loxodonta africana	84.58	1.00e-172	598.00
IUUC-Mcc-055682	Macaca mulatta	89.75	0.00e+00	731.00
IUUC-Meu-056004	Macropus eugenii	72.75	8.00e-150	523.00
IUUC-Mtr-058392	Medicago truncatula	34.60	1.00e-30	127.00
IUUC-Mga-059466	Meleagris gallopavo	79.63	2.00e-179	622.00
IUUC-Mmr-061538	Microcebus murinus	72.59	5.00e-155	540.00
IUUC-Mdo-062122	Monodelphis domestica	84.20	0.00e+00	673.00
IUUC-Mmu-063176	Mus musculus	87.03	0.00e+00	685.00
IUUC-Mpu-065927	Mustela putorius furo	91.42	0.00e+00	714.00
IUUC-Mlu-067079	Myotis lucifugus	91.42	0.00e+00	748.00
IUUC-Nle-070180	Nomascus leucogenys	89.75	0.00e+00	731.00
IUUC-Opr-070847	Ochotona princeps	83.90	0.00e+00	644.00
IUUC-Ont-071846	Oreochromis niloticus	75.18	9.00e-146	509.00
IUUC-Oan-072783	Ornithorhynchus anatinus	81.55	7.00e-135	473.00
IUUC-Ocu-074527	Oryctolagus cuniculus	88.52	0.00e+00	718.00
IUUC-Oba-075256	Oryza barthii	32.63	1.00e-26	114.00
IUUC-Ogl-077097	Oryza glaberrima	31.77	2.00e-27	117.00
IUUC-Ogu-078570	Oryza glumaepatula	31.77	2.00e-27	116.00
IUUC-Olo-080484	Oryza longistaminata	36.43	4.00e-23	101.00
IUUC-Ome-081814	Oryza meridionalis	33.24	7.00e-28	118.00
IUUC-Opu-084176	Oryza punctata	32.49	3.00e-27	116.00
IUUC-Oru-084618	Oryza rufipogon	31.77	2.00e-27	116.00
IUUC-Osa-085602	Oryza sativa	32.96	5.00e-27	115.00
IUUC-Oar-090348	Ovis aries	96.03	0.00e+00	794.00
IUUC-Ptr-091060	Pan troglodytes	89.75	0.00e+00	731.00
IUUC-Pan-091855	Papio anubis	81.38	0.00e+00	633.00
IUUC-Psi-093505	Pelodiscus sinensis	79.42	1.00e-177	615.00
IUUC-Pfo-097396	Poecilia formosa	74.69	4.00e-151	527.00
IUUC-Pab-098591	Pongo abelii	89.12	0.00e+00	718.00
IUUC-Pop-099661	Populus trichocarpa	31.07	9.00e-32	130.00
IUUC-Pca-101029	Procavia capensis	85.59	0.00e+00	651.00
IUUC-Ppe-101495	Prunus persica	31.61	3.00e-37	149.00
IUUC-Pva-102244	Pteropus vampyrus	84.10	0.00e+00	665.00
IUUC-Rno-105861	Rattus norvegicus	87.50	0.00e+00	675.00
IUUC-Sha-107045	Sarcophilus harrisii	84.58	0.00e+00	668.00
IUUC-Smo-109325	Selaginella moellendorffii	35.40	4.00e-36	145.00
IUUC-Sit-110624	Setaria italica	35.29	2.00e-27	116.00
IUUC-Stu-112433	Solanum tuberosum	35.51	2.00e-32	133.00
IUUC-Sar-113169	Sorex araneus	84.89	1.00e-142	499.00
IUUC-Sbi-114305	Sorghum bicolor	33.44	1.00e-25	110.00
IUUC-Ssc-115766	Sus scrofa	92.89	0.00e+00	728.00
IUUC-Tgu-116469	Taeniopygia guttata	84.53	3.00e-139	488.00
IUUC-Tru-117732	Takifugu rubripes	74.21	3.00e-145	508.00
IUUC-Tsy-119624	Tarsius syrichta	79.92	0.00e+00	636.00
IUUC-Tni-119852	Tetraodon nigroviridis	68.61	2.00e-135	475.00
IUUC-Tca-121865	Theobroma cacao	33.42	7.00e-38	151.00
IUUC-Tae-125925	Triticum aestivum	35.53	3.00e-26	113.00
IUUC-Tur-126237	Triticum urartu	35.29	2.00e-25	109.00
IUUC-Tbe-128148	Tupaia belangeri	80.36	2.00e-161	561.00
IUUC-Ttr-128793	Tursiops truncatus	93.93	0.00e+00	729.00
IUUC-Vpa-130625	Vicugna pacos	77.57	9.00e-162	563.00
IUUC-Vvi-131312	Vitis vinifera	37.22	6.00e-19	88.60
IUUC-Xtr-131790	Xenopus tropicalis	76.25	3.00e-157	548.00
IUUC-Xma-133377	Xiphophorus maculatus	73.84	1.00e-148	519.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence