iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	76.29	0.00e+00	669.00	IUUC-Hsa-046905

Active Site

Position(s)	Description	Evidence
409	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MGEEQSTVSG SGGARASGGG SAGQPESPRP RGDRVRTAGP RAAASSSRPN GGGGGRDPGC 60
VDASVQEPAS NRAPAGQPAR LPLSGPLDPQ SLELQLEREA EGAGPREAPP GQQPPDGLLL 120

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Nucleotide Sequence
(Fasta)

ATGGGCGAGG AGCAGAGCAC GGTGAGCGGC AGCGGCGGGG CGCGGGCCTC TGGCGGAGGC 60
TCGGCGGGCC AGCCCGAGTC CCCCAGGCCG CGAGGGGACC GCGTCCGGAC AGCCGGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom

Pfam

PF01485--IBR

SMART

SM00647--IBR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mmu:268291

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000190	Aegilops tauschii	26.42	1.00e-18	87.40
IUUC-Aml-001424	Ailuropoda melanoleuca	95.69	6.00e-123	432.00
IUUC-Atr-002709	Amborella trichopoda	29.81	9.00e-18	85.90
IUUC-Apl-004119	Anas platyrhynchos	89.56	2.00e-125	441.00
IUUC-Aca-004331	Anolis carolinensis	80.36	4.00e-114	404.00
IUUC-Aly-006445	Arabidopsis lyrata	28.04	6.00e-16	79.00
IUUC-Ame-011391	Astyanax mexicanus	63.78	3.00e-118	419.00
IUUC-Bta-013031	Bos taurus	96.80	2.00e-136	478.00
IUUC-Bci-013593	Botrytis cinerea	26.17	6.00e-17	82.40
IUUC-Bra-018037	Brassica rapa	26.98	1.00e-14	74.70
IUUC-Cja-019367	Callithrix jacchus	97.72	0.00e+00	630.00
IUUC-Cfa-020360	Canis familiaris	95.40	3.00e-141	494.00
IUUC-Cpo-022283	Cavia porcellus	95.67	1.00e-121	428.00
IUUC-Csa-023174	Chlorocebus sabaeus	97.07	0.00e+00	629.00
IUUC-Dre-028219	Danio rerio	52.85	3.00e-109	389.00
IUUC-Dno-029150	Dasypus novemcinctus	97.54	2.00e-145	508.00
IUUC-Eca-034129	Equus caballus	97.54	1.00e-157	548.00
IUUC-Fca-036093	Felis catus	96.40	4.00e-136	476.00
IUUC-Fal-037155	Ficedula albicollis	81.82	1.00e-146	512.00
IUUC-Gmo-039328	Gadus morhua	64.13	2.00e-100	358.00
IUUC-Gga-041198	Gallus gallus	81.76	6.00e-147	514.00
IUUC-Gac-041506	Gasterosteus aculeatus	66.19	3.00e-103	367.00
IUUC-Hsa-046905	Homo sapiens	77.76	0.00e+00	743.00
IUUC-Itr-048769	Ictidomys tridecemlineatus	98.82	2.00e-89	320.00
IUUC-Lch-049864	Latimeria chalumnae	92.31	2.00e-81	294.00
IUUC-Loc-052491	Lepisosteus oculatus	67.51	1.00e-123	436.00
IUUC-Laf-054434	Loxodonta africana	94.67	2.00e-131	461.00
IUUC-Mcc-054775	Macaca mulatta	78.53	0.00e+00	742.00
IUUC-Mtr-058155	Medicago truncatula	26.89	4.00e-18	86.30
IUUC-Mga-059829	Meleagris gallopavo	88.71	2.00e-122	431.00
IUUC-Mmr-061731	Microcebus murinus	77.35	0.00e+00	677.00
IUUC-Mdo-062999	Monodelphis domestica	72.93	4.00e-157	548.00
IUUC-Mpu-066110	Mustela putorius furo	97.15	7.00e-155	539.00
IUUC-Mlu-067706	Myotis lucifugus	97.19	2.00e-136	477.00
IUUC-Nle-069289	Nomascus leucogenys	97.39	0.00e+00	630.00
IUUC-Opr-070800	Ochotona princeps	97.60	6.00e-124	436.00
IUUC-Ont-072164	Oreochromis niloticus	70.29	4.00e-109	387.00
IUUC-Oan-073332	Ornithorhynchus anatinus	93.57	1.00e-85	308.00
IUUC-Ocu-074266	Oryctolagus cuniculus	97.54	2.00e-157	547.00
IUUC-Ogu-078368	Oryza glumaepatula	24.41	2.00e-13	70.90
IUUC-Opu-083215	Oryza punctata	26.79	2.00e-19	90.10
IUUC-Ola-087213	Oryzias latipes	66.55	8.00e-106	376.00
IUUC-Oga-088033	Otolemur garnettii	97.39	2.00e-170	590.00
IUUC-Oar-089295	Ovis aries	87.86	0.00e+00	670.00
IUUC-Pan-091768	Papio anubis	97.07	0.00e+00	629.00
IUUC-Psi-093567	Pelodiscus sinensis	83.59	1.00e-149	522.00
IUUC-Ppa-095998	Physcomitrella patens	31.13	7.00e-19	89.00
IUUC-Pfo-096655	Poecilia formosa	65.92	7.00e-114	404.00
IUUC-Pop-099816	Populus trichocarpa	30.39	4.00e-19	89.00
IUUC-Ppe-101728	Prunus persica	27.23	7.00e-17	82.00
IUUC-Pyt-104493	Pyrenophora triticirepentis	29.02	3.00e-17	82.80
IUUC-Rno-105176	Rattus norvegicus	98.75	0.00e+00	662.00
IUUC-Sly-111393	Solanum lycopersicum	29.38	5.00e-19	89.40
IUUC-Stu-112779	Solanum tuberosum	29.47	7.00e-20	91.30
IUUC-Sar-113564	Sorex araneus	97.12	9.00e-124	435.00
IUUC-Sbi-114532	Sorghum bicolor	26.79	4.00e-17	82.00
IUUC-Ssc-115296	Sus scrofa	97.19	2.00e-136	478.00
IUUC-Tgu-117362	Taeniopygia guttata	88.67	1.00e-111	395.00
IUUC-Tru-118499	Takifugu rubripes	67.15	3.00e-105	374.00
IUUC-Tni-119677	Tetraodon nigroviridis	66.31	8.00e-102	363.00
IUUC-Tca-121059	Theobroma cacao	27.44	2.00e-17	83.20
IUUC-Tae-123173	Triticum aestivum	24.09	2.00e-16	80.10
IUUC-Tur-126368	Triticum urartu	27.73	1.00e-17	84.00
IUUC-Vvi-130951	Vitis vinifera	25.85	3.00e-15	75.90
IUUC-Xtr-132796	Xenopus tropicalis	75.85	1.00e-131	462.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence