iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045176

Ensembl Protein ID

ENSGGOP00000014444.2

UniProt Accession

G3RFR8; G3RFR8_GORGO

Protein Name

Ubiquitin-related modifier 1

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014806.2	ENSGGOT00000014857.2	ENSGGOP00000014444.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	36.84	5.00e-07	48.10	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gorilla gorilla

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVEVE FGGGAELLFD GIKKHRVTLP GQEEPWDIRN LLIWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELLV STLGDIPPPA PALAASVGKR WASPQAHIEW LGNPPPHSSP 120

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Nucleotide Sequence
(Fasta)

CCGGAAATTT GCGGGCGCGC CGGAAGTTGA GGGGAGTTTC CTGCGAGCTC GGCTTCCTCA 60
ACATGGCAGC GCCCTTGTCA GTGGAGGTGG AGTTCGGGTG AGTCACAGAG CTGGGGCGCC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	96.20	2.00e-40	156.00
IUUC-Atr-003089	Amborella trichopoda	55.26	6.00e-21	91.70
IUUC-Apl-003382	Anas platyrhynchos	85.51	2.00e-30	122.00
IUUC-Aca-004981	Anolis carolinensis	82.28	2.00e-35	140.00
IUUC-Aly-005517	Arabidopsis lyrata	51.47	2.00e-18	83.60
IUUC-Ath-006718	Arabidopsis thaliana	50.82	3.00e-15	72.80
IUUC-Ago-007917	Ashbya gossypii	36.84	1.00e-12	64.30
IUUC-Acl-008054	Aspergillus clavatus	77.78	1.00e-07	47.40
IUUC-Afl-008704	Aspergillus flavus	54.55	2.00e-12	62.80
IUUC-Aor-009890	Aspergillus oryzae	57.69	5.00e-17	79.30
IUUC-Bta-012448	Bos taurus	93.67	9.00e-40	154.00
IUUC-Bci-013865	Botrytis cinerea	41.77	8.00e-13	64.70
IUUC-Bdi-014980	Brachypodium distachyon	58.06	5.00e-15	72.00
IUUC-Bol-016055	Brassica oleracea	56.14	1.00e-15	73.90
IUUC-Bra-016845	Brassica rapa	56.14	1.00e-15	73.90
IUUC-Cel-018485	Caenorhabditis elegans	32.05	6.00e-06	42.00
IUUC-Cja-019587	Callithrix jacchus	96.20	2.00e-40	156.00
IUUC-Cfa-020653	Canis familiaris	93.67	1.00e-39	154.00
IUUC-Cpo-021622	Cavia porcellus	96.20	2.00e-40	156.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	53.33	2.00e-18	83.60
IUUC-Csa-023756	Chlorocebus sabaeus	95.21	2.00e-67	247.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	43.04	5.00e-13	65.90
IUUC-Cne-026953	Cryptococcus neoformans	55.00	3.00e-17	80.50
IUUC-Cme-027314	Cyanidioschyzon merolae	39.19	2.00e-09	53.50
IUUC-Dre-027884	Danio rerio	74.68	2.00e-32	129.00
IUUC-Dno-029262	Dasypus novemcinctus	94.94	7.00e-39	152.00
IUUC-Dor-030601	Dipodomys ordii	56.96	3.00e-15	72.80
IUUC-Dme-031893	Drosophila melanogaster	60.00	1.00e-21	94.00
IUUC-Ete-032773	Echinops telfairi	86.08	6.00e-35	138.00
IUUC-Eca-034187	Equus caballus	96.20	2.00e-40	156.00
IUUC-Eeu-034808	Erinaceus europaeus	92.41	4.00e-39	152.00
IUUC-Fca-036107	Felis catus	96.20	2.00e-40	156.00
IUUC-Fal-036607	Ficedula albicollis	84.06	5.00e-30	121.00
IUUC-Fox-037698	Fusarium oxysporum	44.44	3.00e-15	73.20
IUUC-Gmo-039492	Gadus morhua	73.42	2.00e-32	130.00
IUUC-Ggr-039965	Gaeumannomyces graminis	43.21	3.00e-12	63.90
IUUC-Gga-041268	Gallus gallus	84.81	6.00e-36	141.00
IUUC-Gac-042111	Gasterosteus aculeatus	74.68	7.00e-34	134.00
IUUC-Gma-043240	Glycine max	50.82	2.00e-14	70.10
IUUC-Hsa-046077	Homo sapiens	100.00	6.00e-33	131.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	95.52	4.00e-25	105.00
IUUC-Kpa-049157	Komagataella pastoris	43.42	1.00e-11	60.80
IUUC-Lch-049889	Latimeria chalumnae	78.48	6.00e-34	134.00
IUUC-Lpe-050783	Leersia perrieri	60.00	2.00e-15	73.90
IUUC-Loc-052400	Lepisosteus oculatus	78.48	6.00e-34	134.00
IUUC-Lma-053259	Leptosphaeria maculans	44.74	4.00e-13	65.90
IUUC-Laf-053596	Loxodonta africana	94.94	5.00e-40	155.00
IUUC-Mcc-054845	Macaca mulatta	89.47	4.00e-34	135.00
IUUC-Meu-055968	Macropus eugenii	92.31	9.00e-39	150.00
IUUC-Mor-057126	Magnaporthe oryzae	40.74	6.00e-11	59.30
IUUC-Mpo-057311	Magnaporthe poae	44.87	1.00e-13	68.60
IUUC-Mtr-058266	Medicago truncatula	49.21	1.00e-14	70.90
IUUC-Mla-058847	Melampsora laricipopulina	36.71	8.00e-06	42.00
IUUC-Mga-059468	Meleagris gallopavo	85.51	1.00e-30	123.00
IUUC-Mvi-060235	Microbotryum violaceum	31.25	5.00e-10	56.60
IUUC-Mdo-061948	Monodelphis domestica	89.74	3.00e-38	149.00
IUUC-Mmu-063946	Mus musculus	92.41	3.00e-39	152.00
IUUC-Mac-064812	Musa acuminata	64.00	1.00e-15	73.90
IUUC-Mpu-066763	Mustela putorius furo	93.67	5.00e-39	151.00
IUUC-Mlu-066970	Myotis lucifugus	96.20	3.00e-40	155.00
IUUC-Ncr-068824	Neurospora crassa	39.74	5.00e-13	65.90
IUUC-Nle-069849	Nomascus leucogenys	96.58	6.00e-71	258.00
IUUC-Opr-070227	Ochotona princeps	96.20	2.00e-40	156.00
IUUC-Ont-072530	Oreochromis niloticus	75.95	1.00e-33	133.00
IUUC-Oan-073191	Ornithorhynchus anatinus	86.57	6.00e-30	121.00
IUUC-Ocu-074460	Oryctolagus cuniculus	94.74	2.00e-38	149.00
IUUC-Oba-075499	Oryza barthii	69.05	7.00e-14	69.70
IUUC-Obr-076896	Oryza brachyantha	56.90	2.00e-13	68.90
IUUC-Ogl-077834	Oryza glaberrima	69.05	2.00e-14	70.10
IUUC-Ogu-078622	Oryza glumaepatula	69.05	2.00e-14	70.10
IUUC-Oin-079358	Oryza indica	69.05	8.00e-14	70.10
IUUC-Olo-081035	Oryza longistaminata	49.37	4.00e-15	73.90
IUUC-Oni-082425	Oryza nivara	69.05	2.00e-14	70.10
IUUC-Opu-083461	Oryza punctata	69.05	3.00e-14	70.50
IUUC-Oru-084875	Oryza rufipogon	60.42	2.00e-12	63.20
IUUC-Oga-089128	Otolemur garnettii	96.20	2.00e-40	156.00
IUUC-Oar-089896	Ovis aries	93.67	9.00e-40	154.00
IUUC-Ptr-091618	Pan troglodytes	99.32	8.00e-65	238.00
IUUC-Pan-092238	Papio anubis	93.15	7.00e-67	245.00
IUUC-Psi-093879	Pelodiscus sinensis	87.34	3.00e-36	142.00
IUUC-Pma-094484	Petromyzon marinus	78.48	2.00e-24	103.00
IUUC-Ppa-095801	Physcomitrella patens	58.62	5.00e-14	68.90
IUUC-Pfo-097192	Poecilia formosa	77.22	1.00e-34	137.00
IUUC-Pab-098203	Pongo abelii	98.73	1.00e-32	130.00
IUUC-Pop-099614	Populus trichocarpa	52.46	1.00e-15	73.90
IUUC-Pca-100507	Procavia capensis	94.94	4.00e-40	155.00
IUUC-Ppe-101174	Prunus persica	52.63	5.00e-20	88.60
IUUC-Pva-102735	Pteropus vampyrus	93.67	1.00e-36	144.00
IUUC-Pgr-103510	Puccinia graminis	37.97	4.00e-07	46.60
IUUC-Ptt-103918	Puccinia triticina	32.91	5.00e-05	39.70
IUUC-Pte-104173	Pyrenophora teres	45.00	1.00e-14	70.90
IUUC-Pyt-104806	Pyrenophora triticirepentis	45.00	9.00e-15	71.20
IUUC-Rno-105820	Rattus norvegicus	93.67	1.00e-39	153.00
IUUC-Sce-106366	Saccharomyces cerevisiae	36.84	6.00e-10	55.10
IUUC-Sja-107727	Schizosaccharomyces japonicus	39.47	2.00e-10	57.80
IUUC-Spo-108074	Schizosaccharomyces pombe	34.25	2.00e-06	43.10
IUUC-Smo-108944	Selaginella moellendorffii	58.21	1.00e-17	80.50
IUUC-Sit-110277	Setaria italica	57.63	4.00e-15	72.40
IUUC-Sly-111505	Solanum lycopersicum	52.46	4.00e-16	75.50
IUUC-Stu-112076	Solanum tuberosum	54.10	1.00e-16	77.40
IUUC-Sbi-114274	Sorghum bicolor	56.36	2.00e-15	73.60
IUUC-Sre-114953	Sporisorium reilianum	55.70	2.00e-18	84.00
IUUC-Ssc-115418	Sus scrofa	93.67	6.00e-40	154.00
IUUC-Tgu-117311	Taeniopygia guttata	84.06	5.00e-30	121.00
IUUC-Tru-118598	Takifugu rubripes	79.10	3.00e-29	119.00
IUUC-Tni-120109	Tetraodon nigroviridis	73.75	2.00e-31	126.00
IUUC-Tca-120942	Theobroma cacao	51.67	4.00e-14	69.30
IUUC-Tre-122099	Trichoderma reesei	44.12	4.00e-11	58.90
IUUC-Tvi-122285	Trichoderma virens	49.37	6.00e-16	75.50
IUUC-Tae-125193	Triticum aestivum	55.93	3.00e-14	69.70
IUUC-Tur-126677	Triticum urartu	46.48	1.00e-11	61.60
IUUC-Tme-127120	Tuber melanosporum	44.44	3.00e-15	73.60
IUUC-Tbe-128050	Tupaia belangeri	62.03	2.00e-20	89.70
IUUC-Ttr-129019	Tursiops truncatus	92.41	2.00e-37	146.00
IUUC-Uma-129483	Ustilago maydis	53.16	5.00e-16	75.50
IUUC-Vda-129690	Verticillium dahliae	37.08	6.00e-09	52.40
IUUC-Vvi-131174	Vitis vinifera	55.00	1.00e-15	73.90
IUUC-Xma-133862	Xiphophorus maculatus	77.22	1.00e-34	137.00
IUUC-Yli-134398	Yarrowia lipolytica	43.42	5.00e-12	62.00
IUUC-Zma-134964	Zea mays	66.67	8.00e-14	68.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence