iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052700

Ensembl Protein ID

ENSLOCP00000011295.1

UniProt Accession

W5MSD6; W5MSD6_LEPOC

Genbank Protein ID

ENSLOCP00000011295

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01015459

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000009253.1	ENSLOCT00000011299.1	ENSLOCP00000011283.1
ENSLOCG00000009253.1	ENSLOCT00000011311.1	ENSLOCP00000011295.1
ENSLOCG00000009253.1	ENSLOCT00000011323.1	ENSLOCP00000011307.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.70e-82	275.7	726	1043

Active Site

Position(s)	Description	Evidence
1016	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+vef++ +++d+ G++ref+  +++e+ +p+ g+f y+e+++  ++p ++s        k ++++G+l+g+a+++ + + 
   Q: 726  ATFREQLMVEFQEKQCQDQRGIQREFFCRVISEIIEPESGMFWYNESSTVIWFPTKASVE-----KKKYYLFGILCGLAVYNYNTVH 807
           567899****************************************************83.....4566688*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ +++k+l+++k +ledl+e++p + +sl+ ++++  +diee  l+l+fs    ++ + k+++L+p+G++ pV+++N++e+v++
   Q: 808  LPFPLALFKKLVDVKPTLEDLKELEPRVGESLQDLLDYSGDDIEER-LALSFS----VCWDNKDVDLIPDGKSKPVNKSNRKEFVSA 889
           **************************************99899986.999998....67899************************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v+y +++ ++  +++fr+Gf +v++ ells F+++el   + G++++d++++k+++ ykg y++d+p+++ Fw+v+ +++ +++k+
   Q: 890  YVDYVFNKAVNGLFDEFRRGFCKVCDAELLSFFQPQELMEAMTGTTDYDWNKFKRNALYKGSYHADHPTVIIFWKVFLDLTLDQKKD 976
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetk 331
           fL F+Tgs+r+P+ G++++k  +++++  ++++d++P++n Cf  L LP+Y++++ l+e+Ll A ++++
   Q: 977  FLMFLTGSDRIPVLGIEYVK--VTIVPLpSSTEDHYPEANVCFLHLLLPDYTTEKRLRERLLQAFSHSR 1043
           ********************..66777767889*******************************98865 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MYCWGEGTSG QLGLDLQEDD SLVLLPAEVH PLLRHVSLVA CGEQHTLFLN EEGNVLSCGS 60
NHRGQLGRQS SLGTKTPAPV QGPTGVVSVA CGQEHSLALC QSGEVYSWGR GSEGQLGTGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCAGATGA CTGGTTTTCA GTAGAGAACA TTGGGTAGTA TCGACATGCC ATGTATTGCA 60
ATACATTCCG TTTAAGCTTA CAGGAAACAT TAGAAGTTCA CAAAATCGCA TGTCACAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	40.27	0.00e+00	686.00
IUUC-Aca-004663	Anolis carolinensis	41.65	0.00e+00	764.00
IUUC-Bta-013080	Bos taurus	40.55	0.00e+00	728.00
IUUC-Cja-018891	Callithrix jacchus	39.51	0.00e+00	727.00
IUUC-Cfa-020763	Canis familiaris	41.03	0.00e+00	689.00
IUUC-Csa-023049	Chlorocebus sabaeus	41.85	0.00e+00	811.00
IUUC-Dno-029093	Dasypus novemcinctus	41.27	0.00e+00	739.00
IUUC-Eca-034098	Equus caballus	41.73	0.00e+00	746.00
IUUC-Fca-036283	Felis catus	40.85	0.00e+00	721.00
IUUC-Ggo-045553	Gorilla gorilla	41.09	0.00e+00	751.00
IUUC-Hsa-046396	Homo sapiens	41.84	0.00e+00	788.00
IUUC-Laf-054433	Loxodonta africana	40.49	0.00e+00	767.00
IUUC-Mcc-055014	Macaca mulatta	39.64	0.00e+00	755.00
IUUC-Mmu-064378	Mus musculus	37.84	0.00e+00	686.00
IUUC-Mpu-066293	Mustela putorius furo	40.21	0.00e+00	671.00
IUUC-Mlu-067407	Myotis lucifugus	39.30	0.00e+00	732.00
IUUC-Nle-069978	Nomascus leucogenys	42.19	0.00e+00	798.00
IUUC-Oga-088780	Otolemur garnettii	39.16	0.00e+00	718.00
IUUC-Oar-090307	Ovis aries	40.56	0.00e+00	741.00
IUUC-Ptr-091567	Pan troglodytes	42.13	0.00e+00	783.00
IUUC-Pan-091802	Papio anubis	38.58	0.00e+00	725.00
IUUC-Pva-102382	Pteropus vampyrus	37.99	0.00e+00	670.00
IUUC-Rno-105768	Rattus norvegicus	39.27	0.00e+00	692.00
IUUC-Sha-106525	Sarcophilus harrisii	38.38	0.00e+00	717.00
IUUC-Sar-113014	Sorex araneus	41.04	1.00e-94	341.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence