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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063934
UUCD1 version UUC-MuM-00018
Ensembl Protein ID ENSMUSP00000101501.1
UniProt Accession Q38HM4; Q8BWC4; TRI63_MOUSE
Genbank Protein ID ABB16283.1; BAC35199.1
Protein Name E3 ubiquitin-protein ligase TRIM63; Muscle-specific RING finger protein 1; RING-type E3 ubiquitin transferase TRIM63; Tripartite motif-containing protein 63
Genbank Nucleotide ID DQ229108; AK052911
Gene Name Trim63; Murf1; Rf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028834.13 ENSMUST00000030638.6 ENSMUSP00000030638.6
ENSMUSG00000028834.13 ENSMUST00000105875.7 ENSMUSP00000101501.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17983583
Classification
Family E-value Score Start End
E3 activity/RING/RING 8.50e-10 40.1 23 79
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...........pglknssskefrCPlCr 46
           C+iCle+f +++++lpC+H  +++C + +            g+ ++s ++frCP Cr
   Q: 23   CPICLEMFTKPVVILPCQHNLCRKCANDIfqaanpywtnrGGSVSMSGGRFRCPSCR 79
           *************************755556667779***999999**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
 E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Protein Sequence
(Fasta)
MDYKSSLIPD GNAMENLEKQ LICPICLEMF TKPVVILPCQ HNLCRKCAND IFQAANPYWT 60
NRGGSVSMSG GRFRCPSCRH EVIMDRHGVY GLQRNLLVEN IIDIYKQECS SRPLQKGSHP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063934|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGAAGTCGGG GGTCAGGGGA CGAAGACAAA GAGGATCCGA GTGGGTTTGG AGACAAAGAC 60
TTGGTGTGAC GCAGGTGGGC GAGACAGTCG CATTTCAAAG CAATATGGAT TATAAATCTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063934|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0514--Muscle protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017903--COS_domain
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51262--COS
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0043292--C:contractile fiber
GO:0005737--C:cytoplasm
GO:0031430--C:M band
GO:0005634--C:nucleus
GO:0030018--C:Z disc
GO:0031432--F:titin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0006936--P:muscle contraction
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010468--P:regulation of gene expression
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0014878--P:response to electrical stimulus involved in regulation of muscle adaptation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001472 Ailuropoda melanoleuca 95.05 0.00e+00 639.00
IUUC-Apl-003286 Anas platyrhynchos 66.56 3.00e-127 448.00
IUUC-Aca-004871 Anolis carolinensis 74.92 3.00e-145 507.00
IUUC-Bta-013137 Bos taurus 92.90 0.00e+00 626.00
IUUC-Cja-019635 Callithrix jacchus 93.19 5.00e-172 596.00
IUUC-Cfa-020506 Canis familiaris 93.19 0.00e+00 629.00
IUUC-Cpo-022289 Cavia porcellus 94.43 0.00e+00 636.00
IUUC-Csa-023387 Chlorocebus sabaeus 93.19 2.00e-172 598.00
IUUC-Dno-029227 Dasypus novemcinctus 82.61 3.00e-167 581.00
IUUC-Dor-030999 Dipodomys ordii 83.59 5.00e-156 543.00
IUUC-Ete-033039 Echinops telfairi 94.12 9.00e-177 612.00
IUUC-Eca-033370 Equus caballus 94.10 1.00e-177 615.00
IUUC-Eeu-035345 Erinaceus europaeus 94.43 0.00e+00 638.00
IUUC-Fca-036216 Felis catus 93.81 0.00e+00 632.00
IUUC-Fal-036673 Ficedula albicollis 66.87 8.00e-122 429.00
IUUC-Gga-040807 Gallus gallus 75.16 1.00e-144 506.00
IUUC-Ggo-044440 Gorilla gorilla 93.81 3.00e-172 597.00
IUUC-Hsa-045762 Homo sapiens 93.50 1.00e-172 598.00
IUUC-Itr-048877 Ictidomys tridecemlineatus 92.88 0.00e+00 632.00
IUUC-Lch-049518 Latimeria chalumnae 68.73 2.00e-135 474.00
IUUC-Loc-052735 Lepisosteus oculatus 58.31 5.00e-124 437.00
IUUC-Laf-054300 Loxodonta africana 92.88 1.00e-180 625.00
IUUC-Mcc-055645 Macaca mulatta 93.50 3.00e-173 600.00
IUUC-Meu-056393 Macropus eugenii 74.30 9.00e-135 473.00
IUUC-Mga-059391 Meleagris gallopavo 75.47 8.00e-140 489.00
IUUC-Mmr-061101 Microcebus murinus 90.13 7.00e-169 586.00
IUUC-Mdo-062275 Monodelphis domestica 90.00 2.00e-175 608.00
IUUC-Mpu-066782 Mustela putorius furo 94.12 0.00e+00 633.00
IUUC-Mlu-067263 Myotis lucifugus 92.96 8.00e-115 405.00
IUUC-Nle-070021 Nomascus leucogenys 91.95 2.00e-170 591.00
IUUC-Opr-070997 Ochotona princeps 93.81 0.00e+00 634.00
IUUC-Oan-072909 Ornithorhynchus anatinus 87.62 7.00e-171 593.00
IUUC-Ocu-073858 Oryctolagus cuniculus 93.50 0.00e+00 637.00
IUUC-Oga-088334 Otolemur garnettii 85.45 1.00e-161 562.00
IUUC-Oar-090426 Ovis aries 93.19 0.00e+00 632.00
IUUC-Ptr-091030 Pan troglodytes 93.81 4.00e-173 600.00
IUUC-Pan-091789 Papio anubis 93.50 3.00e-173 600.00
IUUC-Psi-093437 Pelodiscus sinensis 77.40 4.00e-153 534.00
IUUC-Pab-098375 Pongo abelii 93.81 4.00e-173 600.00
IUUC-Pva-103090 Pteropus vampyrus 90.71 5.00e-170 590.00
IUUC-Rno-105800 Rattus norvegicus 97.83 0.00e+00 654.00
IUUC-Sha-106977 Sarcophilus harrisii 90.71 9.00e-178 615.00
IUUC-Sar-113592 Sorex araneus 95.36 1.00e-176 612.00
IUUC-Ssc-116150 Sus scrofa 92.59 5.00e-171 593.00
IUUC-Tgu-117274 Taeniopygia guttata 75.54 5.00e-145 507.00
Created Date 25-Jun-2017

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