iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.30e-07	30.7	75	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 75   CNICLDTAKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 116
           99********.77788*************...666999999****7 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.

Protein Sequence
(Fasta)

MCILLCPHMF CRPINQRQAD WDCLENLPWK LCWQAAMASK GPSASASTEN SNAGGPSGSS 60
NGTGESGGQD STFECNICLD TAKDAVISLC GHLFCWPCLH QWLETRPNRQ VCPVCKAGIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGAGGCGG CTCCGCGTCA GGTGACCAAG TTCCCGGTAG GAGGGGTCGG AGGTTCAATC 60
TTTCTGACTG ACGCGTCTCT AAGACTGGCT CGGCTACTCC GGGACGGGGG AACGGACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0036503--P:ERAD pathway
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mmu:193670

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001042	Aegilops tauschii	43.08	3.00e-24	105.00
IUUC-Aml-001875	Ailuropoda melanoleuca	100.00	7.00e-62	229.00
IUUC-Atr-002721	Amborella trichopoda	45.83	1.00e-25	108.00
IUUC-Apl-003744	Anas platyrhynchos	100.00	3.00e-39	153.00
IUUC-Aly-006065	Arabidopsis lyrata	56.98	1.00e-25	109.00
IUUC-Ath-007401	Arabidopsis thaliana	54.55	2.00e-24	105.00
IUUC-Ame-011667	Astyanax mexicanus	96.79	3.00e-52	197.00
IUUC-Bta-012734	Bos taurus	100.00	1.00e-61	228.00
IUUC-Bci-013671	Botrytis cinerea	48.98	3.00e-09	56.20
IUUC-Bol-016132	Brassica oleracea	47.50	2.00e-26	112.00
IUUC-Bra-017631	Brassica rapa	33.33	2.00e-26	112.00
IUUC-Cel-018228	Caenorhabditis elegans	61.11	1.00e-34	139.00
IUUC-Cja-019136	Callithrix jacchus	99.38	2.00e-61	228.00
IUUC-Cfa-020308	Canis familiaris	100.00	7.00e-62	229.00
IUUC-Cpo-021347	Cavia porcellus	98.75	5.00e-61	226.00
IUUC-Cre-022829	Chlamydomonas reinhardtii	56.32	5.00e-26	108.00
IUUC-Csa-023755	Chlorocebus sabaeus	98.44	3.00e-66	244.00
IUUC-Dre-028094	Danio rerio	96.86	9.00e-59	219.00
IUUC-Dno-029402	Dasypus novemcinctus	100.00	7.00e-62	229.00
IUUC-Dor-030373	Dipodomys ordii	100.00	7.00e-62	229.00
IUUC-Dme-031966	Drosophila melanogaster	60.98	1.00e-55	209.00
IUUC-Ete-032786	Echinops telfairi	96.88	2.00e-64	238.00
IUUC-Eca-034261	Equus caballus	100.00	7.00e-62	229.00
IUUC-Eeu-034614	Erinaceus europaeus	90.00	3.00e-49	187.00
IUUC-Fca-036049	Felis catus	100.00	7.00e-62	229.00
IUUC-Fal-037085	Ficedula albicollis	98.76	3.00e-61	227.00
IUUC-Gmo-039369	Gadus morhua	90.80	1.00e-56	211.00
IUUC-Gga-040514	Gallus gallus	99.38	4.00e-61	227.00
IUUC-Gac-041719	Gasterosteus aculeatus	95.15	4.00e-56	210.00
IUUC-Gma-043898	Glycine max	59.30	2.00e-26	112.00
IUUC-Ggo-044504	Gorilla gorilla	100.00	7.00e-62	229.00
IUUC-Hsa-045707	Homo sapiens	100.00	7.00e-62	229.00
IUUC-Hvu-047487	Hordeum vulgare	50.00	5.00e-26	110.00
IUUC-Itr-048343	Ictidomys tridecemlineatus	96.88	2.00e-63	234.00
IUUC-Lch-050658	Latimeria chalumnae	93.12	7.00e-59	219.00
IUUC-Loc-052118	Lepisosteus oculatus	96.95	8.00e-57	213.00
IUUC-Laf-054438	Loxodonta africana	96.92	6.00e-65	239.00
IUUC-Mcc-054641	Macaca mulatta	95.31	7.00e-59	219.00
IUUC-Meu-056828	Macropus eugenii	79.61	3.00e-34	135.00
IUUC-Mtr-058107	Medicago truncatula	59.30	3.00e-26	111.00
IUUC-Mga-059554	Meleagris gallopavo	99.38	4.00e-61	227.00
IUUC-Mvi-060316	Microbotryum violaceum	50.88	9.00e-12	63.90
IUUC-Mmr-061662	Microcebus murinus	93.87	4.00e-53	200.00
IUUC-Mdo-062774	Monodelphis domestica	100.00	7.00e-62	229.00
IUUC-Mpu-066033	Mustela putorius furo	89.91	6.00e-63	236.00
IUUC-Mlu-067254	Myotis lucifugus	100.00	7.00e-62	229.00
IUUC-Ncr-068628	Neurospora crassa	43.14	8.00e-10	58.20
IUUC-Nle-069850	Nomascus leucogenys	100.00	7.00e-62	229.00
IUUC-Opr-070197	Ochotona princeps	88.12	2.00e-57	214.00
IUUC-Ont-071950	Oreochromis niloticus	97.45	6.00e-58	216.00
IUUC-Oan-073480	Ornithorhynchus anatinus	100.00	7.00e-62	229.00
IUUC-Ocu-073878	Oryctolagus cuniculus	91.88	8.00e-62	229.00
IUUC-Oba-075248	Oryza barthii	51.09	4.00e-24	103.00
IUUC-Ogu-078463	Oryza glumaepatula	50.47	6.00e-27	113.00
IUUC-Ome-081605	Oryza meridionalis	50.47	7.00e-27	113.00
IUUC-Ola-086800	Oryzias latipes	97.50	5.00e-55	206.00
IUUC-Oga-088197	Otolemur garnettii	97.92	2.00e-67	248.00
IUUC-Ptr-091106	Pan troglodytes	100.00	7.00e-62	229.00
IUUC-Pan-092671	Papio anubis	98.44	3.00e-66	244.00
IUUC-Psi-093323	Pelodiscus sinensis	100.00	1.00e-61	228.00
IUUC-Pno-094942	Phaeosphaeria nodorum	42.68	5.00e-10	58.20
IUUC-Ppa-095474	Physcomitrella patens	52.83	6.00e-27	114.00
IUUC-Pfo-096943	Poecilia formosa	96.25	3.00e-54	204.00
IUUC-Pab-097845	Pongo abelii	100.00	7.00e-62	229.00
IUUC-Ppe-102011	Prunus persica	48.67	1.00e-26	112.00
IUUC-Pva-102298	Pteropus vampyrus	100.00	9.00e-62	229.00
IUUC-Pte-104163	Pyrenophora teres	41.38	4.00e-09	55.10
IUUC-Pyt-104640	Pyrenophora triticirepentis	37.50	9.00e-10	57.40
IUUC-Rno-105293	Rattus norvegicus	99.48	6.00e-68	249.00
IUUC-Sha-107361	Sarcophilus harrisii	94.79	5.00e-65	240.00
IUUC-Sit-110376	Setaria italica	46.77	2.00e-24	105.00
IUUC-Stu-112801	Solanum tuberosum	54.65	7.00e-24	104.00
IUUC-Sar-113669	Sorex araneus	100.00	2.00e-25	107.00
IUUC-Ssc-116228	Sus scrofa	100.00	7.00e-62	229.00
IUUC-Tgu-116886	Taeniopygia guttata	98.76	3.00e-61	227.00
IUUC-Tni-120909	Tetraodon nigroviridis	87.17	3.00e-58	217.00
IUUC-Tae-123670	Triticum aestivum	52.94	6.00e-23	100.00
IUUC-Tur-126676	Triticum urartu	52.94	5.00e-23	100.00
IUUC-Tbe-127360	Tupaia belangeri	100.00	9.00e-43	165.00
IUUC-Ttr-129044	Tursiops truncatus	100.00	7.00e-62	229.00
IUUC-Vpa-130365	Vicugna pacos	99.38	5.00e-61	226.00
IUUC-Vvi-131449	Vitis vinifera	56.32	4.00e-26	111.00
IUUC-Xtr-131916	Xenopus tropicalis	93.67	1.00e-42	165.00
IUUC-Xma-133333	Xiphophorus maculatus	93.90	1.00e-54	205.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence