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Tag Content
UUCD2 ID IUUC-Ssc-115471
UUCD1 version UUC-SuS-00771
Ensembl Protein ID ENSSSCP00000006477.2
UniProt Accession Q2VJ60; Q2VJ61; RN19A_PIG
Genbank Protein ID AAZ41326.1; AAZ41327.1
Protein Name E3 ubiquitin-protein ligase RNF19A; Double ring-finger protein; RING finger protein 19A
Genbank Nucleotide ID DQ091175; DQ091176
Gene Name RNF19A; RNF19
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000006066.2 ENSSSCT00000006656.2 ENSSSCP00000006477.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RBR 1.20e-52 179.3 132 332
Active Site
Position(s) Description Evidence
316 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++Cll++s+++++ +++C+h+ C +Cl+qyl+++i+e++ ++iscp  ec+e++++++i+ +l+++ l+++ye+++l++++ ad++++w
   Q: 132  CPLCLLRHSKDRFPEIMTCHHRSCVDCLRQYLRIEISESR-VNISCP--ECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRW 218
           ****************************************.9*****..89*************************************** PP
   S: 91   cpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeek.......eeaeskelleanskkCpkCkvyi 171
           cpapdC ++v++  +a  +kl++ +e+cg+efC++Ck++wH++++C+++++++a++ + +       + ++++ ++++++k+Cp+C +yi
   Q: 219  CPAPDCGYAVIAFGCAscPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRtirsssiSYSQESGAAADDIKPCPRCAAYI 308
           *************999889************************************99998999*99999999****************** PP
   S: 172  ek..negCnhmtCakCkaefCwlC 193
           +k  +++CnhmtCa C++efCwlC
   Q: 309  IKmnDGSCNHMTCAVCGCEFCWLC 332
           *997889***************** PP
   
Organism Sus scrofa
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR.
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR.
Protein Sequence
(Fasta)
MQEQEIGLLS KYNEGLCINT DPNSILMSIL DMSLHRQMGS DRDLQSSASS VSLPSVKKAP 60
KKRRISIGSL FRRKKENKRK SRELNGGVDG IASIESIHSE MCTDKNSIFS TNTSSDNGLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ssc-115471|E3,RBR|Sus scrofa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGACCCGGC GCTGGCGTCC TCTCAGCGGC GCGGGCGGAG GCGAGGCTTG GGATCCGCCC 60
CGAGCCCGGT CCTCCCGGCC TGGGCAGTCT GGGGCGACGG CGGCCGACTA GGCGGTGTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ssc-115471|E3,RBR|Sus scrofa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG ssc:654326
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001958 Ailuropoda melanoleuca 97.73 0.00e+00 1412.00
IUUC-Apl-003427 Anas platyrhynchos 89.84 0.00e+00 1170.00
IUUC-Aca-004252 Anolis carolinensis 86.83 0.00e+00 1134.00
IUUC-Ame-011434 Astyanax mexicanus 74.97 0.00e+00 885.00
IUUC-Bta-013558 Bos taurus 97.85 0.00e+00 1415.00
IUUC-Cel-018626 Caenorhabditis elegans 55.49 1.00e-111 397.00
IUUC-Cja-019070 Callithrix jacchus 97.14 0.00e+00 1406.00
IUUC-Cfa-020286 Canis familiaris 97.61 0.00e+00 1409.00
IUUC-Cpo-022015 Cavia porcellus 95.23 0.00e+00 1368.00
IUUC-Csa-023975 Chlorocebus sabaeus 96.78 0.00e+00 1377.00
IUUC-Cho-024442 Choloepus hoffmanni 82.10 0.00e+00 1181.00
IUUC-Cin-025143 Ciona intestinalis 55.41 2.00e-43 168.00
IUUC-Dre-028422 Danio rerio 73.10 0.00e+00 878.00
IUUC-Dno-029018 Dasypus novemcinctus 96.68 0.00e+00 1308.00
IUUC-Dor-030548 Dipodomys ordii 92.97 0.00e+00 653.00
IUUC-Eca-034249 Equus caballus 97.85 0.00e+00 1408.00
IUUC-Eeu-035298 Erinaceus europaeus 98.16 0.00e+00 855.00
IUUC-Fca-035912 Felis catus 97.49 0.00e+00 1409.00
IUUC-Fal-037488 Ficedula albicollis 88.36 0.00e+00 1139.00
IUUC-Gmo-038893 Gadus morhua 82.06 0.00e+00 808.00
IUUC-Gga-040380 Gallus gallus 88.72 0.00e+00 1136.00
IUUC-Gac-041421 Gasterosteus aculeatus 76.38 0.00e+00 885.00
IUUC-Ggo-044893 Gorilla gorilla 97.14 0.00e+00 1402.00
IUUC-Hsa-046876 Homo sapiens 97.37 0.00e+00 1405.00
IUUC-Itr-048257 Ictidomys tridecemlineatus 97.26 0.00e+00 1404.00
IUUC-Lch-049774 Latimeria chalumnae 85.14 0.00e+00 1128.00
IUUC-Loc-052040 Lepisosteus oculatus 77.83 0.00e+00 1004.00
IUUC-Laf-053874 Loxodonta africana 96.78 0.00e+00 1373.00
IUUC-Mcc-054817 Macaca mulatta 96.00 1.00e-111 395.00
IUUC-Meu-056648 Macropus eugenii 90.14 3.00e-176 611.00
IUUC-Mga-060175 Meleagris gallopavo 88.53 0.00e+00 1161.00
IUUC-Mmr-060800 Microcebus murinus 97.73 0.00e+00 1412.00
IUUC-Mdo-061827 Monodelphis domestica 87.59 0.00e+00 1129.00
IUUC-Mmu-064134 Mus musculus 92.74 0.00e+00 1277.00
IUUC-Mpu-066076 Mustela putorius furo 97.02 0.00e+00 1397.00
IUUC-Mlu-068218 Myotis lucifugus 95.82 0.00e+00 1317.00
IUUC-Nle-069707 Nomascus leucogenys 98.01 0.00e+00 1101.00
IUUC-Opr-070977 Ochotona princeps 95.45 0.00e+00 1368.00
IUUC-Ont-072373 Oreochromis niloticus 78.33 0.00e+00 937.00
IUUC-Oan-073376 Ornithorhynchus anatinus 98.81 1.00e-160 559.00
IUUC-Ocu-074878 Oryctolagus cuniculus 96.06 0.00e+00 1352.00
IUUC-Ola-086472 Oryzias latipes 78.39 0.00e+00 931.00
IUUC-Oga-088377 Otolemur garnettii 96.77 0.00e+00 1385.00
IUUC-Oar-089540 Ovis aries 97.14 0.00e+00 1402.00
IUUC-Ptr-090613 Pan troglodytes 97.37 0.00e+00 1405.00
IUUC-Pan-092879 Papio anubis 97.02 0.00e+00 1379.00
IUUC-Psi-093201 Pelodiscus sinensis 89.60 0.00e+00 1137.00
IUUC-Pma-094620 Petromyzon marinus 72.36 0.00e+00 813.00
IUUC-Pfo-096615 Poecilia formosa 83.67 0.00e+00 896.00
IUUC-Pca-100625 Procavia capensis 95.09 0.00e+00 1360.00
IUUC-Pva-103110 Pteropus vampyrus 87.35 0.00e+00 1079.00
IUUC-Rno-105998 Rattus norvegicus 92.14 0.00e+00 1279.00
IUUC-Sha-107523 Sarcophilus harrisii 87.05 0.00e+00 1134.00
IUUC-Sar-113089 Sorex araneus 94.29 0.00e+00 967.00
IUUC-Tgu-117080 Taeniopygia guttata 88.60 0.00e+00 1177.00
IUUC-Tru-117547 Takifugu rubripes 78.95 0.00e+00 893.00
IUUC-Tsy-119143 Tarsius syrichta 96.06 0.00e+00 1382.00
IUUC-Tni-119693 Tetraodon nigroviridis 77.60 0.00e+00 885.00
IUUC-Ttr-129175 Tursiops truncatus 97.14 0.00e+00 1386.00
IUUC-Vpa-130594 Vicugna pacos 90.14 0.00e+00 1295.00
IUUC-Xtr-132579 Xenopus tropicalis 84.75 0.00e+00 1143.00
Created Date 25-Jun-2017

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