iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012966

Ensembl Protein ID

ENSBTAP00000034104.4

UniProt Accession

E1BM66; E1BM66_BOVIN

Genbank Protein ID

ENSBTAP00000034104

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

DAAA02020048

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000025426.4	ENSBTAT00000034204.4	ENSBTAP00000034104.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.00e-14	53.6	1712	1752

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1712 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1752
           8*********....*******************....99996.******8 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STASGTSQNA 60
YGQDSPSCYI PLRKLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQSP VVCTSLNPGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCAGA CCTGTGAACT ACCTAGAAGA AATTGTCTGC TGCCCTTTTC CAATCCAGTG 60
AATTTAGATG CCCCTGAAGA CAAGGACAGC CCTTTCGGTA ATGGTCAATC CAATTTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000310	Aegilops tauschii	29.53	7.00e-12	65.90
IUUC-Aml-001795	Ailuropoda melanoleuca	93.75	0.00e+00	4895.00
IUUC-Apl-003953	Anas platyrhynchos	57.14	0.00e+00	2251.00
IUUC-Aca-005339	Anolis carolinensis	50.76	0.00e+00	1758.00
IUUC-Bdi-014781	Brachypodium distachyon	30.10	2.00e-13	70.90
IUUC-Bol-016001	Brassica oleracea	29.51	5.00e-17	84.00
IUUC-Bra-017864	Brassica rapa	28.96	9.00e-16	80.10
IUUC-Cja-018780	Callithrix jacchus	89.66	0.00e+00	4422.00
IUUC-Cfa-020975	Canis familiaris	93.00	0.00e+00	4903.00
IUUC-Cpo-021331	Cavia porcellus	87.81	0.00e+00	2692.00
IUUC-Csa-024226	Chlorocebus sabaeus	89.93	0.00e+00	4168.00
IUUC-Cho-024464	Choloepus hoffmanni	76.90	0.00e+00	1412.00
IUUC-Dre-028152	Danio rerio	62.89	0.00e+00	1253.00
IUUC-Dno-029230	Dasypus novemcinctus	88.06	0.00e+00	4549.00
IUUC-Dor-031016	Dipodomys ordii	81.29	0.00e+00	1322.00
IUUC-Dme-032193	Drosophila melanogaster	36.87	7.00e-123	435.00
IUUC-Eca-033591	Equus caballus	92.73	0.00e+00	4331.00
IUUC-Fca-035791	Felis catus	93.52	0.00e+00	5028.00
IUUC-Fal-037378	Ficedula albicollis	58.12	0.00e+00	2065.00
IUUC-Gmo-038919	Gadus morhua	71.20	0.00e+00	934.00
IUUC-Gga-040881	Gallus gallus	57.04	0.00e+00	2165.00
IUUC-Gac-041378	Gasterosteus aculeatus	77.87	0.00e+00	1071.00
IUUC-Hsa-046436	Homo sapiens	90.93	0.00e+00	4745.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	89.11	0.00e+00	4219.00
IUUC-Lch-049684	Latimeria chalumnae	56.30	0.00e+00	1438.00
IUUC-Laf-054046	Loxodonta africana	90.13	0.00e+00	4140.00
IUUC-Mcc-055593	Macaca mulatta	90.23	0.00e+00	4698.00
IUUC-Mga-059756	Meleagris gallopavo	57.16	0.00e+00	2236.00
IUUC-Mmr-061182	Microcebus murinus	89.82	0.00e+00	4777.00
IUUC-Mdo-061984	Monodelphis domestica	69.04	0.00e+00	3068.00
IUUC-Mmu-063605	Mus musculus	82.84	0.00e+00	4308.00
IUUC-Mpu-066446	Mustela putorius furo	93.00	0.00e+00	4952.00
IUUC-Mlu-067261	Myotis lucifugus	91.38	0.00e+00	4775.00
IUUC-Nle-069818	Nomascus leucogenys	90.27	0.00e+00	4208.00
IUUC-Opr-070842	Ochotona princeps	84.35	0.00e+00	2382.00
IUUC-Ont-072448	Oreochromis niloticus	75.67	0.00e+00	1149.00
IUUC-Oan-073496	Ornithorhynchus anatinus	76.34	0.00e+00	1646.00
IUUC-Ocu-074918	Oryctolagus cuniculus	89.82	0.00e+00	4768.00
IUUC-Obr-076753	Oryza brachyantha	54.84	8.00e-08	53.50
IUUC-Ola-087518	Oryzias latipes	76.70	0.00e+00	1056.00
IUUC-Oga-088743	Otolemur garnettii	88.05	0.00e+00	4029.00
IUUC-Oar-090265	Ovis aries	98.26	0.00e+00	5208.00
IUUC-Ptr-090521	Pan troglodytes	90.90	0.00e+00	4752.00
IUUC-Psi-093245	Pelodiscus sinensis	59.21	0.00e+00	2046.00
IUUC-Pfo-096066	Poecilia formosa	76.18	0.00e+00	1206.00
IUUC-Pab-098644	Pongo abelii	90.10	0.00e+00	4173.00
IUUC-Pva-103094	Pteropus vampyrus	88.88	0.00e+00	2712.00
IUUC-Rno-105803	Rattus norvegicus	82.26	0.00e+00	3784.00
IUUC-Sha-107278	Sarcophilus harrisii	70.08	0.00e+00	3502.00
IUUC-Sar-113402	Sorex araneus	76.99	0.00e+00	2631.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	3.00e-13	67.40
IUUC-Ssc-116193	Sus scrofa	93.57	0.00e+00	4275.00
IUUC-Tgu-116532	Taeniopygia guttata	89.85	0.00e+00	1253.00
IUUC-Tru-117988	Takifugu rubripes	77.86	0.00e+00	1202.00
IUUC-Tsy-118830	Tarsius syrichta	89.21	0.00e+00	3773.00
IUUC-Tca-121456	Theobroma cacao	30.33	2.00e-19	91.30
IUUC-Tae-124687	Triticum aestivum	29.53	8.00e-12	65.90

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence