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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064202
Ensembl Protein ID ENSMUSP00000010241.6
UniProt Accession Q99JX7; O88985; Q3TJA5; NXF1_MOUSE
Genbank Protein ID AAC63368.1; BAE21911.1; BAE39590.1; EDL33363.1; AAH05594.1
Protein Name Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP
Genbank Nucleotide ID AF093140; AK133883; AK167518; CH466612; BC005594
Gene Name Nxf1; Tap
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000010097.13 ENSMUST00000010241.13 ENSMUSP00000010241.6
ENSMUSG00000010097.13 ENSMUST00000184970.7 ENSMUSP00000139124.1
ENSMUSG00000010097.13 ENSMUST00000184756.1 ENSMUSP00000139050.1
ENSMUSG00000010097.13 ENSMUST00000184663.1 ENSMUSP00000139090.1
ENSMUSG00000010097.13 ENSMUST00000184826.1 ENSMUSP00000139229.1
ENSMUSG00000010097.13 ENSMUST00000010248.3 ENSMUSP00000010248.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 23.54 5.00e-10 61.20 IUUC-Sce-106429
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.
 Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.
Protein Sequence
(Fasta)
MADEGKSYNE HDDRVSFPQR RKKGRGPFRW KCGEGNRRSG RGGSGVQSSR FEEDDGDVAM 60
NDPQDGPRVR YNPYTNRPNR RGDGWHDRDR IHITVRRDRA PAERGGAGTS QDGTTKNWFK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064202|UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCCACATC CTGGGGACGT CGGCGGCGCG CGACGTGCTT CGCCGGATAA ATGCGGTGGC 60
GCCGGTCGTA GGAGAGATTC TGTCCTGAGC GCTAAGGCTC CTTGGCGTTT GGTGGCGTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064202|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0488--Methylation
KW-0509--mRNA transport
KW-0944--Nitration
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport
Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR002075--NTF2
IPR032710--NTF2-like_dom
IPR018222--Nuclear_transport_factor_2_euk
IPR012677--Nucleotide-bd_a/b_plait
IPR030217--NXF_fam
IPR000504--RRM_dom
IPR005637--TAP_C_dom
IPR015245--Tap_RNA-bd
IPR009060--UBA-like
PROSITE

PS51450--LRR
PS50177--NTF2_DOMAIN
PS51281--TAP_C
Pfam

PF02136--NTF2
PF09162--Tap-RNA_bind
PF03943--TAP_C
SMART

SM00804--TAP_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0042405--C:nuclear inclusion body
GO:0005643--C:nuclear pore
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000346--C:transcription export complex
GO:0003729--F:mRNA binding
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0003727--F:single-stranded RNA binding
GO:0006406--P:mRNA export from nucleus
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0006405--P:RNA export from nucleus
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001516 Ailuropoda melanoleuca 87.58 0.00e+00 1033.00
IUUC-Apl-003526 Anas platyrhynchos 34.48 6.00e-03 34.70
IUUC-Aca-005187 Anolis carolinensis 62.84 0.00e+00 731.00
IUUC-Ago-007780 Ashbya gossypii 23.39 6.00e-18 85.90
IUUC-Acl-008191 Aspergillus clavatus 24.80 3.00e-21 97.10
IUUC-Afl-008512 Aspergillus flavus 26.12 6.00e-25 109.00
IUUC-Afu-009048 Aspergillus fumigatus 26.77 8.00e-26 112.00
IUUC-Ani-009320 Aspergillus nidulans 22.72 1.00e-17 85.50
IUUC-Ang-009834 Aspergillus niger 23.97 8.00e-20 92.00
IUUC-Aor-010039 Aspergillus oryzae 25.66 4.00e-21 96.70
IUUC-Ate-010321 Aspergillus terreus 24.79 8.00e-19 89.00
IUUC-Ame-011034 Astyanax mexicanus 57.14 0.00e+00 646.00
IUUC-Bgr-012142 Blumeria graminis 27.31 1.00e-20 95.50
IUUC-Bta-013268 Bos taurus 88.06 0.00e+00 1014.00
IUUC-Bci-013951 Botrytis cinerea 27.71 2.00e-21 97.80
IUUC-Cel-018213 Caenorhabditis elegans 32.58 1.50e-02 33.10
IUUC-Cja-019064 Callithrix jacchus 90.47 0.00e+00 1048.00
IUUC-Cfa-020712 Canis familiaris 87.96 0.00e+00 996.00
IUUC-Cpo-021814 Cavia porcellus 90.94 0.00e+00 1055.00
IUUC-Csa-023652 Chlorocebus sabaeus 90.95 0.00e+00 1056.00
IUUC-Cho-024546 Choloepus hoffmanni 35.71 8.00e-03 34.30
IUUC-Cin-025669 Ciona intestinalis 34.65 4.00e-96 345.00
IUUC-Csv-025957 Ciona savignyi 34.00 4.00e-82 298.00
IUUC-Cgl-026395 Colletotrichum gloeosporioides 27.17 1.00e-28 121.00
IUUC-Cne-026967 Cryptococcus neoformans 20.98 5.00e-04 39.70
IUUC-Dre-028476 Danio rerio 53.02 2.00e-147 515.00
IUUC-Dno-029301 Dasypus novemcinctus 88.03 0.00e+00 1012.00
IUUC-Dor-030764 Dipodomys ordii 90.63 0.00e+00 1047.00
IUUC-Dse-031489 Dothistroma septosporum 24.71 3.00e-17 83.60
IUUC-Dme-031623 Drosophila melanogaster 31.31 1.00e-74 274.00
IUUC-Ete-032992 Echinops telfairi 75.82 0.00e+00 786.00
IUUC-Eca-033208 Equus caballus 90.16 0.00e+00 989.00
IUUC-Eeu-034759 Erinaceus europaeus 88.35 0.00e+00 1039.00
IUUC-Fca-035671 Felis catus 89.81 0.00e+00 1046.00
IUUC-Fal-036625 Ficedula albicollis 34.48 8.00e-03 34.30
IUUC-Fox-037892 Fusarium oxysporum 26.91 1.00e-20 95.10
IUUC-Fso-038402 Fusarium solani 25.07 3.00e-19 90.50
IUUC-Gmo-039325 Gadus morhua 55.95 7.00e-153 534.00
IUUC-Ggr-039736 Gaeumannomyces graminis 24.20 4.00e-11 63.20
IUUC-Gga-040508 Gallus gallus 70.22 0.00e+00 770.00
IUUC-Gac-041798 Gasterosteus aculeatus 57.44 0.00e+00 692.00
IUUC-Ggo-044655 Gorilla gorilla 90.62 0.00e+00 1024.00
IUUC-Hsa-047028 Homo sapiens 91.11 0.00e+00 1057.00
IUUC-Itr-048415 Ictidomys tridecemlineatus 88.85 0.00e+00 1045.00
IUUC-Kpa-049280 Komagataella pastoris 22.93 2.00e-20 94.40
IUUC-Lch-049501 Latimeria chalumnae 68.95 0.00e+00 821.00
IUUC-Loc-052299 Lepisosteus oculatus 63.15 2.00e-170 592.00
IUUC-Laf-053523 Loxodonta africana 88.67 0.00e+00 1038.00
IUUC-Mcc-055389 Macaca mulatta 91.59 0.00e+00 985.00
IUUC-Meu-056620 Macropus eugenii 56.29 2.00e-137 481.00
IUUC-Mor-057232 Magnaporthe oryzae 27.55 2.00e-27 117.00
IUUC-Mpo-057539 Magnaporthe poae 24.52 5.00e-11 63.20
IUUC-Mla-059053 Melampsora laricipopulina 25.93 3.00e-25 110.00
IUUC-Mga-059220 Meleagris gallopavo 34.48 8.00e-03 34.30
IUUC-Mvi-060283 Microbotryum violaceum 25.86 8.00e-21 95.50
IUUC-Mmr-061583 Microcebus murinus 91.59 0.00e+00 1068.00
IUUC-Mdo-062158 Monodelphis domestica 78.70 0.00e+00 930.00
IUUC-Mpu-065730 Mustela putorius furo 88.83 0.00e+00 1036.00
IUUC-Mlu-066975 Myotis lucifugus 87.42 0.00e+00 977.00
IUUC-Nfi-068368 Neosartorya fischeri 27.68 3.00e-24 106.00
IUUC-Ncr-068724 Neurospora crassa 25.00 1.00e-15 78.60
IUUC-Nle-069816 Nomascus leucogenys 90.79 0.00e+00 1048.00
IUUC-Opr-070244 Ochotona princeps 43.50 5.00e-130 458.00
IUUC-Ont-072608 Oreochromis niloticus 57.78 0.00e+00 711.00
IUUC-Oan-073580 Ornithorhynchus anatinus 31.86 4.80e-02 31.60
IUUC-Ocu-074226 Oryctolagus cuniculus 88.85 0.00e+00 1083.00
IUUC-Ola-087008 Oryzias latipes 64.41 0.00e+00 677.00
IUUC-Oga-088317 Otolemur garnettii 87.12 0.00e+00 968.00
IUUC-Oar-089720 Ovis aries 87.74 0.00e+00 983.00
IUUC-Ptr-091148 Pan troglodytes 91.11 0.00e+00 1057.00
IUUC-Pan-091764 Papio anubis 90.95 0.00e+00 1054.00
IUUC-Psi-094071 Pelodiscus sinensis 63.97 0.00e+00 770.00
IUUC-Pno-095045 Phaeosphaeria nodorum 22.54 2.00e-04 40.40
IUUC-Pfo-096500 Poecilia formosa 60.03 0.00e+00 734.00
IUUC-Pab-098014 Pongo abelii 89.66 0.00e+00 1056.00
IUUC-Pca-100121 Procavia capensis 87.22 0.00e+00 988.00
IUUC-Pva-102865 Pteropus vampyrus 89.81 0.00e+00 1002.00
IUUC-Pgr-103333 Puccinia graminis 23.86 9.00e-15 75.50
IUUC-Ptt-103702 Puccinia triticina 23.31 2.00e-17 84.70
IUUC-Pte-104388 Pyrenophora teres 24.38 3.00e-04 39.30
IUUC-Rno-106100 Rattus norvegicus 92.56 0.00e+00 1071.00
IUUC-Sce-106429 Saccharomyces cerevisiae 22.50 3.00e-14 73.90
IUUC-Sha-106834 Sarcophilus harrisii 78.85 0.00e+00 949.00
IUUC-Sja-107818 Schizosaccharomyces japonicus 26.61 1.00e-21 98.60
IUUC-Spo-108301 Schizosaccharomyces pombe 27.27 1.00e-33 137.00
IUUC-Ssl-108512 Sclerotinia sclerotiorum 25.98 2.00e-20 94.40
IUUC-Sar-112963 Sorex araneus 44.23 8.00e-127 447.00
IUUC-Sre-114950 Sporisorium reilianum 23.60 1.00e-20 94.70
IUUC-Ssc-116010 Sus scrofa 88.23 0.00e+00 983.00
IUUC-Tgu-116603 Taeniopygia guttata 35.53 7.00e-03 34.70
IUUC-Tru-118148 Takifugu rubripes 58.13 0.00e+00 687.00
IUUC-Tsy-119506 Tarsius syrichta 37.89 7.00e-06 43.90
IUUC-Tni-120552 Tetraodon nigroviridis 30.63 7.00e-04 37.40
IUUC-Tre-121894 Trichoderma reesei 25.77 1.00e-25 111.00
IUUC-Tvi-122501 Trichoderma virens 27.91 9.00e-32 131.00
IUUC-Tme-127084 Tuber melanosporum 25.40 5.00e-27 116.00
IUUC-Tbe-127980 Tupaia belangeri 60.70 7.00e-86 310.00
IUUC-Ttr-128656 Tursiops truncatus 55.59 0.00e+00 657.00
IUUC-Uma-129530 Ustilago maydis 25.69 5.00e-21 96.30
IUUC-Vda-129709 Verticillium dahliae 27.23 3.00e-25 110.00
IUUC-Vpa-130739 Vicugna pacos 43.87 3.00e-100 358.00
IUUC-Xtr-132404 Xenopus tropicalis 59.51 0.00e+00 723.00
IUUC-Xma-133051 Xiphophorus maculatus 58.83 0.00e+00 708.00
IUUC-Yli-134681 Yarrowia lipolytica 25.81 1.00e-31 130.00
Created Date 25-Jun-2017

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