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Tag Content
UUCD2 ID IUUC-Xtr-132266
UUCD1 version UUC-XeT-00945
Ensembl Protein ID ENSXETP00000008619.3
UniProt Accession Q66JG1; DDB2_XENTR
Genbank Protein ID AAH80928.1
Protein Name DNA damage-binding protein 2; Damage-specific DNA-binding protein 2
Genbank Nucleotide ID BC080928
Gene Name ddb2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000003980.3 ENSXETT00000008619.3 ENSXETP00000008619.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-10 41.5 250 286
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           H+ +vt ++f    d+ll+s+s D t+k+WDlr  ++
   Q: 250  HKKKVTHVEFnprCDWLLASASVDQTVKLWDLRNIKD 286
           8899*******9766*****************97665 PP
   
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity).
 Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity).
Protein Sequence
(Fasta)
MPPKRATRGR RNVELSSEEE EEQEEVSPGK RKRDIEKNGE ARLKKPSKKR SGQQCASDVP 60
CSSKESDCGT NLTNKGDKQR SIVHYLYRST LGGNVRAKYL QTPFLRSLAS YILYRTNSPF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132266|E3,WD_repeat|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTGAGAGGA GAATAATGCG AATGTAGCGC CGAGCTCTCT GCGCTGGGTT TGTGCAGTGG 60
CTGCAGCACG GAGAGGGATG GGTGGGCGAT AGAGCCGCTG AGAGGAATGG GTTTGCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132266|E3,WD_repeat|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR033312--DDB2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0006281--P:DNA repair
GO:0016567--P:protein ubiquitination
KEGG xtr:493565
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000470 Aegilops tauschii 31.83 2.00e-40 160.00
IUUC-Aml-002203 Ailuropoda melanoleuca 58.95 1.00e-128 452.00
IUUC-Atr-002957 Amborella trichopoda 33.52 4.00e-44 172.00
IUUC-Apl-003832 Anas platyrhynchos 66.93 2.00e-148 518.00
IUUC-Aca-004358 Anolis carolinensis 59.05 4.00e-157 547.00
IUUC-Aly-006296 Arabidopsis lyrata 33.64 3.00e-42 166.00
IUUC-Ath-007115 Arabidopsis thaliana 32.26 3.00e-42 166.00
IUUC-Ame-010817 Astyanax mexicanus 60.53 2.00e-137 481.00
IUUC-Bta-012914 Bos taurus 62.25 3.00e-131 461.00
IUUC-Bdi-014261 Brachypodium distachyon 31.55 8.00e-40 158.00
IUUC-Bol-015317 Brassica oleracea 33.95 7.00e-43 168.00
IUUC-Bra-016848 Brassica rapa 33.95 1.00e-42 167.00
IUUC-Cja-018967 Callithrix jacchus 61.56 7.00e-130 456.00
IUUC-Cfa-021238 Canis familiaris 59.06 3.00e-124 437.00
IUUC-Cpo-022063 Cavia porcellus 60.85 2.00e-127 448.00
IUUC-Csa-023382 Chlorocebus sabaeus 61.28 4.00e-129 454.00
IUUC-Cho-024805 Choloepus hoffmanni 45.49 2.00e-52 198.00
IUUC-Dre-028732 Danio rerio 58.86 4.00e-124 437.00
IUUC-Dor-030461 Dipodomys ordii 60.94 6.00e-92 330.00
IUUC-Ete-033038 Echinops telfairi 55.22 5.00e-121 427.00
IUUC-Eca-033772 Equus caballus 63.03 5.00e-125 440.00
IUUC-Eeu-034662 Erinaceus europaeus 58.33 2.00e-33 136.00
IUUC-Fca-036095 Felis catus 58.79 3.00e-124 438.00
IUUC-Gmo-039683 Gadus morhua 58.17 2.00e-123 435.00
IUUC-Gga-040530 Gallus gallus 68.68 5.00e-149 520.00
IUUC-Gac-041517 Gasterosteus aculeatus 56.33 9.00e-114 403.00
IUUC-Gma-042883 Glycine max 31.34 2.00e-40 160.00
IUUC-Ggo-045364 Gorilla gorilla 62.40 9.00e-131 459.00
IUUC-Hsa-046354 Homo sapiens 62.40 9.00e-131 459.00
IUUC-Hvu-047151 Hordeum vulgare 31.70 2.00e-32 132.00
IUUC-Itr-048304 Ictidomys tridecemlineatus 62.54 3.00e-131 461.00
IUUC-Lpe-051256 Leersia perrieri 33.33 6.00e-39 155.00
IUUC-Loc-052398 Lepisosteus oculatus 63.90 4.00e-146 511.00
IUUC-Laf-053562 Loxodonta africana 63.86 1.00e-126 446.00
IUUC-Mcc-055197 Macaca mulatta 65.56 8.00e-108 383.00
IUUC-Meu-056151 Macropus eugenii 69.31 4.00e-110 390.00
IUUC-Mtr-057940 Medicago truncatula 32.41 2.00e-42 166.00
IUUC-Mga-059923 Meleagris gallopavo 68.16 2.00e-156 545.00
IUUC-Mmr-061465 Microcebus murinus 66.67 8.00e-109 386.00
IUUC-Mdo-063063 Monodelphis domestica 66.67 7.00e-142 496.00
IUUC-Mmu-064294 Mus musculus 60.34 3.00e-126 444.00
IUUC-Mac-065598 Musa acuminata 33.33 1.00e-37 150.00
IUUC-Mpu-066831 Mustela putorius furo 59.21 3.00e-125 441.00
IUUC-Mlu-067222 Myotis lucifugus 62.08 4.00e-130 457.00
IUUC-Nle-069581 Nomascus leucogenys 62.40 5.00e-131 460.00
IUUC-Opr-070644 Ochotona princeps 64.86 2.00e-130 458.00
IUUC-Ont-072605 Oreochromis niloticus 60.26 3.00e-134 471.00
IUUC-Oan-072973 Ornithorhynchus anatinus 68.99 1.00e-143 501.00
IUUC-Ocu-074615 Oryctolagus cuniculus 56.68 5.00e-129 454.00
IUUC-Oba-075283 Oryza barthii 33.02 5.00e-38 152.00
IUUC-Obr-076605 Oryza brachyantha 34.15 9.00e-41 161.00
IUUC-Ogl-077512 Oryza glaberrima 33.02 6.00e-38 152.00
IUUC-Ogu-078329 Oryza glumaepatula 33.02 6.00e-38 152.00
IUUC-Oin-079980 Oryza indica 33.02 7.00e-38 151.00
IUUC-Olo-080516 Oryza longistaminata 33.02 6.00e-38 151.00
IUUC-Ome-081415 Oryza meridionalis 33.02 9.00e-38 151.00
IUUC-Oni-082985 Oryza nivara 33.02 7.00e-38 151.00
IUUC-Opu-084159 Oryza punctata 33.02 2.00e-38 154.00
IUUC-Oru-085137 Oryza rufipogon 33.02 4.00e-38 152.00
IUUC-Osa-085614 Oryza sativa 33.02 4.00e-38 152.00
IUUC-Ola-087044 Oryzias latipes 53.93 2.00e-119 422.00
IUUC-Oga-088274 Otolemur garnettii 62.57 6.00e-130 457.00
IUUC-Oar-089826 Ovis aries 61.69 9.00e-131 459.00
IUUC-Ptr-091631 Pan troglodytes 62.40 9.00e-131 459.00
IUUC-Pan-092535 Papio anubis 61.84 2.00e-130 459.00
IUUC-Psi-093815 Pelodiscus sinensis 63.70 1.00e-152 532.00
IUUC-Pma-094474 Petromyzon marinus 54.24 8.00e-108 383.00
IUUC-Ppa-095414 Physcomitrella patens 33.75 6.00e-41 162.00
IUUC-Pfo-096559 Poecilia formosa 57.38 4.00e-121 427.00
IUUC-Pab-098528 Pongo abelii 62.12 1.00e-130 459.00
IUUC-Pop-100064 Populus trichocarpa 32.11 3.00e-41 162.00
IUUC-Pca-100803 Procavia capensis 63.75 3.00e-125 441.00
IUUC-Ppe-101966 Prunus persica 34.56 1.00e-44 174.00
IUUC-Pva-103213 Pteropus vampyrus 59.43 5.00e-127 447.00
IUUC-Rno-105087 Rattus norvegicus 58.27 3.00e-125 441.00
IUUC-Sha-107466 Sarcophilus harrisii 64.80 2.00e-142 498.00
IUUC-Smo-108958 Selaginella moellendorffii 31.80 7.00e-36 145.00
IUUC-Sit-109968 Setaria italica 30.53 3.00e-38 152.00
IUUC-Sly-111495 Solanum lycopersicum 33.02 1.00e-41 164.00
IUUC-Sar-113272 Sorex araneus 63.36 4.00e-128 450.00
IUUC-Sbi-114706 Sorghum bicolor 29.20 4.00e-33 135.00
IUUC-Ssc-115437 Sus scrofa 54.35 2.00e-124 438.00
IUUC-Tgu-116602 Taeniopygia guttata 59.77 9.00e-143 499.00
IUUC-Tru-118698 Takifugu rubripes 55.86 2.00e-106 379.00
IUUC-Tsy-119027 Tarsius syrichta 54.42 5.00e-110 390.00
IUUC-Tni-119787 Tetraodon nigroviridis 56.15 2.00e-116 412.00
IUUC-Tca-121447 Theobroma cacao 32.72 1.00e-42 167.00
IUUC-Tae-123253 Triticum aestivum 32.11 4.00e-41 162.00
IUUC-Tur-126724 Triticum urartu 33.64 1.00e-39 157.00
IUUC-Tbe-127680 Tupaia belangeri 63.70 6.00e-99 353.00
IUUC-Ttr-128201 Tursiops truncatus 52.39 9.00e-99 353.00
IUUC-Vpa-130451 Vicugna pacos 45.45 4.00e-45 175.00
IUUC-Vvi-131001 Vitis vinifera 32.53 4.00e-45 175.00
IUUC-Xma-133034 Xiphophorus maculatus 58.73 2.00e-131 462.00
Created Date 25-Jun-2017

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