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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063708
Ensembl Protein ID ENSMUSP00000109548.1
UniProt Accession A2AAX3; Q3TEP6; Q8K1Y4; KLH15_MOUSE
Genbank Protein ID BAC38253.1; BAE41202.1; EDL29751.1; AAH36978.1; AAI41166.1
Protein Name Kelch-like protein 15
Genbank Nucleotide ID AK081546; AK169500; AL646049; BC036978; BC141165
Gene Name Klhl15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000043929.16 ENSMUST00000113915.1 ENSMUSP00000109548.1
ENSMUSG00000043929.16 ENSMUST00000113911.8 ENSMUSP00000109544.2
ENSMUSG00000043929.16 ENSMUST00000096369.9 ENSMUSP00000094097.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.20e-19 70.2 32 96
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lv+++ +f+ahk+ La++S++F+ +f+ +++e++ ++++++k++ ++ f+++l+F+Y g++++
   Q: 32   DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERD-QDKIHLKGLTATGFSHVLQFMYYGTIEL 96
           9***********************************9.************************9876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
 Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Protein Sequence
(Fasta)
MAGDVEGFCS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF 60
TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063708|E3,BTB_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GAAGTGACGC GCCTGGGCTG AAAGATGGCG GCATTGGCGT TCAACCAGGG GGAAGGTAAA 60
CACCCGCCAG GCGGCGCGCC GGCCCCCACG GGGCGCCTTC AGGGGCTAAG GGGGCCTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063708|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030597--KLHL15
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001418 Ailuropoda melanoleuca 99.17 0.00e+00 1163.00
IUUC-Apl-003970 Anas platyrhynchos 94.87 0.00e+00 1121.00
IUUC-Aca-005217 Anolis carolinensis 93.87 0.00e+00 1108.00
IUUC-Ame-011065 Astyanax mexicanus 86.42 0.00e+00 1071.00
IUUC-Bta-012443 Bos taurus 98.51 0.00e+00 1159.00
IUUC-Cja-019831 Callithrix jacchus 99.50 0.00e+00 1166.00
IUUC-Cfa-020941 Canis familiaris 99.34 0.00e+00 1165.00
IUUC-Cpo-021730 Cavia porcellus 99.50 0.00e+00 1168.00
IUUC-Csa-023247 Chlorocebus sabaeus 99.50 0.00e+00 1167.00
IUUC-Dre-028474 Danio rerio 85.43 0.00e+00 1069.00
IUUC-Dno-029411 Dasypus novemcinctus 98.51 0.00e+00 1158.00
IUUC-Dor-030576 Dipodomys ordii 99.17 0.00e+00 1164.00
IUUC-Ete-032327 Echinops telfairi 95.70 0.00e+00 1116.00
IUUC-Eca-033477 Equus caballus 98.84 0.00e+00 1161.00
IUUC-Fca-035546 Felis catus 99.17 0.00e+00 1165.00
IUUC-Fal-037370 Ficedula albicollis 94.87 0.00e+00 1121.00
IUUC-Gmo-038961 Gadus morhua 83.25 0.00e+00 987.00
IUUC-Gga-041049 Gallus gallus 94.70 0.00e+00 1121.00
IUUC-Gac-042003 Gasterosteus aculeatus 82.59 0.00e+00 992.00
IUUC-Ggo-044451 Gorilla gorilla 99.50 0.00e+00 1167.00
IUUC-Hsa-045874 Homo sapiens 99.34 0.00e+00 1165.00
IUUC-Itr-048357 Ictidomys tridecemlineatus 99.67 0.00e+00 1168.00
IUUC-Lch-049603 Latimeria chalumnae 89.58 7.00e-128 449.00
IUUC-Loc-052300 Lepisosteus oculatus 89.74 0.00e+00 1102.00
IUUC-Laf-054459 Loxodonta africana 98.68 0.00e+00 1160.00
IUUC-Mcc-054846 Macaca mulatta 99.50 0.00e+00 1167.00
IUUC-Meu-056797 Macropus eugenii 98.65 2.00e-115 409.00
IUUC-Mga-059446 Meleagris gallopavo 94.87 0.00e+00 1121.00
IUUC-Mmr-061125 Microcebus murinus 98.68 0.00e+00 1160.00
IUUC-Mdo-062947 Monodelphis domestica 93.21 0.00e+00 1085.00
IUUC-Mpu-066447 Mustela putorius furo 99.17 0.00e+00 1156.00
IUUC-Mlu-066999 Myotis lucifugus 94.51 0.00e+00 977.00
IUUC-Nle-069918 Nomascus leucogenys 99.50 0.00e+00 1167.00
IUUC-Ont-071446 Oreochromis niloticus 83.81 0.00e+00 980.00
IUUC-Oan-072872 Ornithorhynchus anatinus 90.73 0.00e+00 1109.00
IUUC-Ocu-073969 Oryctolagus cuniculus 98.77 0.00e+00 911.00
IUUC-Ola-087557 Oryzias latipes 83.54 4.00e-152 530.00
IUUC-Oga-088567 Otolemur garnettii 99.17 0.00e+00 1162.00
IUUC-Oar-089882 Ovis aries 98.34 0.00e+00 1159.00
IUUC-Ptr-091229 Pan troglodytes 99.49 0.00e+00 1135.00
IUUC-Pan-091977 Papio anubis 99.50 0.00e+00 1167.00
IUUC-Psi-093496 Pelodiscus sinensis 95.24 2.00e-156 545.00
IUUC-Pfo-096759 Poecilia formosa 82.90 0.00e+00 996.00
IUUC-Pab-098480 Pongo abelii 99.50 0.00e+00 1167.00
IUUC-Rno-105500 Rattus norvegicus 100.00 0.00e+00 1171.00
IUUC-Sha-106521 Sarcophilus harrisii 93.22 0.00e+00 1056.00
IUUC-Ssc-116372 Sus scrofa 99.17 0.00e+00 1165.00
IUUC-Tgu-116481 Taeniopygia guttata 94.87 0.00e+00 1121.00
IUUC-Tru-118542 Takifugu rubripes 81.45 0.00e+00 988.00
IUUC-Tsy-118848 Tarsius syrichta 99.55 3.00e-128 452.00
IUUC-Tni-119989 Tetraodon nigroviridis 82.06 0.00e+00 930.00
IUUC-Tbe-127485 Tupaia belangeri 99.83 0.00e+00 1169.00
IUUC-Ttr-129214 Tursiops truncatus 98.84 0.00e+00 1159.00
IUUC-Vpa-130261 Vicugna pacos 96.19 0.00e+00 1121.00
IUUC-Xtr-132092 Xenopus tropicalis 89.51 0.00e+00 1021.00
Created Date 25-Jun-2017

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