iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-40	132.6	51	86
UBD/Beta-Prp	9.00e-79	262.8	4	331

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH ++v+++af ++ +l+vsG+dD ++ vW++++ +
   Q: 51   GHDGPVRGIAFhPTqPLFVSGGDDYKVNVWNYKSRK 86
           8***********888****************87765 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
            t +++++s+ + v+f+p +++++t+  +g+i++wd+++g+ll ++ gh+++v+ + f+p+++++v+g++D+ ++vw+++++k + +l gh
   Q: 4    LTKFESRSSRAKGVAFHPTQPWILTSLHNGRIQLWDYRMGTLLDRFDGHDGPVRGIAFHPTQPLFVSGGDDYKVNVWNYKSRKLLFSLCGH 94
           67889999*********************************************************************************** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.................. 166
            d+v+ ++f+ +  +++s s+d+tir+w+++++ c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                  
   Q: 95   MDYVRVCTFHHEYPWILSCSDDQTIRIWNWQSRNCIA-ILTGHSHYVMCAAFHPSEDLIVSASLDQTVRVWDIsglrmknaapvsmsledq 184
           *************************************.***************************************************** PP
   S: 167  ..............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                         +t+ +++   +gh++ v++ +f+++ + ++s+++d+ vklw + +++   v+t++gh +nv++  f+p++e+++s+s
   Q: 185  laqahnsisndlfgSTDAIVKFVLEGHDRGVNWCAFHPTLPLILSAGDDRLVKLWRMTASKAweVDTCRGHFNNVSCCLFHPHQELILSAS 275
           ***99999999996555555555667********************************887778*************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D++ir+Wdl  ++ ++t+ + n++++ ++v +++ n ++++  ds v+++kl++++p
   Q: 276  EDKTIRVWDLNRRTAVQTFRRDNDRFWFITV-HPKLNLFAAA-HDSGVMVFKLERERP 331
           *******************************.5555444433.59********98876 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

Protein Sequence
(Fasta)

MEMLTKFESR SSRAKGVAFH PTQPWILTSL HNGRIQLWDY RMGTLLDRFD GHDGPVRGIA 60
FHPTQPLFVS GGDDYKVNVW NYKSRKLLFS LCGHMDYVRV CTFHHEYPWI LSCSDDQTIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTAGACC AAGGTAGTGA AACGACTTCT CCACAACAAA CAACTGGAAG ATTGGGATTT 60
CTTCCAAACT CTCCAAAACA TTTCTTTGAA TATGGAGATG CTAACAAAAT TTGAGTCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

spo:SPBPJ4664.04

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	52.11	0.00e+00	919.00
IUUC-Aml-001758	Ailuropoda melanoleuca	46.66	0.00e+00	1128.00
IUUC-Atr-002493	Amborella trichopoda	52.35	0.00e+00	899.00
IUUC-Apl-003385	Anas platyrhynchos	49.26	0.00e+00	659.00
IUUC-Aca-005154	Anolis carolinensis	69.57	2.00e-90	322.00
IUUC-Aly-006020	Arabidopsis lyrata	52.69	0.00e+00	909.00
IUUC-Ath-007058	Arabidopsis thaliana	52.40	0.00e+00	909.00
IUUC-Ago-007992	Ashbya gossypii	47.06	0.00e+00	1087.00
IUUC-Acl-008027	Aspergillus clavatus	54.58	0.00e+00	1343.00
IUUC-Afl-008644	Aspergillus flavus	54.58	0.00e+00	1335.00
IUUC-Afu-008964	Aspergillus fumigatus	54.67	0.00e+00	1358.00
IUUC-Ani-009379	Aspergillus nidulans	62.00	0.00e+00	1135.00
IUUC-Ang-009756	Aspergillus niger	54.91	0.00e+00	1361.00
IUUC-Aor-010174	Aspergillus oryzae	54.58	0.00e+00	1333.00
IUUC-Ate-010302	Aspergillus terreus	54.91	0.00e+00	1370.00
IUUC-Ame-011229	Astyanax mexicanus	54.75	0.00e+00	953.00
IUUC-Bgr-012300	Blumeria graminis	52.94	0.00e+00	1285.00
IUUC-Bta-012524	Bos taurus	47.00	0.00e+00	1126.00
IUUC-Bci-013781	Botrytis cinerea	53.35	0.00e+00	1346.00
IUUC-Bdi-014549	Brachypodium distachyon	52.11	0.00e+00	919.00
IUUC-Bol-015925	Brassica oleracea	52.81	0.00e+00	909.00
IUUC-Bra-016978	Brassica rapa	43.87	0.00e+00	1008.00
IUUC-Cel-018115	Caenorhabditis elegans	49.94	0.00e+00	878.00
IUUC-Cja-019107	Callithrix jacchus	46.05	0.00e+00	1107.00
IUUC-Cfa-020675	Canis familiaris	46.23	0.00e+00	1098.00
IUUC-Cpo-021813	Cavia porcellus	47.08	0.00e+00	1132.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	53.27	0.00e+00	942.00
IUUC-Csa-023523	Chlorocebus sabaeus	46.92	0.00e+00	1137.00
IUUC-Cho-024704	Choloepus hoffmanni	63.26	2.00e-122	432.00
IUUC-Cin-025572	Ciona intestinalis	53.41	0.00e+00	927.00
IUUC-Csv-025864	Ciona savignyi	52.86	0.00e+00	908.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	54.43	0.00e+00	1369.00
IUUC-Cne-027053	Cryptococcus neoformans	59.88	0.00e+00	1064.00
IUUC-Cme-027222	Cyanidioschyzon merolae	41.08	7.00e-143	500.00
IUUC-Dre-027421	Danio rerio	47.15	0.00e+00	1127.00
IUUC-Dno-029303	Dasypus novemcinctus	46.76	0.00e+00	1132.00
IUUC-Dor-030290	Dipodomys ordii	46.67	1.00e-145	509.00
IUUC-Dse-031543	Dothistroma septosporum	53.51	0.00e+00	1288.00
IUUC-Dme-031945	Drosophila melanogaster	53.83	0.00e+00	905.00
IUUC-Ete-032873	Echinops telfairi	46.31	0.00e+00	1021.00
IUUC-Eca-033773	Equus caballus	46.27	0.00e+00	1104.00
IUUC-Eeu-034874	Erinaceus europaeus	38.95	4.00e-93	334.00
IUUC-Fca-035739	Felis catus	46.60	0.00e+00	1111.00
IUUC-Fal-037263	Ficedula albicollis	50.78	0.00e+00	833.00
IUUC-Fox-037738	Fusarium oxysporum	54.40	0.00e+00	1384.00
IUUC-Fso-038153	Fusarium solani	54.95	0.00e+00	1394.00
IUUC-Gmo-039602	Gadus morhua	54.43	0.00e+00	925.00
IUUC-Ggr-039931	Gaeumannomyces graminis	62.13	0.00e+00	1150.00
IUUC-Gga-040590	Gallus gallus	55.02	0.00e+00	961.00
IUUC-Gac-041318	Gasterosteus aculeatus	54.03	0.00e+00	951.00
IUUC-Gma-043894	Glycine max	44.94	0.00e+00	1046.00
IUUC-Ggo-045029	Gorilla gorilla	46.41	0.00e+00	1127.00
IUUC-Hsa-046078	Homo sapiens	46.49	0.00e+00	1129.00
IUUC-Hvu-047556	Hordeum vulgare	52.09	0.00e+00	922.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	38.00	4.00e-166	576.00
IUUC-Kpa-049256	Komagataella pastoris	49.10	0.00e+00	1202.00
IUUC-Lch-049706	Latimeria chalumnae	54.97	0.00e+00	954.00
IUUC-Lpe-051316	Leersia perrieri	52.71	0.00e+00	924.00
IUUC-Loc-051867	Lepisosteus oculatus	40.14	0.00e+00	752.00
IUUC-Lma-053138	Leptosphaeria maculans	61.77	0.00e+00	1144.00
IUUC-Laf-053510	Loxodonta africana	46.68	0.00e+00	1125.00
IUUC-Mcc-055836	Macaca mulatta	46.73	0.00e+00	1129.00
IUUC-Meu-056238	Macropus eugenii	49.85	0.00e+00	671.00
IUUC-Mor-057172	Magnaporthe oryzae	54.55	0.00e+00	1382.00
IUUC-Mpo-057300	Magnaporthe poae	54.40	0.00e+00	1365.00
IUUC-Mtr-058248	Medicago truncatula	44.68	0.00e+00	1048.00
IUUC-Mla-059019	Melampsora laricipopulina	60.45	0.00e+00	1092.00
IUUC-Mga-059499	Meleagris gallopavo	54.89	0.00e+00	957.00
IUUC-Mvi-060336	Microbotryum violaceum	59.45	0.00e+00	1077.00
IUUC-Mmr-061102	Microcebus murinus	46.66	0.00e+00	1122.00
IUUC-Mdo-062594	Monodelphis domestica	47.13	0.00e+00	1140.00
IUUC-Mmu-063736	Mus musculus	46.97	0.00e+00	1122.00
IUUC-Mac-065398	Musa acuminata	42.55	0.00e+00	942.00
IUUC-Mpu-066701	Mustela putorius furo	54.65	0.00e+00	963.00
IUUC-Mlu-067392	Myotis lucifugus	46.39	0.00e+00	1117.00
IUUC-Nfi-068270	Neosartorya fischeri	54.50	0.00e+00	1346.00
IUUC-Ncr-068892	Neurospora crassa	54.43	0.00e+00	1370.00
IUUC-Nle-069634	Nomascus leucogenys	58.21	0.00e+00	832.00
IUUC-Opr-070952	Ochotona princeps	34.14	7.00e-138	483.00
IUUC-Ont-072488	Oreochromis niloticus	54.62	0.00e+00	948.00
IUUC-Ocu-074211	Oryctolagus cuniculus	46.92	0.00e+00	1132.00
IUUC-Oba-075761	Oryza barthii	52.71	0.00e+00	923.00
IUUC-Obr-076429	Oryza brachyantha	52.23	0.00e+00	917.00
IUUC-Ogl-077364	Oryza glaberrima	52.71	0.00e+00	923.00
IUUC-Ogu-078257	Oryza glumaepatula	52.88	0.00e+00	923.00
IUUC-Oin-079274	Oryza indica	52.59	0.00e+00	922.00
IUUC-Olo-080466	Oryza longistaminata	52.93	0.00e+00	919.00
IUUC-Ome-081993	Oryza meridionalis	54.45	0.00e+00	879.00
IUUC-Oni-082874	Oryza nivara	52.64	0.00e+00	923.00
IUUC-Opu-083370	Oryza punctata	52.59	0.00e+00	925.00
IUUC-Oru-084274	Oryza rufipogon	52.59	0.00e+00	920.00
IUUC-Osa-085841	Oryza sativa	52.71	0.00e+00	927.00
IUUC-Ola-086921	Oryzias latipes	46.32	0.00e+00	1111.00
IUUC-Olu-087639	Ostreococcus lucimarinus	45.64	0.00e+00	1093.00
IUUC-Oga-087991	Otolemur garnettii	44.62	0.00e+00	1049.00
IUUC-Oar-089590	Ovis aries	47.08	0.00e+00	1136.00
IUUC-Ptr-090808	Pan troglodytes	46.49	0.00e+00	1128.00
IUUC-Pan-092475	Papio anubis	46.72	0.00e+00	1127.00
IUUC-Psi-093044	Pelodiscus sinensis	50.24	0.00e+00	817.00
IUUC-Pno-094839	Phaeosphaeria nodorum	52.31	0.00e+00	1286.00
IUUC-Ppa-095254	Physcomitrella patens	46.48	0.00e+00	1102.00
IUUC-Pfo-097493	Poecilia formosa	46.66	0.00e+00	1111.00
IUUC-Pab-098497	Pongo abelii	47.00	0.00e+00	1137.00
IUUC-Pop-099992	Populus trichocarpa	53.11	0.00e+00	915.00
IUUC-Pca-100413	Procavia capensis	53.41	1.00e-176	612.00
IUUC-Ppe-101899	Prunus persica	52.59	0.00e+00	927.00
IUUC-Pva-102126	Pteropus vampyrus	45.13	0.00e+00	1066.00
IUUC-Pgr-103376	Puccinia graminis	52.50	0.00e+00	1288.00
IUUC-Ptt-103978	Puccinia triticina	46.45	0.00e+00	1069.00
IUUC-Pte-104126	Pyrenophora teres	62.13	0.00e+00	1110.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	53.16	0.00e+00	750.00
IUUC-Rno-105428	Rattus norvegicus	47.00	0.00e+00	1126.00
IUUC-Sce-106464	Saccharomyces cerevisiae	45.57	0.00e+00	1056.00
IUUC-Sha-107301	Sarcophilus harrisii	47.00	0.00e+00	1113.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	67.07	0.00e+00	1723.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	54.19	0.00e+00	1349.00
IUUC-Smo-108819	Selaginella moellendorffii	54.38	0.00e+00	947.00
IUUC-Sit-109697	Setaria italica	52.59	0.00e+00	924.00
IUUC-Sly-111447	Solanum lycopersicum	44.68	0.00e+00	1041.00
IUUC-Stu-112564	Solanum tuberosum	52.71	0.00e+00	925.00
IUUC-Sar-113313	Sorex araneus	33.96	5.00e-134	469.00
IUUC-Sbi-114388	Sorghum bicolor	52.59	0.00e+00	925.00
IUUC-Sre-115209	Sporisorium reilianum	58.88	0.00e+00	1053.00
IUUC-Ssc-115933	Sus scrofa	47.00	0.00e+00	1134.00
IUUC-Tgu-117109	Taeniopygia guttata	42.21	2.00e-84	303.00
IUUC-Tru-117772	Takifugu rubripes	54.27	0.00e+00	929.00
IUUC-Tsy-119105	Tarsius syrichta	49.12	0.00e+00	836.00
IUUC-Tni-120556	Tetraodon nigroviridis	36.46	5.00e-130	457.00
IUUC-Tca-121046	Theobroma cacao	44.84	0.00e+00	1052.00
IUUC-Tre-121951	Trichoderma reesei	53.94	0.00e+00	1320.00
IUUC-Tvi-122359	Trichoderma virens	53.47	0.00e+00	1342.00
IUUC-Tae-123611	Triticum aestivum	52.11	0.00e+00	919.00
IUUC-Tur-126754	Triticum urartu	52.11	0.00e+00	920.00
IUUC-Tme-127170	Tuber melanosporum	55.28	0.00e+00	1369.00
IUUC-Tbe-127882	Tupaia belangeri	44.35	2.00e-138	484.00
IUUC-Ttr-128217	Tursiops truncatus	44.88	0.00e+00	1061.00
IUUC-Uma-129337	Ustilago maydis	58.88	0.00e+00	1050.00
IUUC-Vda-129828	Verticillium dahliae	52.53	0.00e+00	1342.00
IUUC-Vpa-130537	Vicugna pacos	46.57	0.00e+00	1112.00
IUUC-Vvi-130958	Vitis vinifera	52.11	0.00e+00	917.00
IUUC-Xtr-132857	Xenopus tropicalis	45.30	0.00e+00	1053.00
IUUC-Xma-133138	Xiphophorus maculatus	46.57	0.00e+00	1109.00
IUUC-Yli-134399	Yarrowia lipolytica	54.44	0.00e+00	954.00
IUUC-Zma-135612	Zea mays	52.11	0.00e+00	911.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence