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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046870
UUCD1 version UUC-HoS-00101
Ensembl Protein ID ENSP00000368856.3
UniProt Accession Q12986; A8K6H8; Q5VXW6; Q96EL5; Q9BXI1; NFX1_HUMAN
Genbank Protein ID AAK16545.1; BAF84332.1; CAH72745.1; CAH72745.1; CAH72746.1; CAH72746.1; CAH72747.3; CAI13304.1; CAI13304.1; CAI13305.1; CAI13305.1; EAW58510.1; EAW58511.1; AAH12151.1; AAA69517.1
Protein Name Transcriptional repressor NF-X1; Nuclear transcription factor, X box-binding protein 1
Genbank Nucleotide ID AF332009; AK291643; AL356472; AL356218; AL356472; AL356218; AL356472; AL356218; AL356472; AL356218; AL356472; CH471071; CH471071; BC012151; U15306
Gene Name NFX1; NFX2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000086102.18 ENST00000379540.7 ENSP00000368856.3
ENSG00000086102.18 ENST00000379521.8 ENSP00000368836.4
ENSG00000086102.18 ENST00000318524.6 ENSP00000317695.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15367597; 11447293
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
 Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
Protein Sequence
(Fasta)
MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS PPPCHLSRQV 60
PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG LQNQPWQKLR NEKHHIRVKK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046870|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACGTGACCT GGTGACAGTG CTGACTTGGC TGTACAGCTC GATCTAGGTT CTGCGGCACG 60
GGATGGCGGA GGCGCCTCCT GTCTCAGGTA TTGTCCCGGC CCGAGCGGGA CTGGGCCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046870|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0945--Host-virus interaction
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034078--NFX1_fam
IPR001374--R3H_dom
IPR034076--R3H_NF-X1
IPR019786--Zinc_finger_PHD-type_CS
IPR000967--Znf_NFX1
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
PROSITE

PS51061--R3H
PS50089--ZF_RING_2
Pfam

PF01424--R3H
PF01422--zf-NF-X1
SMART

SM00393--R3H
SM00184--RING
SM00438--ZnF_NFX
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0003723--F:RNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0006954--P:inflammatory response
GO:0045347--P:negative regulation of MHC class II biosynthetic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0016032--P:viral process
KEGG hsa:4799
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000224 Aegilops tauschii 38.52 9.00e-84 305.00
IUUC-Aml-001716 Ailuropoda melanoleuca 92.24 0.00e+00 2036.00
IUUC-Atr-002895 Amborella trichopoda 38.96 1.00e-135 478.00
IUUC-Apl-003650 Anas platyrhynchos 59.12 0.00e+00 1188.00
IUUC-Aca-004313 Anolis carolinensis 58.47 0.00e+00 1254.00
IUUC-Aly-006515 Arabidopsis lyrata 38.73 1.00e-131 464.00
IUUC-Ath-007056 Arabidopsis thaliana 36.65 1.00e-130 461.00
IUUC-Ago-007777 Ashbya gossypii 32.07 4.00e-88 319.00
IUUC-Acl-008068 Aspergillus clavatus 35.26 5.00e-81 296.00
IUUC-Afl-008499 Aspergillus flavus 36.16 2.00e-47 183.00
IUUC-Afu-009016 Aspergillus fumigatus 34.80 8.00e-109 389.00
IUUC-Ani-009477 Aspergillus nidulans 35.37 4.00e-114 406.00
IUUC-Ang-009605 Aspergillus niger 35.85 2.00e-115 410.00
IUUC-Aor-010166 Aspergillus oryzae 34.94 5.00e-53 202.00
IUUC-Ame-010640 Astyanax mexicanus 62.36 0.00e+00 973.00
IUUC-Bgr-012024 Blumeria graminis 31.75 3.00e-99 357.00
IUUC-Bta-012789 Bos taurus 90.18 0.00e+00 2003.00
IUUC-Bci-013768 Botrytis cinerea 35.26 2.00e-113 404.00
IUUC-Bdi-014723 Brachypodium distachyon 39.24 6.00e-120 425.00
IUUC-Bol-015394 Brassica oleracea 37.52 5.00e-136 479.00
IUUC-Bra-017266 Brassica rapa 35.52 2.00e-134 473.00
IUUC-Cel-018668 Caenorhabditis elegans 40.81 1.00e-152 534.00
IUUC-Cja-019769 Callithrix jacchus 93.96 0.00e+00 2055.00
IUUC-Cfa-020727 Canis familiaris 92.35 0.00e+00 2031.00
IUUC-Cpo-021741 Cavia porcellus 90.98 0.00e+00 2008.00
IUUC-Csa-024054 Chlorocebus sabaeus 98.21 0.00e+00 2155.00
IUUC-Cho-025031 Choloepus hoffmanni 86.29 0.00e+00 1362.00
IUUC-Cin-025164 Ciona intestinalis 49.53 0.00e+00 661.00
IUUC-Csv-026260 Ciona savignyi 48.63 0.00e+00 700.00
IUUC-Cgl-026451 Colletotrichum gloeosporioides 35.98 3.00e-80 293.00
IUUC-Cne-026923 Cryptococcus neoformans 36.03 3.00e-79 290.00
IUUC-Dre-028227 Danio rerio 65.57 0.00e+00 1033.00
IUUC-Dno-029830 Dasypus novemcinctus 86.92 0.00e+00 1916.00
IUUC-Dor-030436 Dipodomys ordii 85.38 0.00e+00 1104.00
IUUC-Dse-031485 Dothistroma septosporum 34.80 2.00e-106 381.00
IUUC-Dme-031875 Drosophila melanogaster 44.14 3.00e-163 569.00
IUUC-Eca-033415 Equus caballus 88.73 0.00e+00 1122.00
IUUC-Eeu-034528 Erinaceus europaeus 89.15 0.00e+00 1030.00
IUUC-Fca-036238 Felis catus 94.86 0.00e+00 1353.00
IUUC-Fal-037124 Ficedula albicollis 60.44 0.00e+00 1246.00
IUUC-Fox-038075 Fusarium oxysporum 41.46 7.00e-05 43.10
IUUC-Fso-038310 Fusarium solani 34.50 7.00e-97 348.00
IUUC-Gmo-039506 Gadus morhua 65.04 0.00e+00 975.00
IUUC-Ggr-039984 Gaeumannomyces graminis 36.00 3.00e-121 430.00
IUUC-Gga-040674 Gallus gallus 74.12 0.00e+00 1100.00
IUUC-Gac-041416 Gasterosteus aculeatus 64.38 0.00e+00 968.00
IUUC-Gma-043625 Glycine max 39.31 3.00e-128 453.00
IUUC-Ggo-045017 Gorilla gorilla 99.29 0.00e+00 2184.00
IUUC-Hvu-047466 Hordeum vulgare 37.92 1.00e-78 287.00
IUUC-Itr-048703 Ictidomys tridecemlineatus 84.16 0.00e+00 708.00
IUUC-Kpa-049244 Komagataella pastoris 30.98 2.00e-73 270.00
IUUC-Lch-050376 Latimeria chalumnae 59.01 0.00e+00 1187.00
IUUC-Lpe-050955 Leersia perrieri 36.65 4.00e-96 346.00
IUUC-Loc-051948 Lepisosteus oculatus 55.60 0.00e+00 1146.00
IUUC-Lma-052950 Leptosphaeria maculans 35.97 2.00e-102 367.00
IUUC-Laf-054206 Loxodonta africana 89.23 0.00e+00 1293.00
IUUC-Mcc-055005 Macaca mulatta 98.12 0.00e+00 2154.00
IUUC-Meu-056120 Macropus eugenii 60.66 0.00e+00 695.00
IUUC-Mor-057238 Magnaporthe oryzae 34.23 2.00e-112 400.00
IUUC-Mpo-057574 Magnaporthe poae 35.83 4.00e-119 422.00
IUUC-Mtr-057823 Medicago truncatula 39.92 5.00e-117 416.00
IUUC-Mla-058822 Melampsora laricipopulina 34.49 2.00e-99 357.00
IUUC-Mga-059785 Meleagris gallopavo 50.34 6.00e-170 591.00
IUUC-Mvi-060543 Microbotryum violaceum 34.52 6.00e-99 355.00
IUUC-Mmr-060611 Microcebus murinus 91.79 0.00e+00 1995.00
IUUC-Mdo-062719 Monodelphis domestica 70.83 0.00e+00 1493.00
IUUC-Mmu-064376 Mus musculus 88.21 0.00e+00 1897.00
IUUC-Mac-064834 Musa acuminata 35.79 1.00e-104 374.00
IUUC-Mpu-066298 Mustela putorius furo 92.32 0.00e+00 2036.00
IUUC-Mlu-067546 Myotis lucifugus 88.90 0.00e+00 1982.00
IUUC-Nfi-068388 Neosartorya fischeri 35.09 1.00e-113 404.00
IUUC-Ncr-068875 Neurospora crassa 34.35 6.00e-104 372.00
IUUC-Nle-069813 Nomascus leucogenys 98.48 0.00e+00 2171.00
IUUC-Opr-070995 Ochotona princeps 86.45 0.00e+00 1349.00
IUUC-Ont-072084 Oreochromis niloticus 67.14 0.00e+00 1026.00
IUUC-Oan-073545 Ornithorhynchus anatinus 57.42 0.00e+00 1163.00
IUUC-Ocu-074092 Oryctolagus cuniculus 87.41 0.00e+00 1922.00
IUUC-Oba-075828 Oryza barthii 37.43 1.00e-100 361.00
IUUC-Obr-076373 Oryza brachyantha 36.73 2.00e-76 280.00
IUUC-Ogl-077043 Oryza glaberrima 38.91 2.00e-111 397.00
IUUC-Ogu-078647 Oryza glumaepatula 38.77 3.00e-109 390.00
IUUC-Oin-079793 Oryza indica 37.41 7.00e-82 298.00
IUUC-Olo-080815 Oryza longistaminata 37.64 4.00e-101 363.00
IUUC-Ome-081650 Oryza meridionalis 38.66 1.00e-112 401.00
IUUC-Oni-082708 Oryza nivara 38.66 7.00e-113 402.00
IUUC-Opu-084078 Oryza punctata 39.04 8.00e-110 392.00
IUUC-Oru-084549 Oryza rufipogon 38.48 8.00e-113 402.00
IUUC-Osa-086095 Oryza sativa 36.73 6.00e-94 338.00
IUUC-Olu-087617 Ostreococcus lucimarinus 28.18 1.00e-09 58.90
IUUC-Oga-088453 Otolemur garnettii 90.09 0.00e+00 1952.00
IUUC-Oar-089769 Ovis aries 89.92 0.00e+00 1992.00
IUUC-Ptr-090803 Pan troglodytes 100.00 0.00e+00 2198.00
IUUC-Pan-092169 Papio anubis 98.12 0.00e+00 2176.00
IUUC-Psi-094065 Pelodiscus sinensis 62.63 0.00e+00 1372.00
IUUC-Pma-094592 Petromyzon marinus 56.95 0.00e+00 876.00
IUUC-Pno-095016 Phaeosphaeria nodorum 37.84 7.00e-15 75.10
IUUC-Ppa-095597 Physcomitrella patens 36.98 1.00e-125 444.00
IUUC-Pfo-096959 Poecilia formosa 65.47 0.00e+00 1045.00
IUUC-Pab-097732 Pongo abelii 99.71 0.00e+00 1325.00
IUUC-Pop-099062 Populus trichocarpa 39.13 4.00e-132 466.00
IUUC-Pca-100219 Procavia capensis 74.35 0.00e+00 1521.00
IUUC-Ppe-101695 Prunus persica 40.13 4.00e-125 442.00
IUUC-Pva-102402 Pteropus vampyrus 83.57 0.00e+00 1802.00
IUUC-Pgr-103317 Puccinia graminis 30.09 2.00e-92 334.00
IUUC-Ptt-103771 Puccinia triticina 30.49 9.00e-83 302.00
IUUC-Pte-104189 Pyrenophora teres 29.69 3.00e-09 57.00
IUUC-Pyt-104801 Pyrenophora triticirepentis 35.26 4.00e-102 366.00
IUUC-Rno-105721 Rattus norvegicus 88.30 0.00e+00 1929.00
IUUC-Sce-106350 Saccharomyces cerevisiae 31.15 6.00e-83 302.00
IUUC-Sha-106801 Sarcophilus harrisii 69.52 0.00e+00 1484.00
IUUC-Sja-107692 Schizosaccharomyces japonicus 36.71 2.00e-120 427.00
IUUC-Spo-108253 Schizosaccharomyces pombe 36.50 5.00e-119 422.00
IUUC-Ssl-108587 Sclerotinia sclerotiorum 35.52 1.00e-64 241.00
IUUC-Smo-108865 Selaginella moellendorffii 39.51 3.00e-114 406.00
IUUC-Sit-110153 Setaria italica 38.71 2.00e-116 414.00
IUUC-Sly-111638 Solanum lycopersicum 39.38 7.00e-127 448.00
IUUC-Stu-112099 Solanum tuberosum 39.66 4.00e-128 452.00
IUUC-Sar-113030 Sorex araneus 85.93 0.00e+00 669.00
IUUC-Sbi-113944 Sorghum bicolor 38.13 1.00e-118 421.00
IUUC-Sre-115206 Sporisorium reilianum 34.15 5.00e-107 382.00
IUUC-Ssc-115729 Sus scrofa 87.09 0.00e+00 776.00
IUUC-Tgu-117520 Taeniopygia guttata 67.13 0.00e+00 1001.00
IUUC-Tru-118487 Takifugu rubripes 65.79 0.00e+00 1021.00
IUUC-Tsy-119363 Tarsius syrichta 84.55 0.00e+00 1804.00
IUUC-Tca-121813 Theobroma cacao 37.89 6.00e-126 445.00
IUUC-Tre-122248 Trichoderma reesei 35.39 5.00e-102 365.00
IUUC-Tvi-122462 Trichoderma virens 36.15 4.00e-110 392.00
IUUC-Tae-123637 Triticum aestivum 38.95 3.00e-112 400.00
IUUC-Tur-126173 Triticum urartu 38.72 4.00e-102 366.00
IUUC-Tme-127213 Tuber melanosporum 35.84 2.00e-113 404.00
IUUC-Tbe-127399 Tupaia belangeri 90.06 0.00e+00 832.00
IUUC-Ttr-128798 Tursiops truncatus 93.39 0.00e+00 916.00
IUUC-Uma-129421 Ustilago maydis 32.82 6.00e-105 375.00
IUUC-Vda-129863 Verticillium dahliae 32.60 6.00e-100 359.00
IUUC-Vvi-131615 Vitis vinifera 37.73 4.00e-139 489.00
IUUC-Xtr-132309 Xenopus tropicalis 59.42 0.00e+00 1181.00
IUUC-Xma-133235 Xiphophorus maculatus 64.97 0.00e+00 1003.00
IUUC-Yli-134536 Yarrowia lipolytica 31.46 1.00e-90 327.00
IUUC-Zma-135358 Zea mays 37.99 1.00e-112 401.00
Created Date 25-Jun-2017

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