iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000034373.2	ENSGALT00000073460.1	ENSGALP00000057300.1
ENSGALG00000034373.2	ENSGALT00000086373.1	ENSGALP00000059587.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-40	135.6	146	181
UBD/Beta-Prp	1.40e-59	202.1	11	234

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           Ht  v+cl+f +d + l+s++dD+t+k+WDl+ g++
   Q: 146  HTQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGKV 181
           99*********999******************9975 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkf.spdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcle 130
           ++l+++  h++ v+++ + +++g +l+tg++D  ++vw+++++ cv++l+gh+  + sl++s++ + +v+Gs+   irvwdle  + l+
   Q: 11   WKLQEIVAHSSNVSSLVLgKSTGRLLATGGDDCRVNVWSVNKPNCVMSLTGHTTPIESLQISAKEELIVAGSQSGSIRVWDLEAAKILR 99
           55788889999999988824555599*************************************99***********************9 PP
   S: 131  etlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtln 219
            tl gh++ ++++ +hp g+ ++sGslD+ ++lWd++++ ++ + ++ ht++v++l f+++gk l+s+++d tvklwdl +g+++ +++
   Q: 100  -TLLGHKANICSLDFHPYGSFVASGSLDTDIKLWDVRRKGCIFKYKS-HTQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKVMFEFT 186
           .********************************************99.***************************************** PP
   S: 220  ghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           gh+ +v++v+f+p + +l+sgssD++ir+Wdl++  ++++++ +++ v
   Q: 187  GHSGPVNVVEFHPSEYLLASGSSDRTIRFWDLEKFHVVSCIEEEATPV 234
           *********************************999999998877555 PP

Organism

Gallus gallus

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Protein Sequence
(Fasta)

MAAAVVTKTA WKLQEIVAHS SNVSSLVLGK STGRLLATGG DDCRVNVWSV NKPNCVMSLT 60
GHTTPIESLQ ISAKEELIVA GSQSGSIRVW DLEAAKILRT LLGHKANICS LDFHPYGSFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCGTGGCG TGGCCGAGGT TGGCTGGTGG GAGCGGTTGC CGGCGGTTGC CAGGGCCCGG 60
TTGCCAGGCG CCGGGGGGAC GTGCGGGTAG GGGAAAGTAG GGGCATCCGA GGCCTTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007067--P:mitotic nuclear division
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

KEGG

gga:415631

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	44.66	2.00e-83	304.00
IUUC-Aml-002187	Ailuropoda melanoleuca	73.42	0.00e+00	926.00
IUUC-Atr-002899	Amborella trichopoda	52.74	4.00e-101	362.00
IUUC-Apl-003305	Anas platyrhynchos	84.96	0.00e+00	1127.00
IUUC-Aca-004635	Anolis carolinensis	82.03	0.00e+00	992.00
IUUC-Aly-005711	Arabidopsis lyrata	51.83	3.00e-102	365.00
IUUC-Ath-007606	Arabidopsis thaliana	51.83	3.00e-102	366.00
IUUC-Ame-010870	Astyanax mexicanus	54.57	2.00e-94	338.00
IUUC-Bta-012527	Bos taurus	78.28	0.00e+00	1015.00
IUUC-Bdi-014652	Brachypodium distachyon	52.51	1.00e-102	367.00
IUUC-Bol-015242	Brassica oleracea	50.17	5.00e-100	358.00
IUUC-Bra-017390	Brassica rapa	50.50	2.00e-100	360.00
IUUC-Cja-019706	Callithrix jacchus	77.81	0.00e+00	934.00
IUUC-Cfa-020139	Canis familiaris	65.30	0.00e+00	640.00
IUUC-Cpo-021710	Cavia porcellus	78.27	0.00e+00	996.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	40.85	4.00e-68	252.00
IUUC-Csa-023546	Chlorocebus sabaeus	79.03	0.00e+00	913.00
IUUC-Cin-025156	Ciona intestinalis	41.55	5.00e-152	531.00
IUUC-Csv-025962	Ciona savignyi	46.60	4.00e-85	307.00
IUUC-Dre-028215	Danio rerio	60.06	0.00e+00	833.00
IUUC-Dno-029314	Dasypus novemcinctus	78.12	0.00e+00	951.00
IUUC-Dor-030482	Dipodomys ordii	79.18	0.00e+00	1031.00
IUUC-Dme-032188	Drosophila melanogaster	38.92	3.00e-59	223.00
IUUC-Eca-034143	Equus caballus	78.27	0.00e+00	997.00
IUUC-Fca-035924	Felis catus	79.03	0.00e+00	983.00
IUUC-Fal-037387	Ficedula albicollis	85.71	0.00e+00	1102.00
IUUC-Gmo-038692	Gadus morhua	64.23	4.00e-155	541.00
IUUC-Gac-042004	Gasterosteus aculeatus	60.39	0.00e+00	812.00
IUUC-Gma-044134	Glycine max	48.93	1.00e-99	357.00
IUUC-Ggo-044761	Gorilla gorilla	79.03	0.00e+00	938.00
IUUC-Hsa-045698	Homo sapiens	79.18	0.00e+00	954.00
IUUC-Hvu-047649	Hordeum vulgare	50.65	4.00e-102	365.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	78.88	0.00e+00	983.00
IUUC-Lch-049674	Latimeria chalumnae	65.59	0.00e+00	912.00
IUUC-Lpe-051554	Leersia perrieri	53.51	6.00e-105	375.00
IUUC-Loc-052623	Lepisosteus oculatus	65.17	0.00e+00	897.00
IUUC-Laf-054587	Loxodonta africana	79.18	0.00e+00	1000.00
IUUC-Mcc-055851	Macaca mulatta	79.03	0.00e+00	938.00
IUUC-Meu-056704	Macropus eugenii	80.67	0.00e+00	1081.00
IUUC-Mtr-058053	Medicago truncatula	49.54	8.00e-104	371.00
IUUC-Mga-059608	Meleagris gallopavo	93.58	0.00e+00	1227.00
IUUC-Mmr-061154	Microcebus murinus	77.96	0.00e+00	950.00
IUUC-Mdo-062365	Monodelphis domestica	77.05	0.00e+00	1018.00
IUUC-Mmu-063754	Mus musculus	78.82	0.00e+00	988.00
IUUC-Mac-064667	Musa acuminata	51.02	3.00e-99	355.00
IUUC-Mpu-066245	Mustela putorius furo	78.27	0.00e+00	944.00
IUUC-Mlu-067692	Myotis lucifugus	79.11	0.00e+00	979.00
IUUC-Nle-070051	Nomascus leucogenys	77.64	0.00e+00	927.00
IUUC-Opr-070855	Ochotona princeps	78.42	0.00e+00	984.00
IUUC-Ont-071883	Oreochromis niloticus	58.03	0.00e+00	828.00
IUUC-Oan-073293	Ornithorhynchus anatinus	79.48	0.00e+00	945.00
IUUC-Ocu-074644	Oryctolagus cuniculus	79.33	0.00e+00	996.00
IUUC-Oba-075448	Oryza barthii	53.55	3.00e-106	379.00
IUUC-Obr-076385	Oryza brachyantha	52.84	2.00e-104	373.00
IUUC-Ogl-077427	Oryza glaberrima	53.85	1.00e-105	377.00
IUUC-Ogu-079022	Oryza glumaepatula	47.57	2.00e-94	340.00
IUUC-Oin-079811	Oryza indica	51.45	1.00e-102	367.00
IUUC-Olo-080245	Oryza longistaminata	51.45	2.00e-102	367.00
IUUC-Ome-081239	Oryza meridionalis	53.24	4.00e-102	365.00
IUUC-Oni-082640	Oryza nivara	53.55	3.00e-106	379.00
IUUC-Opu-083748	Oryza punctata	53.51	5.00e-105	375.00
IUUC-Oru-084609	Oryza rufipogon	53.55	3.00e-106	379.00
IUUC-Osa-086267	Oryza sativa	47.57	2.00e-94	340.00
IUUC-Ola-087483	Oryzias latipes	55.86	0.00e+00	635.00
IUUC-Oga-087964	Otolemur garnettii	79.21	0.00e+00	1013.00
IUUC-Oar-089483	Ovis aries	77.22	0.00e+00	965.00
IUUC-Ptr-091387	Pan troglodytes	79.33	0.00e+00	956.00
IUUC-Pan-092623	Papio anubis	79.03	0.00e+00	938.00
IUUC-Psi-093830	Pelodiscus sinensis	84.09	0.00e+00	1096.00
IUUC-Pma-094135	Petromyzon marinus	45.54	7.00e-41	159.00
IUUC-Ppa-095379	Physcomitrella patens	53.77	4.00e-96	345.00
IUUC-Pfo-096755	Poecilia formosa	58.18	0.00e+00	813.00
IUUC-Pab-097564	Pongo abelii	76.62	0.00e+00	812.00
IUUC-Pop-099149	Populus trichocarpa	52.82	6.00e-105	375.00
IUUC-Pca-100357	Procavia capensis	85.24	2.00e-111	396.00
IUUC-Ppe-101237	Prunus persica	52.16	5.00e-103	368.00
IUUC-Pva-102397	Pteropus vampyrus	74.47	0.00e+00	915.00
IUUC-Rno-105349	Rattus norvegicus	79.18	0.00e+00	1027.00
IUUC-Smo-109409	Selaginella moellendorffii	52.22	4.00e-99	355.00
IUUC-Sit-110360	Setaria italica	53.85	4.00e-105	375.00
IUUC-Sly-111307	Solanum lycopersicum	51.84	1.00e-99	357.00
IUUC-Stu-112462	Solanum tuberosum	51.03	5.00e-96	344.00
IUUC-Sar-112953	Sorex araneus	67.54	6.00e-91	328.00
IUUC-Sbi-114389	Sorghum bicolor	44.79	2.00e-93	337.00
IUUC-Ssc-115949	Sus scrofa	75.62	0.00e+00	717.00
IUUC-Tgu-117461	Taeniopygia guttata	84.66	0.00e+00	1117.00
IUUC-Tru-117865	Takifugu rubripes	58.45	0.00e+00	805.00
IUUC-Tsy-119036	Tarsius syrichta	84.25	6.00e-61	228.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.97	0.00e+00	787.00
IUUC-Tca-121185	Theobroma cacao	51.83	3.00e-102	366.00
IUUC-Tae-125307	Triticum aestivum	50.63	4.00e-103	369.00
IUUC-Tur-126181	Triticum urartu	46.26	5.00e-92	332.00
IUUC-Tbe-127518	Tupaia belangeri	65.78	7.00e-148	517.00
IUUC-Ttr-128172	Tursiops truncatus	77.66	0.00e+00	979.00
IUUC-Vvi-131489	Vitis vinifera	52.49	2.00e-104	373.00
IUUC-Xtr-132915	Xenopus tropicalis	69.81	0.00e+00	936.00
IUUC-Xma-134133	Xiphophorus maculatus	58.18	0.00e+00	807.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence