iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-117068

Ensembl Protein ID

ENSTGUP00000003468.1

UniProt Accession

H0YYT7; H0YYT7_TAEGU

Genbank Protein ID

ENSTGUP00000003468

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01045354

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000003264.1	ENSTGUT00000003504.1	ENSTGUP00000003468.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-22	78.6	594	632
UBD/Beta-Prp	2.30e-40	138.4	462	632

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 594  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 632
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 462  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 549
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 550  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 632
           88888888999*********************************9.********************************997443 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

FKFTISESCD RIKEEFQFLQ AQYHSLKLEC EKLASEKTEM QRHYVMYYEM SYGLNIEMHK 60
QAEIVKRLNA ICAQVIPFLS QEHQQQVVQA VERAKQVTMA ELNAIIGQQQ LQAQHLSHGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTAAATTCA CCATTTCAGA ATCCTGCGAT CGGATTAAGG AGGAGTTTCA GTTTTTGCAG 60
GCTCAGTACC ACAGGTAAGA CTGCCTACTT TGCCCGAGCC CTGTGCGGTT TTTCCTCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003434	Anas platyrhynchos	87.92	0.00e+00	1135.00
IUUC-Aca-005279	Anolis carolinensis	98.14	0.00e+00	1277.00
IUUC-Ame-010724	Astyanax mexicanus	78.35	0.00e+00	1098.00
IUUC-Bta-012646	Bos taurus	97.34	0.00e+00	1323.00
IUUC-Cel-018361	Caenorhabditis elegans	58.71	6.00e-122	431.00
IUUC-Cja-019079	Callithrix jacchus	98.27	0.00e+00	1340.00
IUUC-Cfa-020987	Canis familiaris	98.14	0.00e+00	1336.00
IUUC-Cpo-021606	Cavia porcellus	96.67	0.00e+00	1295.00
IUUC-Csa-023445	Chlorocebus sabaeus	98.54	0.00e+00	1314.00
IUUC-Cho-024590	Choloepus hoffmanni	88.64	0.00e+00	1184.00
IUUC-Cin-025282	Ciona intestinalis	77.87	4.00e-154	538.00
IUUC-Csv-026174	Ciona savignyi	58.16	3.00e-163	568.00
IUUC-Dre-028595	Danio rerio	79.13	0.00e+00	1091.00
IUUC-Dno-028979	Dasypus novemcinctus	98.33	0.00e+00	1268.00
IUUC-Dor-030533	Dipodomys ordii	91.97	0.00e+00	1140.00
IUUC-Dme-031576	Drosophila melanogaster	86.31	0.00e+00	667.00
IUUC-Ete-032887	Echinops telfairi	87.45	0.00e+00	1190.00
IUUC-Eca-034397	Equus caballus	96.97	0.00e+00	1259.00
IUUC-Fca-036030	Felis catus	98.54	0.00e+00	1347.00
IUUC-Fal-037460	Ficedula albicollis	98.80	0.00e+00	1322.00
IUUC-Gga-040416	Gallus gallus	98.80	0.00e+00	1318.00
IUUC-Ggo-045633	Gorilla gorilla	94.38	0.00e+00	1311.00
IUUC-Hsa-046461	Homo sapiens	94.38	0.00e+00	1313.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	98.67	0.00e+00	1320.00
IUUC-Lch-049943	Latimeria chalumnae	95.74	0.00e+00	1232.00
IUUC-Loc-052835	Lepisosteus oculatus	95.35	0.00e+00	1266.00
IUUC-Laf-053425	Loxodonta africana	98.67	0.00e+00	1342.00
IUUC-Mcc-055766	Macaca mulatta	94.51	0.00e+00	1315.00
IUUC-Mmr-061317	Microcebus murinus	94.99	0.00e+00	1316.00
IUUC-Mdo-062956	Monodelphis domestica	98.40	0.00e+00	1317.00
IUUC-Mmu-063576	Mus musculus	98.27	0.00e+00	1306.00
IUUC-Mpu-066410	Mustela putorius furo	98.46	0.00e+00	1259.00
IUUC-Mlu-067456	Myotis lucifugus	96.95	0.00e+00	1278.00
IUUC-Nle-069495	Nomascus leucogenys	98.54	0.00e+00	1313.00
IUUC-Ont-071419	Oreochromis niloticus	85.94	0.00e+00	1147.00
IUUC-Oan-072842	Ornithorhynchus anatinus	95.34	0.00e+00	1296.00
IUUC-Ocu-074453	Oryctolagus cuniculus	97.73	0.00e+00	1300.00
IUUC-Ola-087090	Oryzias latipes	85.28	0.00e+00	1141.00
IUUC-Oga-087939	Otolemur garnettii	98.54	0.00e+00	1319.00
IUUC-Oar-090347	Ovis aries	97.05	0.00e+00	1247.00
IUUC-Ptr-091048	Pan troglodytes	98.54	0.00e+00	1314.00
IUUC-Pan-091973	Papio anubis	93.74	0.00e+00	1259.00
IUUC-Pfo-097518	Poecilia formosa	85.02	0.00e+00	1117.00
IUUC-Pab-097539	Pongo abelii	94.22	0.00e+00	1233.00
IUUC-Rno-105314	Rattus norvegicus	98.18	0.00e+00	1238.00
IUUC-Sar-113267	Sorex araneus	87.87	0.00e+00	719.00
IUUC-Ssc-116408	Sus scrofa	98.14	0.00e+00	1340.00
IUUC-Tru-118782	Takifugu rubripes	81.19	0.00e+00	1094.00
IUUC-Tsy-118884	Tarsius syrichta	83.92	0.00e+00	1078.00
IUUC-Tni-120404	Tetraodon nigroviridis	84.26	0.00e+00	1147.00
IUUC-Tbe-128013	Tupaia belangeri	90.43	0.00e+00	1241.00
IUUC-Vpa-130577	Vicugna pacos	89.28	0.00e+00	654.00
IUUC-Xtr-132974	Xenopus tropicalis	96.29	0.00e+00	1279.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence