iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072433

Ensembl Protein ID

ENSONIP00000021078.1

UniProt Accession

I3KIY3; I3KIY3_ORENI

Genbank Protein ID

ENSONIP00000021078

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AERX01002559

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000016732.1	ENSONIT00000021097.1	ENSONIP00000021078.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-20	73.4	530	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 530  NAYCNCMIQVLYFLEPIRCLVQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQASNFLRAFRTIPEASAlGLILSDSDEQT 609
           56*********************...55654......57*******************************9999855666666666655 PP
   S: 97   a.flldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
               l +l ++ ++    + +++++e+e+ +  +    ++++  ++++s+i +lF+ +++++  c +c+++++r +  l ++++ p+++
   Q: 610  GkARLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGASSSSLGSSGESVIGKLFGCEVENSSLC-RCGKETVRSSLTLLFTMHYPEQN 695
           3134666666665554323333333333333..45555789999*********************.8*******************888 PP
   S: 181  etkke....slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           +++k+    ++ ++L++      le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k++ ++ ++  ++l   c
   Q: 696  SQEKTikehDFAEILKKSIC---LEQSTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSAKEA--EFWKVQAEIVIKCVVELYTLC 779
           76555444455566655555...5555679*****************************9977665..44599999999999****999 PP
   S: 266  ts...............................................................peekqke.....kkkYeLiavvvH 286
           +                                                                               Y+L+  v H
   Q: 780  SGeeicgmegitfdtrtedlrhiwipatlkmsisksqgleisrwseteeyilvwfaakwetaglsA-----AeeaegASLYDLVVTVPH 863
           996777777777776666666666666666666666666655555555555555555555555541.....0555559*********** PP
   S: 287  sG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
                 +G  va++k            ++++W+lf+D  +++++++e  ++  
   Q: 864  ILdARTGGNLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKTEAAQFDV 916
           **99999*********999988877777888*************999888654 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFDGLDPGM GEYSASLHGT LDAGLEPSMD PHLNPNLLQG VELDPEGLAV TVPEPVHLME 60
GIFSELHSVV SEVGIPVTAT HFDLQEEMLW MGNHRGHVTS FFGPTMARYS SFQVHATDDI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTTTG ACGGTCTCGA CCCTGGAATG GGTGAATACT CAGCCAGCCT TCATGGAACT 60
CTAGATGCAG GCCTGGAGCC CTCCATGGAC CCACACCTAA ACCCAAACCT ACTCCAGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	75.06	0.00e+00	1822.00
IUUC-Apl-003500	Anas platyrhynchos	75.98	0.00e+00	1696.00
IUUC-Aca-004930	Anolis carolinensis	75.98	0.00e+00	1856.00
IUUC-Acl-008214	Aspergillus clavatus	31.42	4.00e-153	536.00
IUUC-Afu-009112	Aspergillus fumigatus	30.76	1.00e-143	504.00
IUUC-Ang-009531	Aspergillus niger	31.66	2.00e-147	516.00
IUUC-Ame-011259	Astyanax mexicanus	86.33	0.00e+00	2117.00
IUUC-Bta-012371	Bos taurus	74.98	0.00e+00	1810.00
IUUC-Bci-013684	Botrytis cinerea	31.30	7.00e-137	482.00
IUUC-Cja-019297	Callithrix jacchus	72.90	0.00e+00	1771.00
IUUC-Cfa-020489	Canis familiaris	74.98	0.00e+00	1810.00
IUUC-Cpo-022392	Cavia porcellus	75.06	0.00e+00	1847.00
IUUC-Csa-023220	Chlorocebus sabaeus	74.49	0.00e+00	1812.00
IUUC-Csv-025841	Ciona savignyi	47.94	2.00e-140	493.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	31.56	4.00e-156	545.00
IUUC-Cne-026932	Cryptococcus neoformans	43.31	3.00e-71	264.00
IUUC-Dre-028482	Danio rerio	84.14	0.00e+00	2063.00
IUUC-Dno-029398	Dasypus novemcinctus	75.06	0.00e+00	1818.00
IUUC-Dor-030307	Dipodomys ordii	70.04	0.00e+00	1011.00
IUUC-Dme-032111	Drosophila melanogaster	40.59	0.00e+00	884.00
IUUC-Eca-033985	Equus caballus	75.14	0.00e+00	1813.00
IUUC-Eeu-034928	Erinaceus europaeus	76.92	9.00e-179	621.00
IUUC-Fca-035587	Felis catus	74.98	0.00e+00	1838.00
IUUC-Fal-037587	Ficedula albicollis	76.10	0.00e+00	1819.00
IUUC-Fso-038133	Fusarium solani	31.70	1.00e-95	345.00
IUUC-Gmo-039076	Gadus morhua	85.19	0.00e+00	2071.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.25	2.00e-140	494.00
IUUC-Gga-040948	Gallus gallus	76.49	0.00e+00	1848.00
IUUC-Gac-042396	Gasterosteus aculeatus	90.02	0.00e+00	2201.00
IUUC-Ggo-045412	Gorilla gorilla	74.57	0.00e+00	1813.00
IUUC-Hsa-046076	Homo sapiens	74.57	0.00e+00	1814.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	69.52	0.00e+00	1630.00
IUUC-Kpa-049178	Komagataella pastoris	31.79	2.00e-88	320.00
IUUC-Lch-050279	Latimeria chalumnae	72.38	0.00e+00	894.00
IUUC-Loc-052872	Lepisosteus oculatus	84.23	0.00e+00	2041.00
IUUC-Lma-052986	Leptosphaeria maculans	30.60	4.00e-92	333.00
IUUC-Laf-054181	Loxodonta africana	72.61	0.00e+00	1769.00
IUUC-Mcc-054812	Macaca mulatta	74.49	0.00e+00	1802.00
IUUC-Meu-056325	Macropus eugenii	76.04	0.00e+00	1839.00
IUUC-Mor-057246	Magnaporthe oryzae	29.16	1.00e-117	418.00
IUUC-Mpo-057464	Magnaporthe poae	31.89	2.00e-141	497.00
IUUC-Mla-058911	Melampsora laricipopulina	42.39	1.00e-70	262.00
IUUC-Mga-059335	Meleagris gallopavo	76.89	0.00e+00	1798.00
IUUC-Mvi-060461	Microbotryum violaceum	34.34	2.00e-144	507.00
IUUC-Mmr-060636	Microcebus murinus	74.90	0.00e+00	1806.00
IUUC-Mmu-063503	Mus musculus	74.55	0.00e+00	1815.00
IUUC-Mpu-066670	Mustela putorius furo	75.14	0.00e+00	1815.00
IUUC-Mlu-068119	Myotis lucifugus	74.65	0.00e+00	1870.00
IUUC-Nfi-068398	Neosartorya fischeri	31.36	3.00e-152	533.00
IUUC-Ncr-068927	Neurospora crassa	28.06	6.00e-119	422.00
IUUC-Nle-069651	Nomascus leucogenys	71.65	0.00e+00	1724.00
IUUC-Opr-070614	Ochotona princeps	74.23	0.00e+00	1783.00
IUUC-Oan-073283	Ornithorhynchus anatinus	67.60	0.00e+00	1285.00
IUUC-Ocu-074401	Oryctolagus cuniculus	74.51	0.00e+00	1817.00
IUUC-Ola-087522	Oryzias latipes	89.89	0.00e+00	2172.00
IUUC-Oga-088226	Otolemur garnettii	74.16	0.00e+00	1820.00
IUUC-Oar-089241	Ovis aries	74.90	0.00e+00	1837.00
IUUC-Pan-092297	Papio anubis	76.18	0.00e+00	1640.00
IUUC-Psi-094043	Pelodiscus sinensis	72.76	0.00e+00	1715.00
IUUC-Pma-094394	Petromyzon marinus	66.40	0.00e+00	1519.00
IUUC-Pno-095053	Phaeosphaeria nodorum	29.57	1.00e-75	278.00
IUUC-Ppa-095188	Physcomitrella patens	32.19	1.00e-161	564.00
IUUC-Pfo-097517	Poecilia formosa	90.69	0.00e+00	2238.00
IUUC-Pca-100471	Procavia capensis	76.11	0.00e+00	1732.00
IUUC-Pva-102805	Pteropus vampyrus	72.55	0.00e+00	1427.00
IUUC-Pte-104021	Pyrenophora teres	32.04	2.00e-161	563.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.83	3.00e-160	559.00
IUUC-Rno-105471	Rattus norvegicus	74.55	0.00e+00	1826.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.29	8.00e-61	229.00
IUUC-Sha-106883	Sarcophilus harrisii	76.13	0.00e+00	1714.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.32	1.00e-143	504.00
IUUC-Sar-113323	Sorex araneus	74.53	0.00e+00	1343.00
IUUC-Sre-115075	Sporisorium reilianum	48.20	9.00e-59	223.00
IUUC-Ssc-116363	Sus scrofa	74.35	0.00e+00	1827.00
IUUC-Tru-118427	Takifugu rubripes	90.29	0.00e+00	2240.00
IUUC-Tni-120218	Tetraodon nigroviridis	90.04	0.00e+00	2243.00
IUUC-Tre-122177	Trichoderma reesei	31.46	3.00e-156	546.00
IUUC-Tme-127176	Tuber melanosporum	32.48	6.00e-137	482.00
IUUC-Tbe-127641	Tupaia belangeri	66.07	9.00e-179	621.00
IUUC-Ttr-128888	Tursiops truncatus	74.11	0.00e+00	1128.00
IUUC-Uma-129361	Ustilago maydis	39.18	9.00e-62	233.00
IUUC-Xtr-132811	Xenopus tropicalis	74.10	0.00e+00	1779.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence