iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087007

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BAAF04013225

Gene Name

usp37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000014960.2	ENSORLT00000018755.2	ENSORLP00000018754.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-81	273.5	308	902

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++p++ ++ll+   +++ ++n   p ++ll+ +++l+ +      ++k+   r++++a++++ae+f g+
   Q: 308  QGFSNLGNTCYMNAILQSLFSLPSFSNDLLK---QSTFWKN--LPINALLRRFAHLMIKKDvgCPETKKDLLRKVKNAISSTAERFFGN 391
           69*****************************...7777775..4677788888888777656788889999****************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+++++k  +k++++      s++s+ +e ++    +++++ +++++++++i+c+ c++v +++e+f+dls+++
   Q: 392  MQNDAHEFLSQCLDQLKDDVEK-ISKSWSNGAAPPASAASELEEADTSHIFTCPVVANMEFEVQHTITCKGCGEVVTKREQFNDLSIDL 479
           ********************55.8999999999999999************************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++t ++ s+qd+L+ f++ ee+e    y+cekc++k  a+  +k++klP+vLilhLkR+sf+ + + ++k+ ++v +p+ L+l ++
   Q: 480  PRRKKTIPLrSIQDSLDLFFRMEEIE----YSCEKCNGKA-ATVAHKFSKLPRVLILHLKRYSFNAQLSLNSKLGQQVVIPRYLTLLSH 563
           *999887645***************9....********99.99********************************************** PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 564  CTEstrppvslgwsfpasvsrtvktsslvnsstaphrrfggkaafsnsscvlldsdceeelnrkvstshkrrlssclseqdshpeevsg 652
           ***99999999999999999999999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 653  fyscsycvvymsrqeaglsapppledeptsspdtgfgdsdindltyhtdqlegdtkqsagipsnmgyvlgsldmtmddnkenqtpesvq 741
           88888888888888888888888888888888888888888888888888888888887777777777777777777776666666665 PP
   S: 268  ..............peekqke.................................................................... 274
                         +     e                                                                    
   Q: 742  qqgeldwvqqynldQ-----Ereeqelqqalaqslqeheaqemredddlkratelslqefnnslpellcsdedsgnedvldmeyteaea 825
           555555555555550.....055555556666666666666677777777777777777777777888888888888888888888888 PP
   S: 275  ............kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
                        ++Y+Li+vv+H G s+ssGHY+++v++ k++ Wl+++D  V+ ++e+ v++++++++Y++fY++
   Q: 826  enlkrnaetgdlANSYRLISVVSHIGsSSSSGHYISDVYDMKKQsWLTYNDLDVSRTQEAAVQRDRDRSGYIFFYMH 902
           888999999999****************************88888******************************98 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

STVKIRFNTI ELGGTKWKEG TFEILEKDNR VNLCLRFSCG GAAKTFQLNH NVKSISQNPN 60
RIMLTLKDNV VIYLDKMPQP LVQRTKEYLE KLKQGKSVLK SSYGSANLSV LGNRSMKNET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACTGTCA AGATTCGCTT TAACACCATT GAGCTGGGCG GCACCAAGTG GAAAGAGGGA 60
ACCTTTGAAA TTTTGGAAAA GGATAACAGA GTTAATCTCT GTTTAAGGTT CAGCTGTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	53.69	0.00e+00	877.00
IUUC-Apl-004033	Anas platyrhynchos	54.26	0.00e+00	880.00
IUUC-Aca-005370	Anolis carolinensis	52.82	0.00e+00	855.00
IUUC-Ame-011884	Astyanax mexicanus	68.82	0.00e+00	1189.00
IUUC-Bta-012725	Bos taurus	54.23	0.00e+00	868.00
IUUC-Cja-019939	Callithrix jacchus	53.25	0.00e+00	862.00
IUUC-Cfa-020835	Canis familiaris	54.25	0.00e+00	899.00
IUUC-Cpo-022067	Cavia porcellus	52.64	0.00e+00	790.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.03	6.00e-23	102.00
IUUC-Csa-023085	Chlorocebus sabaeus	53.66	0.00e+00	880.00
IUUC-Cho-024390	Choloepus hoffmanni	52.71	1.00e-63	238.00
IUUC-Cin-025496	Ciona intestinalis	36.06	6.00e-48	185.00
IUUC-Csv-025812	Ciona savignyi	33.23	7.00e-41	162.00
IUUC-Dre-028255	Danio rerio	67.37	0.00e+00	1124.00
IUUC-Dno-028986	Dasypus novemcinctus	52.94	0.00e+00	856.00
IUUC-Dor-031062	Dipodomys ordii	41.60	9.00e-115	407.00
IUUC-Ete-032359	Echinops telfairi	47.87	1.00e-118	421.00
IUUC-Eca-033964	Equus caballus	54.26	0.00e+00	884.00
IUUC-Eeu-034492	Erinaceus europaeus	51.16	4.00e-117	415.00
IUUC-Fca-036359	Felis catus	53.80	0.00e+00	884.00
IUUC-Fal-037640	Ficedula albicollis	54.86	0.00e+00	861.00
IUUC-Gmo-039600	Gadus morhua	73.92	0.00e+00	1295.00
IUUC-Gga-040126	Gallus gallus	54.52	0.00e+00	834.00
IUUC-Gac-041557	Gasterosteus aculeatus	76.47	0.00e+00	1320.00
IUUC-Ggo-045571	Gorilla gorilla	50.32	0.00e+00	752.00
IUUC-Hsa-046043	Homo sapiens	53.15	0.00e+00	864.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	53.92	0.00e+00	876.00
IUUC-Lch-050357	Latimeria chalumnae	51.38	0.00e+00	752.00
IUUC-Loc-052849	Lepisosteus oculatus	67.54	0.00e+00	1086.00
IUUC-Laf-054570	Loxodonta africana	52.99	0.00e+00	848.00
IUUC-Mcc-054989	Macaca mulatta	52.12	0.00e+00	789.00
IUUC-Meu-056273	Macropus eugenii	44.12	6.00e-38	152.00
IUUC-Mga-059814	Meleagris gallopavo	53.26	0.00e+00	823.00
IUUC-Mmr-061726	Microcebus murinus	54.07	0.00e+00	883.00
IUUC-Mdo-062974	Monodelphis domestica	54.52	0.00e+00	885.00
IUUC-Mmu-064069	Mus musculus	54.07	0.00e+00	873.00
IUUC-Mpu-066008	Mustela putorius furo	53.45	0.00e+00	872.00
IUUC-Mlu-068224	Myotis lucifugus	32.85	4.00e-101	362.00
IUUC-Nle-069259	Nomascus leucogenys	52.95	0.00e+00	860.00
IUUC-Opr-070882	Ochotona princeps	70.51	4.00e-84	306.00
IUUC-Ont-072441	Oreochromis niloticus	79.83	0.00e+00	1411.00
IUUC-Oan-073151	Ornithorhynchus anatinus	62.60	2.00e-86	311.00
IUUC-Ocu-074879	Oryctolagus cuniculus	53.56	0.00e+00	864.00
IUUC-Oga-088385	Otolemur garnettii	53.59	0.00e+00	880.00
IUUC-Oar-090305	Ovis aries	54.42	0.00e+00	883.00
IUUC-Ptr-091299	Pan troglodytes	53.16	0.00e+00	861.00
IUUC-Pan-091996	Papio anubis	54.38	0.00e+00	860.00
IUUC-Psi-093176	Pelodiscus sinensis	55.10	0.00e+00	889.00
IUUC-Pma-094331	Petromyzon marinus	44.44	5.00e-176	611.00
IUUC-Ppa-095685	Physcomitrella patens	29.13	1.00e-23	104.00
IUUC-Pfo-096503	Poecilia formosa	77.67	0.00e+00	1292.00
IUUC-Pab-098543	Pongo abelii	58.11	2.00e-146	512.00
IUUC-Pca-101099	Procavia capensis	53.11	0.00e+00	691.00
IUUC-Pva-103163	Pteropus vampyrus	51.04	2.00e-169	590.00
IUUC-Rno-105766	Rattus norvegicus	53.45	0.00e+00	854.00
IUUC-Sha-106610	Sarcophilus harrisii	51.11	0.00e+00	785.00
IUUC-Sar-113624	Sorex araneus	46.35	5.00e-50	192.00
IUUC-Ssc-116353	Sus scrofa	53.04	0.00e+00	859.00
IUUC-Tgu-116971	Taeniopygia guttata	54.97	0.00e+00	842.00
IUUC-Tru-117932	Takifugu rubripes	55.66	0.00e+00	868.00
IUUC-Tsy-119185	Tarsius syrichta	51.58	3.00e-173	602.00
IUUC-Tni-119842	Tetraodon nigroviridis	69.09	8.00e-132	463.00
IUUC-Tbe-127281	Tupaia belangeri	39.34	2.00e-69	257.00
IUUC-Ttr-128177	Tursiops truncatus	58.05	0.00e+00	744.00
IUUC-Vpa-130031	Vicugna pacos	53.96	0.00e+00	893.00
IUUC-Xtr-132949	Xenopus tropicalis	53.22	0.00e+00	836.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence