iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000005767.6	ENSGALT00000009263.5	ENSGALP00000009249.3
ENSGALG00000005767.6	ENSGALT00000089393.1	ENSGALP00000060305.1
ENSGALG00000005767.6	ENSGALT00000086069.1	ENSGALP00000063547.1
ENSGALG00000005767.6	ENSGALT00000079465.1	ENSGALP00000050524.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-31	107.9	394	425
UBD/Beta-Prp	2.30e-49	168.6	392	670

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDl 30
           gH+++v+cl+      +ll sGs D+tikvWD+
   Q: 394  GHQGPVWCLCVysiG-DLLFSGSSDKTIKVWDT 425
           8********965643.89**************6 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdv.ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           + gh+  v+ c+++   ++ll++gs d+tikvwd+ tt k+ ++l+gh++ v a++++ +   l +gs D ti vwd+++ + v t+++
   Q: 392  FVGHQGPVW-CLCVYSIGDLLFSGSSDKTIKVWDTcTTYKCQKTLEGHDGIVLALCIQGN--KLYSGSADCTIIVWDIQNLQKVNTIRA 477
           556666555.59999*******************846678899****************9..6************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdl.etgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           h++ v++l +s   + l sGs  + i+vwd+  t+ +l++ l+g +++v+ +v ++  n+l sGs+ +t+++Wd+++ ++++ l+    
   Q: 478  HDNPVCTLVSSH--NMLFSGS-LKAIKVWDIvGTELKLKKELTGLNHWVRALVASQ--NYLYSGSY-QTIKIWDIRNLECVHVLQT-SG 559
           *******99999..9******.9*******7368888888**************99..*******9.79***************99.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           +svys++++    ++v g + + + +wd++t+e vrtl+gh  +v+ +++   p+++ + s+s D+s+r+W +++  +++tl +h+ sv
   Q: 560  GSVYSIAVTN--HHIVCGTYENLIHVWDIETKEQVRTLTGHVGTVYALAVIstPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSV 646
           *********9..8***********************************99888************************************ PP
   S: 268  isvavlsfgdnvlvlgsedskvniwkl 294
           ++ av   ++  l++g+ ds+v++w +
   Q: 647  TALAV---SRGRLFSGAVDSTVKVWTC 670
           ****9...*****************86 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MSSNKNARFN RFSSGTPSIT TSENTNGTRM ETTFGPAYSA VTTITKADGT NTFKQHRRTP 60
SSSSTLTYSP RDEDDGMPPI STPRRSDSAI SVRSLHSESN MSLRSTFSLH EEEEEPEPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCCGCTC TTCTGGCCCG GGCGGCAGCT GAGCCGCTAG ACGAGCGAGA GGGAGGCCTG 60
GGGCCGCGAT GTGCCGGGAT CGGGTACCGG CGCTTCGGCC GCCGCCGCTG CCAGGTACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR020472--G-protein_beta_WD-40_rep
IPR008974--TRAF-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00400--WD40
PF13445--zf-RING_UBOX

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000185--P:activation of MAPKKK activity
GO:0006915--P:apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

gga:416555

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001971	Ailuropoda melanoleuca	92.42	0.00e+00	1217.00
IUUC-Apl-004098	Anas platyrhynchos	99.69	0.00e+00	1255.00
IUUC-Aca-004852	Anolis carolinensis	92.28	0.00e+00	1019.00
IUUC-Ame-011275	Astyanax mexicanus	85.30	0.00e+00	966.00
IUUC-Bta-013153	Bos taurus	92.99	0.00e+00	1221.00
IUUC-Cja-019243	Callithrix jacchus	91.90	0.00e+00	1182.00
IUUC-Cfa-020036	Canis familiaris	93.13	0.00e+00	1234.00
IUUC-Cpo-022194	Cavia porcellus	92.50	0.00e+00	1221.00
IUUC-Csa-023363	Chlorocebus sabaeus	93.13	0.00e+00	1230.00
IUUC-Cin-025279	Ciona intestinalis	58.98	0.00e+00	804.00
IUUC-Csv-026163	Ciona savignyi	64.55	0.00e+00	776.00
IUUC-Dre-027998	Danio rerio	92.98	0.00e+00	1143.00
IUUC-Dno-029356	Dasypus novemcinctus	92.86	4.00e-127	446.00
IUUC-Dor-030750	Dipodomys ordii	90.75	0.00e+00	1183.00
IUUC-Eca-033671	Equus caballus	78.12	0.00e+00	951.00
IUUC-Eeu-034765	Erinaceus europaeus	95.07	8.00e-163	566.00
IUUC-Fca-035843	Felis catus	93.13	0.00e+00	1234.00
IUUC-Fal-037237	Ficedula albicollis	98.51	0.00e+00	1300.00
IUUC-Gmo-038779	Gadus morhua	83.21	0.00e+00	1031.00
IUUC-Gac-042233	Gasterosteus aculeatus	87.65	0.00e+00	1147.00
IUUC-Gma-042914	Glycine max	27.54	1.00e-19	90.50
IUUC-Ggo-045147	Gorilla gorilla	92.69	0.00e+00	1225.00
IUUC-Hsa-046117	Homo sapiens	92.84	0.00e+00	1226.00
IUUC-Itr-048899	Ictidomys tridecemlineatus	92.69	0.00e+00	1229.00
IUUC-Lch-050593	Latimeria chalumnae	94.49	0.00e+00	1228.00
IUUC-Loc-052444	Lepisosteus oculatus	92.16	0.00e+00	1249.00
IUUC-Laf-053499	Loxodonta africana	88.34	0.00e+00	1152.00
IUUC-Mcc-055038	Macaca mulatta	92.99	0.00e+00	1228.00
IUUC-Meu-056610	Macropus eugenii	93.24	0.00e+00	929.00
IUUC-Mtr-057641	Medicago truncatula	27.73	2.00e-20	93.20
IUUC-Mga-060183	Meleagris gallopavo	99.11	0.00e+00	1306.00
IUUC-Mmr-061133	Microcebus murinus	91.05	0.00e+00	1155.00
IUUC-Mdo-062312	Monodelphis domestica	94.49	0.00e+00	1246.00
IUUC-Mmu-063844	Mus musculus	92.84	0.00e+00	1200.00
IUUC-Mpu-066552	Mustela putorius furo	92.69	0.00e+00	1214.00
IUUC-Mlu-067719	Myotis lucifugus	92.54	0.00e+00	1195.00
IUUC-Nle-070045	Nomascus leucogenys	94.72	0.00e+00	1166.00
IUUC-Opr-070927	Ochotona princeps	90.60	0.00e+00	1187.00
IUUC-Ont-072680	Oreochromis niloticus	87.32	0.00e+00	1171.00
IUUC-Oan-073521	Ornithorhynchus anatinus	94.00	2.00e-52	196.00
IUUC-Ogu-077987	Oryza glumaepatula	25.43	3.00e-19	89.40
IUUC-Oru-085210	Oryza rufipogon	25.20	2.00e-19	90.10
IUUC-Ola-087454	Oryzias latipes	90.99	0.00e+00	1211.00
IUUC-Oga-088380	Otolemur garnettii	92.84	0.00e+00	1231.00
IUUC-Oar-089558	Ovis aries	75.98	0.00e+00	959.00
IUUC-Ptr-091606	Pan troglodytes	92.69	0.00e+00	1225.00
IUUC-Pan-092227	Papio anubis	92.99	0.00e+00	1228.00
IUUC-Psi-093853	Pelodiscus sinensis	90.45	0.00e+00	1070.00
IUUC-Pma-094541	Petromyzon marinus	81.33	8.00e-157	545.00
IUUC-Pfo-096237	Poecilia formosa	91.13	0.00e+00	1160.00
IUUC-Pab-097589	Pongo abelii	92.84	0.00e+00	1226.00
IUUC-Pca-100375	Procavia capensis	90.99	0.00e+00	1163.00
IUUC-Pva-102434	Pteropus vampyrus	93.13	0.00e+00	1232.00
IUUC-Rno-105443	Rattus norvegicus	92.99	0.00e+00	1204.00
IUUC-Sha-106517	Sarcophilus harrisii	94.20	0.00e+00	1240.00
IUUC-Ssc-115990	Sus scrofa	92.24	0.00e+00	1221.00
IUUC-Tgu-117222	Taeniopygia guttata	97.90	0.00e+00	1285.00
IUUC-Tru-118392	Takifugu rubripes	90.56	0.00e+00	1169.00
IUUC-Tni-120220	Tetraodon nigroviridis	89.74	0.00e+00	1160.00
IUUC-Tbe-128045	Tupaia belangeri	96.53	3.00e-158	551.00
IUUC-Ttr-128203	Tursiops truncatus	89.25	0.00e+00	1164.00
IUUC-Xtr-132043	Xenopus tropicalis	93.73	0.00e+00	1276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence