iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062313

UUCD1 version

UUC-MoD-00884

Ensembl Protein ID

ENSMODP00000036534.2

UniProt Accession

F6TD90; F6TD90_MONDO

Protein Name

Uncharacterized protein

Gene Name

SH3RF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002876.3	ENSMODT00000038126.2	ENSMODP00000036534.2
ENSMODG00000002876.3	ENSMODT00000003571.3	ENSMODP00000003494.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.10e-08	33.2	12	53
UBD/SH3	4.10e-48	161.3	443	498

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle+++   +vlpC+H+f++ Cl  +      s++e rCP Cr
   Q: 12   CPVCLERLDASAKVLPCQHTFCKRCLLGI----VGSRNELRCPECR 53
           **********9**************9777....899*********8 PP

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +  ++y+y++ ++deL+l+kG++ lv  + +   gW kg++  + k G+fP n+v+ +
   Q: 443  VYVAIYPYTPRKEDELELRKGEMFLVF-ERC-QDGWFKGTSMHTSKIGVFPGNYVAPV 498
           5679**********************9.555.569********************988 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP ECRTLVGCGV 60
DELPSNILLV RLLDGIKQRP RKPGSGSGIN CMGGLRAQGT SGVNCVSKDP QGSQGGQQRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCAGACTC CCGGAGCTGC CGGGTGCCTG TTTAGGTTAG CCGCGCAGTC CATATCCCCT 60
GCGATTCACT TCCCAGCCCA GGGAGGGAAG AAGCGTTCAC TGCTAGAGTT GAGGTGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001452--SH3_domain
IPR028502--SH3RF1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00018--SH3_1
PF14604--SH3_9
PF00097--zf-C3HC4

PRINTS

PR00452--SH3DOMAIN

SMART

SM00184--RING
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0046328--P:regulation of JNK cascade

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001528	Ailuropoda melanoleuca	77.48	0.00e+00	1103.00
IUUC-Apl-003961	Anas platyrhynchos	77.41	0.00e+00	1108.00
IUUC-Aca-004386	Anolis carolinensis	72.14	0.00e+00	1078.00
IUUC-Ame-010659	Astyanax mexicanus	58.18	0.00e+00	832.00
IUUC-Bta-012563	Bos taurus	61.16	9.00e-115	407.00
IUUC-Cja-019730	Callithrix jacchus	74.58	0.00e+00	1060.00
IUUC-Cfa-020992	Canis familiaris	76.69	0.00e+00	1140.00
IUUC-Cpo-021304	Cavia porcellus	77.12	0.00e+00	1179.00
IUUC-Csa-023925	Chlorocebus sabaeus	75.17	0.00e+00	1095.00
IUUC-Cho-024630	Choloepus hoffmanni	70.65	0.00e+00	686.00
IUUC-Cin-025274	Ciona intestinalis	50.38	1.00e-71	263.00
IUUC-Csv-026136	Ciona savignyi	42.90	9.00e-70	257.00
IUUC-Cme-027278	Cyanidioschyzon merolae	44.19	3.00e-07	50.80
IUUC-Dre-028290	Danio rerio	58.86	0.00e+00	846.00
IUUC-Dno-029083	Dasypus novemcinctus	79.33	0.00e+00	856.00
IUUC-Dor-030388	Dipodomys ordii	76.60	2.00e-148	520.00
IUUC-Dme-032207	Drosophila melanogaster	44.87	5.00e-62	232.00
IUUC-Ete-032809	Echinops telfairi	66.19	0.00e+00	657.00
IUUC-Eca-034185	Equus caballus	75.79	0.00e+00	917.00
IUUC-Eeu-034816	Erinaceus europaeus	66.00	0.00e+00	904.00
IUUC-Fca-036439	Felis catus	74.86	0.00e+00	1141.00
IUUC-Fal-037074	Ficedula albicollis	76.05	0.00e+00	1099.00
IUUC-Gmo-039443	Gadus morhua	56.84	7.00e-110	391.00
IUUC-Gga-040749	Gallus gallus	75.68	0.00e+00	1037.00
IUUC-Gac-041420	Gasterosteus aculeatus	67.21	2.00e-136	479.00
IUUC-Ggo-045215	Gorilla gorilla	77.29	0.00e+00	1125.00
IUUC-Hsa-046315	Homo sapiens	76.87	0.00e+00	1115.00
IUUC-Lch-049453	Latimeria chalumnae	64.64	0.00e+00	789.00
IUUC-Laf-053651	Loxodonta africana	76.57	0.00e+00	1090.00
IUUC-Mcc-054688	Macaca mulatta	74.55	0.00e+00	1120.00
IUUC-Meu-056291	Macropus eugenii	75.62	0.00e+00	818.00
IUUC-Mga-059944	Meleagris gallopavo	75.34	0.00e+00	1091.00
IUUC-Mmr-061553	Microcebus murinus	72.69	0.00e+00	1037.00
IUUC-Mmu-063516	Mus musculus	76.51	0.00e+00	1163.00
IUUC-Mpu-066064	Mustela putorius furo	77.11	0.00e+00	1112.00
IUUC-Mlu-067312	Myotis lucifugus	74.86	0.00e+00	1080.00
IUUC-Nle-069035	Nomascus leucogenys	77.07	0.00e+00	1122.00
IUUC-Opr-070690	Ochotona princeps	74.77	3.00e-166	578.00
IUUC-Ont-071484	Oreochromis niloticus	56.65	0.00e+00	811.00
IUUC-Oan-073305	Ornithorhynchus anatinus	76.02	0.00e+00	1100.00
IUUC-Ocu-074936	Oryctolagus cuniculus	75.00	0.00e+00	1104.00
IUUC-Ola-086675	Oryzias latipes	56.18	2.00e-158	553.00
IUUC-Oga-087933	Otolemur garnettii	70.31	0.00e+00	868.00
IUUC-Oar-090408	Ovis aries	59.24	6.00e-107	381.00
IUUC-Ptr-090865	Pan troglodytes	77.09	0.00e+00	1121.00
IUUC-Pan-092362	Papio anubis	75.17	0.00e+00	1093.00
IUUC-Psi-093876	Pelodiscus sinensis	74.80	0.00e+00	1096.00
IUUC-Pfo-097116	Poecilia formosa	57.48	0.00e+00	813.00
IUUC-Pab-098127	Pongo abelii	76.87	0.00e+00	1118.00
IUUC-Pca-100485	Procavia capensis	75.24	0.00e+00	798.00
IUUC-Pva-102661	Pteropus vampyrus	73.00	0.00e+00	1073.00
IUUC-Rno-105728	Rattus norvegicus	75.61	0.00e+00	1140.00
IUUC-Sha-106515	Sarcophilus harrisii	82.80	0.00e+00	814.00
IUUC-Smo-109517	Selaginella moellendorffii	40.30	3.00e-08	49.70
IUUC-Sar-113161	Sorex araneus	69.87	0.00e+00	969.00
IUUC-Ssc-115314	Sus scrofa	69.43	0.00e+00	932.00
IUUC-Tgu-117012	Taeniopygia guttata	76.96	0.00e+00	1093.00
IUUC-Tru-118467	Takifugu rubripes	55.54	6.00e-144	504.00
IUUC-Tsy-119566	Tarsius syrichta	67.21	5.00e-137	481.00
IUUC-Tni-120900	Tetraodon nigroviridis	50.54	2.00e-84	307.00
IUUC-Tbe-128070	Tupaia belangeri	79.29	8.00e-159	554.00
IUUC-Ttr-128161	Tursiops truncatus	87.84	2.00e-128	452.00
IUUC-Xtr-132628	Xenopus tropicalis	67.42	0.00e+00	982.00
IUUC-Xma-133732	Xiphophorus maculatus	57.72	0.00e+00	805.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence