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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063906
UUCD1 version UUC-MuM-00248
Ensembl Protein ID ENSMUSP00000140224.1
UniProt Accession G5E870; Q3TY88; Q3UYT5; Q8BM59; Q8K051; TRIPC_MOUSE
Genbank Protein ID EDL02171.1; EDL02178.1; EDL02182.1; BAC28839.1; BAE22126.1; BAE34675.1; AAH34113.2
Protein Name E3 ubiquitin-protein ligase TRIP12; HECT-type E3 ubiquitin transferase TRIP12; Thyroid receptor-interacting protein 12
Genbank Nucleotide ID AC123882; CH466629; CH466629; AK034814; AK134397; AK158807; BC034113
Gene Name Trip12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026219.14 ENSMUST00000186465.6 ENSMUSP00000140224.1
ENSMUSG00000026219.14 ENSMUST00000189670.6 ENSMUSP00000140789.1
ENSMUSG00000026219.14 ENSMUST00000186648.6 ENSMUSP00000139563.1
ENSMUSG00000026219.14 ENSMUST00000187733.1 ENSMUSP00000140675.1
ENSMUSG00000026219.14 ENSMUST00000189841.1 ENSMUSP00000140879.1
ENSMUSG00000026219.14 ENSMUST00000185909.6 ENSMUSP00000139986.1
ENSMUSG00000026219.14 ENSMUST00000190464.6 ENSMUSP00000141035.1
ENSMUSG00000026219.14 ENSMUST00000189496.6 ENSMUSP00000139682.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.60e-94 317.5 1646 2025
Active Site
Position(s) Description Evidence
1992 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dl+l++ +e   ++ +   + +++                         ++  
   Q: 1646 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLCLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1728
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1729 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1815
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl +l++F
   Q: 1816 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLCHLQYF 1890
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1891 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1977
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss +i+++kLl+A +e+ ++F+ls
   Q: 1978 stENPDDFLPSVMTCVNYLKLPDYSSIDIMRDKLLIAAREGqQSFHLS 2025
           988888***************************************985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
 E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Protein Sequence
(Fasta)
MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSCSSSSA VIVPQPEDPD RANTSERQKT 60
GQVPKKDNSR GVKRSASPDY NRTNSPSSAK KPRAFQHIES FSETNKPHSK SKKRHLDQEQ 120
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Protein Fasta Sequence


>IUUC-Mmu-063906|E3,HECT|Mus musculus
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Nucleotide Sequence
(Fasta)
ACACTTTCAA TGGGATAGAA GAGGCTCCAA CAAGGTAAGG GGAAACCCTT CGGTCAGCCA 60
TTCCTTCTAA AAAGAGGAGT TTTGGTGCGG TAATTGTAAA GGCCGAAGCG AGAGGTTCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063906|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
PROSITE

PS50237--HECT
PS50918--WWE
Pfam

PF00632--HECT
PF02825--WWE
SMART

SM00119--HECTc
SM00678--WWE
Gene Ontology

GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046966--F:thyroid hormone receptor binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG mmu:14897
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000750 Aegilops tauschii 38.39 3.00e-124 440.00
IUUC-Aml-001502 Ailuropoda melanoleuca 95.02 0.00e+00 3589.00
IUUC-Atr-002821 Amborella trichopoda 37.30 5.00e-116 413.00
IUUC-Apl-003531 Anas platyrhynchos 90.62 0.00e+00 3331.00
IUUC-Aly-005962 Arabidopsis lyrata 38.66 4.00e-112 400.00
IUUC-Ath-006636 Arabidopsis thaliana 44.11 2.00e-111 398.00
IUUC-Ago-007875 Ashbya gossypii 35.62 1.00e-79 291.00
IUUC-Acl-008242 Aspergillus clavatus 35.53 5.00e-113 403.00
IUUC-Afl-008736 Aspergillus flavus 38.83 3.00e-110 394.00
IUUC-Afu-008812 Aspergillus fumigatus 34.64 2.00e-112 401.00
IUUC-Ani-009407 Aspergillus nidulans 36.67 1.00e-109 392.00
IUUC-Ang-009763 Aspergillus niger 39.82 1.00e-105 378.00
IUUC-Aor-009941 Aspergillus oryzae 30.76 3.00e-112 400.00
IUUC-Ate-010459 Aspergillus terreus 37.10 9.00e-85 309.00
IUUC-Ame-011761 Astyanax mexicanus 87.85 0.00e+00 2970.00
IUUC-Bgr-012265 Blumeria graminis 34.55 4.00e-103 370.00
IUUC-Bta-013070 Bos taurus 95.65 0.00e+00 3571.00
IUUC-Bci-013890 Botrytis cinerea 39.72 2.00e-102 367.00
IUUC-Bdi-014046 Brachypodium distachyon 38.33 7.00e-120 426.00
IUUC-Bol-015942 Brassica oleracea 43.85 2.00e-112 401.00
IUUC-Bra-016849 Brassica rapa 43.85 4.00e-112 400.00
IUUC-Cja-019046 Callithrix jacchus 93.91 0.00e+00 3532.00
IUUC-Cfa-020521 Canis familiaris 93.13 0.00e+00 3440.00
IUUC-Cpo-021639 Cavia porcellus 91.11 0.00e+00 3469.00
IUUC-Cre-022767 Chlamydomonas reinhardtii 39.50 1.00e-87 317.00
IUUC-Csa-023231 Chlorocebus sabaeus 96.42 0.00e+00 3617.00
IUUC-Cho-024380 Choloepus hoffmanni 92.55 0.00e+00 2149.00
IUUC-Cin-025482 Ciona intestinalis 51.02 2.00e-158 552.00
IUUC-Csv-026121 Ciona savignyi 48.17 0.00e+00 1528.00
IUUC-Cgl-026716 Colletotrichum gloeosporioides 39.89 5.00e-110 393.00
IUUC-Cne-026857 Cryptococcus neoformans 39.69 5.00e-94 340.00
IUUC-Cme-027226 Cyanidioschyzon merolae 35.14 4.00e-74 274.00
IUUC-Dre-028174 Danio rerio 88.02 0.00e+00 3026.00
IUUC-Dor-030939 Dipodomys ordii 86.89 0.00e+00 2768.00
IUUC-Dse-031444 Dothistroma septosporum 39.11 6.00e-105 376.00
IUUC-Dme-032162 Drosophila melanogaster 67.73 3.00e-174 607.00
IUUC-Ete-032345 Echinops telfairi 89.89 0.00e+00 2281.00
IUUC-Eca-033229 Equus caballus 94.39 0.00e+00 3501.00
IUUC-Eeu-035205 Erinaceus europaeus 85.63 0.00e+00 3091.00
IUUC-Fca-036444 Felis catus 94.25 0.00e+00 3528.00
IUUC-Fal-037131 Ficedula albicollis 92.31 0.00e+00 3458.00
IUUC-Fox-038035 Fusarium oxysporum 36.42 2.00e-109 389.00
IUUC-Fso-038320 Fusarium solani 37.07 4.00e-110 394.00
IUUC-Gmo-039497 Gadus morhua 86.78 0.00e+00 2983.00
IUUC-Ggr-040057 Gaeumannomyces graminis 35.05 3.00e-108 387.00
IUUC-Gga-041021 Gallus gallus 92.36 0.00e+00 3465.00
IUUC-Gac-042474 Gasterosteus aculeatus 81.76 0.00e+00 3041.00
IUUC-Gma-043060 Glycine max 38.78 1.00e-120 428.00
IUUC-Ggo-044855 Gorilla gorilla 94.01 0.00e+00 3534.00
IUUC-Hsa-046147 Homo sapiens 95.75 0.00e+00 3549.00
IUUC-Hvu-047775 Hordeum vulgare 38.39 2.00e-122 434.00
IUUC-Itr-048131 Ictidomys tridecemlineatus 98.37 0.00e+00 3561.00
IUUC-Kpa-049098 Komagataella pastoris 37.50 2.00e-83 305.00
IUUC-Lch-049818 Latimeria chalumnae 86.46 0.00e+00 3122.00
IUUC-Lpe-051017 Leersia perrieri 38.01 3.00e-116 414.00
IUUC-Loc-051777 Lepisosteus oculatus 86.66 0.00e+00 3314.00
IUUC-Lma-052990 Leptosphaeria maculans 39.36 2.00e-110 394.00
IUUC-Laf-053727 Loxodonta africana 94.39 0.00e+00 3534.00
IUUC-Mcc-055799 Macaca mulatta 94.97 0.00e+00 3522.00
IUUC-Meu-056065 Macropus eugenii 93.53 0.00e+00 2091.00
IUUC-Mor-057054 Magnaporthe oryzae 34.64 5.00e-107 383.00
IUUC-Mpo-057417 Magnaporthe poae 39.17 5.00e-108 386.00
IUUC-Mtr-057849 Medicago truncatula 37.22 3.00e-112 400.00
IUUC-Mla-058870 Melampsora laricipopulina 42.77 9.00e-107 382.00
IUUC-Mga-059580 Meleagris gallopavo 90.62 0.00e+00 2932.00
IUUC-Mvi-060507 Microbotryum violaceum 40.00 9.00e-112 399.00
IUUC-Mmr-060816 Microcebus murinus 96.13 0.00e+00 3600.00
IUUC-Mdo-062866 Monodelphis domestica 91.82 0.00e+00 3326.00
IUUC-Mac-064675 Musa acuminata 40.73 2.00e-109 390.00
IUUC-Mpu-066199 Mustela putorius furo 94.48 0.00e+00 3502.00
IUUC-Mlu-067110 Myotis lucifugus 97.73 0.00e+00 3608.00
IUUC-Nfi-068482 Neosartorya fischeri 34.80 2.00e-112 401.00
IUUC-Ncr-068906 Neurospora crassa 38.94 2.00e-108 388.00
IUUC-Nle-069410 Nomascus leucogenys 94.73 0.00e+00 3524.00
IUUC-Opr-070401 Ochotona princeps 86.09 0.00e+00 1944.00
IUUC-Ont-072100 Oreochromis niloticus 82.20 0.00e+00 3107.00
IUUC-Oan-073121 Ornithorhynchus anatinus 92.65 0.00e+00 3582.00
IUUC-Ocu-074623 Oryctolagus cuniculus 94.39 0.00e+00 3530.00
IUUC-Oba-075380 Oryza barthii 40.59 1.00e-111 398.00
IUUC-Obr-076915 Oryza brachyantha 37.20 3.00e-116 414.00
IUUC-Ogl-077055 Oryza glaberrima 38.28 4.00e-116 413.00
IUUC-Ogu-078892 Oryza glumaepatula 40.59 6.00e-111 395.00
IUUC-Oin-079256 Oryza indica 38.10 7.00e-115 409.00
IUUC-Olo-080343 Oryza longistaminata 38.10 3.00e-115 410.00
IUUC-Ome-081422 Oryza meridionalis 37.82 1.00e-114 408.00
IUUC-Oni-083047 Oryza nivara 40.77 6.00e-113 402.00
IUUC-Opu-083641 Oryza punctata 40.22 1.00e-108 388.00
IUUC-Oru-084439 Oryza rufipogon 40.59 1.00e-111 398.00
IUUC-Osa-085972 Oryza sativa 38.01 2.00e-114 406.00
IUUC-Ola-087173 Oryzias latipes 82.85 0.00e+00 3081.00
IUUC-Olu-087871 Ostreococcus lucimarinus 36.50 2.00e-87 316.00
IUUC-Oga-087908 Otolemur garnettii 93.82 0.00e+00 3533.00
IUUC-Oar-090277 Ovis aries 96.79 0.00e+00 3643.00
IUUC-Ptr-091543 Pan troglodytes 95.80 0.00e+00 3553.00
IUUC-Pan-092243 Papio anubis 94.97 0.00e+00 3522.00
IUUC-Psi-093150 Pelodiscus sinensis 91.78 0.00e+00 3490.00
IUUC-Pno-094891 Phaeosphaeria nodorum 40.75 2.00e-112 401.00
IUUC-Ppa-095181 Physcomitrella patens 36.67 4.00e-106 379.00
IUUC-Pfo-096267 Poecilia formosa 81.62 0.00e+00 3080.00
IUUC-Pab-098072 Pongo abelii 95.02 0.00e+00 3535.00
IUUC-Pop-099190 Populus trichocarpa 40.82 8.00e-114 406.00
IUUC-Pca-100311 Procavia capensis 89.66 0.00e+00 3254.00
IUUC-Ppe-101284 Prunus persica 37.23 4.00e-114 407.00
IUUC-Pva-102215 Pteropus vampyrus 89.34 0.00e+00 1269.00
IUUC-Pgr-103694 Puccinia graminis 40.68 5.00e-104 373.00
IUUC-Ptt-103916 Puccinia triticina 39.00 6.00e-98 353.00
IUUC-Pte-104346 Pyrenophora teres 39.22 7.00e-109 389.00
IUUC-Pyt-104508 Pyrenophora triticirepentis 39.29 4.00e-109 390.00
IUUC-Rno-105315 Rattus norvegicus 95.79 0.00e+00 3521.00
IUUC-Sce-106273 Saccharomyces cerevisiae 35.19 1.00e-70 262.00
IUUC-Sha-106835 Sarcophilus harrisii 94.29 0.00e+00 3613.00
IUUC-Sja-107943 Schizosaccharomyces japonicus 37.37 4.00e-93 336.00
IUUC-Spo-108081 Schizosaccharomyces pombe 38.34 1.00e-93 338.00
IUUC-Ssl-108560 Sclerotinia sclerotiorum 39.92 7.00e-106 379.00
IUUC-Smo-109590 Selaginella moellendorffii 42.54 5.00e-110 393.00
IUUC-Sit-110717 Setaria italica 37.38 2.00e-117 417.00
IUUC-Sly-111469 Solanum lycopersicum 39.26 9.00e-122 432.00
IUUC-Stu-112896 Solanum tuberosum 37.93 2.00e-103 370.00
IUUC-Sar-113224 Sorex araneus 87.89 0.00e+00 1898.00
IUUC-Sbi-114313 Sorghum bicolor 37.88 8.00e-122 432.00
IUUC-Sre-114993 Sporisorium reilianum 33.95 5.00e-100 360.00
IUUC-Ssc-115535 Sus scrofa 93.75 0.00e+00 3482.00
IUUC-Tgu-117493 Taeniopygia guttata 90.30 0.00e+00 2669.00
IUUC-Tru-118669 Takifugu rubripes 79.91 0.00e+00 2980.00
IUUC-Tsy-119373 Tarsius syrichta 93.89 0.00e+00 1855.00
IUUC-Tni-120049 Tetraodon nigroviridis 77.43 0.00e+00 861.00
IUUC-Tca-121779 Theobroma cacao 38.47 2.00e-113 405.00
IUUC-Tre-122195 Trichoderma reesei 36.05 9.00e-105 375.00
IUUC-Tvi-122650 Trichoderma virens 36.47 5.00e-109 390.00
IUUC-Tae-123580 Triticum aestivum 38.29 2.00e-122 433.00
IUUC-Tur-126295 Triticum urartu 38.25 5.00e-123 436.00
IUUC-Tme-126964 Tuber melanosporum 40.08 3.00e-104 374.00
IUUC-Tbe-128149 Tupaia belangeri 84.84 0.00e+00 1264.00
IUUC-Ttr-128165 Tursiops truncatus 94.37 0.00e+00 3036.00
IUUC-Uma-129365 Ustilago maydis 35.89 3.00e-88 321.00
IUUC-Vda-129725 Verticillium dahliae 41.08 1.00e-108 389.00
IUUC-Vpa-130678 Vicugna pacos 96.23 0.00e+00 2658.00
IUUC-Vvi-131147 Vitis vinifera 38.94 3.00e-120 427.00
IUUC-Xtr-132636 Xenopus tropicalis 88.37 0.00e+00 3262.00
IUUC-Xma-133458 Xiphophorus maculatus 82.09 0.00e+00 3120.00
IUUC-Yli-134481 Yarrowia lipolytica 38.97 4.00e-96 347.00
IUUC-Zma-135782 Zea mays 36.95 3.00e-116 414.00
Created Date 25-Jun-2017

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