iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20087442

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.30e-06	28.3	18	56
ULD/UDP/UFD/RAWUL	5.60e-28	98.4	148	228

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           Ca+C   f d + ++ C H f+++C+ ++        ++ +CP C
   Q: 18   CALCGGYFIDATTIVECLHSFCKTCIVRY------LETNKYCPMC 56
           ********999999***************......********** PP

ULD/UDP/UFD/RAWUL

   S: 18   k............lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegpLvLqYr 86
           k            +  ++lrc+a++tV+hl kfl++k++++s+y+v++l+ede+L++++tL++i+yi+ w+++gpL+L+Yr
   Q: 148  KnltengdgdkekTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYR 228
           44455555555559******************************************************************9 PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex.

Protein Sequence
(Fasta)

MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV 60
HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAGGGAGG CGCACCGGCG GCGAAAAGGC GCGCGTCCTC TCTCGACTCC TCGCTTCCTA 60
TTGCGTCGGG GCCTCTCGAA TTCGGCTAGT TATTGTGTCT CTGGCTCGGC GCCCGAGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0070301--P:cellular response to hydrogen peroxide
GO:0048706--P:embryonic skeletal system development
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:22658

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002051	Ailuropoda melanoleuca	93.27	4.00e-153	534.00
IUUC-Aca-004230	Anolis carolinensis	75.00	1.00e-139	489.00
IUUC-Aly-005613	Arabidopsis lyrata	40.96	3.00e-12	66.20
IUUC-Bta-013298	Bos taurus	95.61	9.00e-161	559.00
IUUC-Bol-015090	Brassica oleracea	36.73	4.00e-13	69.30
IUUC-Cja-019674	Callithrix jacchus	95.91	3.00e-160	557.00
IUUC-Cfa-020865	Canis familiaris	89.31	6.00e-144	503.00
IUUC-Cpo-022149	Cavia porcellus	93.27	1.00e-157	548.00
IUUC-Csa-024153	Chlorocebus sabaeus	96.49	8.00e-161	559.00
IUUC-Dno-029941	Dasypus novemcinctus	93.57	9.00e-154	536.00
IUUC-Dor-030557	Dipodomys ordii	95.91	2.00e-160	558.00
IUUC-Eca-033878	Equus caballus	96.86	5.00e-151	526.00
IUUC-Eeu-035039	Erinaceus europaeus	90.64	4.00e-147	514.00
IUUC-Fca-036531	Felis catus	89.21	2.00e-139	488.00
IUUC-Gga-040960	Gallus gallus	83.71	2.00e-128	452.00
IUUC-Ggo-045132	Gorilla gorilla	96.20	8.00e-161	559.00
IUUC-Hsa-045703	Homo sapiens	95.91	2.00e-160	558.00
IUUC-Itr-048008	Ictidomys tridecemlineatus	97.08	5.00e-162	563.00
IUUC-Lch-050240	Latimeria chalumnae	73.47	2.00e-126	445.00
IUUC-Laf-053589	Loxodonta africana	96.21	1.00e-159	555.00
IUUC-Mcc-055228	Macaca mulatta	96.20	2.00e-159	554.00
IUUC-Meu-056268	Macropus eugenii	81.58	1.00e-131	462.00
IUUC-Mga-059555	Meleagris gallopavo	76.77	2.00e-82	298.00
IUUC-Mmr-060605	Microcebus murinus	96.20	1.00e-160	558.00
IUUC-Mdo-061947	Monodelphis domestica	82.08	1.00e-151	528.00
IUUC-Mpu-066061	Mustela putorius furo	95.32	4.00e-160	557.00
IUUC-Mlu-067426	Myotis lucifugus	90.41	5.00e-142	496.00
IUUC-Nle-069772	Nomascus leucogenys	89.40	1.00e-153	535.00
IUUC-Ocu-074159	Oryctolagus cuniculus	81.77	7.00e-141	493.00
IUUC-Oga-088514	Otolemur garnettii	96.20	4.00e-161	560.00
IUUC-Oar-090406	Ovis aries	90.94	2.00e-160	557.00
IUUC-Ptr-091467	Pan troglodytes	95.91	3.00e-160	557.00
IUUC-Psi-093492	Pelodiscus sinensis	82.65	3.00e-149	520.00
IUUC-Pab-098045	Pongo abelii	90.14	5.00e-139	487.00
IUUC-Pca-100551	Procavia capensis	95.91	6.00e-161	560.00
IUUC-Pva-102686	Pteropus vampyrus	96.49	3.00e-161	561.00
IUUC-Rno-105679	Rattus norvegicus	99.42	2.00e-165	574.00
IUUC-Sha-107443	Sarcophilus harrisii	73.04	2.00e-132	465.00
IUUC-Ssc-115591	Sus scrofa	77.68	5.00e-136	476.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence