iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053983

UUCD1 version

UUC-LoA-00674

Ensembl Protein ID

ENSLAFP00000017136.2

UniProt Accession

G3TP62; G3TP62_LOXAF

Protein Name

Uncharacterized protein

Gene Name

CBLC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000022051.2	ENSLAFT00000021368.2	ENSLAFP00000017136.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.20e-06	26.8	352	391

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+ +  Cl +w     + s +++CP Cr
   Q: 352  CKICAENDKD-VKIEPCGHLLCSRCLAAW-----QHSDSQTCPFCR 391
           99********.******************.....6889999****8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAAAAPAPWG RQSGDARALG RVVKLLERLE AHCGDPRLAS SPPSLRDLLP RTAQLLRKVT 60
LARRAEGGRC LEVPGGAWDF LAIYLANLEA KGRQVAMLLP PRGRTEANDE LFREGSRLRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCGG CGGCGCCGGC CCCTTGGGGG CGGCAGTCGG GGGACGCCCG CGCACTCGGC 60
CGGGTGGTGA AGCTGTTGGA GCGCCTGGAA GCGCATTGCG GGGACCCCCG GCTCGCCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	77.64	0.00e+00	706.00
IUUC-Bta-012705	Bos taurus	79.60	0.00e+00	721.00
IUUC-Cja-019179	Callithrix jacchus	79.03	0.00e+00	680.00
IUUC-Cfa-020593	Canis familiaris	76.91	0.00e+00	683.00
IUUC-Cpo-021289	Cavia porcellus	73.32	2.00e-172	598.00
IUUC-Csa-023966	Chlorocebus sabaeus	74.05	0.00e+00	657.00
IUUC-Dor-030246	Dipodomys ordii	75.41	5.00e-126	444.00
IUUC-Eca-033921	Equus caballus	74.33	3.00e-158	551.00
IUUC-Fca-035747	Felis catus	65.29	2.00e-173	602.00
IUUC-Ggo-044622	Gorilla gorilla	83.02	3.00e-159	554.00
IUUC-Hsa-045735	Homo sapiens	80.18	0.00e+00	691.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	80.09	0.00e+00	651.00
IUUC-Mmr-061310	Microcebus murinus	76.75	0.00e+00	668.00
IUUC-Mmu-064155	Mus musculus	71.06	0.00e+00	673.00
IUUC-Mpu-066655	Mustela putorius furo	74.28	0.00e+00	687.00
IUUC-Mlu-067929	Myotis lucifugus	83.39	3.00e-155	540.00
IUUC-Nle-070065	Nomascus leucogenys	68.43	2.00e-159	555.00
IUUC-Ocu-074049	Oryctolagus cuniculus	69.61	8.00e-134	469.00
IUUC-Oga-087952	Otolemur garnettii	79.00	0.00e+00	700.00
IUUC-Oar-089382	Ovis aries	78.40	0.00e+00	690.00
IUUC-Pan-092075	Papio anubis	78.11	0.00e+00	647.00
IUUC-Pab-098100	Pongo abelii	71.20	3.00e-171	594.00
IUUC-Pca-100830	Procavia capensis	88.08	1.00e-125	443.00
IUUC-Pva-102714	Pteropus vampyrus	76.13	3.00e-164	571.00
IUUC-Rno-105348	Rattus norvegicus	70.66	0.00e+00	662.00
IUUC-Ssc-116424	Sus scrofa	77.14	0.00e+00	737.00
IUUC-Ttr-128807	Tursiops truncatus	86.59	5.00e-139	486.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence