iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034205

UUCD1 version

UUC-EqC-00167

Ensembl Protein ID

ENSECAP00000022773.1

UniProt Accession

F6SEB6; F6SEB6_HORSE

Protein Name

Uncharacterized protein

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000001249.2	ENSECAT00000001789.1	ENSECAP00000001322.1
ENSECAG00000001249.2	ENSECAT00000028931.1	ENSECAP00000022773.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	83.80	7.00e-67	250.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Protein Sequence
(Fasta)

TGGEANLLLS AEPAAPFLIR DSSDQRHFFT LSVKNQSGTK NLRIQCERGQ VSRCRATPRS 60
TQPVPRFDCV LKLVHHYMPP PGAPSLPSPP TEPSSSPSSE VPDQPPAQPL PGNPPRRAYY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCGGCGGC GAGGCGAAAC CTGCTGCTCA GCGCTGAGCC GGCCCGGCAC CTTTCCTCAT 60
CCGCGACAGC TCCGGACCAG CGCCACTTTC TTCACGCTCA GCGTCAAGAA CCAGTCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	84.92	4.00e-68	250.00
IUUC-Apl-003607	Anas platyrhynchos	70.95	3.00e-59	220.00
IUUC-Aca-005063	Anolis carolinensis	70.56	3.00e-66	244.00
IUUC-Ame-010859	Astyanax mexicanus	50.28	3.00e-44	171.00
IUUC-Bta-012817	Bos taurus	89.39	8.00e-75	273.00
IUUC-Bra-017963	Brassica rapa	28.17	8.90e-02	31.60
IUUC-Cja-019605	Callithrix jacchus	82.12	2.00e-73	268.00
IUUC-Cfa-021231	Canis familiaris	85.47	4.00e-68	250.00
IUUC-Cpo-022003	Cavia porcellus	82.68	4.00e-68	250.00
IUUC-Csa-023511	Chlorocebus sabaeus	83.24	6.00e-72	263.00
IUUC-Dre-028536	Danio rerio	52.51	1.00e-47	182.00
IUUC-Dno-029003	Dasypus novemcinctus	79.33	7.00e-70	256.00
IUUC-Fca-036317	Felis catus	83.24	4.00e-71	260.00
IUUC-Gmo-038777	Gadus morhua	55.84	3.00e-18	83.60
IUUC-Gga-041258	Gallus gallus	71.67	2.00e-58	218.00
IUUC-Gac-041837	Gasterosteus aculeatus	50.84	3.00e-44	171.00
IUUC-Ggo-045620	Gorilla gorilla	83.24	6.00e-72	263.00
IUUC-Hsa-046909	Homo sapiens	83.24	6.00e-72	263.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	87.50	3.00e-73	268.00
IUUC-Lch-049510	Latimeria chalumnae	60.89	2.00e-56	211.00
IUUC-Loc-052863	Lepisosteus oculatus	56.42	3.00e-50	191.00
IUUC-Laf-054136	Loxodonta africana	83.80	1.00e-69	256.00
IUUC-Mcc-055383	Macaca mulatta	83.24	6.00e-72	263.00
IUUC-Meu-056153	Macropus eugenii	80.45	4.00e-72	263.00
IUUC-Mmr-061185	Microcebus murinus	83.80	3.00e-68	251.00
IUUC-Mdo-061819	Monodelphis domestica	81.56	3.00e-74	270.00
IUUC-Mmu-064231	Mus musculus	82.12	1.00e-74	272.00
IUUC-Mpu-066691	Mustela putorius furo	85.47	4.00e-68	250.00
IUUC-Mlu-067673	Myotis lucifugus	82.68	1.00e-75	275.00
IUUC-Ont-072406	Oreochromis niloticus	48.60	5.00e-41	160.00
IUUC-Oan-073249	Ornithorhynchus anatinus	68.72	2.00e-60	224.00
IUUC-Ocu-074935	Oryctolagus cuniculus	86.96	3.00e-31	125.00
IUUC-Ola-087373	Oryzias latipes	40.88	4.00e-31	127.00
IUUC-Oga-088041	Otolemur garnettii	83.24	1.00e-69	255.00
IUUC-Oar-089646	Ovis aries	87.15	2.00e-66	245.00
IUUC-Ptr-091502	Pan troglodytes	83.24	6.00e-72	263.00
IUUC-Pan-091934	Papio anubis	83.24	6.00e-72	263.00
IUUC-Pfo-096412	Poecilia formosa	36.87	2.00e-28	118.00
IUUC-Pab-098554	Pongo abelii	83.24	6.00e-72	263.00
IUUC-Rno-105874	Rattus norvegicus	81.56	6.00e-75	273.00
IUUC-Sha-107151	Sarcophilus harrisii	80.45	3.00e-72	264.00
IUUC-Ssc-115722	Sus scrofa	77.97	6.00e-59	219.00
IUUC-Tgu-117151	Taeniopygia guttata	70.39	8.00e-58	216.00
IUUC-Tru-118428	Takifugu rubripes	48.60	3.00e-42	164.00
IUUC-Tni-120590	Tetraodon nigroviridis	49.16	4.00e-42	164.00
IUUC-Ttr-129065	Tursiops truncatus	89.94	5.00e-73	266.00
IUUC-Xtr-132167	Xenopus tropicalis	55.87	5.00e-51	193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence