iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19690564; 24068945

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00051	22.2	40	86

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e+++++  p++l C+H+f+a Cl+ + +  +    +++CPlCr
   Q: 40   CLVCREPYSCPrlPKLLACQHAFCAICLKLL-LCVQDNTWSITCPLCR 86
           ********9955566788*********9666.55566666779****8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MACTKTLQQS QPISAGATTT TTAVAPAGGH SGSTECDLEC LVCREPYSCP RLPKLLACQH 60
AFCAICLKLL LCVQDNTWSI TCPLCRKVTA VPGGLICSLR DHEAVVGQLA QPCTEVSLCP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAAACAAG CTGGGCAGCT CTGGGAGAGA GGAGTGTCAG ACAGCTGTTG TCAACAGGCA 60
CCTGGCCAGA GTGAAAAGGA GGGGCAGATT CCATCCAAGT CCCAGCGGCG CCAGCTGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0008270--F:zinc ion binding

KEGG

hsa:54546

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002022	Ailuropoda melanoleuca	72.40	1.00e-77	282.00
IUUC-Apl-003822	Anas platyrhynchos	53.26	1.00e-22	97.40
IUUC-Bta-012953	Bos taurus	68.42	5.00e-53	200.00
IUUC-Cja-019713	Callithrix jacchus	91.63	3.00e-97	347.00
IUUC-Cfa-020891	Canis familiaris	76.00	5.00e-72	263.00
IUUC-Cpo-022031	Cavia porcellus	69.60	7.00e-64	236.00
IUUC-Csa-024044	Chlorocebus sabaeus	93.39	2.00e-96	344.00
IUUC-Dno-029757	Dasypus novemcinctus	70.27	4.00e-69	254.00
IUUC-Dor-030831	Dipodomys ordii	68.83	3.00e-71	261.00
IUUC-Ete-032426	Echinops telfairi	67.10	6.00e-70	256.00
IUUC-Eca-033973	Equus caballus	71.37	3.00e-69	254.00
IUUC-Fca-035690	Felis catus	72.45	7.00e-65	239.00
IUUC-Fal-037610	Ficedula albicollis	42.57	4.00e-22	97.40
IUUC-Itr-047972	Ictidomys tridecemlineatus	72.05	1.00e-65	242.00
IUUC-Loc-051982	Lepisosteus oculatus	43.33	1.00e-08	52.40
IUUC-Laf-054344	Loxodonta africana	71.55	6.00e-69	253.00
IUUC-Mga-059867	Meleagris gallopavo	46.20	4.00e-33	134.00
IUUC-Mdo-062127	Monodelphis domestica	58.79	1.00e-45	176.00
IUUC-Mmu-063214	Mus musculus	66.52	7.00e-65	240.00
IUUC-Mlu-066998	Myotis lucifugus	77.49	2.00e-70	258.00
IUUC-Opr-070757	Ochotona princeps	61.40	4.00e-45	174.00
IUUC-Ocu-074277	Oryctolagus cuniculus	69.74	8.00e-52	196.00
IUUC-Oga-089126	Otolemur garnettii	76.65	6.00e-76	276.00
IUUC-Oar-089211	Ovis aries	46.89	5.00e-32	130.00
IUUC-Ptr-091515	Pan troglodytes	98.68	4.00e-105	373.00
IUUC-Pan-092084	Papio anubis	94.71	4.00e-98	350.00
IUUC-Psi-093947	Pelodiscus sinensis	45.08	3.00e-33	135.00
IUUC-Pab-098119	Pongo abelii	97.80	6.00e-103	366.00
IUUC-Pva-102959	Pteropus vampyrus	69.13	4.00e-58	217.00
IUUC-Rno-105143	Rattus norvegicus	72.64	6.00e-64	237.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence