iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021967

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02052339

Gene Name

KDM2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000011011.3	ENSCPOT00000011112.2	ENSCPOP00000009897.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.00e-14	54.4	631	696
E3 adaptor/Cullin RING/SCF/F-box	8.10e-06	25.9	987	1075

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk++     v++elpn+  w+CpkC+++
   Q: 631  AVCLVCGEAGKEDtveeeEgkfnlMLMECSICNEIIHPGCLKIKesegvVNDELPNC--WECPKCNHA 696
           79*********9977765156789*********************************..*******85 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 56   rrtprqpprgpsaaakpkaglrseaaaapap.apaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqka 141
           r  pr   r p a++ pk+         p p +p p   p    d g  + +  e+++ ++++l++++l+ + rvcr+w++ + +k+
   Q: 987  RSPPRVLSRPPPATSPPKCIQMERHVIRPPPiSPPPDSLP---LDDGAAHVMHREVWMAVFSYLSHRDLCVCMRVCRTWNRWCCDKR 1070
           4456777788888888887655555555555133344444...36677888899**************************5555599 PP
   S: 142  lwktv 146
           lw ++
   Q: 1071 LWTRI 1075
           99876 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MEAEKDSGRR LRPIDRQRYD ENEDLSDVEE IVSVRGFSLE EKLRSQLYQG DFVHAMEGKD 60
FNYEYVQREA LRVPLVFREK DGLGIKMPDP DFTVRDVKLL VGSRRLVDVM DVNTQKGTEM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCAG AGAAAGACTC TGGAAGAAGA TTGGTGTGTA GCTTTTTTTT TTTTTTTTTT 60
CCCAAATCTG TATCTGGTAT ACGATAGATC TATTTTTTTT GGTTGTTTCT TGCTGCCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	92.78	0.00e+00	2225.00
IUUC-Apl-003787	Anas platyrhynchos	81.93	0.00e+00	1902.00
IUUC-Aca-004247	Anolis carolinensis	78.20	0.00e+00	1802.00
IUUC-Ame-011463	Astyanax mexicanus	75.21	9.00e-173	601.00
IUUC-Bta-013531	Bos taurus	94.35	0.00e+00	2271.00
IUUC-Cel-018303	Caenorhabditis elegans	44.86	8.00e-83	302.00
IUUC-Cja-018876	Callithrix jacchus	89.49	0.00e+00	2055.00
IUUC-Cfa-020857	Canis familiaris	93.59	0.00e+00	2253.00
IUUC-Csa-023210	Chlorocebus sabaeus	93.43	0.00e+00	2165.00
IUUC-Dre-028272	Danio rerio	65.11	0.00e+00	1006.00
IUUC-Dno-030034	Dasypus novemcinctus	90.54	0.00e+00	2144.00
IUUC-Dor-030736	Dipodomys ordii	82.30	0.00e+00	952.00
IUUC-Eca-034255	Equus caballus	94.71	0.00e+00	2148.00
IUUC-Eeu-035038	Erinaceus europaeus	92.83	0.00e+00	1133.00
IUUC-Fca-035786	Felis catus	93.23	0.00e+00	2200.00
IUUC-Fal-037589	Ficedula albicollis	81.71	0.00e+00	2018.00
IUUC-Gga-041103	Gallus gallus	83.73	0.00e+00	1105.00
IUUC-Gac-041304	Gasterosteus aculeatus	62.66	0.00e+00	1526.00
IUUC-Ggo-044522	Gorilla gorilla	91.82	0.00e+00	1620.00
IUUC-Hsa-045877	Homo sapiens	93.29	0.00e+00	2174.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	92.91	0.00e+00	1271.00
IUUC-Lch-049950	Latimeria chalumnae	76.32	0.00e+00	1867.00
IUUC-Loc-051972	Lepisosteus oculatus	76.88	0.00e+00	1080.00
IUUC-Laf-053623	Loxodonta africana	91.81	0.00e+00	2154.00
IUUC-Mcc-054943	Macaca mulatta	93.67	0.00e+00	2166.00
IUUC-Meu-056259	Macropus eugenii	83.71	0.00e+00	1988.00
IUUC-Mga-059671	Meleagris gallopavo	83.13	0.00e+00	1960.00
IUUC-Mmr-061003	Microcebus murinus	92.74	0.00e+00	2228.00
IUUC-Mmu-063584	Mus musculus	91.91	0.00e+00	2200.00
IUUC-Mpu-066056	Mustela putorius furo	92.98	0.00e+00	2224.00
IUUC-Mlu-067850	Myotis lucifugus	93.51	0.00e+00	2220.00
IUUC-Nle-069837	Nomascus leucogenys	90.39	0.00e+00	1935.00
IUUC-Opr-070943	Ochotona princeps	89.17	0.00e+00	2081.00
IUUC-Ont-071663	Oreochromis niloticus	66.08	0.00e+00	1583.00
IUUC-Oan-072934	Ornithorhynchus anatinus	72.94	0.00e+00	1233.00
IUUC-Ocu-074706	Oryctolagus cuniculus	93.68	0.00e+00	2229.00
IUUC-Ola-086543	Oryzias latipes	64.52	0.00e+00	1570.00
IUUC-Oga-088671	Otolemur garnettii	82.87	0.00e+00	983.00
IUUC-Oar-089560	Ovis aries	89.76	0.00e+00	2174.00
IUUC-Ptr-090875	Pan troglodytes	93.29	0.00e+00	2188.00
IUUC-Pan-091788	Papio anubis	90.76	0.00e+00	2117.00
IUUC-Psi-093382	Pelodiscus sinensis	81.65	0.00e+00	1988.00
IUUC-Pfo-096272	Poecilia formosa	67.22	0.00e+00	1012.00
IUUC-Pab-097907	Pongo abelii	88.97	0.00e+00	2026.00
IUUC-Pca-100628	Procavia capensis	83.09	0.00e+00	1818.00
IUUC-Pva-102956	Pteropus vampyrus	92.26	0.00e+00	1121.00
IUUC-Rno-105722	Rattus norvegicus	91.76	0.00e+00	1754.00
IUUC-Sha-106626	Sarcophilus harrisii	79.54	0.00e+00	1760.00
IUUC-Ssc-115918	Sus scrofa	91.83	0.00e+00	1686.00
IUUC-Tru-118638	Takifugu rubripes	69.18	0.00e+00	981.00
IUUC-Tsy-118820	Tarsius syrichta	89.00	0.00e+00	723.00
IUUC-Tbe-127654	Tupaia belangeri	84.92	0.00e+00	1204.00
IUUC-Ttr-128821	Tursiops truncatus	86.02	0.00e+00	2002.00
IUUC-Xtr-131823	Xenopus tropicalis	73.67	0.00e+00	1715.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence