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Tag Content
UUCD2 ID IUUC-Pab-097716
UUCD1 version UUC-PoA-00344
Ensembl Protein ID ENSPPYP00000009197.2
UniProt Accession H2NTC8; H2NTC8_PONAB
Genbank Protein ID ENSPPYP00000009197
Protein Name Notchless protein homolog 1
Genbank Nucleotide ID ABGA01101156
Gene Name NLE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000008180.2 ENSPPYT00000009567.1 ENSPPYP00000009196.1
ENSPPYG00000008180.2 ENSPPYT00000009568.2 ENSPPYP00000009197.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.40e-58 190.7 197 240
UBD/Beta-Prp 6.50e-71 239.0 106 299
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg++++WD++ g++++
   Q: 197  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRIWDTTAGRCER 240
           8***************9889**********************86 PP
   

   UBD/Beta-Prp
   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcle 130
           + +sl+gh+++v +v fsp+gk+l  + +D+t  +   dls  ++ +++ gh + vls+s+sp+g+kl+sG +   i +wd +tg+ + 
   Q: 106  CTSSLEGHSEAVISVAFSPTGKLL--ARRDGTTALQpgDLSLISPSSAFLGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVG 192
           6789*****************855..68*******999*************************************************** PP
   S: 131  etlsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec 214
            tl+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv+ l +  +g  l s+s+d+t+k+w  + g  
   Q: 193  RTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTG-HTQSVTYLRWGGDG-LLYSASQDRTIKVWRAHDGVL 279
           ************9873332257889**************************9.************98.********************* PP
   S: 215  vrtlnghtdnvksvrfspnde 235
            rtl+gh  +v+ +++s  d 
   Q: 280  CRTLQGHGHWVNTMALS-TDY 299
           ***************99.333 PP
   
Organism Pongo abelii
Protein Sequence
(Fasta)
MAAAVADEAV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL 60
AFFVHDAEII SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-097716|E3,WD_repeat;UBD,Beta-Prp|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCGGCGG CAGTGGCGGT GGGTGTGCGT GGATGGGGGC GGGGGGCGTC GCCGCGGGGC 60
GCTAGGGCCC GGGTCCCTGA GGCCTGAGAG AGGCGAAGTG GGGCCCTTCT GGGCGGGCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-097716|E3,WD_repeat;UBD,Beta-Prp|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000437 Aegilops tauschii 55.36 3.00e-157 547.00
IUUC-Aml-001793 Ailuropoda melanoleuca 93.23 0.00e+00 896.00
IUUC-Atr-002507 Amborella trichopoda 56.08 3.00e-156 545.00
IUUC-Apl-003964 Anas platyrhynchos 81.06 0.00e+00 773.00
IUUC-Aly-006396 Arabidopsis lyrata 51.49 3.00e-149 521.00
IUUC-Ath-007278 Arabidopsis thaliana 51.70 2.00e-149 521.00
IUUC-Ago-007951 Ashbya gossypii 46.31 1.00e-120 426.00
IUUC-Acl-008298 Aspergillus clavatus 46.04 2.00e-114 405.00
IUUC-Afl-008581 Aspergillus flavus 51.59 3.00e-100 358.00
IUUC-Afu-008906 Aspergillus fumigatus 44.91 1.00e-113 403.00
IUUC-Ani-009189 Aspergillus nidulans 43.61 1.00e-109 390.00
IUUC-Ang-009630 Aspergillus niger 47.51 4.00e-113 401.00
IUUC-Aor-010038 Aspergillus oryzae 45.32 1.00e-117 416.00
IUUC-Ate-010278 Aspergillus terreus 44.60 3.00e-113 402.00
IUUC-Ame-011890 Astyanax mexicanus 77.17 0.00e+00 780.00
IUUC-Bgr-012011 Blumeria graminis 45.66 2.00e-121 429.00
IUUC-Bta-012964 Bos taurus 91.98 0.00e+00 893.00
IUUC-Bci-013592 Botrytis cinerea 43.32 7.00e-113 400.00
IUUC-Bdi-015035 Brachypodium distachyon 55.25 4.00e-158 550.00
IUUC-Bol-015501 Brassica oleracea 52.56 2.00e-149 522.00
IUUC-Bra-017642 Brassica rapa 52.35 9.00e-149 520.00
IUUC-Cel-018430 Caenorhabditis elegans 56.53 5.00e-160 557.00
IUUC-Cja-019125 Callithrix jacchus 94.09 0.00e+00 906.00
IUUC-Cfa-021013 Canis familiaris 91.45 0.00e+00 807.00
IUUC-Cpo-021743 Cavia porcellus 91.33 0.00e+00 888.00
IUUC-Cre-022973 Chlamydomonas reinhardtii 43.95 5.00e-108 384.00
IUUC-Csa-024270 Chlorocebus sabaeus 94.94 0.00e+00 912.00
IUUC-Cin-025795 Ciona intestinalis 62.05 0.00e+00 635.00
IUUC-Csv-025953 Ciona savignyi 63.11 0.00e+00 634.00
IUUC-Cgl-026517 Colletotrichum gloeosporioides 48.01 3.00e-99 355.00
IUUC-Cne-026901 Cryptococcus neoformans 46.52 1.00e-127 449.00
IUUC-Cme-027281 Cyanidioschyzon merolae 45.68 3.00e-107 382.00
IUUC-Dre-028515 Danio rerio 74.42 0.00e+00 762.00
IUUC-Dno-029596 Dasypus novemcinctus 92.60 0.00e+00 894.00
IUUC-Dor-030494 Dipodomys ordii 92.37 0.00e+00 886.00
IUUC-Dse-031538 Dothistroma septosporum 46.17 9.00e-121 427.00
IUUC-Dme-031974 Drosophila melanogaster 56.33 3.00e-156 544.00
IUUC-Ete-032948 Echinops telfairi 96.17 5.00e-117 414.00
IUUC-Eca-033399 Equus caballus 93.84 0.00e+00 899.00
IUUC-Eeu-035013 Erinaceus europaeus 93.78 2.00e-115 409.00
IUUC-Fca-035860 Felis catus 92.62 0.00e+00 893.00
IUUC-Fal-037069 Ficedula albicollis 87.20 1.00e-131 461.00
IUUC-Fox-038059 Fusarium oxysporum 44.26 2.00e-115 409.00
IUUC-Fso-038445 Fusarium solani 45.44 2.00e-116 412.00
IUUC-Gmo-039319 Gadus morhua 71.91 0.00e+00 692.00
IUUC-Ggr-040095 Gaeumannomyces graminis 44.58 1.00e-112 400.00
IUUC-Gga-040303 Gallus gallus 85.20 6.00e-130 456.00
IUUC-Gac-042267 Gasterosteus aculeatus 74.89 0.00e+00 724.00
IUUC-Gma-043974 Glycine max 55.11 1.00e-159 556.00
IUUC-Ggo-044637 Gorilla gorilla 95.12 0.00e+00 907.00
IUUC-Hsa-046128 Homo sapiens 95.36 0.00e+00 917.00
IUUC-Hvu-047373 Hordeum vulgare 54.82 2.00e-156 545.00
IUUC-Itr-048070 Ictidomys tridecemlineatus 92.68 0.00e+00 896.00
IUUC-Kpa-049274 Komagataella pastoris 42.04 3.00e-117 415.00
IUUC-Lch-049907 Latimeria chalumnae 80.25 0.00e+00 811.00
IUUC-Lpe-050778 Leersia perrieri 50.52 2.00e-139 488.00
IUUC-Loc-051889 Lepisosteus oculatus 77.17 0.00e+00 783.00
IUUC-Lma-053041 Leptosphaeria maculans 47.07 2.00e-108 386.00
IUUC-Laf-053598 Loxodonta africana 92.83 0.00e+00 900.00
IUUC-Mcc-055660 Macaca mulatta 94.51 0.00e+00 907.00
IUUC-Meu-056197 Macropus eugenii 77.19 0.00e+00 736.00
IUUC-Mor-056949 Magnaporthe oryzae 43.42 1.00e-109 389.00
IUUC-Mpo-057571 Magnaporthe poae 44.41 9.00e-63 234.00
IUUC-Mtr-058530 Medicago truncatula 55.32 4.00e-155 540.00
IUUC-Mla-059133 Melampsora laricipopulina 45.12 6.00e-118 417.00
IUUC-Mga-059252 Meleagris gallopavo 80.00 5.00e-179 619.00
IUUC-Mvi-060522 Microbotryum violaceum 47.67 2.00e-127 449.00
IUUC-Mmr-061117 Microcebus murinus 92.21 0.00e+00 887.00
IUUC-Mdo-062892 Monodelphis domestica 86.05 0.00e+00 846.00
IUUC-Mmu-064108 Mus musculus 91.75 0.00e+00 863.00
IUUC-Mac-064430 Musa acuminata 56.75 2.00e-161 562.00
IUUC-Mpu-065882 Mustela putorius furo 92.60 0.00e+00 888.00
IUUC-Mlu-068123 Myotis lucifugus 92.62 0.00e+00 902.00
IUUC-Nfi-068484 Neosartorya fischeri 45.30 1.00e-113 403.00
IUUC-Ncr-068649 Neurospora crassa 41.79 6.00e-107 381.00
IUUC-Nle-069140 Nomascus leucogenys 95.12 0.00e+00 906.00
IUUC-Opr-070220 Ochotona princeps 84.71 0.00e+00 770.00
IUUC-Ont-072643 Oreochromis niloticus 77.05 0.00e+00 781.00
IUUC-Ocu-074007 Oryctolagus cuniculus 92.18 0.00e+00 863.00
IUUC-Oba-075904 Oryza barthii 55.67 2.00e-159 555.00
IUUC-Obr-076280 Oryza brachyantha 55.25 2.00e-158 552.00
IUUC-Ogl-077425 Oryza glaberrima 55.67 2.00e-159 555.00
IUUC-Ogu-078586 Oryza glumaepatula 55.67 3.00e-159 555.00
IUUC-Oin-079489 Oryza indica 53.53 2.00e-150 525.00
IUUC-Olo-080766 Oryza longistaminata 55.56 4.00e-159 554.00
IUUC-Ome-081905 Oryza meridionalis 55.67 2.00e-159 555.00
IUUC-Oni-083022 Oryza nivara 55.67 1.00e-159 556.00
IUUC-Opu-083615 Oryza punctata 55.67 2.00e-159 555.00
IUUC-Oru-085076 Oryza rufipogon 55.67 1.00e-159 556.00
IUUC-Osa-085744 Oryza sativa 55.89 4.00e-160 557.00
IUUC-Ola-087290 Oryzias latipes 74.74 0.00e+00 764.00
IUUC-Olu-087898 Ostreococcus lucimarinus 51.05 1.00e-135 476.00
IUUC-Oga-088980 Otolemur garnettii 92.14 0.00e+00 885.00
IUUC-Oar-089580 Ovis aries 91.46 0.00e+00 769.00
IUUC-Ptr-090845 Pan troglodytes 95.54 0.00e+00 911.00
IUUC-Pan-092836 Papio anubis 94.30 0.00e+00 908.00
IUUC-Psi-093965 Pelodiscus sinensis 81.58 6.00e-56 208.00
IUUC-Pno-095052 Phaeosphaeria nodorum 44.56 7.00e-113 400.00
IUUC-Ppa-095432 Physcomitrella patens 55.22 2.00e-157 548.00
IUUC-Pfo-096963 Poecilia formosa 68.63 0.00e+00 665.00
IUUC-Pop-099224 Populus trichocarpa 56.17 5.00e-161 560.00
IUUC-Pca-100682 Procavia capensis 87.85 0.00e+00 632.00
IUUC-Ppe-101819 Prunus persica 56.29 1.00e-159 556.00
IUUC-Pva-102338 Pteropus vampyrus 91.62 0.00e+00 672.00
IUUC-Pgr-103583 Puccinia graminis 52.31 9.00e-123 433.00
IUUC-Ptt-103737 Puccinia triticina 42.26 1.00e-90 327.00
IUUC-Pte-104150 Pyrenophora teres 47.38 2.00e-112 399.00
IUUC-Pyt-104606 Pyrenophora triticirepentis 47.38 2.00e-112 399.00
IUUC-Rno-105987 Rattus norvegicus 91.53 0.00e+00 885.00
IUUC-Sce-106315 Saccharomyces cerevisiae 45.21 2.00e-120 425.00
IUUC-Sha-107273 Sarcophilus harrisii 87.32 0.00e+00 861.00
IUUC-Sja-107677 Schizosaccharomyces japonicus 44.65 1.00e-109 390.00
IUUC-Spo-108092 Schizosaccharomyces pombe 46.68 6.00e-115 407.00
IUUC-Ssl-108442 Sclerotinia sclerotiorum 42.15 2.00e-107 382.00
IUUC-Smo-108855 Selaginella moellendorffii 53.39 5.00e-153 534.00
IUUC-Sit-110329 Setaria italica 56.10 2.00e-159 555.00
IUUC-Sly-111830 Solanum lycopersicum 56.96 3.00e-163 568.00
IUUC-Stu-112603 Solanum tuberosum 56.96 3.00e-163 567.00
IUUC-Sar-113504 Sorex araneus 81.75 7.00e-60 224.00
IUUC-Sbi-114560 Sorghum bicolor 55.46 6.00e-157 547.00
IUUC-Sre-115133 Sporisorium reilianum 40.10 6.00e-116 411.00
IUUC-Ssc-115903 Sus scrofa 93.04 0.00e+00 895.00
IUUC-Tgu-116798 Taeniopygia guttata 81.61 0.00e+00 814.00
IUUC-Tru-118361 Takifugu rubripes 74.95 0.00e+00 767.00
IUUC-Tsy-118849 Tarsius syrichta 93.19 0.00e+00 892.00
IUUC-Tni-120094 Tetraodon nigroviridis 75.53 0.00e+00 766.00
IUUC-Tca-121634 Theobroma cacao 55.53 2.00e-157 548.00
IUUC-Tre-122051 Trichoderma reesei 43.54 5.00e-110 391.00
IUUC-Tvi-122322 Trichoderma virens 45.00 1.00e-113 403.00
IUUC-Tae-123133 Triticum aestivum 55.25 1.00e-157 549.00
IUUC-Tur-126766 Triticum urartu 49.33 5.00e-149 520.00
IUUC-Tme-127175 Tuber melanosporum 48.63 1.00e-121 430.00
IUUC-Tbe-127779 Tupaia belangeri 91.10 0.00e+00 785.00
IUUC-Ttr-128224 Tursiops truncatus 87.85 0.00e+00 763.00
IUUC-Uma-129537 Ustilago maydis 39.97 9.00e-116 410.00
IUUC-Vda-129927 Verticillium dahliae 43.10 3.00e-102 365.00
IUUC-Vpa-130658 Vicugna pacos 80.47 0.00e+00 748.00
IUUC-Vvi-131659 Vitis vinifera 56.08 7.00e-161 560.00
IUUC-Xtr-132918 Xenopus tropicalis 76.84 0.00e+00 777.00
IUUC-Xma-133700 Xiphophorus maculatus 76.84 0.00e+00 776.00
IUUC-Yli-134478 Yarrowia lipolytica 47.85 2.00e-129 456.00
IUUC-Zma-135835 Zea mays 53.14 5.00e-154 537.00
Created Date 25-Jun-2017

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