iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	86.63	0.00e+00	860.00	IUUC-Hsa-046952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAAASVTSPG SLELLQPGFS KTLLGTRLEA KYLCSACRNI LRRPFQAQCG HRYCSFCLTS 60
ILSSGPQNCA ACVHEGLYEE GISILESSSA FPDNAARREV ESLPAVCPND GCTWKGTLKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGAAGACC GTTGGGTGAG GCGGCGCGGA TCTAAGAGGG GGTCGATTCT CAGCGGCGGC 60
CGGGCCCGGG TCAGGCACCG GGTGGGAGTG GCGATTGGGG TTAGATGCGG GGCCGCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-0675--Receptor
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0043234--C:protein complex
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0005102--F:receptor binding
GO:0046625--F:sphingolipid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0006461--P:protein complex assembly
GO:0051291--P:protein heterooligomerization
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

KEGG

rno:311786

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002344	Ailuropoda melanoleuca	79.32	0.00e+00	857.00
IUUC-Apl-004202	Anas platyrhynchos	70.36	0.00e+00	786.00
IUUC-Aca-005029	Anolis carolinensis	55.06	1.00e-138	486.00
IUUC-Ame-011841	Astyanax mexicanus	53.40	6.00e-180	624.00
IUUC-Bta-013180	Bos taurus	80.66	0.00e+00	846.00
IUUC-Cja-019813	Callithrix jacchus	86.23	0.00e+00	901.00
IUUC-Cfa-021205	Canis familiaris	84.63	0.00e+00	864.00
IUUC-Cpo-021346	Cavia porcellus	87.03	0.00e+00	893.00
IUUC-Csa-023809	Chlorocebus sabaeus	85.20	0.00e+00	786.00
IUUC-Dre-027669	Danio rerio	56.55	8.00e-172	596.00
IUUC-Dno-029458	Dasypus novemcinctus	78.10	0.00e+00	842.00
IUUC-Dor-030338	Dipodomys ordii	85.60	0.00e+00	835.00
IUUC-Eca-034401	Equus caballus	84.68	0.00e+00	892.00
IUUC-Eeu-034668	Erinaceus europaeus	90.79	9.00e-82	297.00
IUUC-Fca-036057	Felis catus	81.45	0.00e+00	881.00
IUUC-Fal-037560	Ficedula albicollis	69.63	0.00e+00	711.00
IUUC-Gmo-038964	Gadus morhua	60.64	0.00e+00	641.00
IUUC-Gga-040425	Gallus gallus	70.97	0.00e+00	784.00
IUUC-Gac-041908	Gasterosteus aculeatus	61.98	0.00e+00	652.00
IUUC-Gma-043859	Glycine max	33.05	8.00e-06	47.00
IUUC-Ggo-044606	Gorilla gorilla	79.44	0.00e+00	811.00
IUUC-Hsa-046952	Homo sapiens	86.63	0.00e+00	902.00
IUUC-Itr-049016	Ictidomys tridecemlineatus	76.45	0.00e+00	771.00
IUUC-Lch-049571	Latimeria chalumnae	56.65	0.00e+00	671.00
IUUC-Loc-051973	Lepisosteus oculatus	60.72	4.00e-177	614.00
IUUC-Laf-053815	Loxodonta africana	78.59	0.00e+00	806.00
IUUC-Mcc-054888	Macaca mulatta	86.63	0.00e+00	899.00
IUUC-Meu-056547	Macropus eugenii	81.82	1.00e-135	476.00
IUUC-Mga-059819	Meleagris gallopavo	71.83	0.00e+00	753.00
IUUC-Mdo-062570	Monodelphis domestica	77.49	0.00e+00	816.00
IUUC-Mmu-063133	Mus musculus	94.81	0.00e+00	937.00
IUUC-Mac-064547	Musa acuminata	33.67	8.00e-06	46.60
IUUC-Mpu-065802	Mustela putorius furo	80.66	0.00e+00	860.00
IUUC-Nle-070155	Nomascus leucogenys	87.03	0.00e+00	907.00
IUUC-Opr-070856	Ochotona princeps	78.95	5.00e-105	374.00
IUUC-Ont-071930	Oreochromis niloticus	61.93	0.00e+00	685.00
IUUC-Ola-087397	Oryzias latipes	58.10	0.00e+00	662.00
IUUC-Oga-088109	Otolemur garnettii	85.03	0.00e+00	897.00
IUUC-Oar-090310	Ovis aries	71.35	0.00e+00	748.00
IUUC-Ptr-090643	Pan troglodytes	86.83	0.00e+00	903.00
IUUC-Pan-091933	Papio anubis	86.83	0.00e+00	900.00
IUUC-Psi-093681	Pelodiscus sinensis	69.41	0.00e+00	753.00
IUUC-Pfo-096148	Poecilia formosa	58.10	0.00e+00	669.00
IUUC-Pab-098631	Pongo abelii	86.83	0.00e+00	905.00
IUUC-Pca-100582	Procavia capensis	63.18	7.00e-83	301.00
IUUC-Pva-102396	Pteropus vampyrus	70.80	0.00e+00	716.00
IUUC-Sha-106493	Sarcophilus harrisii	78.09	0.00e+00	845.00
IUUC-Sar-113570	Sorex araneus	92.27	4.00e-100	358.00
IUUC-Ssc-115843	Sus scrofa	80.77	0.00e+00	876.00
IUUC-Tgu-117144	Taeniopygia guttata	68.06	0.00e+00	686.00
IUUC-Tru-117853	Takifugu rubripes	59.24	0.00e+00	660.00
IUUC-Tni-120256	Tetraodon nigroviridis	63.27	0.00e+00	691.00
IUUC-Tbe-127943	Tupaia belangeri	64.53	5.00e-94	337.00
IUUC-Ttr-129246	Tursiops truncatus	84.33	0.00e+00	860.00
IUUC-Xtr-132279	Xenopus tropicalis	57.23	4.00e-163	567.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence