iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090819

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03123966

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013415.5	ENSPTRT00000044151.4	ENSPTRP00000042219.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.50e-136	453.1	563	895

Active Site

Position(s)	Description	Evidence
864	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 563  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 650
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee++l++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 651  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 736
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ y ++s++i wFw++++e+++e+r ++LqFv
   Q: 737  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFV 824
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 825  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 895
           *********************************************************************96 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT 60
NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCTAAC TCGCTCTAGT AGCTGTGGTC GGGGCTCGGG ACCGGCTGCC ATCTTAGTCT 60
AGGGACTGAG GAGTCGCCGC CGCCCCGAGT CCCGGTAAAC ACCCGTGGGC GAACTCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	92.00	0.00e+00	1566.00
IUUC-Apl-003752	Anas platyrhynchos	79.05	0.00e+00	1397.00
IUUC-Aca-005338	Anolis carolinensis	77.11	0.00e+00	1374.00
IUUC-Ame-010601	Astyanax mexicanus	86.88	0.00e+00	1088.00
IUUC-Bta-012782	Bos taurus	91.69	0.00e+00	1534.00
IUUC-Cja-018899	Callithrix jacchus	96.40	0.00e+00	1624.00
IUUC-Cfa-020648	Canis familiaris	90.80	0.00e+00	1531.00
IUUC-Cpo-022073	Cavia porcellus	92.68	0.00e+00	1592.00
IUUC-Csa-023252	Chlorocebus sabaeus	93.02	0.00e+00	1602.00
IUUC-Cho-024695	Choloepus hoffmanni	89.48	0.00e+00	1586.00
IUUC-Dre-028451	Danio rerio	71.76	0.00e+00	1250.00
IUUC-Dno-029884	Dasypus novemcinctus	91.80	0.00e+00	1616.00
IUUC-Eca-033793	Equus caballus	92.46	0.00e+00	1593.00
IUUC-Eeu-034716	Erinaceus europaeus	91.05	0.00e+00	847.00
IUUC-Fca-035605	Felis catus	91.78	0.00e+00	1593.00
IUUC-Fal-037126	Ficedula albicollis	79.07	0.00e+00	1394.00
IUUC-Gmo-038596	Gadus morhua	79.52	0.00e+00	976.00
IUUC-Gga-040832	Gallus gallus	79.80	0.00e+00	1410.00
IUUC-Gac-041658	Gasterosteus aculeatus	85.81	0.00e+00	1086.00
IUUC-Ggo-044535	Gorilla gorilla	90.80	0.00e+00	1577.00
IUUC-Hsa-046564	Homo sapiens	98.78	0.00e+00	1718.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	91.35	0.00e+00	1521.00
IUUC-Lch-050454	Latimeria chalumnae	72.86	0.00e+00	1335.00
IUUC-Loc-052647	Lepisosteus oculatus	74.70	0.00e+00	1349.00
IUUC-Laf-054383	Loxodonta africana	92.79	0.00e+00	1597.00
IUUC-Mcc-055532	Macaca mulatta	93.24	0.00e+00	1603.00
IUUC-Mga-059661	Meleagris gallopavo	79.59	0.00e+00	1401.00
IUUC-Mmr-061135	Microcebus murinus	92.68	0.00e+00	1618.00
IUUC-Mdo-062505	Monodelphis domestica	82.69	0.00e+00	1448.00
IUUC-Mmu-063375	Mus musculus	90.60	0.00e+00	1543.00
IUUC-Mpu-066203	Mustela putorius furo	92.34	0.00e+00	1571.00
IUUC-Mlu-067837	Myotis lucifugus	91.91	0.00e+00	1588.00
IUUC-Nle-069244	Nomascus leucogenys	92.48	0.00e+00	1583.00
IUUC-Opr-070585	Ochotona princeps	90.25	0.00e+00	1549.00
IUUC-Ont-071822	Oreochromis niloticus	72.39	0.00e+00	1299.00
IUUC-Oan-073679	Ornithorhynchus anatinus	66.10	0.00e+00	943.00
IUUC-Ocu-074298	Oryctolagus cuniculus	92.48	0.00e+00	1579.00
IUUC-Ola-086526	Oryzias latipes	84.74	0.00e+00	1088.00
IUUC-Oga-088167	Otolemur garnettii	86.52	0.00e+00	1476.00
IUUC-Oar-090316	Ovis aries	76.09	0.00e+00	1144.00
IUUC-Pan-092454	Papio anubis	93.24	0.00e+00	1603.00
IUUC-Psi-093319	Pelodiscus sinensis	78.08	0.00e+00	1389.00
IUUC-Pfo-096937	Poecilia formosa	88.18	0.00e+00	1098.00
IUUC-Pab-097580	Pongo abelii	90.92	0.00e+00	1535.00
IUUC-Pca-100923	Procavia capensis	74.83	0.00e+00	1308.00
IUUC-Pva-103209	Pteropus vampyrus	90.91	0.00e+00	1537.00
IUUC-Rno-104924	Rattus norvegicus	90.38	0.00e+00	1552.00
IUUC-Sha-107175	Sarcophilus harrisii	84.13	0.00e+00	1453.00
IUUC-Sar-113761	Sorex araneus	86.01	0.00e+00	1456.00
IUUC-Tgu-116632	Taeniopygia guttata	76.04	0.00e+00	1276.00
IUUC-Tru-118442	Takifugu rubripes	87.89	0.00e+00	1088.00
IUUC-Tsy-119198	Tarsius syrichta	85.92	0.00e+00	1476.00
IUUC-Tni-120168	Tetraodon nigroviridis	85.64	0.00e+00	1024.00
IUUC-Tbe-127756	Tupaia belangeri	77.41	0.00e+00	1278.00
IUUC-Ttr-128504	Tursiops truncatus	85.35	0.00e+00	1142.00
IUUC-Vpa-130103	Vicugna pacos	82.74	0.00e+00	1400.00
IUUC-Xtr-132885	Xenopus tropicalis	75.91	0.00e+00	1364.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence