iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089636

Ensembl Protein ID

ENSOARP00000022236.1

UniProt Accession

W5QHN6; W5QHN6_SHEEP

Genbank Protein ID

ENSOARP00000022236

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01009490

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020687.1	ENSOART00000022541.1	ENSOARP00000022236.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-57	194.8	280	804
UBD/Alpha-Helix/UBA	4.80e-18	64.9	674	711

Active Site

Position(s)	Description	Evidence
289	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
767	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 280  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 367
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 368  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 427
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 428  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaesnrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 513
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 514  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDVNHLRARglqpgeeelpdisppivipgdskdrlmtqlidpsdidess 601
           *********************997.*******************999889999999999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 602  vmqlaemgfpleacrkavyftgnmgaevafnwivvhmeepdfaepltmpgyggaasagasvfgatgldnqppeetvaiitsmgfhrnqa 690
           88888888888888888888887777777777777777777777777777777777777777777777777666666666666666666 PP
   S: 268  ...........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                      +     +                                           +  YeL+a ++H+G s+ sGHYv+++k+
   Q: 691  iqalratnsnlE-----RaldwifshpefeedsdfviemennananivseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK 774
           666665555550.....055555555555555555566666666677788888888888889*************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 775  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 804
           .9***********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ ++ +++MGF r++a+qaLra+n nle+A+++++++
   Q: 674  EETVAIITSMGFHRNQAIQALRATNSNLERALDWIFSH 711
           789999******************************97 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

NSEGGLYVCM NTFLAFGREH VERHFRKTGQ SVYMHLKRHV REKVRGASGG ALPKRRNSKI 60
FLDLDTDDDL NSDDYEYEDE AKLVIFPDHY EIALPNIEEL PALVTIACDA VLSSKSPYRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTCTGAAG GCGGACTCTA TGTATGCATG AATACATTTT TGGCCTTTGG AAGGGAACAC 60
GTGGAAAGAC ACTTTCGAAA AACTGGACAG AGTGTCTACA TGCACCTGAA GAGACACGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	97.77	0.00e+00	1501.00
IUUC-Apl-003712	Anas platyrhynchos	82.98	0.00e+00	1349.00
IUUC-Aca-004634	Anolis carolinensis	83.95	0.00e+00	1324.00
IUUC-Ame-011470	Astyanax mexicanus	74.02	0.00e+00	1221.00
IUUC-Bta-013349	Bos taurus	99.50	0.00e+00	1560.00
IUUC-Cja-019021	Callithrix jacchus	97.15	0.00e+00	1492.00
IUUC-Cfa-020614	Canis familiaris	98.14	0.00e+00	1506.00
IUUC-Cpo-022484	Cavia porcellus	97.65	0.00e+00	1503.00
IUUC-Csa-024078	Chlorocebus sabaeus	98.02	0.00e+00	1504.00
IUUC-Cho-024522	Choloepus hoffmanni	80.42	0.00e+00	1173.00
IUUC-Dre-027651	Danio rerio	74.54	0.00e+00	1286.00
IUUC-Dno-028975	Dasypus novemcinctus	97.28	0.00e+00	1496.00
IUUC-Dor-030130	Dipodomys ordii	72.49	0.00e+00	1037.00
IUUC-Ete-032251	Echinops telfairi	82.03	0.00e+00	1275.00
IUUC-Eca-033568	Equus caballus	98.39	0.00e+00	1511.00
IUUC-Eeu-034612	Erinaceus europaeus	79.31	0.00e+00	1150.00
IUUC-Fca-036280	Felis catus	98.26	0.00e+00	1508.00
IUUC-Fal-036610	Ficedula albicollis	83.90	0.00e+00	1326.00
IUUC-Gmo-038906	Gadus morhua	72.64	0.00e+00	1192.00
IUUC-Gga-041215	Gallus gallus	83.35	0.00e+00	1345.00
IUUC-Gac-042441	Gasterosteus aculeatus	71.87	0.00e+00	1207.00
IUUC-Ggo-044446	Gorilla gorilla	97.77	0.00e+00	1503.00
IUUC-Hsa-046546	Homo sapiens	98.02	0.00e+00	1504.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	90.96	0.00e+00	1422.00
IUUC-Lch-050425	Latimeria chalumnae	77.56	0.00e+00	1290.00
IUUC-Loc-052072	Lepisosteus oculatus	77.28	0.00e+00	1242.00
IUUC-Laf-053909	Loxodonta africana	95.68	0.00e+00	1488.00
IUUC-Mcc-054686	Macaca mulatta	98.02	0.00e+00	1504.00
IUUC-Meu-056361	Macropus eugenii	79.73	0.00e+00	1238.00
IUUC-Mga-059972	Meleagris gallopavo	78.75	0.00e+00	1295.00
IUUC-Mmr-060916	Microcebus murinus	97.15	0.00e+00	1498.00
IUUC-Mdo-062302	Monodelphis domestica	88.38	0.00e+00	1431.00
IUUC-Mmu-063639	Mus musculus	95.42	0.00e+00	1523.00
IUUC-Mpu-066533	Mustela putorius furo	98.14	0.00e+00	1506.00
IUUC-Mlu-067786	Myotis lucifugus	91.90	0.00e+00	1425.00
IUUC-Nle-069997	Nomascus leucogenys	97.87	0.00e+00	1492.00
IUUC-Ont-071859	Oreochromis niloticus	72.45	0.00e+00	1212.00
IUUC-Oan-072959	Ornithorhynchus anatinus	88.28	2.00e-128	451.00
IUUC-Ocu-074265	Oryctolagus cuniculus	97.52	0.00e+00	1500.00
IUUC-Ola-087344	Oryzias latipes	71.39	0.00e+00	1214.00
IUUC-Oga-088734	Otolemur garnettii	97.65	0.00e+00	1499.00
IUUC-Ptr-090982	Pan troglodytes	98.14	0.00e+00	1508.00
IUUC-Pan-091991	Papio anubis	98.14	0.00e+00	1505.00
IUUC-Psi-093509	Pelodiscus sinensis	86.67	0.00e+00	1380.00
IUUC-Pfo-096029	Poecilia formosa	74.21	0.00e+00	1263.00
IUUC-Pab-098672	Pongo abelii	93.43	0.00e+00	1404.00
IUUC-Pca-100860	Procavia capensis	73.39	0.00e+00	1031.00
IUUC-Pva-102545	Pteropus vampyrus	89.84	0.00e+00	1369.00
IUUC-Rno-105210	Rattus norvegicus	94.55	0.00e+00	1500.00
IUUC-Sar-113733	Sorex araneus	96.29	0.00e+00	772.00
IUUC-Tgu-116591	Taeniopygia guttata	84.81	0.00e+00	1350.00
IUUC-Tru-118627	Takifugu rubripes	70.73	0.00e+00	1224.00
IUUC-Tsy-119278	Tarsius syrichta	88.72	0.00e+00	1344.00
IUUC-Tni-120804	Tetraodon nigroviridis	73.94	0.00e+00	1251.00
IUUC-Tbe-127699	Tupaia belangeri	78.69	0.00e+00	873.00
IUUC-Ttr-128295	Tursiops truncatus	89.36	0.00e+00	1363.00
IUUC-Vpa-130170	Vicugna pacos	86.74	0.00e+00	1332.00
IUUC-Xtr-132809	Xenopus tropicalis	74.17	0.00e+00	1199.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence