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Tag Content
UUCD2 ID IUUC-Ocu-074265
UUCD1 version UUC-OrC-01065
Ensembl Protein ID ENSOCUP00000005236.2
UniProt Accession G1SQ76; G1SQ76_RABIT
Genbank Protein ID ENSOCUP00000005236
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAGW02014191
Gene Name USP13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000006043.3 ENSOCUT00000033606.1 ENSOCUP00000026651.1
ENSOCUG00000006043.3 ENSOCUT00000006045.2 ENSOCUP00000005236.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.40e-56 192.1 332 856
UBD/Alpha-Helix/UBA 7.40e-20 70.5 726 763
Active Site
Position(s) Description Evidence
341 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
819 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                      +k +++ 
   Q: 332  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeQKPHQNG 419
           7******************************788777765.79*****************8888888888877777765543477777* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 420  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 479
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f++++++++   ++++  ++k+  +
   Q: 480  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPDNVDD---FWSSALQAKSAGV 565
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 566  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 653
           *********************997.*******************999889999999999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 654  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasifgatgldnqppeeivaiitsmgfqrnqa 742
           88777777777777777777777777777777777777777777777777777777777777777777776666666666666666666 PP
   S: 268  ..........peekqke............................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                           e                                            +  YeL+a ++H+G s+ sGHYv+++k+
   Q: 743  vqalratsnnL-----EraldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK 826
           66655555550.....055555555555555555666666666677788888888888888**************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 827  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 856
           .9***********999..78888...99******98 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra++nnle+A+++++++
   Q: 726  EEIVAIITSMGFQRNQAVQALRATSNNLERALDWIFSH 763
           899*********************************97 PP
   
Organism Oryctolagus cuniculus
Protein Sequence
(Fasta)
GAPVRHPGGS GGRKMAAGDI GELLVPLMPT IRVPRSGDRV YKNECAFSYD SPNSEGGLYV 60
CMNTFLAFGR EHVERHFRKT GQSVYMHLKR HVREKVRGAS GGALPKRRNS KIFLDLDTDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074265|DUB,USP;UBD,UBA|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGCGCCGG GGCACCTGTT CGGCATCCGG GCGGCAGCGG TGGCAGGAAG ATGGCTGCAG 60
GAGACATCGG CGAGCTGCTT GTACCGCTCA TGCCCACGAT CCGCGTGCCC CGCTCCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074265|DUB,USP;UBD,UBA|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 97.67 0.00e+00 1594.00
IUUC-Apl-003712 Anas platyrhynchos 83.48 0.00e+00 1351.00
IUUC-Aca-004634 Anolis carolinensis 84.41 0.00e+00 1401.00
IUUC-Ame-011470 Astyanax mexicanus 74.10 0.00e+00 1281.00
IUUC-Bta-013349 Bos taurus 96.97 0.00e+00 1625.00
IUUC-Cja-019021 Callithrix jacchus 96.48 0.00e+00 1569.00
IUUC-Cfa-020614 Canis familiaris 97.79 0.00e+00 1599.00
IUUC-Cpo-022484 Cavia porcellus 98.28 0.00e+00 1511.00
IUUC-Csa-024078 Chlorocebus sabaeus 98.02 0.00e+00 1600.00
IUUC-Cho-024522 Choloepus hoffmanni 81.04 0.00e+00 1177.00
IUUC-Dre-027651 Danio rerio 74.36 0.00e+00 1342.00
IUUC-Dno-028975 Dasypus novemcinctus 97.56 0.00e+00 1597.00
IUUC-Dor-030130 Dipodomys ordii 73.65 0.00e+00 1068.00
IUUC-Ete-032251 Echinops telfairi 82.40 0.00e+00 1277.00
IUUC-Eca-033568 Equus caballus 98.64 0.00e+00 1511.00
IUUC-Eeu-034612 Erinaceus europaeus 79.43 0.00e+00 1148.00
IUUC-Fca-036280 Felis catus 98.51 0.00e+00 1506.00
IUUC-Fal-036610 Ficedula albicollis 84.27 0.00e+00 1328.00
IUUC-Gmo-038906 Gadus morhua 71.89 0.00e+00 1251.00
IUUC-Gga-041215 Gallus gallus 83.51 0.00e+00 1423.00
IUUC-Gac-042441 Gasterosteus aculeatus 71.02 0.00e+00 1263.00
IUUC-Ggo-044446 Gorilla gorilla 97.79 0.00e+00 1602.00
IUUC-Hsa-046546 Homo sapiens 98.02 0.00e+00 1602.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 89.91 0.00e+00 1436.00
IUUC-Lch-050425 Latimeria chalumnae 77.51 0.00e+00 1350.00
IUUC-Loc-052072 Lepisosteus oculatus 77.36 0.00e+00 1306.00
IUUC-Laf-053909 Loxodonta africana 95.94 0.00e+00 1580.00
IUUC-Mcc-054686 Macaca mulatta 98.25 0.00e+00 1605.00
IUUC-Meu-056361 Macropus eugenii 80.45 0.00e+00 1303.00
IUUC-Mga-059972 Meleagris gallopavo 78.87 0.00e+00 1294.00
IUUC-Mmr-060916 Microcebus murinus 97.21 0.00e+00 1593.00
IUUC-Mdo-062302 Monodelphis domestica 89.52 0.00e+00 1512.00
IUUC-Mmu-063639 Mus musculus 96.30 0.00e+00 1593.00
IUUC-Mpu-066533 Mustela putorius furo 98.02 0.00e+00 1599.00
IUUC-Mlu-067786 Myotis lucifugus 91.43 0.00e+00 1469.00
IUUC-Nle-069997 Nomascus leucogenys 98.37 0.00e+00 1494.00
IUUC-Ont-071859 Oreochromis niloticus 72.24 0.00e+00 1267.00
IUUC-Oan-072959 Ornithorhynchus anatinus 88.28 3.00e-128 450.00
IUUC-Ola-087344 Oryzias latipes 71.03 0.00e+00 1266.00
IUUC-Oga-088734 Otolemur garnettii 98.08 0.00e+00 1551.00
IUUC-Oar-089636 Ovis aries 97.52 0.00e+00 1569.00
IUUC-Ptr-090982 Pan troglodytes 98.02 0.00e+00 1605.00
IUUC-Pan-091991 Papio anubis 98.14 0.00e+00 1603.00
IUUC-Psi-093509 Pelodiscus sinensis 86.78 0.00e+00 1450.00
IUUC-Pfo-096029 Poecilia formosa 73.81 0.00e+00 1314.00
IUUC-Pab-098672 Pongo abelii 93.83 0.00e+00 1504.00
IUUC-Pca-100860 Procavia capensis 74.62 0.00e+00 1045.00
IUUC-Pva-102545 Pteropus vampyrus 90.50 0.00e+00 1457.00
IUUC-Rno-105210 Rattus norvegicus 95.58 0.00e+00 1570.00
IUUC-Sar-113733 Sorex araneus 95.54 0.00e+00 768.00
IUUC-Tgu-116591 Taeniopygia guttata 84.88 0.00e+00 1422.00
IUUC-Tru-118627 Takifugu rubripes 70.60 0.00e+00 1280.00
IUUC-Tsy-119278 Tarsius syrichta 89.47 0.00e+00 1352.00
IUUC-Tni-120804 Tetraodon nigroviridis 72.65 0.00e+00 1305.00
IUUC-Tbe-127699 Tupaia belangeri 79.03 0.00e+00 875.00
IUUC-Ttr-128295 Tursiops truncatus 89.19 0.00e+00 1449.00
IUUC-Vpa-130170 Vicugna pacos 86.74 0.00e+00 1330.00
IUUC-Xtr-132809 Xenopus tropicalis 73.78 0.00e+00 1263.00
Created Date 25-Jun-2017

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