iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097776

Ensembl Protein ID

ENSPPYP00000004178.2

UniProt Accession

H2NEK8; H2NEK8_PONAB

Genbank Protein ID

ENSPPYP00000004178

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01229217

Gene Name

ATG16L2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000003655.2	ENSPPYT00000004349.2	ENSPPYP00000004178.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-27	94.1	423	453
UBD/Beta-Prp	3.40e-46	157.9	417	706

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++v++++f ++  ll++G+ D  i++W++
   Q: 423  HLSEVNAVRFgPNsSLLATGGADRLIHLWNV 453
           99*********7779***************7 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvht 89
           ++++++h s +++v f p++sllatg++d+ i +w+v    l   ++l+g  + +t+v+f+p+g   + +   +++++w +   +   t
   Q: 417  QEVQDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLeaNQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKET 505
           6789***********************************99988899*****************888888889**************** PP
   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           l+gh+d+v++ +f   ++  v+Gs+drt++ wdl   +c++ t ++ +    c  v + + +++sG++D+++r+Wd++   + +     
   Q: 506  LSGHKDKVTAAKFKL-THQAVTGSRDRTVKEWDLGRAYCSR-TINVLS---YCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIP-- 587
           *************99.999*********************9.666655...4555555556*************************5.. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgec.....vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
            +++v+sls+++++ +l+s+s+d+t+k+ dl+ +++      + +++ +d++k   fsp+  + + gs+Dg ++iWd+++g+l + lq+
   Q: 588  VQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIrqvfrADGFKCGSDWTK-AVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQG 675
           589*****************************888833334444555556666.8899******************************* PP
   S: 263  hnssvisvavlsfgdnvlvlgsedskvniwk 293
           ++ + +   +++++++++v++++  kv +w+
   Q: 676  PHCTAVNAVAWCYSGSHMVSVDQGRKVVLWQ 706
           **777777778****************9995 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MTLAATGAPT KVNISDGAPA VQTRRRLLPE TAPPGVGLRS SPPKPSWDKP GIPRRRPPPG 60
VMEFPRGPAP AWRRPGREER AARLESAAMA GPGVPGAPAA RWKRHIVRQL RLRDRTQKAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCCTTG CAGCCACAGG AGCCCCCACT AAGGTGAACA TTTCGGACGG GGCCCCGGCG 60
GTTCAGACCC GGAGGCGGCT CCTCCCGGAG ACGGCTCCTC CCGGCGTCGG CCTTCGGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0039689--P:negative stranded viral RNA replication

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001470	Ailuropoda melanoleuca	68.20	0.00e+00	743.00
IUUC-Atr-003073	Amborella trichopoda	31.35	6.00e-26	112.00
IUUC-Aca-004664	Anolis carolinensis	72.49	2.00e-98	352.00
IUUC-Ame-011152	Astyanax mexicanus	41.97	5.00e-115	408.00
IUUC-Bta-013118	Bos taurus	84.98	0.00e+00	935.00
IUUC-Cja-020002	Callithrix jacchus	89.68	0.00e+00	995.00
IUUC-Cfa-020878	Canis familiaris	82.54	0.00e+00	919.00
IUUC-Cpo-022476	Cavia porcellus	83.44	0.00e+00	897.00
IUUC-Csa-024134	Chlorocebus sabaeus	93.72	0.00e+00	1038.00
IUUC-Cho-024853	Choloepus hoffmanni	70.62	7.00e-176	610.00
IUUC-Dre-027949	Danio rerio	41.54	4.00e-124	438.00
IUUC-Dno-029683	Dasypus novemcinctus	84.69	0.00e+00	764.00
IUUC-Dor-030897	Dipodomys ordii	78.19	0.00e+00	928.00
IUUC-Ete-032957	Echinops telfairi	92.43	2.00e-129	456.00
IUUC-Eca-033303	Equus caballus	89.51	9.00e-161	558.00
IUUC-Eeu-035336	Erinaceus europaeus	73.76	2.00e-152	532.00
IUUC-Fca-036232	Felis catus	85.16	0.00e+00	996.00
IUUC-Gmo-038880	Gadus morhua	50.00	2.00e-70	259.00
IUUC-Gac-042500	Gasterosteus aculeatus	40.81	3.00e-92	332.00
IUUC-Ggo-045130	Gorilla gorilla	98.51	0.00e+00	747.00
IUUC-Hsa-046359	Homo sapiens	97.69	0.00e+00	1024.00
IUUC-Itr-048780	Ictidomys tridecemlineatus	86.09	0.00e+00	972.00
IUUC-Lch-050669	Latimeria chalumnae	54.22	4.00e-94	337.00
IUUC-Loc-052789	Lepisosteus oculatus	42.22	8.00e-115	407.00
IUUC-Laf-053699	Loxodonta africana	85.92	0.00e+00	943.00
IUUC-Mcc-055657	Macaca mulatta	89.01	0.00e+00	927.00
IUUC-Meu-056639	Macropus eugenii	49.90	4.00e-109	388.00
IUUC-Mmr-061314	Microcebus murinus	80.23	0.00e+00	848.00
IUUC-Mdo-061841	Monodelphis domestica	63.74	0.00e+00	684.00
IUUC-Mmu-064065	Mus musculus	82.92	0.00e+00	939.00
IUUC-Mpu-066742	Mustela putorius furo	82.90	0.00e+00	900.00
IUUC-Mlu-067019	Myotis lucifugus	87.84	0.00e+00	669.00
IUUC-Nle-069037	Nomascus leucogenys	97.03	0.00e+00	1078.00
IUUC-Opr-071039	Ochotona princeps	81.58	0.00e+00	896.00
IUUC-Oan-073431	Ornithorhynchus anatinus	71.91	6.00e-138	483.00
IUUC-Ocu-074772	Oryctolagus cuniculus	84.42	0.00e+00	833.00
IUUC-Ola-086964	Oryzias latipes	52.60	4.00e-83	301.00
IUUC-Oga-088188	Otolemur garnettii	86.59	0.00e+00	899.00
IUUC-Oar-090231	Ovis aries	78.77	0.00e+00	907.00
IUUC-Ptr-091434	Pan troglodytes	94.58	0.00e+00	977.00
IUUC-Pan-091868	Papio anubis	94.67	0.00e+00	1022.00
IUUC-Psi-093652	Pelodiscus sinensis	63.66	4.00e-164	570.00
IUUC-Pfo-096960	Poecilia formosa	42.53	4.00e-101	361.00
IUUC-Pca-100220	Procavia capensis	65.59	5.00e-178	617.00
IUUC-Pva-103135	Pteropus vampyrus	86.50	0.00e+00	868.00
IUUC-Rno-105529	Rattus norvegicus	81.06	0.00e+00	965.00
IUUC-Sha-107062	Sarcophilus harrisii	64.10	0.00e+00	717.00
IUUC-Sar-113109	Sorex araneus	67.00	3.00e-132	464.00
IUUC-Ssc-115271	Sus scrofa	86.15	0.00e+00	920.00
IUUC-Tni-120373	Tetraodon nigroviridis	51.39	7.00e-85	306.00
IUUC-Ttr-128267	Tursiops truncatus	82.23	0.00e+00	893.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence