iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106507

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01093892

Gene Name

ZNRF3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000002703.1	ENSSHAT00000003087.1	ENSSHAP00000003051.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-05	26.1	152	193

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCle +   ++++v pC H fh+ C+  w        ++ +CP Cr
   Q: 152  CAICLEKYidGEELRVIPCTHRFHKRCVDPW------LLQHHTCPHCR 193
           ********66334******************......9999******8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

QAKRAVQRGA TAVIFDVSEN PDAIDQLNQG SEDPLKRPVV YVKGADAVKL MNIVNKQKVA 60
RARIQHRPPR QPTEYFDMGI FLAFFVVVSL VCLFLLVKIK LKQRRSQNSM NRLAVQALEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGCCAAGC GAGCTGTGCA GCGCGGAGCA ACTGCGGTCA TCTTTGACGT CTCCGAAAAT 60
CCAGATGCCA TCGACCAGGT AAAATCCTTG GCTCCCTTCA TTGGCCACCC TGTGCCATCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0072089--P:stem cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0038018--P:Wnt receptor catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001916	Ailuropoda melanoleuca	54.15	4.00e-161	561.00
IUUC-Apl-004188	Anas platyrhynchos	54.07	4.00e-179	621.00
IUUC-Aly-005850	Arabidopsis lyrata	41.38	3.00e-15	73.90
IUUC-Ath-007372	Arabidopsis thaliana	41.67	1.00e-14	72.40
IUUC-Ame-011764	Astyanax mexicanus	50.35	2.00e-133	469.00
IUUC-Bta-012478	Bos taurus	94.12	2.00e-93	336.00
IUUC-Bol-015877	Brassica oleracea	50.91	1.00e-14	72.80
IUUC-Bra-017407	Brassica rapa	55.32	1.00e-13	68.60
IUUC-Cja-019504	Callithrix jacchus	57.60	1.00e-177	616.00
IUUC-Cfa-020048	Canis familiaris	55.28	4.00e-167	582.00
IUUC-Cpo-021725	Cavia porcellus	89.85	2.00e-98	353.00
IUUC-Csa-023586	Chlorocebus sabaeus	56.20	1.00e-166	580.00
IUUC-Cho-024867	Choloepus hoffmanni	89.81	5.00e-93	335.00
IUUC-Cin-025569	Ciona intestinalis	46.53	1.00e-39	157.00
IUUC-Dre-027553	Danio rerio	90.36	5.00e-90	325.00
IUUC-Dno-029370	Dasypus novemcinctus	54.09	9.00e-164	570.00
IUUC-Dor-030816	Dipodomys ordii	55.67	1.00e-152	533.00
IUUC-Ete-033060	Echinops telfairi	51.02	2.00e-122	432.00
IUUC-Eca-034044	Equus caballus	55.04	5.00e-172	597.00
IUUC-Eeu-034591	Erinaceus europaeus	50.29	5.00e-56	212.00
IUUC-Fca-036000	Felis catus	55.36	4.00e-171	595.00
IUUC-Fal-037147	Ficedula albicollis	54.68	0.00e+00	655.00
IUUC-Gga-041243	Gallus gallus	49.79	2.00e-140	493.00
IUUC-Gac-041340	Gasterosteus aculeatus	41.36	9.00e-28	118.00
IUUC-Gma-044387	Glycine max	55.32	5.00e-14	70.90
IUUC-Ggo-044953	Gorilla gorilla	56.75	2.00e-170	593.00
IUUC-Hsa-046484	Homo sapiens	56.69	3.00e-171	595.00
IUUC-Itr-048470	Ictidomys tridecemlineatus	54.91	1.00e-170	593.00
IUUC-Lch-050004	Latimeria chalumnae	69.42	2.00e-59	223.00
IUUC-Loc-051830	Lepisosteus oculatus	48.85	5.00e-124	438.00
IUUC-Laf-053975	Loxodonta africana	55.86	4.00e-175	608.00
IUUC-Mcc-055302	Macaca mulatta	84.12	1.00e-93	337.00
IUUC-Meu-056263	Macropus eugenii	64.08	5.00e-148	518.00
IUUC-Mtr-058744	Medicago truncatula	37.78	3.00e-13	67.40
IUUC-Mga-059706	Meleagris gallopavo	54.28	0.00e+00	647.00
IUUC-Mmr-061372	Microcebus murinus	54.99	1.00e-167	583.00
IUUC-Mdo-062651	Monodelphis domestica	62.58	0.00e+00	692.00
IUUC-Mmu-064339	Mus musculus	54.13	9.00e-168	583.00
IUUC-Mac-064877	Musa acuminata	51.92	1.00e-12	66.60
IUUC-Mpu-066211	Mustela putorius furo	52.78	2.00e-159	556.00
IUUC-Mlu-067058	Myotis lucifugus	54.64	6.00e-166	577.00
IUUC-Nle-069886	Nomascus leucogenys	55.63	1.00e-163	570.00
IUUC-Opr-070218	Ochotona princeps	55.13	6.00e-167	580.00
IUUC-Ont-072483	Oreochromis niloticus	47.14	9.00e-134	471.00
IUUC-Oan-073718	Ornithorhynchus anatinus	53.37	2.00e-149	523.00
IUUC-Ocu-073847	Oryctolagus cuniculus	51.22	8.00e-139	487.00
IUUC-Ola-087358	Oryzias latipes	89.85	4.00e-89	322.00
IUUC-Oga-088362	Otolemur garnettii	55.18	3.00e-172	598.00
IUUC-Oar-090197	Ovis aries	94.12	3.00e-94	338.00
IUUC-Ptr-091350	Pan troglodytes	56.69	3.00e-171	595.00
IUUC-Pan-091700	Papio anubis	84.12	1.00e-93	337.00
IUUC-Psi-093301	Pelodiscus sinensis	53.44	3.00e-170	592.00
IUUC-Pfo-096917	Poecilia formosa	48.56	2.00e-128	452.00
IUUC-Pab-097932	Pongo abelii	55.25	5.00e-178	617.00
IUUC-Pop-099512	Populus trichocarpa	55.32	9.00e-14	69.70
IUUC-Pca-101054	Procavia capensis	84.55	2.00e-93	337.00
IUUC-Ppe-101991	Prunus persica	52.94	2.00e-13	68.60
IUUC-Pva-102879	Pteropus vampyrus	53.29	5.00e-164	571.00
IUUC-Sit-110656	Setaria italica	65.12	2.00e-12	65.50
IUUC-Stu-112500	Solanum tuberosum	62.79	4.00e-13	67.40
IUUC-Sar-113182	Sorex araneus	94.39	3.00e-89	323.00
IUUC-Ssc-115966	Sus scrofa	55.01	4.00e-164	571.00
IUUC-Tgu-116864	Taeniopygia guttata	43.35	8.00e-105	374.00
IUUC-Tru-118502	Takifugu rubripes	89.34	9.00e-89	321.00
IUUC-Tsy-119210	Tarsius syrichta	56.19	4.00e-166	578.00
IUUC-Tni-120344	Tetraodon nigroviridis	45.43	3.00e-35	143.00
IUUC-Tca-121477	Theobroma cacao	34.78	3.00e-13	68.60
IUUC-Tre-121978	Trichoderma reesei	38.67	3.00e-13	69.70
IUUC-Tbe-127735	Tupaia belangeri	97.17	1.00e-45	178.00
IUUC-Ttr-128714	Tursiops truncatus	61.37	2.00e-63	237.00
IUUC-Vvi-131731	Vitis vinifera	51.06	9.00e-13	66.20
IUUC-Xtr-132280	Xenopus tropicalis	79.91	2.00e-90	327.00
IUUC-Xma-134192	Xiphophorus maculatus	48.16	3.00e-129	455.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence