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Tag Content
UUCD2 ID IUUC-Bta-013063
UUCD1 version UUC-BoT-01111
Ensembl Protein ID ENSBTAP00000027070.5
UniProt Accession A7Z056; UBP20_BOVIN
Genbank Protein ID AAI53255.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme 20; Ubiquitin thioesterase 20; Ubiquitin-specific-processing protease 20
Genbank Nucleotide ID BC153254
Gene Name USP20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000020311.5 ENSBTAT00000027070.5 ENSBTAP00000027070.5
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.50e-111 372.2 145 682
Active Site
Position(s) Description Evidence
154 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
641 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w  ++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhRKRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+              +++++++e           +                                  
   Q: 229  QQDTQEFLRCLMDQLHEELKEpvvataaalteardSDSSDTDE-----------Kregdrspsedeflscdsssdrgegdgqgrsgggs 306
           *******************998875554444444434444444...........355556666666*********************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 307  qaeaellmadeagraisekermkdrkfswgqqrtnseqvdedadvdtamaaleqqppetqppsprstspcrtpepdneahmrssrpcsp 395
           ***************************************************************************************** PP
   S: 130  ...................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
                                              ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +
   Q: 396  vhhheghaklassphraspvrmgpayvlkkaqvpgSRRRKEQSYRSVISDIFDGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLA 484
           **************************************************************************************998 PP
   S: 184  ke.................................................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
           k+                                                 +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+
   Q: 485  KLhsaiyqnvpakpgacgdsyvaqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKV 573
           88*************************************************************************************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfd 310
            +lPe+L++hLkRf  ++e + + ki+++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fd
   Q: 574  LRLPEILCIHLKRF--RHEVMYSFKISSHVSFPLEgLDLRPFLAKECTSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFD 658
           **************..9999***************************999..9**************************78999***** PP
   S: 311  DskVtevkeeevleetgstaYvlfYkr 337
           D++Vtev+e+ v++   ++aYvlfY++
   Q: 659  DQYVTEVHETVVQN---AEAYVLFYRK 682
           **************...********98 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MGDSRDLCPH LDSIGEVTKE DLLLKSKSTC QSCGVSGPNL WACLQVSCSY VGCGESFADH 60
STLHAQAKKH NLTVNLTTFR VWCYACEKEV FLEPRLAAHP PGPAPKFSEQ DSPPPSHPLK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013063|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGCGGCGG TGGCGGCGCG GTTGCGACTG CAGGTGAGTT CCGGGCCGCC GCCGGCTGTT 60
TCAGGGGGCC GGGTCTCTCC GAGCAGGGGC GACCCCAGTC CGGCTCCGGG CCGGCGGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013063|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP
SMART

SM00695--DUSP
SM00290--ZnF_UBP
Gene Ontology

GO:0005813--C:centrosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:505839
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002209 Ailuropoda melanoleuca 93.77 0.00e+00 1682.00
IUUC-Apl-003351 Anas platyrhynchos 85.53 0.00e+00 1578.00
IUUC-Aca-005077 Anolis carolinensis 76.25 0.00e+00 1112.00
IUUC-Ame-011777 Astyanax mexicanus 75.00 0.00e+00 1334.00
IUUC-Cja-019868 Callithrix jacchus 92.90 0.00e+00 1705.00
IUUC-Cfa-020761 Canis familiaris 93.88 0.00e+00 1689.00
IUUC-Cpo-022267 Cavia porcellus 87.55 0.00e+00 1566.00
IUUC-Csa-024251 Chlorocebus sabaeus 93.99 0.00e+00 1721.00
IUUC-Cho-024483 Choloepus hoffmanni 97.17 4.00e-125 442.00
IUUC-Dre-028061 Danio rerio 74.14 0.00e+00 1220.00
IUUC-Dno-029423 Dasypus novemcinctus 94.54 0.00e+00 1700.00
IUUC-Dor-030877 Dipodomys ordii 92.33 0.00e+00 1084.00
IUUC-Dme-031837 Drosophila melanogaster 49.57 1.00e-138 487.00
IUUC-Ete-032802 Echinops telfairi 80.06 6.00e-136 478.00
IUUC-Eca-034283 Equus caballus 93.01 0.00e+00 1674.00
IUUC-Eeu-034620 Erinaceus europaeus 90.64 0.00e+00 1179.00
IUUC-Fca-036357 Felis catus 94.97 0.00e+00 1673.00
IUUC-Fal-037411 Ficedula albicollis 85.62 0.00e+00 1575.00
IUUC-Gga-041101 Gallus gallus 84.90 0.00e+00 1549.00
IUUC-Gac-041315 Gasterosteus aculeatus 74.17 0.00e+00 1323.00
IUUC-Ggo-045600 Gorilla gorilla 93.26 0.00e+00 1655.00
IUUC-Hsa-045825 Homo sapiens 93.88 0.00e+00 1671.00
IUUC-Itr-048549 Ictidomys tridecemlineatus 80.93 0.00e+00 1374.00
IUUC-Lch-050002 Latimeria chalumnae 75.70 0.00e+00 1330.00
IUUC-Loc-052574 Lepisosteus oculatus 77.87 0.00e+00 1406.00
IUUC-Laf-054428 Loxodonta africana 92.58 0.00e+00 1659.00
IUUC-Mcc-055736 Macaca mulatta 93.77 0.00e+00 1716.00
IUUC-Mga-059781 Meleagris gallopavo 84.58 0.00e+00 1551.00
IUUC-Mdo-063048 Monodelphis domestica 85.71 0.00e+00 1522.00
IUUC-Mmu-064079 Mus musculus 92.36 0.00e+00 1660.00
IUUC-Mpu-066616 Mustela putorius furo 92.58 0.00e+00 1718.00
IUUC-Mlu-067294 Myotis lucifugus 93.22 0.00e+00 1624.00
IUUC-Nle-070015 Nomascus leucogenys 93.77 0.00e+00 1645.00
IUUC-Opr-070328 Ochotona princeps 92.48 0.00e+00 1670.00
IUUC-Ont-071464 Oreochromis niloticus 75.93 0.00e+00 1318.00
IUUC-Oan-073259 Ornithorhynchus anatinus 78.64 0.00e+00 1323.00
IUUC-Ocu-074630 Oryctolagus cuniculus 90.17 0.00e+00 1598.00
IUUC-Ola-087240 Oryzias latipes 74.95 0.00e+00 1301.00
IUUC-Oga-088761 Otolemur garnettii 92.46 0.00e+00 1684.00
IUUC-Oar-089490 Ovis aries 93.32 0.00e+00 1569.00
IUUC-Ptr-091662 Pan troglodytes 93.88 0.00e+00 1669.00
IUUC-Pan-092199 Papio anubis 93.57 0.00e+00 1709.00
IUUC-Psi-093726 Pelodiscus sinensis 86.35 0.00e+00 1571.00
IUUC-Pma-094389 Petromyzon marinus 64.65 9.00e-100 356.00
IUUC-Pab-098632 Pongo abelii 93.55 0.00e+00 1661.00
IUUC-Pca-100614 Procavia capensis 86.12 0.00e+00 1305.00
IUUC-Pva-102922 Pteropus vampyrus 92.08 0.00e+00 980.00
IUUC-Rno-105215 Rattus norvegicus 92.02 0.00e+00 1659.00
IUUC-Sha-106601 Sarcophilus harrisii 84.63 0.00e+00 1498.00
IUUC-Ssc-115533 Sus scrofa 93.20 0.00e+00 1657.00
IUUC-Tgu-117364 Taeniopygia guttata 85.57 0.00e+00 1538.00
IUUC-Tru-117770 Takifugu rubripes 72.78 0.00e+00 1305.00
IUUC-Tni-120001 Tetraodon nigroviridis 73.79 0.00e+00 1279.00
IUUC-Ttr-128732 Tursiops truncatus 96.28 0.00e+00 1706.00
IUUC-Xtr-132157 Xenopus tropicalis 75.90 0.00e+00 1356.00
Created Date 25-Jun-2017

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