iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011259

Ensembl Protein ID

ENSAMXP00000005548.1

UniProt Accession

W5KD87; W5KD87_ASTMX

Genbank Protein ID

ENSAMXP00000005548

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

APWO01029623

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000005418.1	ENSAMXT00000005548.1	ENSAMXP00000005548.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-19	68.9	525	907

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 525  NAYCNCMIQVLYFLEPIRCLVQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQASNFLRAFRTIPEASAlGLILADSDEQT 604
           56*********************...55654......57*******************************9999855666666666655 PP
   S: 97   a.flldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
               l +l ++ ++    + +++++e+e+ +  +    ++++  ++++s+i +lF+ +++++  c +c+++++r +  l ++++ p+++
   Q: 605  GkARLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGASSSSLGSSGESVIGRLFGCEVENSSLC-RCGKETVRSSLTLLFTMHYPEQS 690
           3134566666665544323333333333333..45555789999*********************.8*******************998 PP
   S: 181  etkke...slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           + +k    +++++L++    e   ++ + +ce+c+k+q ++++  ++ lP+vL+++    s++e++    k + ++ f++ L+ +   +
   Q: 691  SADKVqeyEFTEILKNSICLE---QSTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSVKEAEF--WKAQAEYAFNKALKKEA-AE 773
           776554446666666666555...55579*****************************998877644..48889999988888772.22 PP
   S: 267  s.....peekqke...............................................................kkkYeLiavvvHs 287
                 p                                                                        Y+L+  v H 
   Q: 774  PpkpkeP-----MptewciedelcnvegltfdtraedlrhvwiplslkmciskthglevccwpegeelsaaeeaegAAVYDLVVTVPHI 857
           2233330.....13444444444445566666666666666666666666666666666666666666677777779************ PP
   S: 288  G.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevlee 325
                +G  va++k            ++++W+lf+D  +++++++e  ++
   Q: 858  LdARTGGNLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKTEAAQF 907
           *99999*********999988877777888************99988775 PP

Organism

Astyanax mexicanus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MMNFEGLDPG LGDYAPGLHG SLEPGLDSSL DPALLQGVEL DPDALAVPVP ESVHLLEGMY 60
SELHSVAAEV GIPVTATHFD LQEELLWMGN HRGHASSFFG PTMGRYSSFQ VHLTDDIRHI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGCACCTCC GTCCTCATGA TGAACTTCGA GGGTTTGGAT CCAGGCCTGG GCGACTATGC 60
CCCGGGCCTG CACGGGAGCC TGGAGCCCGG CCTGGATTCC TCCCTCGACC CTGCTCTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	76.69	0.00e+00	1806.00
IUUC-Apl-003500	Anas platyrhynchos	77.89	0.00e+00	1705.00
IUUC-Aca-004930	Anolis carolinensis	76.40	0.00e+00	1826.00
IUUC-Acl-008214	Aspergillus clavatus	31.35	9.00e-154	538.00
IUUC-Afu-009112	Aspergillus fumigatus	30.72	2.00e-143	503.00
IUUC-Ang-009531	Aspergillus niger	31.65	1.00e-149	524.00
IUUC-Bta-012371	Bos taurus	76.43	0.00e+00	1795.00
IUUC-Bci-013684	Botrytis cinerea	31.34	3.00e-134	473.00
IUUC-Cja-019297	Callithrix jacchus	74.59	0.00e+00	1754.00
IUUC-Cfa-020489	Canis familiaris	76.43	0.00e+00	1794.00
IUUC-Cpo-022392	Cavia porcellus	76.49	0.00e+00	1820.00
IUUC-Csa-023220	Chlorocebus sabaeus	76.20	0.00e+00	1793.00
IUUC-Csv-025841	Ciona savignyi	47.03	6.00e-138	485.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	29.02	1.00e-86	314.00
IUUC-Cne-026932	Cryptococcus neoformans	44.65	1.00e-72	268.00
IUUC-Dre-028482	Danio rerio	90.40	0.00e+00	2136.00
IUUC-Dno-029398	Dasypus novemcinctus	76.64	0.00e+00	1801.00
IUUC-Dor-030307	Dipodomys ordii	71.97	0.00e+00	999.00
IUUC-Dme-032111	Drosophila melanogaster	41.29	0.00e+00	873.00
IUUC-Eca-033985	Equus caballus	76.43	0.00e+00	1795.00
IUUC-Eeu-034928	Erinaceus europaeus	77.31	1.00e-175	610.00
IUUC-Fca-035587	Felis catus	76.61	0.00e+00	1820.00
IUUC-Fal-037587	Ficedula albicollis	77.07	0.00e+00	1795.00
IUUC-Fso-038133	Fusarium solani	32.78	2.00e-93	337.00
IUUC-Gmo-039076	Gadus morhua	86.63	0.00e+00	2058.00
IUUC-Ggr-039957	Gaeumannomyces graminis	29.09	9.00e-75	275.00
IUUC-Gga-040948	Gallus gallus	78.44	0.00e+00	1841.00
IUUC-Gac-042396	Gasterosteus aculeatus	86.41	0.00e+00	2100.00
IUUC-Ggo-045412	Gorilla gorilla	76.36	0.00e+00	1796.00
IUUC-Hsa-046076	Homo sapiens	76.36	0.00e+00	1797.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	70.19	0.00e+00	1609.00
IUUC-Kpa-049178	Komagataella pastoris	41.02	7.00e-66	246.00
IUUC-Lch-050279	Latimeria chalumnae	73.33	0.00e+00	887.00
IUUC-Loc-052872	Lepisosteus oculatus	87.61	0.00e+00	2072.00
IUUC-Lma-052986	Leptosphaeria maculans	31.87	6.00e-155	541.00
IUUC-Laf-054181	Loxodonta africana	73.91	0.00e+00	1761.00
IUUC-Mcc-054812	Macaca mulatta	76.10	0.00e+00	1784.00
IUUC-Meu-056325	Macropus eugenii	77.34	0.00e+00	1816.00
IUUC-Mor-057246	Magnaporthe oryzae	28.00	3.00e-112	400.00
IUUC-Mpo-057464	Magnaporthe poae	29.40	3.00e-71	263.00
IUUC-Mla-058911	Melampsora laricipopulina	43.41	3.00e-67	250.00
IUUC-Mga-059335	Meleagris gallopavo	78.71	0.00e+00	1808.00
IUUC-Mvi-060461	Microbotryum violaceum	32.15	2.00e-136	480.00
IUUC-Mmr-060636	Microcebus murinus	76.26	0.00e+00	1788.00
IUUC-Mmu-063503	Mus musculus	74.63	0.00e+00	1782.00
IUUC-Mpu-066670	Mustela putorius furo	76.51	0.00e+00	1799.00
IUUC-Mlu-068119	Myotis lucifugus	76.01	0.00e+00	1855.00
IUUC-Nfi-068398	Neosartorya fischeri	31.57	4.00e-152	532.00
IUUC-Ncr-068927	Neurospora crassa	28.93	6.00e-124	439.00
IUUC-Nle-069651	Nomascus leucogenys	73.33	0.00e+00	1709.00
IUUC-Opr-070614	Ochotona princeps	75.31	0.00e+00	1752.00
IUUC-Ont-072433	Oreochromis niloticus	85.60	0.00e+00	2115.00
IUUC-Oan-073283	Ornithorhynchus anatinus	67.13	0.00e+00	1263.00
IUUC-Ocu-074401	Oryctolagus cuniculus	75.35	0.00e+00	1790.00
IUUC-Ola-087522	Oryzias latipes	86.53	0.00e+00	2051.00
IUUC-Oga-088226	Otolemur garnettii	75.14	0.00e+00	1803.00
IUUC-Oar-089241	Ovis aries	76.45	0.00e+00	1822.00
IUUC-Pan-092297	Papio anubis	77.66	0.00e+00	1618.00
IUUC-Psi-094043	Pelodiscus sinensis	75.25	0.00e+00	1736.00
IUUC-Pma-094394	Petromyzon marinus	67.39	0.00e+00	1518.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.20	1.00e-140	494.00
IUUC-Ppa-095188	Physcomitrella patens	30.65	5.00e-88	319.00
IUUC-Pfo-097517	Poecilia formosa	88.18	0.00e+00	2132.00
IUUC-Pca-100471	Procavia capensis	77.54	0.00e+00	1713.00
IUUC-Pva-102805	Pteropus vampyrus	73.92	0.00e+00	1402.00
IUUC-Pte-104021	Pyrenophora teres	31.53	4.00e-155	542.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.35	3.00e-154	539.00
IUUC-Rno-105471	Rattus norvegicus	75.35	0.00e+00	1796.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.22	7.00e-59	222.00
IUUC-Sha-106883	Sarcophilus harrisii	76.87	0.00e+00	1687.00
IUUC-Spo-108169	Schizosaccharomyces pombe	49.66	1.00e-73	271.00
IUUC-Sar-113323	Sorex araneus	76.28	0.00e+00	1332.00
IUUC-Sre-115075	Sporisorium reilianum	48.20	6.00e-57	216.00
IUUC-Ssc-116363	Sus scrofa	75.02	0.00e+00	1805.00
IUUC-Tru-118427	Takifugu rubripes	87.33	0.00e+00	2145.00
IUUC-Tni-120218	Tetraodon nigroviridis	86.93	0.00e+00	2150.00
IUUC-Tre-122177	Trichoderma reesei	31.43	1.00e-149	524.00
IUUC-Tme-127176	Tuber melanosporum	30.29	6.00e-69	256.00
IUUC-Tbe-127641	Tupaia belangeri	66.46	1.00e-176	613.00
IUUC-Ttr-128888	Tursiops truncatus	76.42	0.00e+00	1117.00
IUUC-Uma-129361	Ustilago maydis	49.10	5.00e-59	223.00
IUUC-Xtr-132811	Xenopus tropicalis	74.94	0.00e+00	1774.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence