iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040948

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AJ851450

Gene Name

PAN2; USP52; RCJMB04_3e13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000031512.1	ENSGALT00000058110.1	ENSGALP00000044566.1
ENSGALG00000031512.1	ENSGALT00000051091.1	ENSGALP00000056405.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-19	69.4	525	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l ++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 525  NAYCNCMIQVLYFLEPVRCLVQN---HLCQK------EFCLGCELGLLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlGLILADSDEAT 604
           56*********************...55654......57********************************999944599999999998 PP
   S: 97   afl.ldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
             + l +l ++ ++    + +++++e+e+ +  +     ++   ++++s+i +lF  ++++  +c +c+++++r ++ l ++l+ p++ 
   Q: 605  GKVnLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGAGSSTFGSSGDSVIGQLFSCEVENCSMC-RCGKETVRVSSTLLFTLSYPESA 690
           6544899999998875433333333333333..4444577888999***************9999.8*******************999 PP
   S: 181  etkkeslqdc.Lesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fct 266
           e+    ++d  ++++ k+   le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k + ++ f + L  +  f +
   Q: 691  EK---PVKDYeFAQILKRSIcLEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKEA--DFWKTQAEYAFQRALMKRGgFEI 774
           87...4444325555555542677778****************************999955444..44589999999877655533555 PP
   S: 267  s...........................................................peekqkekkkYeLiavvvHsG.slssGHY 295
           +                                                           p+++ ++ + Y+L+a vvH   s  +G  
   Q: 775  TkgkeislgdwkelgnpevghsypsveelkniwiphaikmrltknkeldvcnwsesdelsPNDDPESVYVYDLMATVVHILdSRTGGSL 863
           55677777777777777777777777777777777777777777777776666666666655555559*************9******* PP
   S: 296  vayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
           v ++k            ++++W+lf+D  +++v++ e +++    + + +l+Y
   Q: 864  VGHIKVgetyhqrkegvTHQQWYLFNDFLIEPVDKCEAVQFDMswKVPAILYY 916
           ******999988877777888*********99998776665444555555555 PP

Organism

Gallus gallus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPSL AEYAPTLHPA LDPVLDPHLN PSLLQNVELD PEGVPLEGIA VPESVHIVEG 60
MYSELHTAVS EVGVPVSVSH FDLHEEMLWV GNHGGHATSF FGPTLERYSS FQVNSSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGGAAACT GCTGCGGCGG TCTCGGCGCT GCGCCGCTCC CCGCTGCCTC GGGACAGCCG 60
GCTGCTCCCC CCCGCCCCCC GTTTCCCCCG CGTTGCACGC GGCTCCGCAA TCGCGGCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0000175--F:3'-5'-exoribonuclease activity
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

gga:429172

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	85.54	0.00e+00	2060.00
IUUC-Apl-003500	Anas platyrhynchos	97.59	0.00e+00	2111.00
IUUC-Aca-004930	Anolis carolinensis	90.14	0.00e+00	2145.00
IUUC-Acl-008214	Aspergillus clavatus	32.45	1.00e-156	547.00
IUUC-Afu-009112	Aspergillus fumigatus	32.26	4.00e-146	512.00
IUUC-Ang-009531	Aspergillus niger	31.46	2.00e-148	520.00
IUUC-Ame-011259	Astyanax mexicanus	78.44	0.00e+00	1878.00
IUUC-Bta-012371	Bos taurus	86.01	0.00e+00	2067.00
IUUC-Bci-013684	Botrytis cinerea	43.41	1.00e-70	261.00
IUUC-Cja-019297	Callithrix jacchus	82.86	0.00e+00	2000.00
IUUC-Cfa-020489	Canis familiaris	85.60	0.00e+00	2048.00
IUUC-Cpo-022392	Cavia porcellus	85.12	0.00e+00	2068.00
IUUC-Csa-023220	Chlorocebus sabaeus	85.54	0.00e+00	2064.00
IUUC-Csv-025841	Ciona savignyi	46.50	0.00e+00	912.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.70	8.00e-163	567.00
IUUC-Cne-026932	Cryptococcus neoformans	42.62	3.00e-71	263.00
IUUC-Dre-028482	Danio rerio	75.77	0.00e+00	1829.00
IUUC-Dno-029398	Dasypus novemcinctus	85.57	0.00e+00	2056.00
IUUC-Dor-030307	Dipodomys ordii	78.59	0.00e+00	1139.00
IUUC-Dme-032111	Drosophila melanogaster	42.17	0.00e+00	890.00
IUUC-Eca-033985	Equus caballus	86.01	0.00e+00	2066.00
IUUC-Eeu-034928	Erinaceus europaeus	75.60	0.00e+00	702.00
IUUC-Fca-035587	Felis catus	85.45	0.00e+00	2059.00
IUUC-Fal-037587	Ficedula albicollis	95.00	0.00e+00	2205.00
IUUC-Fso-038133	Fusarium solani	30.19	4.00e-133	469.00
IUUC-Gmo-039076	Gadus morhua	75.66	0.00e+00	1800.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.12	6.00e-142	498.00
IUUC-Gac-042396	Gasterosteus aculeatus	76.40	0.00e+00	1855.00
IUUC-Ggo-045412	Gorilla gorilla	85.37	0.00e+00	2057.00
IUUC-Hsa-046076	Homo sapiens	85.54	0.00e+00	2061.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	79.73	0.00e+00	1863.00
IUUC-Kpa-049178	Komagataella pastoris	39.88	8.00e-66	245.00
IUUC-Lch-050279	Latimeria chalumnae	77.93	0.00e+00	927.00
IUUC-Loc-052872	Lepisosteus oculatus	79.21	0.00e+00	1882.00
IUUC-Lma-052986	Leptosphaeria maculans	31.59	3.00e-91	330.00
IUUC-Laf-054181	Loxodonta africana	83.68	0.00e+00	2028.00
IUUC-Mcc-054812	Macaca mulatta	85.60	0.00e+00	2058.00
IUUC-Meu-056325	Macropus eugenii	87.85	0.00e+00	2102.00
IUUC-Mor-057246	Magnaporthe oryzae	29.49	2.00e-121	430.00
IUUC-Mpo-057464	Magnaporthe poae	32.06	2.00e-145	510.00
IUUC-Mla-058911	Melampsora laricipopulina	32.55	5.00e-102	365.00
IUUC-Mga-059335	Meleagris gallopavo	99.65	0.00e+00	2283.00
IUUC-Mvi-060461	Microbotryum violaceum	34.15	1.00e-145	511.00
IUUC-Mmr-060636	Microcebus murinus	85.85	0.00e+00	2061.00
IUUC-Mmu-063503	Mus musculus	84.35	0.00e+00	2018.00
IUUC-Mpu-066670	Mustela putorius furo	85.76	0.00e+00	2058.00
IUUC-Mlu-068119	Myotis lucifugus	85.18	0.00e+00	2088.00
IUUC-Nfi-068398	Neosartorya fischeri	32.93	8.00e-156	544.00
IUUC-Ncr-068927	Neurospora crassa	29.82	6.00e-129	455.00
IUUC-Nle-069651	Nomascus leucogenys	81.73	0.00e+00	1965.00
IUUC-Opr-070614	Ochotona princeps	84.25	0.00e+00	2009.00
IUUC-Ont-072433	Oreochromis niloticus	76.73	0.00e+00	1885.00
IUUC-Oan-073283	Ornithorhynchus anatinus	74.32	0.00e+00	1409.00
IUUC-Ocu-074401	Oryctolagus cuniculus	84.45	0.00e+00	2042.00
IUUC-Ola-087522	Oryzias latipes	76.54	0.00e+00	1837.00
IUUC-Oga-088226	Otolemur garnettii	84.56	0.00e+00	2050.00
IUUC-Oar-089241	Ovis aries	85.70	0.00e+00	2088.00
IUUC-Pan-092297	Papio anubis	85.97	0.00e+00	1845.00
IUUC-Psi-094043	Pelodiscus sinensis	89.22	0.00e+00	2069.00
IUUC-Pma-094394	Petromyzon marinus	70.14	0.00e+00	1578.00
IUUC-Pno-095053	Phaeosphaeria nodorum	32.64	1.00e-148	520.00
IUUC-Ppa-095188	Physcomitrella patens	30.87	1.00e-86	315.00
IUUC-Pfo-097517	Poecilia formosa	77.21	0.00e+00	1885.00
IUUC-Pca-100471	Procavia capensis	85.26	0.00e+00	1931.00
IUUC-Pva-102805	Pteropus vampyrus	81.24	0.00e+00	1601.00
IUUC-Pte-104021	Pyrenophora teres	32.26	2.00e-160	560.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	32.09	8.00e-160	557.00
IUUC-Rno-105471	Rattus norvegicus	84.74	0.00e+00	2025.00
IUUC-Sce-106235	Saccharomyces cerevisiae	36.46	8.00e-61	228.00
IUUC-Sha-106883	Sarcophilus harrisii	87.38	0.00e+00	1941.00
IUUC-Spo-108169	Schizosaccharomyces pombe	31.99	5.00e-140	492.00
IUUC-Sar-113323	Sorex araneus	85.30	0.00e+00	1532.00
IUUC-Sre-115075	Sporisorium reilianum	39.36	5.00e-62	233.00
IUUC-Ssc-116363	Sus scrofa	84.78	0.00e+00	2070.00
IUUC-Tru-118427	Takifugu rubripes	77.19	0.00e+00	1927.00
IUUC-Tni-120218	Tetraodon nigroviridis	77.23	0.00e+00	1917.00
IUUC-Tre-122177	Trichoderma reesei	31.79	4.00e-156	545.00
IUUC-Tme-127176	Tuber melanosporum	32.72	3.00e-142	499.00
IUUC-Tbe-127641	Tupaia belangeri	78.30	0.00e+00	723.00
IUUC-Ttr-128888	Tursiops truncatus	84.13	0.00e+00	1281.00
IUUC-Uma-129361	Ustilago maydis	39.18	1.00e-62	235.00
IUUC-Xtr-132811	Xenopus tropicalis	82.36	0.00e+00	1962.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence