iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054181

UUCD1 version

UUC-LoA-01117

Ensembl Protein ID

ENSLAFP00000019990.1

UniProt Accession

G3TWN2; G3TWN2_LOXAF

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000014873.3	ENSLAFT00000026355.1	ENSLAFP00000019990.1
ENSLAFG00000014873.3	ENSLAFT00000014878.3	ENSLAFP00000012462.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.80e-21	75.4	525	912

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9*****************9999855655555444444 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++           +e +  ++ + a  +  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 605  gkGSLARLIQRWNRFILTQLHQDM-----------QELEVPQAYRGAGGSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 681
           444444444555566666666666...........3334445666688999*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+   r  ++ ++ f+  + +
   Q: 682  TLSYPEDKTGKNYDFAQVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWR--MQAEFAFK--MAI 763
           **********999**99999888766665...69***************************9999666654444..55566655..666 PP
   S: 262  spfcts........peekqke.................................................................... 274
           +++  +                                                                                   
   Q: 764  KKHGGEisknkefaL-----Adwkelgspdgilicpsieelknvwlpfsirmkmtknkgldvcnwtdgdelsslgpsqwgparaeeehg 847
           666666333444440.....055555555555555555555555555555555555555666666666666666666666666666666 PP
   S: 275  kkkYeLiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
            + Y+L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 848  VYVYDLMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 912
           9*************9*************999988877777888************9999888654 PP

Organism

Loxodonta africana

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGGDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTTCG AGGGTCTGGA CCCTGGACTG GCAGAGTATG CTCCGGCCAT GCATTCTGCC 60
CTGGACCCTG TTCTGGATGC CCACCTGAAC CCAAGTCTGC TGCAGAATGT GGAACTGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	95.53	0.00e+00	2274.00
IUUC-Apl-003500	Anas platyrhynchos	83.19	0.00e+00	1831.00
IUUC-Aca-004930	Anolis carolinensis	82.59	0.00e+00	1973.00
IUUC-Acl-008214	Aspergillus clavatus	31.09	1.00e-151	530.00
IUUC-Afu-009112	Aspergillus fumigatus	31.27	6.00e-143	501.00
IUUC-Ang-009531	Aspergillus niger	30.76	1.00e-144	507.00
IUUC-Ame-011259	Astyanax mexicanus	73.91	0.00e+00	1778.00
IUUC-Bta-012371	Bos taurus	95.68	0.00e+00	2280.00
IUUC-Bci-013684	Botrytis cinerea	43.04	8.00e-72	265.00
IUUC-Cja-019297	Callithrix jacchus	92.57	0.00e+00	2213.00
IUUC-Cfa-020489	Canis familiaris	95.43	0.00e+00	2263.00
IUUC-Cpo-022392	Cavia porcellus	94.21	0.00e+00	2268.00
IUUC-Csa-023220	Chlorocebus sabaeus	95.45	0.00e+00	2285.00
IUUC-Csv-025841	Ciona savignyi	44.60	0.00e+00	863.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	29.40	1.00e-82	301.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	6.00e-73	269.00
IUUC-Dre-028482	Danio rerio	71.84	0.00e+00	1727.00
IUUC-Dno-029398	Dasypus novemcinctus	95.02	0.00e+00	2260.00
IUUC-Dor-030307	Dipodomys ordii	89.37	0.00e+00	1295.00
IUUC-Dme-032111	Drosophila melanogaster	40.93	0.00e+00	850.00
IUUC-Eca-033985	Equus caballus	96.01	0.00e+00	2283.00
IUUC-Eeu-034928	Erinaceus europaeus	79.96	0.00e+00	719.00
IUUC-Fca-035587	Felis catus	95.53	0.00e+00	2276.00
IUUC-Fal-037587	Ficedula albicollis	82.84	0.00e+00	1938.00
IUUC-Fso-038133	Fusarium solani	42.00	6.00e-77	282.00
IUUC-Gmo-039076	Gadus morhua	71.39	0.00e+00	1691.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.06	2.00e-134	474.00
IUUC-Gga-040948	Gallus gallus	83.68	0.00e+00	2006.00
IUUC-Gac-042396	Gasterosteus aculeatus	72.32	0.00e+00	1737.00
IUUC-Ggo-045412	Gorilla gorilla	95.45	0.00e+00	2281.00
IUUC-Hsa-046076	Homo sapiens	95.45	0.00e+00	2286.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	89.46	0.00e+00	2083.00
IUUC-Kpa-049178	Komagataella pastoris	40.82	7.00e-67	249.00
IUUC-Lch-050279	Latimeria chalumnae	70.92	0.00e+00	1656.00
IUUC-Loc-052872	Lepisosteus oculatus	74.37	0.00e+00	1778.00
IUUC-Lma-052986	Leptosphaeria maculans	32.56	6.00e-153	535.00
IUUC-Mcc-054812	Macaca mulatta	95.76	0.00e+00	2283.00
IUUC-Meu-056325	Macropus eugenii	90.23	0.00e+00	2152.00
IUUC-Mor-057246	Magnaporthe oryzae	27.02	2.00e-61	231.00
IUUC-Mpo-057464	Magnaporthe poae	31.90	4.00e-136	479.00
IUUC-Mla-058911	Melampsora laricipopulina	40.48	3.00e-69	257.00
IUUC-Mga-059335	Meleagris gallopavo	84.22	0.00e+00	1957.00
IUUC-Mvi-060461	Microbotryum violaceum	34.20	4.00e-142	499.00
IUUC-Mmr-060636	Microcebus murinus	95.76	0.00e+00	2281.00
IUUC-Mmu-063503	Mus musculus	94.68	0.00e+00	2244.00
IUUC-Mpu-066670	Mustela putorius furo	96.10	0.00e+00	2282.00
IUUC-Mlu-068119	Myotis lucifugus	94.85	0.00e+00	2293.00
IUUC-Nfi-068398	Neosartorya fischeri	31.94	2.00e-152	533.00
IUUC-Ncr-068927	Neurospora crassa	30.13	3.00e-124	439.00
IUUC-Nle-069651	Nomascus leucogenys	91.56	0.00e+00	2182.00
IUUC-Opr-070614	Ochotona princeps	94.14	0.00e+00	2223.00
IUUC-Ont-072433	Oreochromis niloticus	72.45	0.00e+00	1785.00
IUUC-Oan-073283	Ornithorhynchus anatinus	72.32	0.00e+00	1389.00
IUUC-Ocu-074401	Oryctolagus cuniculus	95.27	0.00e+00	2275.00
IUUC-Ola-087522	Oryzias latipes	72.30	0.00e+00	1733.00
IUUC-Oga-088226	Otolemur garnettii	95.77	0.00e+00	2299.00
IUUC-Oar-089241	Ovis aries	95.45	0.00e+00	2297.00
IUUC-Pan-092297	Papio anubis	95.59	0.00e+00	2038.00
IUUC-Psi-094043	Pelodiscus sinensis	80.66	0.00e+00	1869.00
IUUC-Pma-094394	Petromyzon marinus	67.40	0.00e+00	1502.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.66	6.00e-143	501.00
IUUC-Ppa-095188	Physcomitrella patens	32.37	6.00e-153	535.00
IUUC-Pfo-097517	Poecilia formosa	73.11	0.00e+00	1791.00
IUUC-Pca-100471	Procavia capensis	94.96	0.00e+00	2128.00
IUUC-Pva-102805	Pteropus vampyrus	90.41	0.00e+00	1771.00
IUUC-Pte-104021	Pyrenophora teres	30.75	3.00e-89	323.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	30.46	6.00e-88	319.00
IUUC-Rno-105471	Rattus norvegicus	93.60	0.00e+00	2223.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.76	3.00e-60	227.00
IUUC-Sha-106883	Sarcophilus harrisii	89.96	0.00e+00	2000.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.05	6.00e-139	488.00
IUUC-Sar-113323	Sorex araneus	95.09	0.00e+00	1708.00
IUUC-Sre-115075	Sporisorium reilianum	38.19	1.00e-61	232.00
IUUC-Ssc-116363	Sus scrofa	95.68	0.00e+00	2308.00
IUUC-Tru-118427	Takifugu rubripes	72.41	0.00e+00	1801.00
IUUC-Tni-120218	Tetraodon nigroviridis	72.67	0.00e+00	1802.00
IUUC-Tre-122177	Trichoderma reesei	31.06	6.00e-145	508.00
IUUC-Tme-127176	Tuber melanosporum	32.51	2.00e-135	476.00
IUUC-Tbe-127641	Tupaia belangeri	83.77	0.00e+00	752.00
IUUC-Ttr-128888	Tursiops truncatus	95.76	0.00e+00	1464.00
IUUC-Uma-129361	Ustilago maydis	38.71	3.00e-64	241.00
IUUC-Xtr-132811	Xenopus tropicalis	76.96	0.00e+00	1854.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence