iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ppa-095188

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

DS544947

Gene Name

PAN2; PHYPADRAFT_76382

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PP1S58_255V6	PP1S58_255V6.1	PP1S58_255V6.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-09	37.1	480	551

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeae 82
           Gl+N     Y+N++LQ+L++ip l+ ++ +   + +++      + +l+++l  +++ l   + +  +p++ll+al++++e
   Q: 480  GLENDIVNSYCNALLQVLYFIPALQAAVTS---HVCER------EFCLTCELGFVLHMLDVAQGGTCQPSNLLRALRQIKE 551
           9*****************************...66665......57***********9999999***********999876 PP

Organism

Physcomitrella patens

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MVRAKLRELA YVTQQRANEP VCCTLFDPLL DLLWTASSAG SLHSFICPTL DKYSFFGAHP 60
SAVVGLLGAA EGILSVSSEY VRMHTRGGVS LMSFSRDDDV LGITCCDWER PGAGRVLIGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTACGTG CTAAGCTTAG AGAGTTGGCG TACGTCACTC AGCAGCGTGC CAATGAACCC 60
GTCTGTTGTA CCCTCTTTGA TCCGCTTTTG GATCTTCTGT GGACAGCCTC TTCTGCTGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

ppp:PHYPADRAFT_76382

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	32.37	4.00e-158	551.00
IUUC-Apl-003500	Anas platyrhynchos	30.26	2.00e-138	486.00
IUUC-Aca-004930	Anolis carolinensis	31.85	5.00e-167	581.00
IUUC-Acl-008214	Aspergillus clavatus	29.21	5.00e-121	428.00
IUUC-Afu-009112	Aspergillus fumigatus	28.98	5.00e-113	402.00
IUUC-Ang-009531	Aspergillus niger	28.66	7.00e-115	408.00
IUUC-Ame-011259	Astyanax mexicanus	30.71	6.00e-88	318.00
IUUC-Bta-012371	Bos taurus	32.39	1.00e-159	556.00
IUUC-Bci-013684	Botrytis cinerea	40.40	2.00e-54	207.00
IUUC-Cja-019297	Callithrix jacchus	32.26	5.00e-158	551.00
IUUC-Cfa-020489	Canis familiaris	32.26	1.00e-157	550.00
IUUC-Cpo-022392	Cavia porcellus	32.14	1.00e-159	556.00
IUUC-Csa-023220	Chlorocebus sabaeus	32.65	2.00e-159	556.00
IUUC-Csv-025841	Ciona savignyi	32.38	3.00e-67	249.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	26.39	6.00e-67	248.00
IUUC-Cne-026932	Cryptococcus neoformans	27.59	3.00e-56	213.00
IUUC-Dre-028482	Danio rerio	31.94	1.00e-160	560.00
IUUC-Dno-029398	Dasypus novemcinctus	32.04	2.00e-158	553.00
IUUC-Dor-030307	Dipodomys ordii	32.27	8.00e-102	364.00
IUUC-Dme-032111	Drosophila melanogaster	41.54	8.00e-66	245.00
IUUC-Eca-033985	Equus caballus	32.01	3.00e-158	552.00
IUUC-Eeu-034928	Erinaceus europaeus	28.81	4.00e-34	139.00
IUUC-Fca-035587	Felis catus	32.51	2.00e-160	559.00
IUUC-Fal-037587	Ficedula albicollis	31.39	2.00e-158	552.00
IUUC-Fso-038133	Fusarium solani	41.61	2.00e-60	227.00
IUUC-Gmo-039076	Gadus morhua	31.34	9.00e-157	547.00
IUUC-Ggr-039957	Gaeumannomyces graminis	27.97	3.00e-67	249.00
IUUC-Gga-040948	Gallus gallus	31.64	2.00e-157	549.00
IUUC-Gac-042396	Gasterosteus aculeatus	32.49	2.00e-159	556.00
IUUC-Ggo-045412	Gorilla gorilla	32.26	7.00e-158	551.00
IUUC-Hsa-046076	Homo sapiens	32.26	6.00e-158	551.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.33	1.00e-137	483.00
IUUC-Kpa-049178	Komagataella pastoris	37.54	2.00e-51	197.00
IUUC-Lch-050279	Latimeria chalumnae	32.46	1.00e-78	287.00
IUUC-Loc-052872	Lepisosteus oculatus	32.10	3.00e-159	555.00
IUUC-Lma-052986	Leptosphaeria maculans	29.19	2.00e-124	439.00
IUUC-Laf-054181	Loxodonta africana	32.39	9.00e-156	543.00
IUUC-Mcc-054812	Macaca mulatta	32.45	1.00e-158	553.00
IUUC-Meu-056325	Macropus eugenii	32.26	9.00e-161	560.00
IUUC-Mor-057246	Magnaporthe oryzae	26.59	2.00e-61	230.00
IUUC-Mpo-057464	Magnaporthe poae	29.43	1.00e-126	447.00
IUUC-Mla-058911	Melampsora laricipopulina	40.38	1.00e-58	221.00
IUUC-Mga-059335	Meleagris gallopavo	31.94	3.00e-153	535.00
IUUC-Mvi-060461	Microbotryum violaceum	30.56	3.00e-116	412.00
IUUC-Mmr-060636	Microcebus murinus	32.34	1.00e-157	550.00
IUUC-Mmu-063503	Mus musculus	31.99	1.00e-161	563.00
IUUC-Mpu-066670	Mustela putorius furo	32.51	4.00e-159	555.00
IUUC-Mlu-068119	Myotis lucifugus	32.62	5.00e-166	578.00
IUUC-Nfi-068398	Neosartorya fischeri	29.71	2.00e-120	426.00
IUUC-Ncr-068927	Neurospora crassa	39.20	8.00e-59	221.00
IUUC-Nle-069651	Nomascus leucogenys	31.63	1.00e-149	523.00
IUUC-Opr-070614	Ochotona princeps	32.26	3.00e-159	555.00
IUUC-Ont-072433	Oreochromis niloticus	32.35	6.00e-163	568.00
IUUC-Oan-073283	Ornithorhynchus anatinus	31.11	2.00e-125	442.00
IUUC-Ocu-074401	Oryctolagus cuniculus	32.06	1.00e-159	556.00
IUUC-Ola-087522	Oryzias latipes	31.92	4.00e-161	561.00
IUUC-Oga-088226	Otolemur garnettii	32.31	3.00e-161	562.00
IUUC-Oar-089241	Ovis aries	32.43	2.00e-160	559.00
IUUC-Pan-092297	Papio anubis	33.06	8.00e-152	530.00
IUUC-Psi-094043	Pelodiscus sinensis	30.56	2.00e-146	513.00
IUUC-Pma-094394	Petromyzon marinus	31.14	2.00e-152	532.00
IUUC-Pno-095053	Phaeosphaeria nodorum	28.92	2.00e-114	406.00
IUUC-Pfo-097517	Poecilia formosa	32.12	5.00e-165	574.00
IUUC-Pca-100471	Procavia capensis	32.11	3.00e-157	548.00
IUUC-Pva-102805	Pteropus vampyrus	33.93	2.00e-103	370.00
IUUC-Pte-104021	Pyrenophora teres	28.38	3.00e-121	429.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	28.29	1.00e-120	427.00
IUUC-Rno-105471	Rattus norvegicus	32.34	2.00e-161	562.00
IUUC-Sce-106235	Saccharomyces cerevisiae	46.70	6.00e-47	182.00
IUUC-Sha-106883	Sarcophilus harrisii	31.94	2.00e-153	536.00
IUUC-Spo-108169	Schizosaccharomyces pombe	28.77	3.00e-68	253.00
IUUC-Sar-113323	Sorex araneus	33.51	3.00e-128	452.00
IUUC-Sre-115075	Sporisorium reilianum	44.05	4.00e-49	190.00
IUUC-Ssc-116363	Sus scrofa	32.34	3.00e-160	558.00
IUUC-Tru-118427	Takifugu rubripes	32.06	1.00e-164	573.00
IUUC-Tni-120218	Tetraodon nigroviridis	32.38	2.00e-165	575.00
IUUC-Tre-122177	Trichoderma reesei	26.70	1.00e-65	244.00
IUUC-Tme-127176	Tuber melanosporum	28.71	7.00e-114	404.00
IUUC-Tbe-127641	Tupaia belangeri	32.34	4.00e-26	113.00
IUUC-Ttr-128888	Tursiops truncatus	35.09	7.00e-117	414.00
IUUC-Uma-129361	Ustilago maydis	31.93	6.00e-56	212.00
IUUC-Xtr-132811	Xenopus tropicalis	31.47	2.00e-161	562.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence