iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/JAMM	1.10e-07	31.7	135	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/JAMM

   S: 1    HSHPgftcwlSsVD 14
           HSHPg++cwlS++D
   Q: 135  HSHPGYGCWLSGID 148
           *************9 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis. Also involved in regulation of axis formation by checkpoint-dependent, translational control of Gurken.

Protein Sequence
(Fasta)

MDSDAAQKTW ELENNIQTLP SCDEIFRYDA EQQRQIIDAK PWEKDPHFFK DIKISALALL 60
KMVMHARSGG TLEVMGLMLG KVEDNTMIVM DAFALPVEGT ETRVNAQAQA YEYMTAYMEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAGTTCAT CTCTAGAATT GAGCCGGAAA ACAAAAACTT GCAACAAAAG ACTACAATTT 60
TCGGCATAAG TACAATCACA ATGGACTCCG ACGCCGCACA AAAGACCTGG GAGCTGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0896--Oogenesis
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0862--Zinc

Interpro

IPR000555--JAMM/MPN+_dom

Pfam

PF01398--JAB

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0034399--C:nuclear periphery
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0019781--F:NEDD8 activating enzyme activity
GO:0019784--F:NEDD8-specific protease activity
GO:0007409--P:axonogenesis
GO:0001751--P:compound eye photoreceptor cell differentiation
GO:0036099--P:female germ-line stem cell population maintenance
GO:0007281--P:germ cell development
GO:0048142--P:germarium-derived cystoblast division
GO:0008347--P:glial cell migration
GO:0048140--P:male germ-line cyst encapsulation
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0007275--P:multicellular organism development
GO:0035207--P:negative regulation of hemocyte proliferation
GO:0035204--P:negative regulation of lamellocyte differentiation
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0007310--P:oocyte dorsal/ventral axis specification
GO:0048477--P:oogenesis
GO:0045787--P:positive regulation of cell cycle
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:0000338--P:protein deneddylation
GO:0050821--P:protein stabilization

KEGG

dme:Dmel_CG14884

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000468	Aegilops tauschii	63.55	1.00e-119	422.00
IUUC-Aml-001429	Ailuropoda melanoleuca	75.00	6.00e-139	486.00
IUUC-Atr-003048	Amborella trichopoda	66.06	6.00e-127	446.00
IUUC-Apl-003610	Anas platyrhynchos	74.43	3.00e-127	447.00
IUUC-Aca-004662	Anolis carolinensis	76.84	9.00e-123	431.00
IUUC-Aly-005914	Arabidopsis lyrata	67.17	3.00e-127	447.00
IUUC-Ath-007496	Arabidopsis thaliana	65.47	5.00e-124	436.00
IUUC-Ago-007860	Ashbya gossypii	44.49	7.00e-54	203.00
IUUC-Acl-008155	Aspergillus clavatus	56.57	3.00e-105	374.00
IUUC-Afu-008820	Aspergillus fumigatus	56.53	7.00e-107	379.00
IUUC-Ani-009303	Aspergillus nidulans	56.06	2.00e-107	380.00
IUUC-Ang-009617	Aspergillus niger	55.10	3.00e-99	353.00
IUUC-Aor-009888	Aspergillus oryzae	55.73	1.00e-102	365.00
IUUC-Ate-010575	Aspergillus terreus	56.67	5.00e-108	383.00
IUUC-Ame-010617	Astyanax mexicanus	74.85	1.00e-139	488.00
IUUC-Bgr-012019	Blumeria graminis	54.29	2.00e-102	364.00
IUUC-Bta-013211	Bos taurus	74.70	6.00e-140	489.00
IUUC-Bci-013645	Botrytis cinerea	55.79	3.00e-108	384.00
IUUC-Bdi-014727	Brachypodium distachyon	64.76	6.00e-118	416.00
IUUC-Bol-015205	Brassica oleracea	65.26	4.00e-122	430.00
IUUC-Bra-017649	Brassica rapa	65.26	4.00e-122	430.00
IUUC-Cel-018469	Caenorhabditis elegans	58.51	4.00e-113	400.00
IUUC-Cja-019703	Callithrix jacchus	74.70	7.00e-140	489.00
IUUC-Cfa-020181	Canis familiaris	74.70	8.00e-140	488.00
IUUC-Cpo-021499	Cavia porcellus	74.70	7.00e-140	489.00
IUUC-Cre-022735	Chlamydomonas reinhardtii	59.44	6.00e-115	405.00
IUUC-Csa-024200	Chlorocebus sabaeus	74.70	7.00e-140	489.00
IUUC-Cho-024915	Choloepus hoffmanni	73.43	6.00e-92	329.00
IUUC-Cin-025353	Ciona intestinalis	70.90	3.00e-125	440.00
IUUC-Csv-026118	Ciona savignyi	70.15	1.00e-125	441.00
IUUC-Cgl-026511	Colletotrichum gloeosporioides	49.26	2.00e-95	341.00
IUUC-Cne-026988	Cryptococcus neoformans	48.57	6.00e-93	333.00
IUUC-Dre-028134	Danio rerio	74.54	7.00e-139	485.00
IUUC-Dno-029658	Dasypus novemcinctus	74.70	7.00e-140	489.00
IUUC-Dor-031074	Dipodomys ordii	74.70	7.00e-140	489.00
IUUC-Dse-031497	Dothistroma septosporum	52.45	1.00e-99	355.00
IUUC-Ete-032739	Echinops telfairi	77.44	6.00e-66	243.00
IUUC-Eca-034095	Equus caballus	74.70	6.00e-140	489.00
IUUC-Eeu-034934	Erinaceus europaeus	79.42	3.00e-111	394.00
IUUC-Fca-035569	Felis catus	74.70	7.00e-140	489.00
IUUC-Fal-037553	Ficedula albicollis	77.19	4.00e-123	432.00
IUUC-Fox-037945	Fusarium oxysporum	48.63	9.00e-94	335.00
IUUC-Fso-038385	Fusarium solani	49.85	2.00e-97	348.00
IUUC-Gmo-039438	Gadus morhua	75.54	8.00e-137	478.00
IUUC-Ggr-039968	Gaeumannomyces graminis	56.23	9.00e-98	349.00
IUUC-Gga-040344	Gallus gallus	75.08	4.00e-139	486.00
IUUC-Gac-042256	Gasterosteus aculeatus	74.54	2.00e-136	477.00
IUUC-Gma-043226	Glycine max	64.14	6.00e-123	432.00
IUUC-Ggo-044523	Gorilla gorilla	68.90	6.00e-123	432.00
IUUC-Hsa-046659	Homo sapiens	74.70	7.00e-140	489.00
IUUC-Itr-048834	Ictidomys tridecemlineatus	75.15	1.00e-139	488.00
IUUC-Kpa-049139	Komagataella pastoris	58.49	3.00e-59	221.00
IUUC-Lch-049562	Latimeria chalumnae	75.46	1.00e-140	491.00
IUUC-Lpe-050737	Leersia perrieri	63.64	4.00e-123	433.00
IUUC-Loc-051798	Lepisosteus oculatus	74.38	1.00e-135	474.00
IUUC-Lma-052979	Leptosphaeria maculans	53.69	5.00e-100	357.00
IUUC-Laf-053391	Loxodonta africana	79.53	8.00e-96	342.00
IUUC-Mcc-055667	Macaca mulatta	74.70	7.00e-140	489.00
IUUC-Meu-056067	Macropus eugenii	53.31	9.00e-60	222.00
IUUC-Mor-057084	Magnaporthe oryzae	50.75	1.00e-98	352.00
IUUC-Mpo-057347	Magnaporthe poae	50.59	1.00e-100	358.00
IUUC-Mtr-057781	Medicago truncatula	66.67	8.00e-126	442.00
IUUC-Mla-059106	Melampsora laricipopulina	51.30	2.00e-106	377.00
IUUC-Mga-059473	Meleagris gallopavo	77.19	4.00e-123	432.00
IUUC-Mvi-060540	Microbotryum violaceum	52.62	2.00e-110	391.00
IUUC-Mmr-061138	Microcebus murinus	81.62	6.00e-85	305.00
IUUC-Mdo-062893	Monodelphis domestica	74.39	1.00e-139	488.00
IUUC-Mmu-063637	Mus musculus	74.47	8.00e-140	488.00
IUUC-Mac-064683	Musa acuminata	62.57	5.00e-124	436.00
IUUC-Mpu-066096	Mustela putorius furo	65.34	2.00e-111	394.00
IUUC-Mlu-067872	Myotis lucifugus	72.87	3.00e-134	470.00
IUUC-Nfi-068443	Neosartorya fischeri	56.23	1.00e-105	375.00
IUUC-Ncr-068953	Neurospora crassa	49.35	8.00e-92	329.00
IUUC-Nle-068972	Nomascus leucogenys	74.70	7.00e-140	489.00
IUUC-Opr-070215	Ochotona princeps	65.75	1.00e-115	408.00
IUUC-Ont-072538	Oreochromis niloticus	74.85	2.00e-136	478.00
IUUC-Oan-073143	Ornithorhynchus anatinus	74.39	2.00e-139	487.00
IUUC-Ocu-074197	Oryctolagus cuniculus	74.70	7.00e-140	489.00
IUUC-Oba-075884	Oryza barthii	59.89	2.00e-117	415.00
IUUC-Obr-076874	Oryza brachyantha	63.75	2.00e-121	427.00
IUUC-Ogl-077169	Oryza glaberrima	64.74	2.00e-121	428.00
IUUC-Ogu-078258	Oryza glumaepatula	64.74	2.00e-121	427.00
IUUC-Oin-079101	Oryza indica	60.17	6.00e-118	416.00
IUUC-Olo-080708	Oryza longistaminata	51.69	1.00e-92	332.00
IUUC-Ome-081571	Oryza meridionalis	60.17	7.00e-118	416.00
IUUC-Oni-082888	Oryza nivara	60.17	6.00e-118	416.00
IUUC-Opu-083182	Oryza punctata	64.74	2.00e-121	428.00
IUUC-Oru-084895	Oryza rufipogon	60.17	6.00e-118	416.00
IUUC-Osa-085331	Oryza sativa	64.74	2.00e-121	428.00
IUUC-Ola-086850	Oryzias latipes	74.85	6.00e-137	479.00
IUUC-Olu-087607	Ostreococcus lucimarinus	58.80	5.00e-89	320.00
IUUC-Oga-088640	Otolemur garnettii	75.00	5.00e-139	486.00
IUUC-Oar-090299	Ovis aries	75.00	7.00e-139	485.00
IUUC-Ptr-091499	Pan troglodytes	74.70	7.00e-140	489.00
IUUC-Pan-091751	Papio anubis	77.11	3.00e-122	430.00
IUUC-Psi-092978	Pelodiscus sinensis	73.85	7.00e-138	482.00
IUUC-Pma-094634	Petromyzon marinus	74.92	2.00e-138	483.00
IUUC-Pno-095094	Phaeosphaeria nodorum	51.94	2.00e-99	354.00
IUUC-Ppa-095440	Physcomitrella patens	65.96	7.00e-129	452.00
IUUC-Pfo-097332	Poecilia formosa	74.85	8.00e-137	478.00
IUUC-Pab-097998	Pongo abelii	74.70	7.00e-140	489.00
IUUC-Pop-098905	Populus trichocarpa	63.72	4.00e-130	456.00
IUUC-Pca-100521	Procavia capensis	74.78	9.00e-45	172.00
IUUC-Ppe-101309	Prunus persica	64.62	4.00e-132	463.00
IUUC-Pva-102953	Pteropus vampyrus	74.70	7.00e-140	489.00
IUUC-Pgr-103452	Puccinia graminis	61.40	2.00e-96	344.00
IUUC-Ptt-103777	Puccinia triticina	61.04	2.00e-91	328.00
IUUC-Pte-104273	Pyrenophora teres	53.75	6.00e-103	366.00
IUUC-Pyt-104627	Pyrenophora triticirepentis	54.27	2.00e-101	361.00
IUUC-Rno-105666	Rattus norvegicus	74.47	6.00e-139	486.00
IUUC-Sha-106602	Sarcophilus harrisii	74.39	1.00e-139	488.00
IUUC-Sja-107822	Schizosaccharomyces japonicus	45.41	1.00e-49	189.00
IUUC-Spo-108318	Schizosaccharomyces pombe	41.97	5.00e-69	253.00
IUUC-Ssl-108428	Sclerotinia sclerotiorum	56.40	1.00e-108	385.00
IUUC-Smo-108821	Selaginella moellendorffii	64.39	1.00e-126	445.00
IUUC-Sit-110526	Setaria italica	62.73	2.00e-115	408.00
IUUC-Sly-110851	Solanum lycopersicum	66.07	3.00e-132	463.00
IUUC-Stu-112151	Solanum tuberosum	65.77	2.00e-131	461.00
IUUC-Sar-113459	Sorex araneus	74.47	7.00e-140	489.00
IUUC-Sbi-114873	Sorghum bicolor	63.94	1.00e-119	422.00
IUUC-Sre-114919	Sporisorium reilianum	63.33	1.00e-99	355.00
IUUC-Ssc-116102	Sus scrofa	74.70	7.00e-140	489.00
IUUC-Tgu-116937	Taeniopygia guttata	79.77	6.00e-112	395.00
IUUC-Tru-118615	Takifugu rubripes	75.15	2.00e-137	480.00
IUUC-Tsy-119173	Tarsius syrichta	75.57	6.00e-130	456.00
IUUC-Tni-120246	Tetraodon nigroviridis	75.15	2.00e-137	481.00
IUUC-Tca-121859	Theobroma cacao	66.87	2.00e-131	461.00
IUUC-Tre-122030	Trichoderma reesei	50.62	6.00e-99	353.00
IUUC-Tvi-122506	Trichoderma virens	51.49	5.00e-99	353.00
IUUC-Tae-125382	Triticum aestivum	63.25	4.00e-119	420.00
IUUC-Tur-126517	Triticum urartu	64.94	4.00e-116	409.00
IUUC-Tme-127122	Tuber melanosporum	54.22	2.00e-107	381.00
IUUC-Tbe-128108	Tupaia belangeri	74.09	7.00e-136	475.00
IUUC-Ttr-128644	Tursiops truncatus	74.70	7.00e-140	489.00
IUUC-Uma-129390	Ustilago maydis	51.61	2.00e-100	358.00
IUUC-Vda-129932	Verticillium dahliae	48.28	8.00e-95	339.00
IUUC-Vpa-130110	Vicugna pacos	74.70	7.00e-140	489.00
IUUC-Vvi-131534	Vitis vinifera	65.65	1.00e-128	451.00
IUUC-Xtr-132739	Xenopus tropicalis	74.54	7.00e-140	489.00
IUUC-Xma-133919	Xiphophorus maculatus	74.85	8.00e-137	478.00
IUUC-Yli-134677	Yarrowia lipolytica	51.50	6.00e-92	329.00
IUUC-Zma-135578	Zea mays	64.24	3.00e-120	424.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence