iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106952

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01177359

Gene Name

WSB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000003955.1	ENSSHAT00000004544.1	ENSSHAP00000004498.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-13	50.6	375	420
E3 adaptor/Cullin RING/DCX/DWD	7.90e-32	108.1	169	203
UBD/Beta-Prp	3.50e-48	164.5	134	379

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++ +++SLqhLCR++Irr + + ++   +kL  P++L ++L y+
   Q: 375  VYFWATPKQVPSLQHLCRMSIRRVMSTGEV---QKLSVPPKLLEFLCYQ 420
           689************************777...*************997 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
            kf +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh++ v+s+sf
   Q: 134  FKFGQDQLLLATGLSNGRIKIWDVYTGKLLLNLMDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHQNWVYSCSF 222
           68899999***********************************************************9799****************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tggh 179
           sp+++ l s ++ + + +w++++++ ++  l+gh+  v   +++pdg ll+++s D+ v +Wd   g++l ++             g++
   Q: 223  SPDSSMLCSVGASKAVFLWNMDKYTMIR-KLEGHHNDVVACEFSPDGALLATASHDTRVYVWDPHIGSILMEFghlfppptpifaGGAN 310
           ****************************.999999999999********************************************889* PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           ++ v+ lsf+++g +++s ++d+ v++w + + +    + +  +n ++ +fs ++  l+ g+sDgs+++W 
   Q: 311  DGWVRALSFSHDGLHIASLADDKMVRFWRIDEDH--PVQVATLSNGLCCAFSTDGSVLAAGTSDGSVYFWA 379
           ******************************9997..5678889999999*********************4 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MNQVTESALF LSLVRSRTIG ELLAPAAPFD KKCGHENWTV AFAPDGSYFA WSQGHRTVKL 60
VPWSQCLKNF LLHGTKNVTN SSNSRLSRQN SFGVSKNKPC EHVIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATCAGG TCACTGAGAG TGCTCTTTTC TTGTCTTTAG TGAGATCCCG TACCATAGGA 60
GAACTTTTGG CCCCGGCAGC TCCTTTTGAC AAGAAATGTG GTCATGAAAA CTGGACGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR023294--Tachylectin2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	90.00	0.00e+00	756.00
IUUC-Apl-003903	Anas platyrhynchos	86.99	0.00e+00	763.00
IUUC-Aca-005214	Anolis carolinensis	76.94	0.00e+00	674.00
IUUC-Ame-011740	Astyanax mexicanus	74.45	0.00e+00	657.00
IUUC-Bta-013475	Bos taurus	90.73	0.00e+00	761.00
IUUC-Cja-019053	Callithrix jacchus	90.71	0.00e+00	776.00
IUUC-Cfa-020103	Canis familiaris	90.49	0.00e+00	759.00
IUUC-Cpo-022438	Cavia porcellus	89.76	0.00e+00	774.00
IUUC-Csa-024062	Chlorocebus sabaeus	90.98	0.00e+00	781.00
IUUC-Cho-024334	Choloepus hoffmanni	80.24	0.00e+00	651.00
IUUC-Cin-025590	Ciona intestinalis	40.45	1.00e-79	289.00
IUUC-Csv-026023	Ciona savignyi	39.47	2.00e-78	285.00
IUUC-Dre-028089	Danio rerio	73.46	0.00e+00	645.00
IUUC-Dno-029436	Dasypus novemcinctus	85.95	0.00e+00	632.00
IUUC-Dor-031107	Dipodomys ordii	83.90	0.00e+00	685.00
IUUC-Ete-032326	Echinops telfairi	90.17	0.00e+00	749.00
IUUC-Eca-033401	Equus caballus	89.76	0.00e+00	756.00
IUUC-Eeu-034520	Erinaceus europaeus	88.02	0.00e+00	763.00
IUUC-Fca-036386	Felis catus	90.49	0.00e+00	760.00
IUUC-Fal-036616	Ficedula albicollis	84.50	0.00e+00	741.00
IUUC-Gmo-039335	Gadus morhua	71.74	3.00e-178	617.00
IUUC-Gga-040856	Gallus gallus	87.53	0.00e+00	766.00
IUUC-Gac-042140	Gasterosteus aculeatus	73.30	0.00e+00	640.00
IUUC-Ggo-044619	Gorilla gorilla	90.49	0.00e+00	780.00
IUUC-Hsa-046300	Homo sapiens	90.24	0.00e+00	778.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	90.98	0.00e+00	782.00
IUUC-Lch-049550	Latimeria chalumnae	80.35	2.00e-169	587.00
IUUC-Loc-051769	Lepisosteus oculatus	75.31	0.00e+00	653.00
IUUC-Laf-054576	Loxodonta africana	90.98	0.00e+00	763.00
IUUC-Mcc-054666	Macaca mulatta	91.22	2.00e-143	501.00
IUUC-Meu-055989	Macropus eugenii	94.86	0.00e+00	684.00
IUUC-Mga-059722	Meleagris gallopavo	87.47	0.00e+00	768.00
IUUC-Mmr-060970	Microcebus murinus	90.00	0.00e+00	753.00
IUUC-Mdo-062249	Monodelphis domestica	83.98	0.00e+00	661.00
IUUC-Mmu-063742	Mus musculus	88.73	0.00e+00	756.00
IUUC-Mpu-066518	Mustela putorius furo	90.49	0.00e+00	782.00
IUUC-Mlu-068063	Myotis lucifugus	89.76	0.00e+00	751.00
IUUC-Nle-069561	Nomascus leucogenys	90.00	0.00e+00	777.00
IUUC-Opr-071158	Ochotona princeps	89.22	0.00e+00	764.00
IUUC-Ont-072542	Oreochromis niloticus	71.84	0.00e+00	626.00
IUUC-Oan-073217	Ornithorhynchus anatinus	91.44	0.00e+00	773.00
IUUC-Ocu-074251	Oryctolagus cuniculus	89.07	0.00e+00	768.00
IUUC-Ola-086549	Oryzias latipes	71.01	0.00e+00	628.00
IUUC-Oga-088382	Otolemur garnettii	90.73	0.00e+00	767.00
IUUC-Oar-090263	Ovis aries	89.49	0.00e+00	763.00
IUUC-Ptr-090922	Pan troglodytes	90.00	0.00e+00	777.00
IUUC-Pan-092518	Papio anubis	90.98	0.00e+00	781.00
IUUC-Psi-093512	Pelodiscus sinensis	88.26	0.00e+00	760.00
IUUC-Pma-094324	Petromyzon marinus	57.48	3.00e-133	468.00
IUUC-Pfo-096264	Poecilia formosa	72.46	0.00e+00	638.00
IUUC-Pab-098018	Pongo abelii	88.54	0.00e+00	761.00
IUUC-Pca-101034	Procavia capensis	89.68	0.00e+00	729.00
IUUC-Pva-102862	Pteropus vampyrus	87.62	0.00e+00	697.00
IUUC-Rno-106116	Rattus norvegicus	88.29	0.00e+00	756.00
IUUC-Sar-113211	Sorex araneus	81.45	8.00e-146	509.00
IUUC-Ssc-116440	Sus scrofa	90.24	0.00e+00	758.00
IUUC-Tgu-116675	Taeniopygia guttata	85.50	0.00e+00	740.00
IUUC-Tru-118295	Takifugu rubripes	70.19	1.00e-177	615.00
IUUC-Tsy-118916	Tarsius syrichta	78.05	0.00e+00	631.00
IUUC-Tni-120302	Tetraodon nigroviridis	71.36	1.00e-176	612.00
IUUC-Tbe-127416	Tupaia belangeri	78.38	0.00e+00	631.00
IUUC-Ttr-128185	Tursiops truncatus	90.24	0.00e+00	758.00
IUUC-Xtr-132465	Xenopus tropicalis	83.58	0.00e+00	723.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence