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Tag Content
UUCD2 ID IUUC-Dre-027480
UUCD1 version UUC-DaR-00584
Ensembl Protein ID ENSDARP00000047775.6
UniProt Accession F1Q5B6; F1Q5B6_DANRE
Genbank Protein ID ENSDARP00000047775
Protein Name Cbl proto-oncogene B, E3 ubiquitin protein ligase
Genbank Nucleotide ID BX005366
Gene Name cblb
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000015199.10 ENSDART00000137508.2 ENSDARP00000116090.1
ENSDARG00000015199.10 ENSDART00000047776.7 ENSDARP00000047775.6
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 8.10e-07 30.4 368 407
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + s ++  CP Cr
   Q: 368  CKICAENDKD-VKIEPCGHLMCTSCLTSW----QDSDGQG-CPFCR 407
           99********.******************....6666776.****8 PP
   
Organism Danio rerio
Protein Sequence
(Fasta)
MATALSGRPP NNRKGRILGI IDAIQDAVGP PKQAAADRRT VEKTWKLMDK VVRLCQNPRL 60
QLKNSPPYIL DILPDTYQHL RLILCKYEEN QRLTQLSEND YFKVYIDSLM KKSKRAIRLF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027480|E3,RING|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTTTTAAC CGAGCAGTGT CACGACCATA TCATACAGCG AGAAAAGCGG GATTGTACTG 60
CGTTTAAGCG GTTTCTGCGA GAGGATACGA AACAGCCGCT TCTCGTTTGT GAACATCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027480|E3,RING|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
SMART

SM00184--RING
SM00165--UBA
Gene Ontology

GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis
KEGG dre:556277
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001412 Ailuropoda melanoleuca 66.12 0.00e+00 1040.00
IUUC-Apl-004148 Anas platyrhynchos 64.58 0.00e+00 1048.00
IUUC-Aca-005204 Anolis carolinensis 66.29 0.00e+00 1048.00
IUUC-Ame-011919 Astyanax mexicanus 75.59 0.00e+00 1277.00
IUUC-Bta-013044 Bos taurus 65.36 0.00e+00 1023.00
IUUC-Cel-018674 Caenorhabditis elegans 57.18 8.00e-134 470.00
IUUC-Cja-018813 Callithrix jacchus 83.40 0.00e+00 882.00
IUUC-Cfa-021054 Canis familiaris 65.17 0.00e+00 1066.00
IUUC-Cpo-022514 Cavia porcellus 64.44 0.00e+00 1050.00
IUUC-Csa-024110 Chlorocebus sabaeus 66.05 0.00e+00 1051.00
IUUC-Cho-024886 Choloepus hoffmanni 53.21 0.00e+00 650.00
IUUC-Dno-028923 Dasypus novemcinctus 66.22 0.00e+00 1025.00
IUUC-Dor-031040 Dipodomys ordii 82.37 0.00e+00 714.00
IUUC-Ete-032406 Echinops telfairi 63.74 0.00e+00 956.00
IUUC-Eca-033849 Equus caballus 65.67 0.00e+00 1048.00
IUUC-Fca-036224 Felis catus 65.71 0.00e+00 1043.00
IUUC-Fal-036860 Ficedula albicollis 82.77 0.00e+00 894.00
IUUC-Gga-040159 Gallus gallus 66.19 0.00e+00 1051.00
IUUC-Gac-042312 Gasterosteus aculeatus 83.37 0.00e+00 874.00
IUUC-Ggo-045175 Gorilla gorilla 62.58 0.00e+00 1011.00
IUUC-Hsa-046306 Homo sapiens 65.95 0.00e+00 1049.00
IUUC-Loc-052524 Lepisosteus oculatus 71.84 0.00e+00 1142.00
IUUC-Laf-053635 Loxodonta africana 62.45 0.00e+00 972.00
IUUC-Mcc-055536 Macaca mulatta 65.95 0.00e+00 1049.00
IUUC-Meu-056045 Macropus eugenii 57.51 0.00e+00 745.00
IUUC-Mga-060177 Meleagris gallopavo 75.16 0.00e+00 845.00
IUUC-Mmr-061088 Microcebus murinus 65.61 0.00e+00 1050.00
IUUC-Mdo-062020 Monodelphis domestica 66.26 0.00e+00 1046.00
IUUC-Mmu-063114 Mus musculus 65.38 0.00e+00 1026.00
IUUC-Mpu-066632 Mustela putorius furo 65.88 0.00e+00 1061.00
IUUC-Mlu-067145 Myotis lucifugus 65.40 0.00e+00 1051.00
IUUC-Ont-072323 Oreochromis niloticus 69.11 0.00e+00 957.00
IUUC-Oan-073165 Ornithorhynchus anatinus 66.74 0.00e+00 1077.00
IUUC-Ocu-074723 Oryctolagus cuniculus 65.88 0.00e+00 1054.00
IUUC-Oga-088021 Otolemur garnettii 65.54 0.00e+00 1043.00
IUUC-Oar-089809 Ovis aries 65.67 0.00e+00 1026.00
IUUC-Ptr-090834 Pan troglodytes 65.95 0.00e+00 1049.00
IUUC-Pan-092225 Papio anubis 66.05 0.00e+00 1051.00
IUUC-Psi-093317 Pelodiscus sinensis 67.22 0.00e+00 1084.00
IUUC-Pma-094249 Petromyzon marinus 74.47 7.00e-127 446.00
IUUC-Pab-097595 Pongo abelii 66.05 0.00e+00 1051.00
IUUC-Pca-100844 Procavia capensis 57.09 0.00e+00 736.00
IUUC-Pva-103216 Pteropus vampyrus 61.62 0.00e+00 1015.00
IUUC-Rno-105381 Rattus norvegicus 64.86 0.00e+00 1054.00
IUUC-Sha-107574 Sarcophilus harrisii 65.09 0.00e+00 1050.00
IUUC-Sar-113500 Sorex araneus 55.89 0.00e+00 802.00
IUUC-Ssc-115856 Sus scrofa 62.17 0.00e+00 843.00
IUUC-Tgu-116866 Taeniopygia guttata 65.42 0.00e+00 1065.00
IUUC-Tru-118579 Takifugu rubripes 67.01 0.00e+00 1063.00
IUUC-Tsy-119167 Tarsius syrichta 67.03 0.00e+00 754.00
IUUC-Tni-120788 Tetraodon nigroviridis 86.59 0.00e+00 897.00
IUUC-Tbe-127830 Tupaia belangeri 72.41 0.00e+00 836.00
IUUC-Ttr-128631 Tursiops truncatus 65.88 0.00e+00 1053.00
IUUC-Vpa-130713 Vicugna pacos 68.23 0.00e+00 945.00
Created Date 25-Jun-2017

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