iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000035681.7	ENST00000038176.7	ENSP00000038176.3
ENSG00000035681.7	ENST00000427130.6	ENSP00000411012.2
ENSG00000035681.7	ENST00000518229.5	ENSP00000430195.1
ENSG00000035681.7	ENST00000518159.5	ENSP00000430982.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.10e-20	72.7	743	771
UBD/Beta-Prp	1.70e-54	186.7	712	946

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWD 29
           gH d v+ ++++d++l s+s+D t+kvW+
   Q: 743  GHDDAVSKICWHDNRLYSASWDSTVKVWS 771
           8**********779**************7 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvw...dls.......tgkcvhtlkghedsvlsl 100
            p++  ++t+s+d+ +  +++  g    +l gh+++v+ ++++++   l ++s D t+kvw   + +        ++ +  l+ h+ sv ++
   Q: 712  LPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDN--RLYSASWDSTVKVWsgvPAEmpgtkrhHFDLLAELE-HDVSVDTI 800
           489999***************************************..7*************8773336566566777777777.******** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng 192
           s+++ +  lvsG++  t+++wdl t + ++     h+g+v+ ++++pd++ + s ++D+++++ d++tg l+  +t+  +++ ++  +d n 
   Q: 801  SLNAASTLLVSGTKEGTVNIWDLTTATLMH-QIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTS--DEPQRCFVWDGN- 888
           ******************************.8889****************************************98..88889******6. PP
   S: 193  kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
            +++sgs+ g + +wdl   ++ ++ +ght  v+++ + ++   +++g++D++i +W l
   Q: 889  -SVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKL 946
           .6*******************************************************66 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MTGQARFHRG AEACRAIRQC RSRRPRAAHP EGRAGSGRGS RHASPGVRRG GFSLLLLNLE 60
EYYFEQHRAN HILHKGSHHE RKIRGSLKIC SKSVIFEPDS ISQPIIKIPL RDCIKIGKHG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGAGTCCC CACGCGAGGA TGCTGCGGTG AGCGCGGCCG GGACGCCGCG TCGGGCTCTC 60
GGCCGCCCAG CGGCGCCGCA GGGGAAGCCA GGCCGGCAGC CGCGCGCTCC CCAGCCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000409--BEACH_dom
IPR004182--GRAM
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF02138--Beach
PF02893--GRAM
PF00400--WD40

SMART

SM01026--Beach
SM00568--GRAM
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005057--F:signal transducer activity, downstream of receptor
GO:0016230--F:sphingomyelin phosphodiesterase activator activity
GO:0006672--P:ceramide metabolic process
GO:0043065--P:positive regulation of apoptotic process
GO:2000304--P:positive regulation of ceramide biosynthetic process
GO:0007165--P:signal transduction

KEGG

hsa:8439

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001408	Ailuropoda melanoleuca	93.24	0.00e+00	1764.00
IUUC-Apl-004000	Anas platyrhynchos	80.04	0.00e+00	1519.00
IUUC-Aca-005253	Anolis carolinensis	76.85	0.00e+00	1455.00
IUUC-Ame-011654	Astyanax mexicanus	70.30	0.00e+00	1289.00
IUUC-Bta-013201	Bos taurus	89.74	0.00e+00	1697.00
IUUC-Cja-019039	Callithrix jacchus	96.84	0.00e+00	1899.00
IUUC-Cfa-020722	Canis familiaris	94.04	0.00e+00	1763.00
IUUC-Cpo-022247	Cavia porcellus	89.56	0.00e+00	1668.00
IUUC-Csa-023753	Chlorocebus sabaeus	98.88	0.00e+00	1844.00
IUUC-Cho-024757	Choloepus hoffmanni	92.61	0.00e+00	1410.00
IUUC-Dre-027693	Danio rerio	70.67	0.00e+00	1270.00
IUUC-Dno-028878	Dasypus novemcinctus	92.94	0.00e+00	1712.00
IUUC-Dor-030632	Dipodomys ordii	82.05	0.00e+00	1481.00
IUUC-Ete-032305	Echinops telfairi	84.51	0.00e+00	1001.00
IUUC-Eca-034177	Equus caballus	94.78	0.00e+00	1773.00
IUUC-Eeu-034512	Erinaceus europaeus	75.43	0.00e+00	1216.00
IUUC-Fca-036028	Felis catus	92.25	0.00e+00	1743.00
IUUC-Fal-036685	Ficedula albicollis	79.10	0.00e+00	1457.00
IUUC-Gmo-038959	Gadus morhua	69.90	0.00e+00	1164.00
IUUC-Gga-040819	Gallus gallus	78.95	0.00e+00	1470.00
IUUC-Gac-041843	Gasterosteus aculeatus	67.71	0.00e+00	1286.00
IUUC-Ggo-045488	Gorilla gorilla	91.44	0.00e+00	1668.00
IUUC-Itr-048950	Ictidomys tridecemlineatus	94.83	0.00e+00	1442.00
IUUC-Lch-050024	Latimeria chalumnae	63.18	0.00e+00	1127.00
IUUC-Loc-052831	Lepisosteus oculatus	74.25	0.00e+00	1394.00
IUUC-Laf-053693	Loxodonta africana	91.22	0.00e+00	1685.00
IUUC-Mcc-054769	Macaca mulatta	96.74	0.00e+00	1821.00
IUUC-Mga-059891	Meleagris gallopavo	79.06	0.00e+00	1450.00
IUUC-Mmr-060948	Microcebus murinus	95.22	0.00e+00	1765.00
IUUC-Mdo-062721	Monodelphis domestica	84.98	0.00e+00	1620.00
IUUC-Mmu-064167	Mus musculus	91.89	0.00e+00	1737.00
IUUC-Mpu-066243	Mustela putorius furo	93.00	0.00e+00	1743.00
IUUC-Mlu-068009	Myotis lucifugus	91.20	0.00e+00	1682.00
IUUC-Nle-069459	Nomascus leucogenys	98.32	0.00e+00	1936.00
IUUC-Opr-071145	Ochotona princeps	83.27	0.00e+00	1375.00
IUUC-Ont-071781	Oreochromis niloticus	68.81	0.00e+00	1299.00
IUUC-Oan-073456	Ornithorhynchus anatinus	85.33	0.00e+00	1569.00
IUUC-Ocu-073989	Oryctolagus cuniculus	94.11	0.00e+00	1771.00
IUUC-Ola-087535	Oryzias latipes	66.59	0.00e+00	1265.00
IUUC-Oga-089183	Otolemur garnettii	91.30	0.00e+00	1670.00
IUUC-Oar-090420	Ovis aries	89.11	0.00e+00	1663.00
IUUC-Ptr-091559	Pan troglodytes	99.89	0.00e+00	1864.00
IUUC-Pan-092213	Papio anubis	98.89	0.00e+00	1845.00
IUUC-Psi-093142	Pelodiscus sinensis	80.86	0.00e+00	1505.00
IUUC-Ppa-095631	Physcomitrella patens	39.66	3.00e-121	430.00
IUUC-Pfo-096451	Poecilia formosa	68.16	0.00e+00	1281.00
IUUC-Pab-098016	Pongo abelii	97.77	0.00e+00	1817.00
IUUC-Pca-100416	Procavia capensis	82.61	0.00e+00	1516.00
IUUC-Pva-102630	Pteropus vampyrus	90.41	0.00e+00	1687.00
IUUC-Rno-105516	Rattus norvegicus	92.44	0.00e+00	1743.00
IUUC-Sha-107116	Sarcophilus harrisii	86.02	0.00e+00	1626.00
IUUC-Smo-108747	Selaginella moellendorffii	39.75	4.00e-113	402.00
IUUC-Sar-113361	Sorex araneus	78.04	0.00e+00	1383.00
IUUC-Ssc-115516	Sus scrofa	90.57	0.00e+00	1706.00
IUUC-Tgu-117386	Taeniopygia guttata	77.33	0.00e+00	1443.00
IUUC-Tru-117680	Takifugu rubripes	67.31	0.00e+00	1254.00
IUUC-Tsy-119137	Tarsius syrichta	93.42	0.00e+00	1741.00
IUUC-Tni-120537	Tetraodon nigroviridis	66.89	0.00e+00	1267.00
IUUC-Tbe-127862	Tupaia belangeri	82.27	0.00e+00	1474.00
IUUC-Ttr-128350	Tursiops truncatus	86.95	0.00e+00	1602.00
IUUC-Xtr-131946	Xenopus tropicalis	72.46	0.00e+00	1318.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence