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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046818
Ensembl Protein ID ENSP00000301843.8
UniProt Accession Q14247; Q8N707; Q96H99; SRC8_HUMAN
Genbank Protein ID AAA58455.1; BAF83786.1; EAW74766.1; EAW74768.1; AAH08799.1; AAH33889.1
Protein Name Src substrate cortactin; Amplaxin; Oncogene EMS1
Genbank Nucleotide ID M98343; AK291097; AP000487; CH471076; BC008799; BC033889
Gene Name CTTN; EMS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000085733.15 ENST00000346329.7 ENSP00000317189.4
ENSG00000085733.15 ENST00000301843.12 ENSP00000301843.8
ENSG00000085733.15 ENST00000376561.7 ENSP00000365745.3
ENSG00000085733.15 ENST00000529736.5 ENSP00000431421.1
ENSG00000085733.15 ENST00000533931.1 ENSP00000436613.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.80e-12 48.0 498 547
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +lydy+a+ dde ++   d+++ i  e  d gW++g    +g+ GlfP+n+ve
   Q: 498  VALYDYQAAGDDEISFDPDDIITNI--EMIDDGWWRG--VCKGRYGLFPANYVE 547
           69***********************..9*********..7************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
 Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
Protein Sequence
(Fasta)
MWKASAGHAV SIAQDDAGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE 60
NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046818|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCCGGGCTA GCGCTTAGCC AGCTGCGGGC GGACCCCCGG GACTCTTGCG GGCCAAGACG 60
CGGGAGGAGG CGGGGCAGGG GGCGGGGTCG CGCGGGGACC CGGATGCGGC CCCGCCCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046818|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0168--Coated pit
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0832--Ubl conjugation
Interpro

IPR015503--Cortactin
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain
PROSITE

PS51090--CORTACTIN
PS50002--SH3
Pfam

PF02218--HS1_rep
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0005938--C:cell cortex
GO:0005905--C:clathrin-coated pit
GO:0030863--C:cortical cytoskeleton
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0030027--C:lamellipodium
GO:1990023--C:mitotic spindle midzone
GO:0005886--C:plasma membrane
GO:0002102--C:podosome
GO:0001726--C:ruffle
GO:0008076--C:voltage-gated potassium channel complex
GO:0045296--F:cadherin binding
GO:0005522--F:profilin binding
GO:0031532--P:actin cytoskeleton reorganization
GO:0030041--P:actin filament polymerization
GO:0048870--P:cell motility
GO:0097062--P:dendritic spine maintenance
GO:0048041--P:focal adhesion assembly
GO:0006886--P:intracellular protein transport
GO:0097581--P:lamellipodium organization
GO:0061024--P:membrane organization
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0048812--P:neuron projection morphogenesis
GO:0030838--P:positive regulation of actin filament polymerization
GO:0045987--P:positive regulation of smooth muscle contraction
GO:0006898--P:receptor-mediated endocytosis
GO:0030516--P:regulation of axon extension
GO:1903146--P:regulation of mitophagy
GO:0006930--P:substrate-dependent cell migration, cell extension
KEGG hsa:2017
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002064 Ailuropoda melanoleuca 90.35 0.00e+00 935.00
IUUC-Apl-003745 Anas platyrhynchos 85.20 0.00e+00 800.00
IUUC-Aca-004438 Anolis carolinensis 81.11 0.00e+00 872.00
IUUC-Ame-011504 Astyanax mexicanus 55.80 4.00e-97 348.00
IUUC-Bgr-012041 Blumeria graminis 57.89 6.00e-16 79.70
IUUC-Bta-013563 Bos taurus 88.55 0.00e+00 884.00
IUUC-Cfa-020718 Canis familiaris 87.30 0.00e+00 932.00
IUUC-Cpo-022303 Cavia porcellus 89.82 0.00e+00 1014.00
IUUC-Csa-023431 Chlorocebus sabaeus 98.36 0.00e+00 1021.00
IUUC-Cin-025677 Ciona intestinalis 62.54 1.00e-120 426.00
IUUC-Csv-026140 Ciona savignyi 65.00 6.00e-110 391.00
IUUC-Dre-028127 Danio rerio 60.00 3.00e-133 468.00
IUUC-Dno-029332 Dasypus novemcinctus 82.58 0.00e+00 782.00
IUUC-Dme-031931 Drosophila melanogaster 62.17 8.00e-74 271.00
IUUC-Eca-033801 Equus caballus 92.55 0.00e+00 939.00
IUUC-Fca-035633 Felis catus 89.13 0.00e+00 771.00
IUUC-Fal-036775 Ficedula albicollis 83.57 0.00e+00 805.00
IUUC-Gmo-038507 Gadus morhua 60.00 1.00e-20 94.70
IUUC-Gga-040568 Gallus gallus 85.02 0.00e+00 824.00
IUUC-Gac-042253 Gasterosteus aculeatus 56.52 4.00e-116 411.00
IUUC-Itr-048833 Ictidomys tridecemlineatus 87.98 0.00e+00 873.00
IUUC-Lch-050199 Latimeria chalumnae 71.39 2.00e-146 512.00
IUUC-Loc-052855 Lepisosteus oculatus 75.07 9.00e-153 533.00
IUUC-Laf-053866 Loxodonta africana 90.76 0.00e+00 985.00
IUUC-Mcc-055515 Macaca mulatta 98.36 0.00e+00 990.00
IUUC-Mga-059791 Meleagris gallopavo 80.73 0.00e+00 817.00
IUUC-Mmr-061147 Microcebus murinus 94.20 0.00e+00 898.00
IUUC-Mdo-062660 Monodelphis domestica 61.14 4.00e-176 612.00
IUUC-Mmu-064023 Mus musculus 92.18 0.00e+00 953.00
IUUC-Mpu-065867 Mustela putorius furo 82.88 0.00e+00 806.00
IUUC-Mlu-067704 Myotis lucifugus 84.78 0.00e+00 801.00
IUUC-Ont-071873 Oreochromis niloticus 80.11 6.00e-167 580.00
IUUC-Oan-073528 Ornithorhynchus anatinus 83.54 2.00e-166 578.00
IUUC-Oga-088028 Otolemur garnettii 92.55 0.00e+00 957.00
IUUC-Oar-090203 Ovis aries 88.72 0.00e+00 817.00
IUUC-Pan-092594 Papio anubis 93.47 0.00e+00 926.00
IUUC-Psi-093389 Pelodiscus sinensis 83.01 0.00e+00 815.00
IUUC-Pma-094161 Petromyzon marinus 47.40 2.00e-86 313.00
IUUC-Pfo-097391 Poecilia formosa 55.15 3.00e-112 399.00
IUUC-Pab-097913 Pongo abelii 90.91 0.00e+00 884.00
IUUC-Rno-105489 Rattus norvegicus 91.45 0.00e+00 897.00
IUUC-Sce-106228 Saccharomyces cerevisiae 50.00 8.00e-07 48.90
IUUC-Sha-107308 Sarcophilus harrisii 70.86 0.00e+00 696.00
IUUC-Sja-107956 Schizosaccharomyces japonicus 55.17 1.00e-14 75.50
IUUC-Tgu-117049 Taeniopygia guttata 77.64 0.00e+00 732.00
IUUC-Tru-118718 Takifugu rubripes 75.70 9.00e-158 550.00
IUUC-Tni-120535 Tetraodon nigroviridis 58.26 2.00e-167 582.00
IUUC-Vda-129766 Verticillium dahliae 57.89 1.00e-13 72.00
IUUC-Xtr-131797 Xenopus tropicalis 61.26 0.00e+00 662.00
Created Date 25-Jun-2017

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