iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cin-025635

Ensembl Protein ID

ENSCINP00000012594.3

UniProt Accession

F6YWK0; F6YWK0_CIOIN

Genbank Protein ID

ENSCINP00000012594

Protein Name

Defective in cullin neddylation protein

Genbank Nucleotide ID

EAAA01002894

Gene Name

LOC100183493

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000006105.3	ENSCINT00000012594.3	ENSCINP00000012594.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/DCUN1	56.71	5.00e-51	197.00	IUUC-Hsa-046320

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ciona intestinalis

Functional Description
(View)

Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Protein Sequence
(Fasta)

MERLCKSIKV EPGDVVMLVL AHQLNAKKMG FFTLEEWSRG MQKIQCDSSA KLERKLEVLR 60
ESLNDPVQLK SVFRYAFDFA KEPGQRTMEL DTANIMLELL LSERWTLFSK FQQFLKQTKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCAGAAGG AATGGAAAGA CTTTGTAAAT CAATAAAAGT TGAACCTGGG GATGTTGTTA 60
TGCTTGTATT GGCGCACCAA CTTAATGCAA AGAAAATGGG TTTCTTCACG CTTGAGGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001567	Ailuropoda melanoleuca	56.71	2.00e-52	197.00
IUUC-Apl-003338	Anas platyrhynchos	56.71	2.00e-52	197.00
IUUC-Aca-004660	Anolis carolinensis	56.71	1.00e-52	198.00
IUUC-Bta-013463	Bos taurus	56.71	1.00e-52	197.00
IUUC-Cja-019665	Callithrix jacchus	56.71	2.00e-52	197.00
IUUC-Cfa-020873	Canis familiaris	56.71	2.00e-52	197.00
IUUC-Csa-023661	Chlorocebus sabaeus	56.71	2.00e-52	197.00
IUUC-Csv-025976	Ciona savignyi	79.52	1.00e-78	284.00
IUUC-Dre-028080	Danio rerio	56.10	1.00e-52	197.00
IUUC-Dno-029984	Dasypus novemcinctus	56.71	4.00e-52	197.00
IUUC-Dor-030556	Dipodomys ordii	56.71	2.00e-52	197.00
IUUC-Eca-034108	Equus caballus	56.71	2.00e-52	197.00
IUUC-Fca-035374	Felis catus	56.71	2.00e-52	197.00
IUUC-Fal-037284	Ficedula albicollis	57.32	3.00e-53	199.00
IUUC-Gga-040330	Gallus gallus	56.71	1.00e-52	197.00
IUUC-Gac-042443	Gasterosteus aculeatus	57.93	7.00e-52	195.00
IUUC-Ggo-044892	Gorilla gorilla	56.71	2.00e-52	197.00
IUUC-Hsa-046320	Homo sapiens	56.71	2.00e-52	197.00
IUUC-Itr-048437	Ictidomys tridecemlineatus	56.45	5.00e-38	147.00
IUUC-Lch-049750	Latimeria chalumnae	56.36	1.00e-51	194.00
IUUC-Loc-052941	Lepisosteus oculatus	56.36	1.00e-52	197.00
IUUC-Laf-054402	Loxodonta africana	56.71	2.00e-52	197.00
IUUC-Mcc-055269	Macaca mulatta	56.71	2.00e-52	197.00
IUUC-Meu-056847	Macropus eugenii	53.64	1.00e-43	168.00
IUUC-Mga-059420	Meleagris gallopavo	56.71	9.00e-53	198.00
IUUC-Mmr-061732	Microcebus murinus	56.71	2.00e-52	197.00
IUUC-Mdo-062269	Monodelphis domestica	56.71	2.00e-52	197.00
IUUC-Mmu-063396	Mus musculus	56.10	5.00e-52	196.00
IUUC-Mpu-066206	Mustela putorius furo	56.71	6.00e-53	198.00
IUUC-Mlu-067871	Myotis lucifugus	56.71	1.00e-52	197.00
IUUC-Nle-069808	Nomascus leucogenys	56.71	2.00e-52	197.00
IUUC-Ont-072416	Oreochromis niloticus	56.79	3.00e-52	196.00
IUUC-Oan-072930	Ornithorhynchus anatinus	55.95	1.00e-52	197.00
IUUC-Ocu-073767	Oryctolagus cuniculus	56.71	1.00e-52	197.00
IUUC-Ola-086378	Oryzias latipes	57.93	2.00e-53	200.00
IUUC-Oga-088583	Otolemur garnettii	56.71	2.00e-52	197.00
IUUC-Oar-089612	Ovis aries	56.71	1.00e-52	197.00
IUUC-Ptr-090753	Pan troglodytes	56.71	2.00e-52	197.00
IUUC-Pan-091951	Papio anubis	56.71	2.00e-52	197.00
IUUC-Psi-093385	Pelodiscus sinensis	56.10	3.00e-52	196.00
IUUC-Pma-094582	Petromyzon marinus	58.54	7.00e-54	201.00
IUUC-Pfo-096222	Poecilia formosa	55.15	1.00e-51	195.00
IUUC-Pab-097692	Pongo abelii	56.71	2.00e-52	197.00
IUUC-Pva-102620	Pteropus vampyrus	55.63	1.00e-46	177.00
IUUC-Rno-105023	Rattus norvegicus	56.10	4.00e-52	196.00
IUUC-Sha-107177	Sarcophilus harrisii	56.71	2.00e-52	197.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	33.54	8.00e-21	92.40
IUUC-Sar-113248	Sorex araneus	57.32	4.00e-52	196.00
IUUC-Ssc-116272	Sus scrofa	56.71	1.00e-52	197.00
IUUC-Tgu-116631	Taeniopygia guttata	57.32	4.00e-53	199.00
IUUC-Tsy-119350	Tarsius syrichta	56.71	2.00e-52	197.00
IUUC-Tbe-127937	Tupaia belangeri	57.32	3.00e-52	197.00
IUUC-Vpa-130543	Vicugna pacos	56.71	2.00e-52	197.00
IUUC-Xtr-132448	Xenopus tropicalis	56.71	9.00e-53	198.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence