iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.70e-31	109.9	9	145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkee 89
           l++e+ el++d+ + i+a pv++ d+++w+++i+G  +++ eg vF l++ef+++Y++ PP+vkf+t  fhPnv++  Gk  +++l+++
   Q: 9    LEREFRELKRDTRKDITAYPVSD-DMMNWKAEIEGLRNSVCEGLVFYLTLEFSQEYNSVPPNVKFTTIPFHPNVDPYtGKPSIDFLDKP 96
           689********************.9***************************************************99*********** PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
            kW++ ++v s+ll++q ll+ p  ++p+n eaa+ll +n ++yk  ++
   Q: 97   GKWNTNYTVLSILLDLQMLLSYPVLKNPVNLEAAQLLIRNASTYKMVIQ 145
           ********************************************98775 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MYSKAYILLE REFRELKRDT RKDITAYPVS DDMMNWKAEI EGLRNSVCEG LVFYLTLEFS 60
QEYNSVPPNV KFTTIPFHPN VDPYTGKPSI DFLDKPGKWN TNYTVLSILL DLQMLLSYPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCTTTACT TGTCAGGTAG AAAGAGAACT TGGCAGTGCT GCTTCGGGTT TGCATTTTTT 60
TCCTCTTGGC CAGCCAACAA CTCCGGCATC TCTCAAGTGG TCCCCAAGTT TGTCTAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

mmu:381534

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002211	Ailuropoda melanoleuca	51.69	1.00e-51	195.00
IUUC-Aca-004682	Anolis carolinensis	45.58	3.00e-48	184.00
IUUC-Bta-013054	Bos taurus	42.26	2.00e-74	272.00
IUUC-Cja-018784	Callithrix jacchus	45.86	9.00e-74	270.00
IUUC-Cfa-020877	Canis familiaris	52.86	1.00e-66	245.00
IUUC-Cpo-022462	Cavia porcellus	51.38	4.00e-49	187.00
IUUC-Csa-023486	Chlorocebus sabaeus	55.07	7.00e-72	263.00
IUUC-Cho-024685	Choloepus hoffmanni	37.55	1.00e-31	130.00
IUUC-Dno-029061	Dasypus novemcinctus	44.13	1.00e-66	246.00
IUUC-Ete-032233	Echinops telfairi	40.53	4.00e-47	181.00
IUUC-Eca-033400	Equus caballus	59.46	7.00e-39	152.00
IUUC-Fca-035778	Felis catus	42.69	6.00e-73	267.00
IUUC-Ggo-044718	Gorilla gorilla	46.20	1.00e-78	286.00
IUUC-Hsa-046798	Homo sapiens	45.16	5.00e-77	281.00
IUUC-Lch-050337	Latimeria chalumnae	32.07	2.00e-51	196.00
IUUC-Loc-051819	Lepisosteus oculatus	30.61	3.00e-42	165.00
IUUC-Laf-054536	Loxodonta africana	53.07	4.00e-68	250.00
IUUC-Mcc-055028	Macaca mulatta	44.44	2.00e-76	279.00
IUUC-Mmr-061623	Microcebus murinus	44.35	8.00e-66	243.00
IUUC-Mdo-062614	Monodelphis domestica	44.12	6.00e-50	191.00
IUUC-Mpu-066467	Mustela putorius furo	42.23	8.00e-69	253.00
IUUC-Mlu-067976	Myotis lucifugus	48.47	2.00e-56	212.00
IUUC-Nle-069407	Nomascus leucogenys	45.91	2.00e-75	275.00
IUUC-Opr-070526	Ochotona princeps	50.29	3.00e-40	157.00
IUUC-Oan-073005	Ornithorhynchus anatinus	46.54	9.00e-45	172.00
IUUC-Ocu-074953	Oryctolagus cuniculus	52.28	7.00e-67	247.00
IUUC-Oga-089061	Otolemur garnettii	45.54	7.00e-77	280.00
IUUC-Oar-090147	Ovis aries	41.64	3.00e-67	248.00
IUUC-Ptr-090873	Pan troglodytes	57.59	9.00e-74	270.00
IUUC-Pan-091873	Papio anubis	55.07	6.00e-72	263.00
IUUC-Psi-093780	Pelodiscus sinensis	34.27	7.00e-28	117.00
IUUC-Pab-098662	Pongo abelii	56.83	2.00e-74	271.00
IUUC-Pca-100167	Procavia capensis	41.52	4.00e-43	168.00
IUUC-Pva-102119	Pteropus vampyrus	41.10	1.00e-23	103.00
IUUC-Rno-105522	Rattus norvegicus	60.34	5.00e-111	394.00
IUUC-Sar-113070	Sorex araneus	45.27	2.00e-46	178.00
IUUC-Ssc-115890	Sus scrofa	43.11	3.00e-76	278.00
IUUC-Tsy-119341	Tarsius syrichta	53.23	4.00e-58	218.00
IUUC-Tbe-127433	Tupaia belangeri	35.96	2.00e-42	166.00
IUUC-Ttr-128614	Tursiops truncatus	39.58	3.00e-53	202.00
IUUC-Vpa-130777	Vicugna pacos	54.27	3.00e-61	228.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence