iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088399

Ensembl Protein ID

ENSOGAP00000016561.1

UniProt Accession

H0XKC1; H0XKC1_OTOGA

Genbank Protein ID

ENSOGAP00000016561

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAQR03091972

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000027052.1	ENSOGAT00000033144.1	ENSOGAP00000016561.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	2.00e-125	445.00	IUUC-Dme-031700
E3 activity/RING/RING	100.00	3.00e-169	591.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.65	1.00e-168	589.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL 60
VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY ASSGCEITLP HTEKADHEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAAATGAG CCGTCAGACT GCCACAGCAT TACCTACCGG TACCTCCAAG TGTCCACCAT 60
CCCAGAGGGT GCCTGCCCTG ACCGGCACAA CCGCGTCCAA CAATGACTTG GCCAGTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.36	2.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	99.65	1.00e-169	588.00
IUUC-Atr-002857	Amborella trichopoda	36.19	2.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	99.65	1.00e-169	588.00
IUUC-Aca-005014	Anolis carolinensis	99.65	6.00e-170	589.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	2.00e-41	162.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	1.00e-41	163.00
IUUC-Ame-011196	Astyanax mexicanus	97.16	2.00e-167	581.00
IUUC-Bta-012887	Bos taurus	99.65	1.00e-169	588.00
IUUC-Bdi-014200	Brachypodium distachyon	36.14	5.00e-45	174.00
IUUC-Bol-015523	Brassica oleracea	35.83	8.00e-42	164.00
IUUC-Cel-018320	Caenorhabditis elegans	71.21	4.00e-114	404.00
IUUC-Cja-019796	Callithrix jacchus	100.00	3.00e-170	590.00
IUUC-Cfa-020642	Canis familiaris	99.65	1.00e-170	591.00
IUUC-Cpo-022348	Cavia porcellus	100.00	2.00e-170	591.00
IUUC-Csa-023974	Chlorocebus sabaeus	100.00	1.00e-170	591.00
IUUC-Cin-025674	Ciona intestinalis	78.01	2.00e-134	471.00
IUUC-Csv-026233	Ciona savignyi	84.25	4.00e-132	463.00
IUUC-Dre-028041	Danio rerio	97.52	2.00e-168	584.00
IUUC-Dno-029764	Dasypus novemcinctus	99.65	9.00e-170	589.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	8.00e-120	422.00
IUUC-Ete-032423	Echinops telfairi	99.25	6.00e-159	553.00
IUUC-Eca-033536	Equus caballus	99.65	1.00e-169	588.00
IUUC-Eeu-035314	Erinaceus europaeus	99.25	3.00e-159	553.00
IUUC-Fca-035362	Felis catus	99.65	6.00e-170	589.00
IUUC-Fal-037487	Ficedula albicollis	99.65	1.00e-169	588.00
IUUC-Gga-040269	Gallus gallus	99.65	1.00e-169	588.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.52	2.00e-167	581.00
IUUC-Ggo-045444	Gorilla gorilla	100.00	1.00e-170	591.00
IUUC-Hsa-046357	Homo sapiens	100.00	1.00e-170	591.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	100.00	2.00e-170	591.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	1.00e-168	585.00
IUUC-Loc-052191	Lepisosteus oculatus	99.29	9.00e-169	585.00
IUUC-Laf-053668	Loxodonta africana	99.65	1.00e-169	588.00
IUUC-Mcc-054640	Macaca mulatta	100.00	1.00e-170	591.00
IUUC-Mtr-058747	Medicago truncatula	34.81	4.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	99.65	8.00e-170	588.00
IUUC-Mmr-060794	Microcebus murinus	100.00	2.00e-170	591.00
IUUC-Mmu-064129	Mus musculus	99.65	5.00e-170	589.00
IUUC-Mac-065670	Musa acuminata	35.44	1.00e-42	166.00
IUUC-Mpu-066488	Mustela putorius furo	99.65	1.00e-169	588.00
IUUC-Mlu-067207	Myotis lucifugus	99.65	4.00e-170	590.00
IUUC-Nle-069706	Nomascus leucogenys	100.00	2.00e-170	591.00
IUUC-Ont-071849	Oreochromis niloticus	97.52	2.00e-167	581.00
IUUC-Ocu-074876	Oryctolagus cuniculus	100.00	3.00e-170	590.00
IUUC-Oba-075454	Oryza barthii	40.66	1.00e-42	166.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	1.00e-42	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.83	2.00e-42	166.00
IUUC-Oin-079749	Oryza indica	40.66	1.00e-42	166.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	1.00e-42	166.00
IUUC-Opu-084065	Oryza punctata	41.08	7.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	1.00e-42	166.00
IUUC-Osa-085610	Oryza sativa	40.66	1.00e-42	166.00
IUUC-Ola-086814	Oryzias latipes	97.52	2.00e-167	581.00
IUUC-Oar-089323	Ovis aries	99.65	2.00e-169	587.00
IUUC-Ptr-090692	Pan troglodytes	100.00	1.00e-170	591.00
IUUC-Pan-092012	Papio anubis	100.00	1.00e-170	591.00
IUUC-Psi-093687	Pelodiscus sinensis	99.65	4.00e-170	590.00
IUUC-Pma-094387	Petromyzon marinus	93.99	6.00e-160	556.00
IUUC-Pfo-097134	Poecilia formosa	97.52	2.00e-167	581.00
IUUC-Pab-097555	Pongo abelii	100.00	1.00e-170	591.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	171.00
IUUC-Rno-104866	Rattus norvegicus	99.65	5.00e-170	589.00
IUUC-Sha-106547	Sarcophilus harrisii	99.65	7.00e-170	589.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	3.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	99.65	1.00e-169	588.00
IUUC-Tru-118250	Takifugu rubripes	92.91	2.00e-158	551.00
IUUC-Tni-120488	Tetraodon nigroviridis	97.16	5.00e-164	569.00
IUUC-Tae-123647	Triticum aestivum	37.36	2.00e-44	172.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	5.00e-143	500.00
IUUC-Vvi-131233	Vitis vinifera	34.64	5.00e-42	164.00
IUUC-Xtr-132553	Xenopus tropicalis	99.29	4.00e-170	590.00
IUUC-Xma-133670	Xiphophorus maculatus	97.52	2.00e-167	581.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence