iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066700

Ensembl Protein ID

ENSMPUP00000014520.1

UniProt Accession

M3YT60; M3YT60_MUSPF

Genbank Protein ID

ENSMPUP00000014520

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AEYP01095591

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000014629.1	ENSMPUT00000014753.1	ENSMPUP00000014520.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.80e-28	97.1	276	325

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrsk 54
           kvC  C+++g+d+ ++++Ce C++ +H  Clk++  eelp ++ w C+ Cr +
   Q: 276  KVCQACRKPGNDS-KMLVCETCDKGYHTFCLKPP-MEELPAHS-WKCKACRVC 325
           58*********87.6*******************.*******8.******965 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MDSQKPPGED KDSEPAADGP VASEESGTTE ADLPNPHVGE VSVPNSGGPR LQDPPQDCSG 60
GPARRCALCN CGEPSLHGQR ELRRFELPFD WPQCPVVSPG GNPGPNEAAL PSEDLSQIGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTCCCCGA GAGGGCCCTG CCCAGTCGGA GAGAGGGATG GACAGCCAGA AGCCGCCTGG 60
TGAGGATAAA GATTCAGAAC CGGCAGGTGA GTAGGGCAAA TTCTGCATTT GCTGGTAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001806	Ailuropoda melanoleuca	96.55	0.00e+00	3912.00
IUUC-Aca-005364	Anolis carolinensis	52.74	0.00e+00	1217.00
IUUC-Ame-010612	Astyanax mexicanus	81.35	0.00e+00	1012.00
IUUC-Bta-013011	Bos taurus	92.28	0.00e+00	3784.00
IUUC-Cja-019841	Callithrix jacchus	90.89	0.00e+00	3823.00
IUUC-Cfa-021131	Canis familiaris	95.38	0.00e+00	3858.00
IUUC-Cpo-021957	Cavia porcellus	89.55	0.00e+00	3716.00
IUUC-Csa-023722	Chlorocebus sabaeus	91.86	0.00e+00	3762.00
IUUC-Dno-029932	Dasypus novemcinctus	86.72	0.00e+00	2310.00
IUUC-Dor-030192	Dipodomys ordii	86.75	0.00e+00	1713.00
IUUC-Ete-032572	Echinops telfairi	86.49	0.00e+00	1989.00
IUUC-Eca-034166	Equus caballus	95.61	0.00e+00	770.00
IUUC-Eeu-034848	Erinaceus europaeus	93.44	0.00e+00	1340.00
IUUC-Fca-035424	Felis catus	95.84	0.00e+00	3849.00
IUUC-Fal-037179	Ficedula albicollis	66.80	0.00e+00	1179.00
IUUC-Gmo-038719	Gadus morhua	82.41	0.00e+00	910.00
IUUC-Gga-040815	Gallus gallus	58.78	0.00e+00	1910.00
IUUC-Gac-042436	Gasterosteus aculeatus	80.04	0.00e+00	996.00
IUUC-Ggo-044711	Gorilla gorilla	93.22	0.00e+00	3667.00
IUUC-Hsa-046567	Homo sapiens	92.09	0.00e+00	3714.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	92.11	0.00e+00	3695.00
IUUC-Loc-051979	Lepisosteus oculatus	82.99	0.00e+00	1060.00
IUUC-Laf-054377	Loxodonta africana	92.61	0.00e+00	3664.00
IUUC-Mcc-055577	Macaca mulatta	91.25	0.00e+00	3710.00
IUUC-Meu-055992	Macropus eugenii	79.60	0.00e+00	1345.00
IUUC-Mmr-061772	Microcebus murinus	89.34	0.00e+00	3679.00
IUUC-Mdo-062876	Monodelphis domestica	78.56	0.00e+00	1167.00
IUUC-Mmu-063903	Mus musculus	88.08	0.00e+00	3504.00
IUUC-Mlu-068180	Myotis lucifugus	92.25	0.00e+00	3931.00
IUUC-Nle-069362	Nomascus leucogenys	93.25	0.00e+00	3673.00
IUUC-Opr-070304	Ochotona princeps	87.83	0.00e+00	3472.00
IUUC-Ont-071881	Oreochromis niloticus	64.62	0.00e+00	1402.00
IUUC-Oan-073663	Ornithorhynchus anatinus	86.27	0.00e+00	906.00
IUUC-Ocu-074053	Oryctolagus cuniculus	87.30	0.00e+00	3681.00
IUUC-Ola-086384	Oryzias latipes	60.25	0.00e+00	1332.00
IUUC-Oga-088450	Otolemur garnettii	89.66	0.00e+00	3956.00
IUUC-Oar-089975	Ovis aries	94.65	0.00e+00	2045.00
IUUC-Ptr-091073	Pan troglodytes	93.94	0.00e+00	3670.00
IUUC-Pan-092871	Papio anubis	90.18	0.00e+00	3773.00
IUUC-Pfo-097525	Poecilia formosa	63.82	0.00e+00	1322.00
IUUC-Pab-097679	Pongo abelii	93.23	0.00e+00	3727.00
IUUC-Pca-100499	Procavia capensis	88.24	0.00e+00	2259.00
IUUC-Pva-102898	Pteropus vampyrus	94.33	0.00e+00	3659.00
IUUC-Rno-105660	Rattus norvegicus	88.49	0.00e+00	3566.00
IUUC-Sha-107431	Sarcophilus harrisii	79.68	0.00e+00	3143.00
IUUC-Sbi-113816	Sorghum bicolor	33.71	3.00e-13	70.90
IUUC-Ssc-115678	Sus scrofa	93.55	0.00e+00	3615.00
IUUC-Tru-117922	Takifugu rubripes	80.57	0.00e+00	1011.00
IUUC-Tsy-118905	Tarsius syrichta	85.56	0.00e+00	1654.00
IUUC-Tbe-127625	Tupaia belangeri	84.34	1.00e-154	543.00
IUUC-Ttr-129162	Tursiops truncatus	93.00	0.00e+00	2173.00
IUUC-Xtr-132455	Xenopus tropicalis	64.20	0.00e+00	1309.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence