iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048144

Ensembl Protein ID

ENSSTOP00000004485.2

UniProt Accession

I3M597; I3M597_ICTTR

Genbank Protein ID

ENSSTOP00000004485

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01100517

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000004968.2	ENSSTOT00000004999.2	ENSSTOP00000004485.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-15	56.0	718	769

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 718  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 769
           688*********************9.999999*****..9*************86 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

FSQVIETLSR LSRTPTALAT GIRPFPTEES VNDEDIYKGL PDLIDETRVQ DEEDLYDCVY 60
GEDEGGEVYE DLMKAEEAHQ PKCSENDIRS CCLAEIKQTE EKYTETLESI EKYFMAPLKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCTCAGG TTATAGAAAC TTTATCGCGA CTTTCTCGAA CGCCCACAGC ATTGGCCACA 60
GGAATCAGGT ATGTGGTTCA TATGTCACAT GCTGTTCATT GTCATGATTA TGTATGAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	92.35	0.00e+00	1367.00
IUUC-Apl-003734	Anas platyrhynchos	83.27	0.00e+00	1270.00
IUUC-Aca-004477	Anolis carolinensis	84.82	0.00e+00	1274.00
IUUC-Ame-011279	Astyanax mexicanus	61.49	0.00e+00	907.00
IUUC-Bta-012722	Bos taurus	91.57	0.00e+00	1358.00
IUUC-Cja-018941	Callithrix jacchus	93.00	0.00e+00	1382.00
IUUC-Cfa-020266	Canis familiaris	92.61	0.00e+00	1375.00
IUUC-Cpo-021966	Cavia porcellus	93.26	0.00e+00	1378.00
IUUC-Csa-023892	Chlorocebus sabaeus	92.61	0.00e+00	1379.00
IUUC-Cme-027247	Cyanidioschyzon merolae	22.60	8.00e-10	58.50
IUUC-Dre-028199	Danio rerio	64.73	0.00e+00	955.00
IUUC-Dno-029474	Dasypus novemcinctus	92.22	0.00e+00	1368.00
IUUC-Eca-033961	Equus caballus	93.00	0.00e+00	1408.00
IUUC-Eeu-034719	Erinaceus europaeus	71.30	0.00e+00	762.00
IUUC-Fca-036572	Felis catus	91.83	0.00e+00	1357.00
IUUC-Fal-036802	Ficedula albicollis	87.42	0.00e+00	1355.00
IUUC-Gmo-039409	Gadus morhua	64.39	0.00e+00	952.00
IUUC-Gga-040884	Gallus gallus	82.10	0.00e+00	1254.00
IUUC-Gac-041395	Gasterosteus aculeatus	66.32	0.00e+00	1025.00
IUUC-Ggo-044460	Gorilla gorilla	93.26	0.00e+00	1387.00
IUUC-Hsa-046099	Homo sapiens	96.89	0.00e+00	1464.00
IUUC-Lch-049650	Latimeria chalumnae	72.08	1.00e-103	368.00
IUUC-Loc-052487	Lepisosteus oculatus	68.47	0.00e+00	1025.00
IUUC-Laf-054564	Loxodonta africana	91.05	0.00e+00	1352.00
IUUC-Mcc-054622	Macaca mulatta	96.24	0.00e+00	1455.00
IUUC-Meu-056680	Macropus eugenii	81.19	0.00e+00	1191.00
IUUC-Mga-060013	Meleagris gallopavo	78.65	0.00e+00	1189.00
IUUC-Mmr-061251	Microcebus murinus	94.56	0.00e+00	1473.00
IUUC-Mdo-061875	Monodelphis domestica	89.23	0.00e+00	1337.00
IUUC-Mmu-063735	Mus musculus	91.57	0.00e+00	1384.00
IUUC-Mpu-065856	Mustela putorius furo	92.09	0.00e+00	1363.00
IUUC-Mlu-068108	Myotis lucifugus	92.61	0.00e+00	1314.00
IUUC-Nle-069863	Nomascus leucogenys	96.11	0.00e+00	1451.00
IUUC-Opr-070372	Ochotona princeps	80.71	0.00e+00	820.00
IUUC-Ont-072286	Oreochromis niloticus	67.01	0.00e+00	1017.00
IUUC-Ocu-074194	Oryctolagus cuniculus	93.00	0.00e+00	1375.00
IUUC-Ola-086336	Oryzias latipes	66.19	0.00e+00	1015.00
IUUC-Oar-089272	Ovis aries	91.05	0.00e+00	1394.00
IUUC-Ptr-090652	Pan troglodytes	90.43	0.00e+00	1364.00
IUUC-Pan-092550	Papio anubis	96.24	0.00e+00	1457.00
IUUC-Psi-093784	Pelodiscus sinensis	84.33	0.00e+00	1280.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	69.77	0.00e+00	1085.00
IUUC-Pab-098698	Pongo abelii	90.40	0.00e+00	1365.00
IUUC-Pva-102262	Pteropus vampyrus	91.82	0.00e+00	1306.00
IUUC-Rno-105421	Rattus norvegicus	91.18	0.00e+00	1385.00
IUUC-Sha-107325	Sarcophilus harrisii	89.36	0.00e+00	1356.00
IUUC-Sar-113456	Sorex araneus	88.10	0.00e+00	1290.00
IUUC-Tgu-116595	Taeniopygia guttata	79.07	0.00e+00	1184.00
IUUC-Tru-118577	Takifugu rubripes	67.38	0.00e+00	1054.00
IUUC-Tsy-119429	Tarsius syrichta	84.82	0.00e+00	1243.00
IUUC-Tni-119951	Tetraodon nigroviridis	66.80	0.00e+00	992.00
IUUC-Tbe-127995	Tupaia belangeri	81.59	2.00e-126	446.00
IUUC-Ttr-128281	Tursiops truncatus	92.22	0.00e+00	1365.00
IUUC-Xtr-132427	Xenopus tropicalis	70.71	0.00e+00	1113.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence