iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060158

UUCD1 version

UUC-MeG-00155

Ensembl Protein ID

ENSMGAP00000002894.2

UniProt Accession

G1MW12; G1MW12_MELGA

Protein Name

Uncharacterized protein

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000003180.2	ENSMGAT00000003584.2	ENSMGAP00000002894.2
ENSMGAG00000003180.2	ENSMGAT00000019887.1	ENSMGAP00000017857.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-30	102.9	379	412
UBD/Beta-Prp	2.00e-50	171.4	220	450

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 379  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 412
           8**********976699**************986 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++ ++tg++d+ ++v+d t+++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he sv+ ls++++gd
   Q: 220  PSDTNKILTGGADKNVIVFDKTSEQILATLKGHSKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHEGSVTGLSLHATGD 308
           568899*********************************************************************************** PP
   S: 108  klvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkel 195
           +l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l
   Q: 309  YLLSSSDDQYWAFSDIQTGRVLTKvTDESSGCALTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYL 396
           **********************997777777799************************************9.***************** PP
   S: 196  vsgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           +++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 397  ATAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 450
           ***************999999999866527********************9998 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

PTSPHISPNR RLIEKYIAEN GTDPVNNQPL SEEQLIDIKR VAHPIRPKPP SATSIPAILK 60
ALQDEWVSCR EDAVMLHSFT LRQQLQTTRQ ELSHALYQHD AACRVIARLT KEVTAAREAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTACATCTC CCCATATATC CCCCAATAGA GGCNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50231--RICIN_B_LECTIN
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	40.24	2.00e-92	333.00
IUUC-Aml-001230	Ailuropoda melanoleuca	87.04	0.00e+00	830.00
IUUC-Atr-002594	Amborella trichopoda	44.17	4.00e-108	384.00
IUUC-Apl-003686	Anas platyrhynchos	90.19	0.00e+00	749.00
IUUC-Aca-005272	Anolis carolinensis	89.78	0.00e+00	881.00
IUUC-Aly-005586	Arabidopsis lyrata	43.12	5.00e-105	374.00
IUUC-Ath-007696	Arabidopsis thaliana	43.87	1.00e-102	366.00
IUUC-Acl-008335	Aspergillus clavatus	35.96	2.00e-64	239.00
IUUC-Afl-008527	Aspergillus flavus	36.79	3.00e-63	235.00
IUUC-Afu-008957	Aspergillus fumigatus	37.37	5.00e-70	258.00
IUUC-Ani-009280	Aspergillus nidulans	37.00	4.00e-56	211.00
IUUC-Ang-009746	Aspergillus niger	35.52	5.00e-57	214.00
IUUC-Aor-009905	Aspergillus oryzae	36.58	6.00e-67	247.00
IUUC-Ate-010412	Aspergillus terreus	36.52	9.00e-56	210.00
IUUC-Ame-011561	Astyanax mexicanus	80.43	2.00e-92	331.00
IUUC-Bgr-012283	Blumeria graminis	32.61	9.00e-48	184.00
IUUC-Bta-013242	Bos taurus	90.58	0.00e+00	887.00
IUUC-Bci-013901	Botrytis cinerea	34.47	7.00e-55	207.00
IUUC-Bdi-014277	Brachypodium distachyon	44.07	8.00e-109	387.00
IUUC-Bol-016207	Brassica oleracea	45.09	5.00e-105	374.00
IUUC-Bra-017902	Brassica rapa	42.92	1.00e-103	369.00
IUUC-Cel-018271	Caenorhabditis elegans	49.19	7.00e-134	470.00
IUUC-Cja-019879	Callithrix jacchus	90.58	0.00e+00	890.00
IUUC-Cfa-020175	Canis familiaris	90.38	0.00e+00	886.00
IUUC-Cpo-022379	Cavia porcellus	90.18	0.00e+00	884.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	41.01	1.00e-86	313.00
IUUC-Csa-023500	Chlorocebus sabaeus	90.78	0.00e+00	888.00
IUUC-Cho-025065	Choloepus hoffmanni	80.07	7.00e-127	446.00
IUUC-Cin-025699	Ciona intestinalis	66.21	2.00e-164	571.00
IUUC-Csv-026128	Ciona savignyi	63.47	1.00e-175	608.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	33.63	5.00e-56	211.00
IUUC-Cne-026860	Cryptococcus neoformans	35.57	3.00e-82	298.00
IUUC-Dre-028187	Danio rerio	78.60	0.00e+00	758.00
IUUC-Dno-029453	Dasypus novemcinctus	90.58	0.00e+00	886.00
IUUC-Dor-030150	Dipodomys ordii	95.38	1.00e-124	439.00
IUUC-Dse-031220	Dothistroma septosporum	31.81	2.00e-49	189.00
IUUC-Dme-031906	Drosophila melanogaster	62.80	1.00e-171	595.00
IUUC-Ete-033035	Echinops telfairi	78.36	0.00e+00	737.00
IUUC-Eca-033478	Equus caballus	90.58	0.00e+00	886.00
IUUC-Eeu-034974	Erinaceus europaeus	92.40	1.00e-180	625.00
IUUC-Fca-036194	Felis catus	90.38	0.00e+00	886.00
IUUC-Fal-037417	Ficedula albicollis	91.78	0.00e+00	897.00
IUUC-Fox-037922	Fusarium oxysporum	34.28	4.00e-55	208.00
IUUC-Fso-038256	Fusarium solani	33.41	1.00e-55	210.00
IUUC-Gmo-038713	Gadus morhua	81.00	0.00e+00	778.00
IUUC-Ggr-039854	Gaeumannomyces graminis	31.49	4.00e-42	165.00
IUUC-Gga-041143	Gallus gallus	92.79	0.00e+00	902.00
IUUC-Gac-042129	Gasterosteus aculeatus	80.20	0.00e+00	798.00
IUUC-Gma-044273	Glycine max	43.89	2.00e-108	385.00
IUUC-Ggo-045262	Gorilla gorilla	90.78	0.00e+00	888.00
IUUC-Hsa-046036	Homo sapiens	90.78	0.00e+00	888.00
IUUC-Hvu-047442	Hordeum vulgare	42.90	2.00e-58	218.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	90.18	0.00e+00	850.00
IUUC-Lch-050105	Latimeria chalumnae	83.37	0.00e+00	832.00
IUUC-Lpe-050976	Leersia perrieri	43.66	2.00e-105	375.00
IUUC-Loc-052042	Lepisosteus oculatus	70.32	1.00e-176	612.00
IUUC-Lma-053143	Leptosphaeria maculans	34.20	4.00e-56	213.00
IUUC-Laf-053451	Loxodonta africana	88.65	0.00e+00	884.00
IUUC-Mcc-055786	Macaca mulatta	90.78	0.00e+00	888.00
IUUC-Meu-056161	Macropus eugenii	96.68	7.00e-139	486.00
IUUC-Mor-057215	Magnaporthe oryzae	31.95	1.00e-44	173.00
IUUC-Mpo-057419	Magnaporthe poae	30.21	2.00e-39	155.00
IUUC-Mtr-057756	Medicago truncatula	44.28	1.00e-105	376.00
IUUC-Mla-059085	Melampsora laricipopulina	38.38	1.00e-76	280.00
IUUC-Mvi-060441	Microbotryum violaceum	35.39	7.00e-64	237.00
IUUC-Mmr-061085	Microcebus murinus	90.78	0.00e+00	888.00
IUUC-Mdo-061804	Monodelphis domestica	90.98	0.00e+00	889.00
IUUC-Mmu-063608	Mus musculus	87.72	0.00e+00	877.00
IUUC-Mac-064972	Musa acuminata	43.66	6.00e-102	364.00
IUUC-Mpu-065700	Mustela putorius furo	90.38	0.00e+00	887.00
IUUC-Mlu-068223	Myotis lucifugus	89.46	0.00e+00	882.00
IUUC-Nfi-068504	Neosartorya fischeri	36.94	1.00e-69	256.00
IUUC-Ncr-068729	Neurospora crassa	35.43	7.00e-54	204.00
IUUC-Nle-069754	Nomascus leucogenys	90.78	0.00e+00	888.00
IUUC-Opr-070621	Ochotona princeps	89.98	0.00e+00	880.00
IUUC-Ont-071377	Oreochromis niloticus	80.20	0.00e+00	772.00
IUUC-Oan-073498	Ornithorhynchus anatinus	67.59	9.00e-109	385.00
IUUC-Ocu-074182	Oryctolagus cuniculus	88.54	0.00e+00	887.00
IUUC-Oba-075509	Oryza barthii	43.15	5.00e-106	377.00
IUUC-Obr-076480	Oryza brachyantha	43.78	1.00e-107	382.00
IUUC-Ogl-077052	Oryza glaberrima	43.15	5.00e-106	377.00
IUUC-Ogu-078919	Oryza glumaepatula	43.15	5.00e-106	377.00
IUUC-Oin-079357	Oryza indica	42.17	5.00e-99	354.00
IUUC-Olo-080376	Oryza longistaminata	42.80	3.00e-102	365.00
IUUC-Ome-081973	Oryza meridionalis	42.71	9.00e-102	363.00
IUUC-Oni-082849	Oryza nivara	43.15	2.00e-106	379.00
IUUC-Opu-083243	Oryza punctata	43.15	7.00e-106	377.00
IUUC-Oru-084613	Oryza rufipogon	43.04	2.00e-106	379.00
IUUC-Osa-085407	Oryza sativa	43.15	4.00e-106	377.00
IUUC-Ola-086566	Oryzias latipes	79.01	0.00e+00	761.00
IUUC-Olu-087757	Ostreococcus lucimarinus	40.00	1.00e-86	313.00
IUUC-Oga-089010	Otolemur garnettii	86.90	0.00e+00	844.00
IUUC-Oar-089638	Ovis aries	90.58	0.00e+00	887.00
IUUC-Ptr-091141	Pan troglodytes	90.78	0.00e+00	888.00
IUUC-Pan-092662	Papio anubis	90.78	0.00e+00	888.00
IUUC-Psi-093777	Pelodiscus sinensis	92.84	0.00e+00	772.00
IUUC-Pno-095115	Phaeosphaeria nodorum	34.86	2.00e-56	212.00
IUUC-Ppa-095841	Physcomitrella patens	44.28	6.00e-109	387.00
IUUC-Pfo-096390	Poecilia formosa	79.40	0.00e+00	772.00
IUUC-Pab-098250	Pongo abelii	91.86	0.00e+00	869.00
IUUC-Pop-099854	Populus trichocarpa	43.87	9.00e-107	380.00
IUUC-Pca-100553	Procavia capensis	90.18	0.00e+00	878.00
IUUC-Ppe-101383	Prunus persica	42.92	3.00e-99	355.00
IUUC-Pva-102189	Pteropus vampyrus	90.78	0.00e+00	887.00
IUUC-Pgr-103304	Puccinia graminis	35.56	3.00e-72	265.00
IUUC-Ptt-103984	Puccinia triticina	36.74	1.00e-77	283.00
IUUC-Pte-104385	Pyrenophora teres	32.75	2.00e-60	226.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	33.19	3.00e-61	228.00
IUUC-Rno-105581	Rattus norvegicus	90.18	0.00e+00	884.00
IUUC-Sha-107071	Sarcophilus harrisii	87.98	0.00e+00	882.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	30.14	1.00e-26	114.00
IUUC-Spo-108315	Schizosaccharomyces pombe	31.29	5.00e-34	138.00
IUUC-Ssl-108628	Sclerotinia sclerotiorum	35.24	1.00e-56	213.00
IUUC-Smo-109648	Selaginella moellendorffii	44.79	2.00e-110	392.00
IUUC-Sit-109873	Setaria italica	43.04	1.00e-105	377.00
IUUC-Sly-111673	Solanum lycopersicum	44.47	3.00e-100	358.00
IUUC-Stu-112125	Solanum tuberosum	44.26	2.00e-99	355.00
IUUC-Sbi-114696	Sorghum bicolor	41.33	1.00e-93	337.00
IUUC-Sre-115134	Sporisorium reilianum	31.62	4.00e-64	238.00
IUUC-Ssc-116260	Sus scrofa	90.58	0.00e+00	887.00
IUUC-Tgu-116533	Taeniopygia guttata	92.18	0.00e+00	899.00
IUUC-Tru-117800	Takifugu rubripes	79.20	0.00e+00	795.00
IUUC-Tsy-118980	Tarsius syrichta	84.96	0.00e+00	813.00
IUUC-Tni-120334	Tetraodon nigroviridis	79.58	1.00e-162	565.00
IUUC-Tca-121807	Theobroma cacao	43.96	3.00e-107	382.00
IUUC-Tre-121920	Trichoderma reesei	32.60	3.00e-55	208.00
IUUC-Tvi-122294	Trichoderma virens	31.95	7.00e-46	177.00
IUUC-Tae-125794	Triticum aestivum	44.51	4.00e-110	391.00
IUUC-Tur-126664	Triticum urartu	40.19	1.00e-102	366.00
IUUC-Tme-127026	Tuber melanosporum	33.83	2.00e-59	223.00
IUUC-Tbe-127582	Tupaia belangeri	92.71	1.00e-180	625.00
IUUC-Ttr-128313	Tursiops truncatus	90.38	0.00e+00	879.00
IUUC-Uma-129626	Ustilago maydis	33.20	1.00e-64	240.00
IUUC-Vda-129699	Verticillium dahliae	34.02	2.00e-60	226.00
IUUC-Vpa-130593	Vicugna pacos	92.76	0.00e+00	835.00
IUUC-Vvi-131668	Vitis vinifera	43.45	2.00e-106	379.00
IUUC-Xtr-132186	Xenopus tropicalis	85.05	0.00e+00	727.00
IUUC-Xma-133212	Xiphophorus maculatus	79.40	0.00e+00	770.00
IUUC-Zma-135662	Zea mays	43.66	5.00e-107	380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence